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Case Comprehensive Cancer Center Newsletter

February 15, 2010

CASE CCC IN THE NEWS

UH Case Medical Center Researchers Publish Promising Findings for Advanced Cervical Cancer
Genetic Engineering News - Feb 9, 2010
...shows a great deal of promise for cervical cancer patients who are at high risk for relapse and cancer-related death," says Charles Kunos, MD, ... "Cervical cancer affects half a million women worldwide each year," says Steven Waggoner, MD,...


MESSAGE FROM JOHN PINK AND AFSHIN DOWLATI– Pre-Clinical and Clinical Studies on IGF-1 Signaling

As members of the Developmental Therapeutics Program (DTP), we are polling CWRU faculty to identify those with interests and expertise in any aspect of the IGF-1 signaling pathway, particularly as it relates to cancer.

The DTP would like to initiate discussions and interactions that will result in the design and implementation of both pre-clinical and clinical projects to investigate the efficacy, mechanism of action, and potential biomarkers for a novel IGF-1R inhibitor, soon to be available for clinical trials.

We are interested in organizing a group of investigators who are willing to be involved directly, or indirectly, in the design and performance of studies that will culminate in the development of novel therapeutic regimens utilizing this new IGF-1R inhibitor, as either a single agent, or in combination with other treatment regimens. Investigators with preliminary data supporting novel concepts, or therapeutic combinations are particularly important to the success of this program.

We will be organizing an introductory meeting to discuss overall strategy and concepts within the few weeks, again, please make sure to contact Afshin (afshin.dowlati@case.edu) or John Pink (john.pink@case.edu) if you are interested in contributing to this effort.

Click here for more information.


FUNDING OPPORTUNITY– DOD Ovarian Cancer Research Program (OCRP) Translational Pilot Award

NEW for FY10, the OCRP Translational Pilot Award mechanism supports innovative translational research addressing a critical problem or question in ovarian cancer that will accelerate the movement of promising ideas toward clinical applications. The proposed research should provide a catalyst to challenge or expand current thinking and/or approaches to ovarian cancer. It must involve early-stage translation of an idea from the laboratory to the clinic, or from the clinic back to the laboratory. Observations that generate a translational pilot research idea may be derived from a laboratory discovery, literature review, population-based studies, novel findings from a clinical trial, or a clinician's firsthand knowledge of patients and anecdotal data. Preliminary data are not required, but are allowed. The strength of the proposal should be based on sound scientific rationale and logical reasoning.

Pre-Application Deadline: March 11
Application Deadline: June 10

Please click here for more information.


FUNDING OPPORTUNITY– James S. McDonnell 21st Century Research Awards

21st Century Research Awards are designed to support research projects with a high probability of generating new knowledge and insights. Projects submitted for funding consideration should be at an early, even preliminary stage of development, and should be intended to break new ground or to revisit commonly-held assumptions. Projects submitted should be sufficiently cross-disciplinary or heterodox to have a strong likelihood of influencing the development of new ways of thinking about important problems. All projects must qualify for one of the 21st Century Science Initiative's two program areas: Studying Complex Systems or Brain Cancer Research.

Deadline: March 17

For more information, please click here.


FUNDING OPPORTUNITY– Cancer Research Institute Investigator Awards

The Cancer Research Institute is accepting applications for Investigator Awards. These awards are not tied to any specific research project. Rather, as these scientists embark on their careers, the awards provide them the freedom to pursue promising lines of inquiry that their new responsibilities otherwise might not allow them to follow. The aim of the program is to provide flexibility and a degree of stability in what is essentially a make-or-break period in the scientist's life. Candidates must hold a doctoral degree and be a tenure-track Assistant Professor at the time of award activation. CRI has no citizenship restrictions, and research supported by the award may be conducted at medical schools and research centers in the United States or abroad.

Deadline: March 1

For details, please click here.


FUNDING OPPORTUNITY– Samuel Waxman Cancer Research Foundation

The Case CCC has been invited to submit ONE application for a Samuel Waxman Cancer Research Foundation Institute Without Walls grant. Investigators of the Foundation have long been interested in differentiation therapy of cancer- the notion that the cancer cell can be re-programmed to re-acquire aspects of normal cell differentiation including terminal cell division and programmed cell death. In 2010, the Foundation will offer several grants of up to $100,000 per year to fund novel research along these lines.

Applicants must be established investigators with a tenure-track or tenured appointment, holding as PI at least one grant from a major funding source, such as NIH, NSF, DOD or ACS. The applicant may hold a K08, K99/R00, or other major career transition grant, such as those from Burroughs Wellcome Foundation or HHMI. The goal of the program is to leverage existing cancer research expertise into translational and collaborative cancer research.

Please send a one-page proposal and biosketch to Bonnie West (bonnie.west@case.edu) TODAY, February 15. Completed applications are due to Waxman Foundation April 1.

For more information, please click here.


CALL FOR APPLICATIONS– K12 Clinical Oncology Research Training Program

The Case CCC invites applications for its two-year NCI-funded K12 Clinical Oncology Research Training Program, led by Stanton Gerson, MD, Director, and Alvin Schmaier, MD, Co-Director.

This career development program provides interdisciplinary training in clinical and translational oncology research for clinical oncologist who are interested in pursuing academic research careers as oncology physician scientists.

Application Deadline: February 28
Start Date: July 1

For more information and application materials, please click here.


CALL FOR APPLICATIONS – Komen Ohio 2010 Class of Pink Tie Guys

Susan G. Komen for the Cure® Northeast Ohio Affiliate is now accepting applications for its 2010 class of Pink Tie Guys. The program, which was introduced last year, features eight executives from our region who serve as Ambassadors for breast health. Case CCC Director Dr. Stan Gerson was a 2009 Pink Tie Guy.

By simply wearing a special Komen pink ribbon tie at community events, the men hope to spark conversations about the importance of early detection, the best protection against deadly breast cancer. This initiative is also aimed at engaging more men in the breast cancer movement and empowering them to be involved in women's health issues. The eight men are selected to represent the one in eight women who will be diagnosed with breast cancer in their lifetimes.

Candidates for the Pink Tie Guy program should have a personal connection to breast cancer and be willing to share the message of early detection. Komen will also consider a candidate's geographical location as representation of the 22 county service is important. Finally, a candidate's ability and willingness to leverage their sphere of influence to further Komen's promise to end breast cancer forever is important.

Application Deadline: March 10

Click here for more information.

EVENTS

**All events are open to anyone interested in attending

February 15

Pathology Seminar
Karen Dobos, PhD
Assistant Professor, Microbiology, Immunology and Pathology
Colorado State University
Topic: Portrait of a Pathogen: The Mycobacterium Tuberculosis Proteome in vivo
12:00 pm WRB 1413

SDIG Seminar
Xiaodong Bai, PhD
Postdoctoral Researcher, Entomology
Ohio State University
Topic: Identifying HEXIM1-Interaction Factor Binding Sites Using ChIP-Seq Data Analysis
2:30 pm WRB 1413


February 16

MSTP Winter Retreat Keynote Speaker
Owen Witte, MD
Professor, Microbiology, Immunology and Molecular Genetics
Director, Broad Stem Cell Research Center
University of California, Los Angeles
Topic: Imaging Cancer and the Immune Response
10:30 am - 12:00 pm WRB 1413

Immunology Seminar
Sachiko Sato
Assistant Professor, Research Center for Infectious Diseases
McGill University
Topic: Galectins in Innate Immunity: Dual Functions of Host Soluble Galactoside Binding Lectins
12:30 pm WRB 1413

Taussig Cancer Institute Special Seminar
Michael Stubblefield, MD
Assistant Professor, Rehabilitation Medicine
Cornell University
Topic: The Radiation Fibrosis Syndrome
5:00 pm R3-002/003 Cleveland Clinic


February 17

Grand Rounds
Lalitha Nayak, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: Platelet Functions – Hemostasis and Beyond
8:00 am Lerner B-151

Emerging Biotechnologies in Biomedical Research Seminar
Andras Nagy, PhD
Senior Investigator, Molecular Genetics
Samuel Lunenfeld Research Institute (Toronto, Canada)
Topic: Transposon-Mediated Pluripotent Stem Cell Induction
11:00 am WRB 1413

Cancer Biology Seminar
Tushar Patel, MB, ChB
Professor, Medicine- Gastroenterology
Director, Hepatology
Ohio State University Medical Center
Topic: Cholangiocarcinoma: from Pathogenesis to Therapy
11:30 am NE1-205 Cleveland Clinic

Emerging Biotechnologies in Biomedical Research Seminar
Andras Nagy, PhD
Senior Investigator, Molecular Genetics
Samuel Lunenfeld Research Institute (Toronto, Canada)
Topic: Understanding the Process of Reprogramming
4:00 pm WRB 1413


February 18

Cancer Trainee Seminar Series
Gina Bernardo
PhD Candidate, Keri Lab, Pharmacology
CWRU
Topic: The Role of FOXA1 in Mammary Gland Development and Its Implications in Breast Cancer
12:00 WRB 3-136

Neurosciences Seminar
Nathaniel Urban, PhD
Associate Professor, Biological Sciences
Carnegie Mellon University
Topic: Neuronal Diversity in the Olfactory Bulb
12:10 pm BRB 105

Tumor Signaling Metastasis Meeting
2:00 pm WRB 3-136

Developmental Therapeutics Meeting
5:00 pm WRB 2-136


February 19

Hem/Onc Fellows Seminar
Anita Schwandt, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Stephen Edge, MD
Professor, Oncology
Roswell Park Cancer Institute
Topic: Community-Wide Evaluation and Improvement of the Quality of Cancer Care: National Models Applied in Ohio
8:00 am R3/002-003 Cleveland Clinic

Cancer Biology
Todd Ridky, MD, PhD
Instructor, Dermatology
Stanford University
Topic: Invasive 3-Dimensional Organotypic Neoplasia from Multiple Normal Human Epithelia
10:30 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Amitabh Chak, MD
Professor, Medicine-Gastroenterology
CWRU/ UH
Topic: Barrett's Cancers: Environment and Genetics
12:00 pm BRB 105

Cancer Center Research in Progress Seminar
Sanford Markowitz, MD, PhD
Professor, Medicine-Hematology/Oncology
CWRU/ UH
Topic: New Approaches for Cancer Genetics Studies
4:00 pm WRB 3-136

more

For a complete listing of LRI seminars click here.


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case CCC Scientific Retreat
July 9-10
The Lodge at Sawmill Creek Resort


ADDITIONAL UPCOMING SEMINARS & EVENTS

caHUB Development Public Meetings
February 19 (Bethesda, MD) and March 1 (Los Angeles, CA); both meetings will also be videocast
Details

13th Annual Meeting of the Translational Research Cancer Centers Consortium
March 1-2
Blackwell Inn, Columbus, OH
Details

NCI 3rd Annual Biospecimen Research Network Symposium
March 24-25
Bethesda, Maryland
Details

AACR 101st Annual Meeting
April 17-21
Washington, DC
Details


NCI CANCER BULLETIN

Featured Article
Melanoma Drugs Have Unintended Effects in Some Tumors

Cancer Research Highlights
Symptoms of Ovarian Cancer May Not Help Early Detection

Trastuzumab Benefits Women with Locally Advanced, Inflammatory Breast Cancer

Tumor-targeting Antibodies Against Glycoproteins May Be Markers of Early Cancer

Gene Mutation Linked to Poor Survival in Children with Medulloblastoma

Guest Director's Update: Dr. Lenora E. Johnson, Director of NCI's Office of Communications and Education
Join the Cancer.gov Evolution


MARK YOUR CALENDARS– Oncomine Workshop

Mark your calendars for an Workshop on Thursday, March 4 at 2:00 pm in WRB 1413. Come hear presenter, Oncomine's Gary Daubresse, explain how this powerful software and database can benefit your proposal writing and cancer research. Light refreshments will be served. This workshop is presented by the Case CCC/Gene Expression and Genotyping Facility (GEGF) and ONCOMINE. Contact Patrick Leahy patrick.leahy@case.edu, 368-0761 with any questions.


FUNDING OPPORTUNITY— Title Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4)

NIH is accepting applications for the "Title Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas" (RC4) (RFA-OD-10-005).

This program will support projects that address research endeavors in specific areas that will benefit from significant three-year funds without the expectation of continued NIH funding beyond this period. The research supported by the program should have high short-term impact, and a high likelihood of enabling growth and investment in biomedical research and development, public health, and health care delivery.

This FOA solicits applications proposing to develop and implement critical research innovations in one or more of the following five thematic areas:

  1. Applying Genomics and Other High Throughput Technologies
  2. Translating Basic Science Discoveries into New and Better Treatments
  3. Using Science to Enable Health Care Reform
  4. Focusing on Global Health
  5. Reinvigorating the Biomedical Research Community

Only applications for projects that require $500,000 or more in total costs per year are expected to be considered for funding.

LOI Deadline: February 15 (requested, not required)
Proposal Deadline: March 15

For details, please click here.

Case CCC Leadership would like to review potential responses, and can assist in developing themes as responsive to the RFA.



CALL FOR APPLICATIONS– 2010 NASA Space Radiation Summer School

Applications are now being accepted for the 2010 NASA Space Radiation Summer School. Up to 15 students will be selected for the course to be held this summer at the Brookhaven National Laboratory (BNL) in Long Island, NY from May 20 – June 11. The goal of the course is to provide scientific and practical information to students and scientists who are either new to the NASA program or to charged particle radiobiology. At the completion of the summer school, students will have received the full complement of training required to conduct their own experiments at BNL.

Both foreign nationals and US citizens may apply to the program. All selected students must satisfy BNL and Department of Energy safety and security requirements in order to be admitted. Due to the intense nature of the course, applicants must demonstrate oral and written proficiency in the English language.

Deadline: February 28

For more information, please click here.


FACULTY CANDIDATE SEARCH– Associate Director for Basic Research

The Case CCC is currently accepting applications for the position of Associate Director for Basic Research. As we continue our search, we ask that people in the Cancer Center community encourage any qualified candidate to apply for the position. If you would like to nominate someone for the position, please contact Tracy Rehl (tracy.rehl@case.edu).

Click here to view the job description.


CASE CCC ON FACEBOOK AND LINKEDIN– Join Us!

We are always trying to foster communication and collaboration across the cancer center community any way that we can. The Case CCC has set up a page on Facebook and LinkedIn, so please become a fan of us on Facebook or join our group on LinkedIn, and encourage others to do so as well. Please help us spread the word.

We encourage you to post events, relevant news articles, items of discussion, etc… Your feedback is appreciated!


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Leukemia Research Foundation Hollis Brownstein Research Grants Program
Deadline: February 15

Ohio Cancer Research Associates
Deadline: February 19

American Institute for Cancer Research (AICR) Investigator Initiated Grants
Deadline: February 19

American Institute for Cancer Research (AICR) Matching Grants
Deadline: February 19

American Institute for Cancer Research (AICR) Postdoctoral Awards
Deadline: February 19

Hope Street Kids
Deadline: March 1

ACS Cancer Research Fellowship
Deadline: March 3

DOD Prostate Cancer Research Program (PCRP) Idea Development Awards
Pre-Application Deadline: March 3
Application Deadline: June 9

DOD Prostate Cancer Research Program (PCRP) Synergistic Idea Development Awards
Pre-Application Deadline: March 3
Application Deadline: June 9

CanLiv's 2010 Translational Research Grants Program
Deadline: March 5

DOD Prostate Cancer Research Program (PCRP) Exploration–Hypothesis Development Award
Pre-Application Deadline: March 10
Application Deadline: March 31

DOD Prostate Cancer Research Program (PCRP) Impact Award
Pre-Application Deadline: March 10
Application Deadline: March 31

DOD Ovarian Cancer Research Program (OCRP) Idea Award
Pre-Application Deadline: March 11

DOD Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award
Pre-Application Deadline: March 11
Application Deadline: August 5

DOD Peer Reviewed Medical Research Program (PRMRP) Concept Award
Pre-Application Deadline: March 25
Application Deadline: April 8

DOD Prostate Cancer Research Program (PCRP) Exploration–Hypothesis Development Award
Application Deadline: March 31


DOD Prostate Cancer Research Program (PCRP) Impact Award
Application Deadline: March 31

DOD Peer Reviewed Medical Research Program (PRMRP) Concept Award
Application Deadline: April 8

DOD Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Awards
Pre-Application Deadline: April 22
Application Deadline: May 13

DOD Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award
Pre-Application Deadline: April 22
Application Deadline: May 13

DOD Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award
Application Deadline: May 13

DOD Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Awards
Application Deadline: May 13

IOTF Oncology Product Research/Review Fellows
Deadline: May 30

DOD Prostate Cancer Research Program (PCRP) Idea Development Awards
Application Deadline: June 9

DOD Prostate Cancer Research Program (PCRP) Synergistic Idea Development Awards
Application Deadline: June 9

DOD Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award
Application Deadline: August 5

IOTF Cancer Prevention Fellows
Deadline: September 1

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Delays in Grant Application Submission due to Widespread Winter Storm (NOT-OD-10-061)

UPDATE TO RFA-AE-10-001: OS Recovery Act Limited Competition: Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18) - Announcing Additional Funds Availability and Clarifying Eligible Institutions/Organizations (NOT-AE-10-001)

ARRA OS Recovery Act 2009 Limited Competition: Comparative Effectiveness Delivery System Evaluation Grants (R01) (RFA-HS-10-012)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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