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Case Comprehensive Cancer Center Newsletter

December 13, 2010


Philip H. Howe, PhD Appointed Case CCC Associate Director for Basic Research at the LRI

Dr. Howe The Case CCC announces the appointment of Philip H. Howe, PhD, Staff in the Cancer Biology Department of the Lerner Research Institute, to the position of Case CCC Associate Director for Basic Research at the LRI. Janet Houghton, PhD, Chair of the Department of Cancer Biology, remains an active member of our scientific programs and provides her leadership and Cancer Center advocacy as department chair.

Phil is an active investigator in cancer signaling including TGF–beta, Wnt, FoxO3 and related pathways. He is organizing a TGF–beta multi investigator effort.

Please contact Phil for strategic advice if you plan to form a multi–investigator working group. The Cancer Center will support these activities, with assistance for meetings, collaborations and grant applications. Likewise, with these initiatives, Phil will recommend areas for investment to the Cancer Center Senior Leaders and will assist in developing RFAs for focused research ideas.

Please join me in congratulating Phil and, when he calls on you, offer your enthusiastic support and creative ideas for cutting edge cancer research. He and I are available to meet with members any time.

Thank you for your commitment to cancer research at the Case Comprehensive Cancer Center.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center

Click here to read the full announcement.


Cancer Doctors Urge Caution Over Taking Daily Aspirin
Plain Dealer - Dec 8, 2010
... can be potentially harmful -- this isn't a trivial drug," said Dr. Derek Raghavan, chairman of the Taussig Cancer Institute at the Cleveland Clinic. ...Dr. Neal Meropol, chief of the division of hematology and oncology at University Hospitals Case Medical Center, says the study adds to a growing body of ...

NIH Awards $6.4M to Case Western Reserve School of Medicine Researchers
CWRU News Center

Case Western Reserve University School of Medicine faculty members are reaping the rewards of funding from the National Institutes of Health (NIH), in the form of grants and contracts. The funding totals more than $6.4 million for four different research endeavors.

Researchers Mark Chance, PhD, professor of physiology and biophysics, director of the Center for Proteomics and Bioinformatics, and interim chair of the Department of Genetics, and W. Henry Boom, MD, professor of medicine and director of the Tuberculosis Research Unit, are working to tackle the easily transmissible, and often deadly, Mycobacterium tuberculosis (MTB)...

The Case Comprehensive Cancer Center was awarded a new $2.5 million grant from the National Cancer Institute (NCI) to evaluate the introduction and expression of the modified MGMT gene in hematopoietic stem cells in an effort to improve efficacy of chemotherapy for glioblastoma multiforme (GBM), the most common and most aggressive type of primary brain tumor in humans...

This trial will build on the more than two decades of research by Stanton Gerson, MD, principal investigator of the study, the Asa and Patricia Shiverick-Jane Shiverick (Tripp) Professor of Hematological Oncology, and director of the NCI-designated Case Comprehensive Cancer Center. ..

In another example of a team science approach, members of the Case Comprehensive Cancer Center have been tapped to join an important NCI multisite prospective study of all grade II, III and IV glioma patients within the state... researchers will be part of The Cancer Genome Atlas (TCGA) Project, which is a national comprehensive and coordinated effort to accelerate understanding of the genetics of cancer using innovative genome analysis technologies... Under the direction of principal investigator Jill Barnholtz-Sloan, PhD, assistant professor of general medical sciences, newly diagnosed patients with gliomas will be prospectively accrued from her Ohio Brain Tumor Study (OBTS), a multisite study within Ohio...

Case Western Reserve faculty have worked closely with TCGA for many years; Barnholtz-Sloan and Andrew Sloan, MD, the Peter D. Cristal Chair in Neurosurgery at the School of Medicine and director of the Brain Tumor and Neuro-Oncology Center at UHCMC are active members of the TCGA Glioma Disease Expert Working groups... In addition, Neal Meropol, MD, Chief, Division of Hematology and Oncology, Case Western Reserve University School of Medicine and UH Case Medical Center and Associate Director for Clinical Research, Case Comprehensive Cancer Center, is a member of the TCGA Colorectal Cancer Disease Expert Working group.

The Department of Bioethics was awarded a $2.5 million continuation grant from the National Human Genome Research Institute that will extend funding for its Center for Genetic Research Ethics and Law (CGREAL) for an additional four years... It is co-directed through the collaborative partnership of Patricia Marshall, PhD, professor of bioethics, and Richard Sharp, PhD, director of research in the Department of Bioethics at the Cleveland Clinic. The mission of the CGREAL is to conduct transdisciplinary studies of ethical and societal issues in human genetic research and the introduction of new genetic technologies into patient care and public health; additionally it seeks to prepare young scholars for successful careers in Ethical, Legal, Social Issues (ELSI) research...


Basic, Clinical, or Translational Human Tissue Based Cancer Research Project Awards

The Case Comprehensive Cancer Center is pleased to announce the recipients of pilot funding to support basic, clinical or translational human tissue based research. The purpose of these awards is to foster collaborations and to promote and increase institution-wide capacity and competitiveness in research.

James Jacobberger, PhD: Cell Signaling as an Acute Myeloid Leukemia Biomarker

Ruth Keri, PhD: Follistatin as an Inhibitor of Metastatic Progression in Breast Cancer

Andrew Sloan, MD: Targeted Proteomics to Predict Differential Glioblastoma Survival

Jill Barnholtz-Sloan, PhD: Development of Human Brain Tumor Tissue Microarrays

Ge Jin, PhD: Human β–defensins as Novel Biomarkers for Precancerous Lesions of Colorectal Cancer

Cheryl Thompson, PhD: A Biorepository for Research in Lung Cancer Risk, Detection and Prognosis

William Schiemann, PhD Oncogenic TGF–β Effectors are Novel Biomarkers for Recurrent Cancer



**All events are open to anyone interested in attending

December 13

December 14

Cancer Biology Invited Speaker Seminar
Brian Rubin, MD, PhD
Staff, Anatomic Pathology and Molecular Genetics
Cleveland Clinic
Topic: Therapeutic Implications of Autophagy-mediated Cell Survival in Gastrointestinal Stromal Tumor After Treatment With Imatinib Mesylate
11 am NC1-202 Cleveland Clinic

Immunology Seminar
W. Henry Boom, MD
Professor and Vice Chair for Research
Department of Medicine
Topic: TB Vaccine Development: Battling an Immune Manipulating, Chronic Pathogen
12 pm WRB 1-413

Oncomine Workshop
2-3 pm SOM E324
Contact Patrick.Leahy@case.edu to reserve your spot.

December 15

Hematology and Oncology Division Research Conference
Cheng-Kui Qu, MD, PhD
Associate Professor, Medicine- Hem/Onc
Topic: Tyrosine Phosphatase PTPN11 (SHP2) in Leukemogenesis: What Have We Learned from Mouse Models
8 am Lerner Tower B-151

Immunology Invited Speaker Seminar Series
Anton Gorbachev, PhD
Instructor, Immunology
CWRU/ Cleveland Clinic
Topic: CXCL9/Mig-Dependent Suppression of Cutaneous Tumors (Update)
12 pm NC1-202 Cleveland Clinic

Developmental Therapeutics Program Meeting
5 pm WRB 2-136

December 16

December 17

Special Seminar
Richard Lopez, MD
Associate Professor, Div. of Hematology and Oncology
Director of Translational Research, BMT Program
University of Alabama at Birmingham
Topic: Allogeneic Hematopoietic Stem Cell Transplantation: A Platform for the Next Generation of Cell-based Immunotherapies for the Treatment of Malignant Diseases
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Timothy Gilligan, MD
Assistant Professor, Solid Tumor Oncology
CWRU/ Cleveland Clinic
Topic: Establishing Trust, Effectively Communicating with Patients and Families
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Man-Sun Sy, PhD
Professor, Pathology
Topic: Prion, Filamin A and Inegrin in Tumor Cell Migration and Invasion
12 pm BRB 105

Cancer Center Research in Progress Seminar
Reema Wahdan-Alaswad
Graduate Student, Danielpour Lab
Topic: Control of BMP Signaling By mTOR in Prostate Cancer Cells
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar



Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriott Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham in Washington, DC
Abstract Deadline: December 16

Cancer Health Disparities Summit 2011
July 13-15, 2011
Bethesda North Marriott Hotel in Rockville, Maryland

NCI Website on Transforming the NCI Clinical Trials Enterprise

The Institute of Medicine (IOM) issued a report in April 2010 about reinvigorating the NCI Cooperative Group Program. The NCI met with the Chairs for the US Cooperative Groups that conduct clinical trials on November 29 in Bethesda, MD, to begin to discuss the issues raised by the IOM as well as other stakeholders in the NCI Clinical Trials Enterprise.

The NCI has now launched a website to address general issues about transforming the Clinical Trials Enterprise and to begin the process of collecting data/input on these issues more specifically with various stakeholders over the next six months. The website can be accessed at: http://transformingtrials.cancer.gov/. The link to the information on transforming the program is listed under NCI's Clinical Trials Cooperative Group Program: Infrastructure in Transition. NCI will be making updates to the website as we move forward with this process. In the interim, if you have any questions or concerns, please contact: Meg Mooney, MD, Chief, NCI Clinical Investigations Branch at mooneym@ctep.nci.nih.gov.


ACS Joseph S. Silber Student Research Fellowship

The American Cancer Society East Central Division, Ohio, offers the Joseph S. Silber Student Research Fellowship to undergraduate and graduate science majors and first-year medical students to encourage their participation in a sponsor's team-oriented project in cancer research at a Cleveland-area institution. The purpose is to expose students early in their careers to the problem of cancer in hopes that cancer research will become a lifelong interest and and pursuit.

Deadline: January 28, 2011


Second Oncomine Workshop

The Second Oncomine workshop will occur on Tuesday December 14 from 2-3 pm in SOM E324. To derive any benefit from the workshop, you must be registered with www.oncomine.org. We will revisit the basics covered in the first workshop, and extend ourselves a little further. Don't miss this opportunity to learn how to make your next grant proposal look better. Places are limited contact Patrick.Leahy@case.edu to reserve your spot.

Cancer Imaging Nanotechnology Sub-group Meeting

Drs. Jim Basilion and Zhenghong Lee would like to extend an invitation to the Case Comprehensive Cancer Imaging Program members to attend the next meeting of the Cancer Imaging Nanotechnology Sub-Group. The meeting will take place January 10 from 4-5 pm in the CCIR Conference Room, Wearn B-37. Please contact Marianne Sperk with any questions.


AACR Basic Cancer Research Fellowships
Deadline: December 13

AACI Translational Cancer Research Fellowship
Deadline: December 17

Landon Foundation-AACR INNOVATOR Award for International Collaboration
Deadline Extended: December 20

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research
Deadline Extended: December 20

Landon Foundation-AACR INNOVATOR Award for Research in Personalized Cancer Medicine
Deadline Extended: December 20

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Prostate Cancer Foundation (PCF) 2011 Creativity Awards
Deadline: January 13, 2011

Interinstitutional Basic, Clinical and Translational Research Projects in Cancer
Deadline: January 18, 2011

AICR Research Grant Program
External LOI Deadline: January 25, 2011
External Full Application Deadline: May 2, 2011

AICR Investigator Initiated Grants (IIGs)
LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

AICR Matching Grants
LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

AICR Postdoctoral Awards (PDAs)
LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

SU2C Innovative Research Grants
Application Deadline: January 31, 2011

2011 Jane Coffin Childs Memorial Fund for Medical Research Fellowship Awards
Deadline: February 1, 2011

Leukemia Research Foundation
Deadline: February 15, 2011

James S. McDonnell Foundation 21st Century Science Research Awards
Deadline: March 15, 2011

AICR Investigator Initiated Grants (IIGs)
Full Application Deadline: May 2, 2011

AICR Matching Grants
Full Application Deadline: May 2, 2011

AICR Postdoctoral Awards (PDAs)
Full Application Deadline: May 2, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice to Highlight Applicability of Current NIH Funding Opportunity on Methodology and Measurement for Multiple Chronic Health Conditions (NOT-OD-11-020)

Reminder: Beginning January 1, 2011, the NIH Will Require Use of xTrain for the Electronic Submission of Appointment Forms and/or Termination Notices for Institutional Research Training and Career Awards, Individual Fellowships and Research Education Awards (NOT-OD-11-026)

New Page Limits for NIH Individual Career Development (K) Award Applications: Due Dates After January 7, 2011 (NOT-OD-11-027)

Pre-Solicitation Announcement: The Lasker Clinical Research Scholars Program (NOT-OD-11-030)

NCI Will Participate on PAR-10-257, Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (D43) (NOT-CA-11-004)

Advanced In Vivo Imaging to Understand Cancer Systems (R01) (RFA-CA-11-005)

Translating Basic Behavioral and Social Science Discoveries into Interventions to Improve Health-Related Behaviors (R01) (PA-11-063)

Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01) (PA-11-073)

Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R21) (PA-11-074)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.