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Case Comprehensive Cancer Center Newsletter

December 6, 2010


This Year at the ASH Annual Meeting

Members of the Case Comprehensive Cancer Center have made major contributions to the field of hematology and oncology, and were recognized at this year's ASH Annual Meeting in Orlando.

Last week, we provided a list of the abstract titles and today, some of the presentations have yet to be given. I would like to recognize the many labs and clinical groups who made presentations in hematology, hematological malignancies, and stem cell transplantation. Of note, for the first time in at least 30 years, and I suspect, ever, TWO of the six abstracts presented in the ASH plenary session were from Cancer Center members. Anna Jankowska from the lab led by Jaroslaw Maciejewski, MD, PhD gave a wonderful talk to over 10,000 members of ASH on Impaired Hydroxylation of 5-Methylcytosine In TET2 mutated Patients with Myeloid Malignancies. They were the first to show the frequency of TET2 mutations in hematological malignancies – AML and MDS – and to show how loss of TET2 alters the genomic methylation patterns by decreasing the conversion of Methylcytosine to Hydroxymethylcytosine, giving rise to altered gene expression that provides epigenetic changes that appear essential for the function of these hematologic malignancies.

The second plenary abstract was from the lab of Ed Plow, PhD and was presented by Elzbieta Pluskota, PhD, titled The Integrin Co-Activator Kindlin-2 Plays a Critical Role In Angiogenesis and Blood Vessel Integrity. Ed has studied the integrin binding protein Kindlin-2, and has discovered its role in vasculogenesis with very clear data on the function it has in endothelial cells in mediating proper vascular development. Kindlin-2 mutation results in loss of function, loss of endothelial cell migration, and a clear impact in nonvascular development. This opens the door for further studies in congenital diseases and the targeting of this molecule as an antiangiogenesis strategy.

Many other outstanding presentations are ongoing through Tuesday.

Drs. Eric Hsi, Mikkael A. Sekeres, Jaroslaw Maciejewski, and Hillard Lazarus deserve to be singled out for their multiple abstracts representing our institutions.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center


Just Breathe: Body Has A Built-In Stress Reliever
NPR - Gretchen Cuda - Dec 6, 2010
Mladen Golubic, a physician in the Cleveland Clinic's Center for Integrative Medicine, says that breathing can have a profound impact on our physiology and ...

Glaxo Fails to Win Panel's Backing to Expand Avodart for Cancer
Bloomberg - Dec 1, 2010
... what risk we will accept," said panel member Mikkael Sekeres, associate professor of medicine at the Cleveland Clinic Taussig Cancer Institute in Ohio. ...

R. Livingston Ireland's effort helped create UH's Cancer Center
Plain Dealer - Nov 30, 2010
"Because of his political clout, he was able to get the whole process started," said oncologist Dr. Stanton Gerson, who joined UH in 1983 and has served as director of UH's cancer center since 2004...

Jane and Lee Seidman Donate $42 Million to University Hospitals for Cancer Center
PR Newswire - Nov 30, 2010
"Jane and Lee's inspirational gift to University Hospitals has created a lasting legacy in Northeast Ohio," says Stan Gerson, MD, Director of the newly named UH Seidman Cancer Center. "UH has had a renowned cancer program dating back to our hospital's earliest days and the Seidman Cancer Center will build upon that strong foundation to further establish our position as one of the premier cancer programs in the nation."..."We are so grateful to Liv Ireland for his impact in helping to secure funding which was catalytic in advancing our nationally ranked cancer center," says Nathan Levitan, MD, President of the UH Seidman Cancer Center.


Please join us in welcoming the newest members of the Case CCC:

Fadi Abdul-Karim, MD
Professor, Pathology
Cancer Cell Signaling Program

Kenneth Cummings, MD
Assistant Professor, Anesthesiology
Cancer Genetics Program

Jung-won Lim, PhD
Assistant Professor, Social Work
Aging-Cancer Research Program

Nicole Steinmetz, PhD
Assistant Professor, Biomedical Engineering
Cancer Imaging Program


Applied Biostatistics in Clinical Research Course

The CTSC is pleased to offer a free 9-week seminar series on applied biostatistics in clinical research. Dr. Mark Schluchter, Professor of Epidemiology & Biostatistics and Director of the Biostatistics Core Facility, will teach the course Wednesdays from 4-5:30 pm, starting January 12, 2011. Click here to register for the course of for additional information.


AACI Translational Cancer Research Fellowship

Applications are now open for the inaugural AACI Translational Cancer Research Fellowship. This $50,000 one-year non-renewable grant will support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution.

Only ONE application per institution. Anyone interested in applying should send an abstract to tld6@case.edu by Wednesday, December 8.

External Deadline: December 17

Interinstitutional Basic, Clinical and Translational Research Projects in Cancer

The Case CCC will provide seed money to foster collaborations and promote and increase institution-wide capacity and competitiveness in basic, clinical or translational research that is aligned with the Cancer Center Scientific Programs and spans the institutions of the Case CCC. 2-3 awards of $75,000 - $100,000 will be made.

Faculty at all levels with interests in cancer research are encouraged to apply. Proposals require a minimum of two PIs: one from Case/UH and one from Cleveland Clinic. Proposals must involve new collaborative work with no joint publications or grants related to the current project. Applications will be submitted through http://webgrants.case.edu.

Deadline: January 18, 2011

Complete information is available on the Cancer Center website.

James S. McDonnell Foundation: 21st Century Science Initiative

The James S. McDonnell Foundation announces updated program descriptions and application guidelines for its 21st Century Science Initiative Research Awards. These awards support investigator-initiated research in two topical areas: Studying Complex Systems and Brain Cancer Research.

Deadline: March 15, 2011

AICR Research Grant Program

The AICR Research Grant Program encourages innovative research on food, nutrition, physical activity and weight management in relation to cancer prevention, treatment, and survivorship. AICR offers three types of research grants: Investigator Initiated Grants (IIGs), Matching Grants, and Postdoctoral Awards (PDAs).

All applications must bear the signature of the official head of the organization or that of a designee, since grants are not made to individual researchers, but to the relevant institution.

External LOI Deadline: January 25, 2011
External Full Application Deadline: May 2, 2011

AACR Colorectal Cancer Coalition-AACR Fellowship, in memory of Lisa Dubow

The Colorectal Cancer Coalition-AACR Fellowship, in memory of Lisa Dubow is a one‐year grant of $45,000 to support the salary and benefits of the fellow. Research projects are restricted to translational or clinical cancer research that has an ultimate goal of developing or improving therapeutic interventions for patients with metastatic colorectal cancer. It is anticipated one Fellowship will be funded.

*Extended* Application Deadline: December 8



**All events are open to anyone interested in attending

December 6

Pathology Research Seminar
Hyoung-Gon Lee, PhD
Instructor, Pathology
Topic: Cell Cycle Re-Entry in Neurodegeneration
12 pm WRB 1-413

December 7

December 8

Hematology and Oncology Division Research Conference
Afshin Dowlati, MD
Associate Professor, Div. of Hem/Onc
Topic: Treating Non Small Cell Lung Cancer in the Era of Molecular Therapeutics
8 am Lerner Tower B-151

Department of Genetics, Office of Graduate Education, Minority Graduate Education Student Organization, and PREP Program Seminar
Guillermina Lozano, PhD
Professor and Chair, Genetics
MD Anderson Cancer Center
Topic: Modulating p53 Activity for Better or for Worst
11 am BRB 105

Immunology Invited Speaker Seminar Series
Steven F. Ziegler, PhD
Benaroya Research Institute
Topic: FOXP3, TSLP, and the Regulation of Immunity and Inflammation
12 pm NC1-202 Cleveland Clinic

Pathology Graduate Student Seminar
Wataru Kudo
Smith Lab, Pathology
Topic: The Role of Neuronal Cell Cycle in Alzheimer's Disease
12 pm WRB 1-413

NCRM Seminar
Saba Valadkhan, MD, PhD
Assistant Professor, RNA Molecular Biology
Topic: Reprogramming of Mesodermal Cells into Neurons by a Long Non-Coding RNA
4:30 pm NA5-08 Cleveland Clinic

December 9

Biochemistry Seminar
Cam Patterson, MD
Professor, Cardiovascular Medicine
University of North Carolina
Topic: Signaling Events in Endothelial Cells and Angiogenesis
12 pm SOM W428

Neurosciences Seminar
Ben Strowbridge, PhD
Associate Professor, Neurosciences
Topic: Role of Cortical Input in Governing Local Circuit Processing in the Olfactory Bulb
12:10 pm BRB 105

Biochemistry Seminar
Hsiu-Ming Shih, PhD
Research Fellow
Institute of Biomedical Sciences
Topic: Structural and Functional Aspects of Daxx in Wrestling with SUMO
2:45 pm SOM W428

Cell Death Regulation Program Meeting
Lili Liu, PhD: Synthetic Lethality: A New Therapeutic Strategy for the Treatment of CLL Disease
Clark Distelhorst, PhD: Novel Concepts About the Role of Bcl-2 in CLL
Alex Almasan, PhD: TBD
4-6 pm WRB 3-136

December 10

Hematology and Oncology Fellows Conference
Rami Manochakian, MD
Greg Manson, MD
Fellows, Div. of Hem/Onc
Topic: Secondary MGUS: A Matter of Undetermined Significance
8 am Wearn 137

Cell Biology Seminar Series
Suneel Apte, MBBS, D.Phil
Associate Professor, Biomedical Engineering
CWRU/ Cleveland Clinic
Topic: Cell Biology of Provisional Extracellular Matrix-Insights from Mouse Genetics
10 am NC1-202 Cleveland Clinic

Cancer Center Research in Progress Seminar
Zhanwen Du, PhD
Postdoctoral Scholar, Wang Lab
Topic: DNMT1 Stability Is Regulated By Protein Coordinating De-ubiquitination and Acetylationdriven Ubiquitination
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


Cancer Center Seminar Series
December 17
12 pm BRB 105
Man-Sun Sy, PhD
Professor, Pathology
Topic: Prion, Filamin A and Inegrin in Tumor Cell Migration and Invasion


Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriott Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham in Washington, DC
Abstract Deadline: December 16

Cancer Health Disparities Summit 2011
July 13-15, 2011
Bethesda North Marriott Hotel in Rockville, Maryland


Cancer Imaging Nanotechnology Sub-group Meeting

Drs. Jim Basilion and Zhenghong Lee would like to extend an invitation to the Case Comprehensive Cancer Imaging Program members to attend the next meeting of the Cancer Imaging Nanotechnology Sub-Group. The meeting will take place January 10 from 4-5 pm in the CCIR Conference Room, Wearn B-37. Please contact Marianne Sperk with any questions.

Second Oncomine Workshop

The Second Oncomine workshop will occur on Tuesday, December 14 from 2-3 pm in SOM E324. To derive any benefit from the workshop, you must be registered with www.oncomine.org. We will revisit the basics covered in the first workshop, and extend ourselves a little further. Don't miss this opportunity to learn how to make your next grant proposal look better. Places are limited contact Patrick.Leahy@case.edu to reserve your spot.

Clinical Assay Development Program Workshop

Registration is open for a December 14 workshop on the NCI's new Clinical Assay Development Program (CADP), which aims to bridge the gap between promising research-based assays under development and validated, clinically useful cancer diagnostic tests. The CADP will assess and advise on how to develop an assay further and offer services to optimize analytical performance and establish clinical validity. This effort will allow the clinical utility of the assay and its diagnostic significance to be evaluated in well-designed clinical studies. This is not a grant program but provides access to services for clinical assay development. Applications for CADP resources will be accepted early in 2011.

Workshop participants will have an opportunity to learn more about the Clinical Assay Development Program, and to provide input on improving this resource. A description of what the CADP offers, who is eligible to apply, and how the program will function will be discussed. Click here to register. Registration open through December 6. Space at the workshop is limited to 200 attendees.


Special Issue: Global Collaboration

Where Science Meets Culture: The Art of Health Diplomacy

In Bangladesh, Developing Models for Cancer Care

The Cancer Expert Corps: An Idea for Building Human Capital

Cancer Communicators in Latin America Get Support at NCI Workshop

Considering Culture When Providing Cancer Care

NCI's International Cancer Research Resources

Prostate Cancer Hormone Treatments May Raise Risk of Colorectal Cancer

Strategy to Screen for Lynch Syndrome May Save Lives and Be Cost Effective

Anemia Drug May Interfere with Trastuzumab's Anticancer Effects

Possible Causes of Resistance to Melanoma Drug Reported

Radiation Treatment for Head and Neck Cancer May Produce Hearing Loss

FDA Update

CMS Update

Cancer.gov Update



Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

AACR Basic Cancer Research Fellowships
Deadline: December 13

AACI Translational Cancer Research Fellowship
Deadline: December 17

Landon Foundation-AACR INNOVATOR Award for International Collaboration
Deadline Extended: December 20

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research
Deadline Extended: December 20

Landon Foundation-AACR INNOVATOR Award for Research in Personalized Cancer Medicine
Deadline Extended: December 20

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Prostate Cancer Foundation (PCF) 2011 Creativity Awards
Deadline: January 13, 2011

AICR Investigator Initiated Grants (IIGs)
LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

AICR Matching Grants
LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

AICR Postdoctoral Awards (PDAs)
LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

SU2C Innovative Research Grants
Application Deadline: January 31, 2011

2011 Jane Coffin Childs Memorial Fund for Medical Research Fellowship Awards
Deadline: February 1, 2011

Leukemia Research Foundation
Deadline: February 15, 2011

AICR Investigator Initiated Grants (IIGs)
Full Application Deadline: May 2, 2011

AICR Matching Grants
Full Application Deadline: May 2, 2011

AICR Postdoctoral Awards (PDAs)
Full Application Deadline: May 2, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Correction in Key Dates for PAR-10-283, Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01) (NOT-CA-11-002)

Developmental Pharmacology (R01) (PAR-11-057)

Developmental Pharmacology (R03) (PAR-11-058)

Developmental Pharmacology (R21) (PAR-11-059)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.