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Case Comprehensive Cancer Center Newsletter

November 29, 2010


Why Family Medical History is Key
Newsweek - Nov 14, 2010
... do – or indirectly but in context, which family medical history provides, points out Charis Eng of the Genomic Medicine Institute of the Cleveland Clinic ...


Cancer Center Presentations

The upcoming American Society of Hematology (ASH) Annual Meeting, December 4-7, will feature updates on groundbreaking research. We are pleased to have research conducted by Case CCC members well represented at the poster sessions. Click here to view a listing of all Cancer Center abstracts.

Also, please make an effort to attend the 9:30 am session on Saturday, December 4, where Dr. Keith McCrae will present Platelets In Pregnancy – Numbers and Function.

Congratulations to all participants!


Insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTOR Signaling
Wahdan-Alaswad RS, Song K, Krebs TL, Shola DT, Gomez JA, Matsuyama S, Danielpour D.
Cancer Res. 2010 Nov 9.

Ten-Year Outcomes: The Clinical Utility of Single Photon Emission Computed Tomography/Computed Tomography Capromab Pendetide (Prostascint) in a Cohort Diagnosed with Localized Prostate Cancer
Ellis RJ, Kaminsky DA, Zhou EH, Fu P, Chen WD, Brelin A, Faulhaber PF, Bodner D
Int J Radiat Oncol Biol Phys. 2010 Oct 18.

Low-dose abdominal radiation as a docetaxel chemosensitizer for recurrent epithelial ovarian cancer: A phase I study of the Gynecologic Oncology Group
Kunos CA, Sill MW, Buekers TE, Walker JL, Schilder JM, Yamada SD, Waggoner SE, Mohiuddin M, Fracasso PM
Gynecol Oncol. 2010 Nov 12.

Higher Biologically Effective Dose of Radiotherapy is Associated with Improved Outcomes for Locally Advanced Non-Small Cell Lung Carcinoma Treated with Chemoradiation: An Analysis of the Radiation Therapy Oncology Group
Machtay M, Bae K, Movsas B, Paulus R, Gore EM, Komaki R, Albain K, Sause WT, Curran WJ
Int J Radiat Oncol Biol Phys. 2010 Oct 25.

A Phase II Study of Radiotherapy and Concurrent Paclitaxel Chemotherapy in Breast-Conserving Treatment for Node-Positive Breast Cancer
Chen WC, Kim J, Kim E, Silverman P, Overmoyer B, Cooper BW, Anthony S, Shenk R, Leeming R, Hanks SH, Lyons JA
Int J Radiat Oncol Biol Phys. 2010 Oct 29.


Cell Death Regulation Program Meeting

The Cell Death Regulation Program (Program 2) will continue its monthly research meetings. The next meeting with be Thursday, December 9 from 4-6 pm in Wolstein Research Building 3-136. Refreshments will be provided. Please contact Kristin Waite with any questions.

Lili Liu, PhD: Synthetic Lethality: A New Therapeutic Strategy for the Treatment of CLL Disease
Clark Distelhorst, PhD: Novel Concepts About the Role of Bcl-2 in CLL
Alex Almasan, PhD: TBD

Cancer Center Seminar Series

The next Cancer Center Seminar Series is scheduled for Friday, December 17 at 12 pm in BRB 105. Dr. Man-Sun Sy, Professor of Pathology at CWRU, will present Prion, Filamin A and Inegrin in Tumor Cell Migration and Invasion.


Leukemia Research Foundation

The Leukemia Research Foundation is now accepting applications for the 2011-2012 funding cycle. Preference will be given to proposals that focus on leukemia, lymphoma and MDS. The Leukemia Research Foundation currently funds new investigator grants only. New investigators are considered to be within seven years of their first independent position; years as a resident physician, fellow physician, or post-doctoral fellow are considered to be training years.

Deadline: February 15, 2011

AICR Research Grant Program

The AICR Research Grant Program encourages innovative research on food, nutrition, physical activity and weight management in relation to cancer prevention, treatment, and survivorship. AICR offers three types of research grants:

Investigator Initiated Grants (IIGs) are awarded to researchers at not-for-profit universities, hospitals or research centers. These three-year grants will be awarded to support the start up of epidemiologic or intervention studies requiring additional time. The PI must have a PhD, MD or equivalent degree and be a research staff or faculty member at a nonprofit academic or research institution at the level of an assistant professor (or its equivalent) or higher.

Matching Grants follow the same eligibility requirements as Investigator Initiated Grants. AICR is interested in working with for-profit corporations and/or not-for profit organizations in funding cancer research consistent with AICR's areas of interest. The PI must have a PhD, MD or equivalent degree and be a research staff or faculty member at a nonprofit academic or research institution at the level of an assistant professor (or its equivalent) or higher.

Postdoctoral Awards (PDAs) are awarded to postdoctoral trainees at not-for-profit universities, hospitals or research centers. The PI must have a PhD, MD, or equivalent degree, awarded no more than four years prior to the date of application. The applicant must be sponsored by an academic mentor or professor from the facility or laboratory in which the applicant is to perform the research.

All applications must bear the signature of the official head of the organization or that of a designee, since grants are not made to individual researchers, but to the relevant institution.

LOI Deadline: January 25, 2011
Full Application Deadline: May 2, 2011

CTSC Pilot Funding

The Clinical and Translational Science Collaborative (CTSC) announces the December 1, 2010 quarterly competition for core utilization pilot funding of up to $10,000 to support activities provided by any of the CTSC Core facilities. This program is being supported by CWRU, UH, and MetroHealth Medical Center, and investigators whose primary appointments are based at these sites are eligible for this competition. Details and instructions will be posted on the CTSC website. Please contact the CTSC research concierge with any questions.

Investigators at the Cleveland Clinic have access to internal pilot funds for clinical and translational research through the RPC Program. Information and details can be found on the Lerner Research Institute website. Click "Apply" on the right sidebar for the on-line application. Contact Charlotte Bhasin with any questions about the Cleveland Clinic program.



**All events are open to anyone interested in attending

November 29

Pathology Research Seminar
Yang Liu, PhD
Professor, Surgery
Director, Div. of Immunotherapy
University of Michigan
Topic: Discriminating DAMP from PAMP
12 pm WRB 1-413

Physiology and Biophysics Seminar
Christopher G. Wilson, PhD
Associate Professor, Pediatrics and Neurosciences
Topic: Modulation and Generation of Breathing Rhythm in the Rat
4 pm SOM E501

November 30

Immunology Seminar
Kenneth Rock, MD
Professor and Chair, Pathology
University of Massachusetts Medical School
Topic: The Sterile Inflammatory Response
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
James Cook, MD, PhD
Clinical Pathology
Cleveland Clinic
Topic: Ancillary Molecular Testing in Hematologic Malignancy
12 pm R3-002 Cleveland Clinic

December 1

Hematology and Oncology Division Research Conference
Joseph Bokar, MD, PhD
Assistant Professor, Div. of Hem/Onc
Topic: Sickle Cell Anemia
8 am Lerner Tower B-151

Pathology Graduate Student Seminar
Pauline Ogolla
Subauste Lab, Pathology
Topic: The Role of PKR in the Control of Toxoplasma Gondii
12 pm WRB 1-413

December 2

Neurosciences Seminar
Sanjay Pimplikar, PhD
Associate Staff, Neurosciences
Cleveland Clinic
Topic: What Causes Alzheimer's Disease and How Does it Cause it?
12:10 pm BRB 105

Aging-Cancer-Energetics Seminar
Julia Rose, PhD
Professor, Medicine-Geriatrics
CWRU/ MetroHealth
Topic: Trajectories and Predictors of Engagement in a Coping and Communication Support Intervention for Older Advanced Cancer Survivors
4 pm BRB 732

December 3

Cancer Center Research in Progress Seminar canceled

Cancer Center Seminar Series canceled

Hematology and Oncology Fellows Seminar canceled

Taussig Cancer Institute Grand Rounds canceled

Special Seminar
Tunghi May Pini, MD, MPH
Fellow, Div. of Hem/Onc
University of Michigan
Topic: Improving Cancer Care Quality
8 am Wearn 137


Case CCC Calendar

LRI Calendar


Department of Genetics, Office of Graduate Education, Minority Graduate Education Student Organization, and PREP Program Seminar
December 8
11 am BRB 105
Dr. Guillermina Lozano
Professor and Chair, Department of Genetics
MD Anderson Cancer Center
Topic: Modulating p53 Activity for Better or for Worst
Contact Melana Bey if you are interested in meeting with Dr. Lozano.

Cancer Center Seminar Series
December 17
12 pm BRB 105
Man-Sun Sy, PhD
Professor, Pathology
Topic: Prion, Filamin A and Inegrin in Tumor Cell Migration and Invasion


Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriott Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham in Washington, DC
Abstract Deadline: December 16

Cancer Health Disparities Summit 2011
July 13-15, 2011
Bethesda North Marriott Hotel in Rockville, Maryland


AACR-Women in Cancer Research (WICR) Scholar Awards
Deadline: November 30

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Sidney Kimmel Scholar Award
Deadline: December 1

Sidney Kimmel Translational Science Award
Deadline: December 1

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Application Deadline: December 2

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Landon Foundation-AACR INNOVATOR Award for International Collaboration
Deadline: December 8

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research
Deadline: December 8

Landon Foundation-AACR INNOVATOR Award for Research in Personalized Cancer Medicine
Deadline: December 8

AACR Basic Cancer Research Fellowships
Deadline: December 13

AACI Translational Cancer Research Fellowship
Deadline: December 17

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Prostate Cancer Foundation (PCF) 2011 Creativity Awards
Deadline: January 13, 2011

SU2C Innovative Research Grants
Application Deadline: January 31, 2011

2011 Jane Coffin Childs Memorial Fund for Medical Research Fellowship Awards
Deadline: February 1, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Reminder: Policies Affecting Submission of NIH Grant Applications for Due Dates on or after January 25, 2011

NIH Basic Behavioral and Social Science Opportunity Network (OppNet) Short-term Mentored Career Development Awards in the Basic Behavioral and Social Sciences for Mid-career and Senior Investigators (K18) (RFA-DE-11-003)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.