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Case Comprehensive Cancer Center Newsletter

November 8, 2010


If You Only Have Time to Attend One Talk on Autophagy Today–This is the One!

Friday, November 12, 2010
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, November 12 at the next Cancer Center Seminar Series featuring guest speaker Daniel Klionsky, PhD. Dr. Klionsky, Alexander G. Ruthven Professor of Life Sciences University of Michigan, will present If You Only Have Time to Attend One Talk on Autophagy Today–This is the One!

Dr. Klionsky's research focuses on protein targeting, organelle biogenesis and autophagy in baker's yeast. His lab made the pioneering discovery of the cytoplasm to vacuole targeting pathway, a specific type of autophagy, and the only example of a biosynthetic function for this normally degradative process. His lab's work has led to a molecular understanding of cargo recognition and packaging, and membrane recycling during autophagy. In 2004, Dr. Klionsky edited the first textbook on "Autophagy." He helped launch the Gordon Research Conference on "Autophagy in Stress, Development and Disease," and served as Chair in 2005. Dr. Klionsky is the founding Editor-in-Chief of the journal Autophagy. In recognition of his research and teaching, Dr. Klionsky was elected a Fellow of the American Association for the Advancement of Science in 2009.


Cancer Center Scientific Series Series: ACS IRG Pilot Projects

Please join us Monday, November 8 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413) at the Cancer Center Scientific Series to hear updates on research funded by the American Cancer Society IRG Pilot Projects.

Derek Taylor, PhD
Structural and Functional Analysis of Human Telomeres and Telomerase

Ge Jin, PhD
Role of Human beta-Defensin-3 in the Progression of Tumors

David Wald, MD, PhD
ATP Depletion as a Therapeutic Strategy for AML

Reception to follow presentations.

Department of Genetics, Office of Graduate Education, Minority Graduate Education Student Organization, and PREP Program Seminar

The Department of Genetics, Office of Graduate Education, The Minority Graduate Student Organization, and The Prep Program will host Dr. Guillermina Lozano, Professor and Chair of the Department of Genetics at the MD Anderson Cancer Center. Dr. Lozano will present a seminar titled, Modulating p53 Activity for Better or for Worst, at 11 am on December 8 in BRB 105. Please contact Melana Bey (mcb19@case.edu) if you are interested in meeting with Dr. Lozano.


A paper by Cancer Center researchers, titled DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination, was recently published in the prestigious journal "Science Signaling".

Zhanwen Du1, Jing Song, Yong Wang1, Yiqing Zhao1, Kishore Guda, Shuming Yang, Hung-Ying Kao, Yan Xu, Joseph Willis, Sanford D. Markowitz, David Sedwick, Robert M. Ewing, and Zhenghe Wang
Methylation is an important chemical modification of DNA that determines the expression of genes in cells. Alteration of the patterns of DNA methylation can lead to altered programs of gene-expression and may result in cells becoming cancerous and forming tumors. Understanding the regulation of DNA methylation in cells is therefore of great importance. We studied a protein that is an important regulator of DNA methylation, called DNA methyltransferase I (DNMT1) and identified several other proteins that associate with DNMT1 and control the levels of DNMT1 in the cell. By identifying the mechanisms by which DNMT1 is regulated, we have identified possible novel means of therapeutic approaches to cancer.


AACI Translational Cancer Research Fellowship

Applications are now open for the inaugural AACI Translational Cancer Research Fellowship. This $50,000 one-year non-renewable grant will support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution.

Deadline: December 17

CTSC Pilot Funding

The Clinical and Translational Science Collaborative (CTSC) announces the December 1, 2010 quarterly competition for core utilization pilot funding of up to $10,000 to support activities provided by any of the CTSC Core facilities. This program is being supported by CWRU, UH, and MetroHealth Medical Center, and investigators whose primary appointments are based at these sites are eligible for this competition. Details and instructions will be posted on the CTSC website. Please contact the CTSC research concierge with any questions.

Investigators at the Cleveland Clinic have access to internal pilot funds for clinical and translational research through the RPC Program. Information and details can be found on the Lerner Research Institute website. Click "Apply" on the right sidebar for the on-line application. Contact Charlotte Bhasin with any questions about the Cleveland Clinic program.


Crizotinib Continues to Show Promise for Some Lung Tumors, Faces Challenge of Drug Resistance

Pancreatic Cancers May Develop Slowly Over Many Years

Cetuximab May Benefit Some Patients with KRAS Gene Mutations

Protein Found on Tumor Blood Vessels Might Be Cancer Target

More Evidence Suggests Aspirin May Prevent Colorectal Cancer

In Depth
Engineering Progress Against a Rare Cancer

Featured Clinical Trial: Targeted Antibody Therapy for Metastatic Adrenocortical Carcinoma

Recognition of Animal Welfare in Biomedical Science Takes Center Stage


FDA Update




**All events are open to anyone interested in attending

November 8

Pathology Research Seminar canceled

SDIG Meeting
Shuying Sun, PhD
Assistant Professor, General Medical Sciences (Oncology)
Topic: Exploratory Analysis of Bisulfite-Converted Methylation Sequencing Data
2:30 pm WRB 1-403

Physiology and Biophysics Seminar
Robert Brown, PhD
Professor, Physics
Topic: Magnetic Particle Imaging- A New Imaging Modality
4 pm SOM E501

Cancer Center Scientific Series: ACS IRG Pilot Projects
Derek Taylor, PhD: Structural and Functional Analysis of Human Telomeres and Telomerase
Ge Jin, PhD: Role of Human beta-Defensin-3 in the Progression of Tumors
David Wald, MD, PhD: ATP Depletion as a Therapeutic Strategy for AML
4-6:30 pm WRB 1-413
Reception to follow

November 9

Immunology Seminar
Andrew Gewirtz, PhD
Associate Professor, Pathology and Laboratory Medicine
Emory University
Topic: TLR5-Mediated Control of Enteric Bacteria
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
Topic: Bioethics
12 pm R3-002 Cleveland Clinic

Case CCC Clinical Research Retreat
November 9
6 pm Dively Building

November 10

Hematology and Oncology Division Research Conference
Ken Cooke, MD
Director, Pediatric BMT Program, Div. of Hem/Onc
Topic: Pulmonary Dysfunction after BMT: Can the lung be considered a target organ of GVHD?
8 am Lerner Tower B-151

Frontiers in Biological Sciences Lecture Series
David P. Bartel, PhD
Professor, Biology
Whitehead Institute for Biomedical Research/MIT/HHMI
Topic: MicroRNAs in Biology and Disease
4 pm SOM E501
Reception to follow in T501

CSCRM Seminar
Hoonkyo Suh, PhD
Stem Cell Biology and Regenerative Medicine
Cleveland Clinic
Topic: Fate Analysis of Adult Hippocampal Neurl Stem Cells
4:30 pm WRB 1-413

November 11

Molecular Genetics Seminar
James Alwine, PhD
Professor, Cancer Biology
University of Pennsylvania
Topic: Taking Advantage of Cellular Stress Responses: How Human Cytomegalovirus Deals with Stress
9:30 am NE1-205 Cleveland Clinic

November 12

Cancer Center Research in Progress Seminar canceled

Hematology and Oncology Special Seminar
Afsaneh Barzi, MD, PhD
Fellow, Hem/Onc
Cleveland Clinic
Topic: The Dilemma of Stage II Colon Cancer
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Melody Cobleigh, MD
Medical Oncology
Rush University Medical Center
Topic: Ductal Carcinoma in situ
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Daniel Klionsky, PhD
Alexander G. Ruthven Professor of Life Sciences
University of Michigan
Topic: If You Only Have Time to Attend One Talk on Autophagy Today- This is the One!
12 pm Frohring Auditorium (BRB 105)


Case CCC Calendar

LRI Calendar




Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16


AACR-GlaxoSmithKline Outstanding Clinical Scholar Awards
Deadline: November 15

SU2C Innovative Research Grants
LOI Deadline: November 15
Application Deadline: January 31, 2011

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Pre-Application Deadline: November 18
Application Deadline: December 2

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Pre-application Deadline: November 19
Application Deadline: December 7

NCRM Stem Cell-related Pilot Projects (SCPP)
Deadline: November 22

AACR-Women in Cancer Research (WICR) Scholar Awards
Deadline: November 30

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Sidney Kimmel Scholar Award
Deadline: December 1

Sidney Kimmel Translational Science Award
Deadline: December 1

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Application Deadline: December 2

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

SU2C Innovative Research Grants
Application Deadline: January 31, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Need to Expire and Reissue Fellowship Applications (Fs) to Comply with Language in New Application Forms (NOT-OD-11-018)

Notice of Correction for RFA-RM-10-012 - Knockout Mouse Phenotyping Project Database (NOT-RM-11-002)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.