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Case Comprehensive Cancer Center Newsletter

November 1, 2010


This week, the Cancer Center will be hosting two guests as part of the Cancer Center Seminar Series.

The KLF6 Gene Family in Human Cancer

Monday, November 1, 2010
4-5 pm
Wolstein Auditorium (WRB 1-413)

Please join us Monday, November 1 at the a special Cancer Center Seminar Series featuring guest speaker Goutham Narla, MD, PhD. Dr. Narla, Assistant Professor of Genetics and Genomic Sciences, Medicine, and Medical Education at the Mount Sinai School of Medicine, will present The KLF6 Gene Family in Human Cancer. A reception will follow the presentation

Dr. Narla's laboratory studies the regulation of KLF6 alternative splicing in the development and progression of human cancer, has identified new signaling pathways regulated by this gene family, and have provided new insight into cancer diagnosis, prognosis and treatment. His group was the first to describe an anti-apoptotic function for KLF6-SV1, in prostate cancer. His laboratory investigates the potential utility of the expression pattern of the KLF6 gene family as a cancer prognostic marker, studies the molecular mechanisms and pathways regulated by KLF6 and KLF6-SV1 in cancer, and examines the role of the KLF6 gene family in oncogenic signaling. He also works on developing relevant cell culture and mouse model systems to identify and validate rationally designed to create a system to identify cancer relevant pathways, and develop small-molecule or other molecular therapies to target these molecular alterations in vivo.

Current Controversies in Vitamin D and Cancer

Friday, November 5, 2010
12-1 pm
Frohring Auditorium - BRB 105

The Case CCC and the Helen Moss Breast Cancer Research Foundation are pleased to co-sponsor the Friday, November 5 Cancer Center Seminar Series featuring guest speaker Greg Plotnikoff, MD MTS FACP. Dr. Plotnikoff will present Current Controversies in Vitamin D and Cancer.

Dr. Plotnikoff is a board-certified internist and pediatrician who has received national and international honors for his work in crosscultural and integrative medicine. A graduate of Carleton College, Harvard Divinity School, and the University of Minnesota Medical School, Plotnikoff co-chaired the task force that led to the development of the University of Minnesota's Center for Spirituality and Healing. He served there as the first medical director from 1997-2002 at which time he joined the faculty at Keio University School of Medicine in Tokyo, Japan. In Japan, he studied and taught traditional Japanese herbal medicine in Japanese to Japanese medical students and was active in East-West medical integration issues with the Japanese Society of Oriental Medicine, National Geographic Society and the World Health Organization. While in Japan, he received several international awards for research and teaching as well as the Early Career Distinguished Achievement Award from the University of Minnesota Medical School.


Does the PSA Test for Prostate Cancer Save Lives?
NewsNet5.com - Oct 28, 2010
Eric Klein, MD, a urologist at the Cleveland Clinic, oversaw an analysis of 1700 of the Clinic's prostate cancer patients. It showed that patients treated ...

PSA Tests Cut Risk of Prostate Cancer Spread
WebMD - Oct 25, 2010
"Based on the results, we feel patients should be screened," says co-investigator Jay Ciezki, MD, also of the Cleveland Clinic. ...


Paul Tesar PhD named NYSCF-Robertson Investigator

Paul Tesar, PhD was recently named a New York Stem Cell Foundation (NYSCF)-Robertson Investigator. Each of the NYSCF-Robertson Investigators will receive up to $1.5 million over the next five years to expand their own laboratories, train other scientists and foster innovative high-risk/high reward research to explore the therapeutic potential of stem cells derived from humans and model organisms. The NYSCF Investigators were selected on the basis of a research proposal, research accomplishments, and references. Applicants were required to show true innovation for translation of basic science to a clinical setting.


CTSC Pilot Funding

The Clinical and Translational Science Collaborative (CTSC) announces the December 1, 2010 quarterly competition for core utilization pilot funding of up to $10,000 to support activities provided by any of the CTSC Core facilities. This program is being supported by CWRU, UH, and MetroHealth Medical Center, and investigators whose primary appointments are based at these sites are eligible for this competition. Details and instructions will be posted on the CTSC website. Please contact the CTSC research concierge with any questions.

Investigators at the Cleveland Clinic have access to internal pilot funds for clinical and translational research through the RPC Program. Information and details can be found on the Lerner Research Institute website. Click "Apply" on the right sidebar for the on-line application. Contact Charlotte Bhasin with any questions about the Cleveland Clinic program.

National Center for Regenerative Medicine Stem Cell-related Pilot Projects

The National Center for Regenerative Medicine (NCRM) is accepting proposals for funding of Stem Cell-related Pilot Projects (SCPP) for the period from February 1, 2011 – January 31, 2012. With CTSC Core Facility usage, NCRM can provide up to five $50,000 grants this year to promote new projects in stem cell research. In addition to providing seed money for new research ideas, priority will be given to projects that bring new researchers into the stem cell arena or provide funding to researchers not currently receiving NCRM research support. Projects must have a clinical and/or commercial direction though it may be more rudimentary than for a fully developed project.

Deadline: November 22


Graft versus Host Disease Conference

Together with the Case CCC, the Meredith A. Cowden Foundation presents the 2010 National GVHD Symposium to be held at Corporate College East on Thursday, November 4. This unique one-day program will be a two-track conference (one for physicians and one for patients) focusing on cutting edge research and new treatments. Continuing medical education credits will be offered for attending and participating medical providers.

Featured Case CCC presenters include: Drs. Stan Gerson, Ken Cooke, Matt Kalaycio and Jeff Auletta.

Cancer Center Scientific Series Series: ACS IRG Pilot Projects

Please join us Monday, November 8 from 4-6:30 pm in Wolstein Auditorium at the Cancer Center Scientific Series to hear updates on research funded by the American Cancer Society IRG Pilot Projects.

Derek Taylor, PhD
Structural and Functional Analysis of Human Telomeres and Telomerase

Ge Jin, PhD
Role of Human beta-Defensin-3 in the Progression of Tumors

David Wald, MD, PhD
ATP Depletion as a Therapeutic Strategy for AML

Reception to follow presentations.


Excerpt from the SOM Dean's Email Update Newsletter, November 2010

Medical researchers say that the lack of clinical research volunteers is reaching crisis proportions and is rapidly becoming a major health care issue. In an effort to increase the health literacy in the Cleveland community, Case Western Reserve, through the Cleveland CTSA, is sponsoring a clinical research education day through the Center for Information and Study on Clinical Research Participation (CISCRP). CISCRP is an independent non-profit organization dedicated to educating and empowering people to make informed decisions regarding participation in clinical research.

CISCRP is working hard to resolve a number of major health care issues by getting to the root of one of the health system's most significant problems: the severe shortage of volunteers to participate in the clinical research trials that are vital to any new medications or behavioral interventions reaching the people who need them.

On Saturday, November 6, the National AWARE for All: Clinical Research Education Day for the Public will answer questions that patients and the public should ask themselves before deciding to participate in clinical research. From 11:00 a.m. – 3:00 p.m. at the YMCA of Greater Cleveland, the public will have the opportunity to increase their health literacy and make informed decisions regarding participation in clinical trials. Faculty and staff are welcome to join the Education Day.

For more information, contact Mary Ellen Lawless at mel15@case.edu.



**All events are open to anyone interested in attending

November 1

Pathology Research Seminar
Robert Mays, PhD
Senior Director, Regenerative Medicine
Athersys Inc.
Topic: Clinical Development of MultiStem for Treatment of CNS Injury and Disease
12 pm WRB 1-413

Cancer Center Seminar Series
Goutham Narla, MD, PhD
Assistant Professor, Genetics and Medicine
Assistant Director, MSTP Program
Mount Sinai School of Medicine
Topic: The KLF6 Gene Family in Human Cancer
4 pm WRB 1-413

Physiology and Biophysics Seminar
Robert Bridges, PhD
Professor and Chair, Physiology and Biophysics
Rosalind Franklin University
Topic: Functional Approaches for Cystic Fibrosis Drug Discovery
4 pm SOM E501

November 2

Immunology Seminar
Gerald Pier, PhD
Professor, Medicine- Microbiology and Molecular Genetics
Harvard Medical School
Brigham and Women's Hospital
Topic: Impact of CFTR-dependent Innate Immunity and Inflammation on Pathogenesis of Pseudomonas Aeruginosa Lung and Corneal Disease
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
David Adelstein, MD
Professor, Solid Tumor Oncology
CWRU/ Cleveland Clinic
Topic: Head and Neck Cancer
12 pm R3-002 Cleveland Clinic

November 3

Hematology and Oncology Division Research Conference
Paula Silverman, MD
Ashley Rosko, MD
Chris Sydenstricker, RN
Raymond Krncevic
Topic: Introduction to the Inpatient Quality and Safety Committee
8 am Lerner Tower B-151

November 4

Graft versus Host Disease Conference
7:45 am Corporate College East

Department of Molecular Genetics Seminar
George Stark, PhD
Professor, Molecular Genetics
CWRU/ Cleveland Clinic
Topic: Validation-Based Insertional Mutagenesis: Current Status and Prospects
9:30 am NE1-205 Cleveland Clinic

Center for Proteomics and Bioinformatics Seminar
Kun Huang, PhD
Associate Professor, Biomedical Informatics
Ohio State University
Topic: Cancer Biomarker Discovery Using Gene Co-Expression Network
12 pm BRB 932

November 5

Hematology and Oncology Fellows
Tycel Phillips, MD
Anita Schwandt, MD
Fellows, Division of Hematology and Oncology
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Brian Herts, MD
Section Head, Diagnostic Radiology
Cleveland Clinic
Topic: Contrast-Enhanced Imaging in Patients with Kidney Disease
8 am R3/002-003 Cleveland Clinic

Helen Moss Breast Cancer Research Foundation Lecture
Gregory Plotnikoff, MD MTS FACP
Senior Consultant
Allina Center for Health Care Innovation
Topic: Current Controversies in Vitamin D and Cancer
12 pm BRB 105

Cancer Center Research in Progress Seminar
Damian Junk, PhD
Postdoctoral Fellow, Jackson Lab
Topic: Human Mammary Epithelial Cell Cultural Models of Transformation and Epithelial to Mesenchymal Transition (EMT)
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series: ACS IRG Pilot Projects
November 8
4-7 pm WRB 1-413

Case CCC Clinical Research Retreat
November 9
6-9pm Dively Building


Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH

Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16


AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research
Deadline: November 2

Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

AACR-GlaxoSmithKline Outstanding Clinical Scholar Awards
Deadline: November 15

SU2C Innovative Research Grants
LOI Deadline: November 15
Application Deadline: January 31, 2011

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Pre-Application Deadline: November 18
Application Deadline: December 2

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Pre-application Deadline: November 19
Application Deadline: December 7

AACR-Women in Cancer Research (WICR) Scholar Awards
Deadline: November 30

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Sidney Kimmel Scholar Award
Deadline: December 1

Sidney Kimmel Translational Science Award
Deadline: December 1

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Application Deadline: December 2

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

SU2C Innovative Research Grants
Application Deadline: January 31, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Small Grants Program for Cancer Epidemiology (R03) (PAR-08-237)

Notice of Correction of Opening Date for PAR-10-286 Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology (SBIR [U43/U44]) (NOT-CA-10-039)

Deepwater Horizon Disaster Research Consortia: Health Impacts and Community Resiliency (U19) (RFA-ES-11-006)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.