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Case Comprehensive Cancer Center Newsletter

October 25, 2010


Rare Lung Diseases: From Mechanisms to Therapeutic Targeting

Friday, October 29, 2010
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, October 29 at the Cancer Center Seminar Series and hear guest speaker Vera P. Krymskaya, PhD present Rare Lung Diseases: From Mechanisms to Therapeutic Targeting.

Dr. Vera P. Krymskaya's research interests are in the signal transduction mechanisms of vascular and airway smooth muscle cell remodeling in pulmonary arterial hypertension (PAH), asthma, and COPD; and cellular and molecular mechanisms of rare lung diseases. Dr. Krymskaya has dedicated the last several years of her career to combating pulmonary lymphangioleiomyomatosis (LAM). Her lab was responsible for the breakthrough step of discovering the function of the Tuberous Sclerosis Complex 2 (TSC2) gene. Dr. Krymskaya's study linked mutational inactivation of TSC2 in human LAM cells to the constitutive activation of mTOR/S6K1 signaling pathway and abnormal LAM cell growth. Dr. Krymskaya has also dramatically advanced translational LAM research by demonstrating that rapamycin inhibits LAM cell growth. This discovery identified rapamycin as a promising therapeutic strategy for LAM patients, and paved the way for rapamycin clinical trials worldwide. For this achievement Dr. Krymskaya has honored by the Science Advancement Award from The LAM Foundation.


New Clinical Trial Explores Role of Vitamin D in Preventing Esophageal Cancer
EurekAlert - Oct 19, 2010
...are exploring the role of Vitamin D in preventing esophageal cancer. Principal Investigator Linda Cummings, MD, along with Amitabh Chak, MD, and Gregory Cooper, MD, from the UH Digestive Health Institute... According to co-investigator Sanford Markowitz, MD, Ingalls Professor of Cancer Genetics at Case Western Reserve University School of Medicine and oncologist with UH Case Medical Center...


AACR-GlaxoSmithKline Outstanding Clinical Scholar Awards

AACR-GlaxoSmithKline Outstanding Clinical Scholar Awards are presented to promising young cancer researchers who are the first authors and presenters of highly meritorious abstracts related to clinical cancer research. These Awards provide a $4,000 travel grant to be spent over two years to support the Scholar's attendance at the AACR 102nd Annual Meeting 2011 and future AACR meetings and conferences.

Deadline: November 15

AACR Women in Cancer Research Scholar Awards

AACR-Women in Cancer Research (WICR) Scholar Awards are awarded to ten members of Women in Cancer Research who are scientists-in-training and presenters of meritorious scientific papers at AACR Annual Meetings.

Eligible candidates for these awards must fit the following criteria:

  • Candidates must be members of WICR.
  • Candidates must be full time scientists-in-training who are graduate students, medical students, residents, clinical fellows or equivalent, or postdoctoral fellows.
  • Candidates may be traveling from within the United States or abroad. There are no citizenship or residency requirements.
  • Candidates must be first authors on abstracts submitted for consideration for presentation at the AACR Annual Meeting.

Deadline: November 30

CTSC Pilot Funding

The Clinical and Translational Science Collaborative (CTSC) announces the December 1, 2010 quarterly competition for core utilization pilot funding of up to $10,000 to support activities provided by any of the CTSC Core facilities. This program is being supported by CWRU, UH, and MetroHealth Medical Center, and investigators whose primary appointments are based at these sites are eligible for this competition. Details and instructions will be posted on the CTSC website. Please contact the CTSC research concierge with any questions.

Investigators at the Cleveland Clinic have access to internal pilot funds for clinical and translational research through the RPC Program. Information and details can be found on the Lerner Research Institute website. Click "Apply" on the right sidebar for the on-line application. Contact Charlotte Bhasin with any questions about the Cleveland Clinic program.

National Center for Regenerative Medicine Stem Cell-related Pilot Projects

The National Center for Regenerative Medicine (NCRM) is accepting proposals for funding of Stem Cell-related Pilot Projects (SCPP) for the period from February 1, 2011 – January 31, 2012. Current funds for this program come from the April 2009 award from the Research Commercialization Program (RCP) of $5 million which includes $200,000 annual funding for pilot projects. Additional funds of up to $50,000 from the CWRU Clinical and Translational Science Collaborative (CTSC) for Core Utilization Pilot Awards will be added into this year's funds. With CTSC Core Facility usage, NCRM can provide up to five $50,000 grants this year to promote new projects in stem cell research. In addition to providing seed money for new research ideas, priority will be given to projects that bring new researchers into the stem cell arena or provide funding to researchers not currently receiving NCRM research support. Projects must have a clinical and/or commercial direction though it may be more rudimentary than for a fully developed project.

Deadline: November 22

Proposals must be submitted in electronic format using either Word or PDF files though the WebGrants portal ID number 1247 – National Center for Regenerative Medicine: Stem Cell Pilot.


Oncomine Hands-On Workshop

The first hands-on Oncomine workshop for registered users is scheduled for Wednesday, October 27 at 2 pm. The workshop will cover the basics of navigation in this valuable database. For access to the Oncomine database, visit http://www.oncomine.com and register using your Case.edu or CCF.org email address. You will then need to sign up for the limited space hands-on tutorial workshop on October 27 by emailing Patrick.Leahy@case.edu. Extra sessions will be run if necessary. Please contact Patrick Leahy with any questions.


Featured Article: Cancer Screening Continues Even after Patients Are Diagnosed with Terminal Cancer

Abiraterone Improves Survival in Metastatic Prostate Cancer

Similar Early-phase Trials Prohibit Different Drugs, Undermining Outcomes

Surgical Procedure Reduces Disability and Pain Caused by Spine Fractures in Cancer Patients

Guest Commentary: Bringing Science to the Market

In Depth
Hormone Therapy Linked to Modest Increase in Breast Cancer Deaths

Testing a "Smarter" Biopsy for Prostate Cancer

Partners in Crime: Using Synthetic Lethality to Identify New Cancer Targets

Featured Clinical Trial: Eliminating Hairy Cell Leukemia Minimal Residual Disease

FDA Update

HHS Update




**All events are open to anyone interested in attending

October 25

Pathology Research Seminar
Jonathan Stamler, MD
Director, Institute for Transformative Molecular Medicine
Topic: S-nitrosylation in Health and Disease
12 pm WRB 1-413

SDIG Meeting
Mark Adams, PhD
Associate Professor, Genetics
Topic: Exome Sequencing Identifies MLL2 Mutations as a Cause of Kabuki Syndrome
2:30 pm WRB 1-403

Allen H. and Constance C. Ford Distinguished Lecture
Muthiah Manoharan, PhD
Senior Vice President, Drug Discovery
Alnylam Pharmaceuticals
Topic: Making Drugs Out of siRNAs
4:30-5:00 pm WRB 1-413

October 26

Immunology Seminar
Fabio Cominelli, MD
Professor and Chief, Div. of Gastrointestinal and Liver Disease
Topic: Role of Innate Immunity in Intestinal Inflammation
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
Brian Rini, MD
Associate Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Renal Cell Cancer
12 pm R3-002 Cleveland Clinic

October 27

Hematology and Oncology Division Research Conference
Clark Distelhorst, MD
Professor, Medicine- Hem/Onc
Topic: Novel Approach to Kill CLL Cells
8 am Lerner Tower B-151

Ribonucleotide Reductase Journal Club
Charles Kunos, MD, PhD
Director, Gynecologic Radiation Oncology
Topic: Poly(ADP-ribose) Polymerase Inhibition Delays Repair of DNA Damage
1:30 pm SOM W331

Hands-on Oncomine Workshop
2 pm
Pre-registration required

October 28

Neurosciences Seminar
Douglas McMahon, PhD
Professor, Biological Sciences and Pharmacology
Vanderbilt University
Topic: Nature and Nurture in Rhythms and Blues: Genetic and Environmental Inputs Organizing the Brain's Biological Clock and Mood
12:10 pm BRB 105

October 29

Hematology and Oncology Special Seminar
Charu Aggarwal, MD, MPH
Medical Oncology Fellow
Fox Chase Cancer Center
Topic: Locally Advanced Non Small Cell Lung Cancer
8 am WRB 2-136

Taussig Cancer Institute Grand Rounds
Michael Williams, MD
Director, Hematologic Malignancy Program
Div. of Hem/Onc
University of Virginia Health System
Topic: Mantle Cell Lymphoma: 20 Years of Progress
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Vera P. Krymskaya, PhD
Associate Professor, Medicine- Pulmonary, Allergy & Critical Care
Cardiovascular Institute
Abramson Cancer Center
University of Pennsylvania
Topic: Rare Lung Disease: From Mechanisms to Therapeutic Targeting
12 pm BRB 105

Hematology and Oncology Special Seminar
Sameer Gupta, MD, MPH
Hematology and Oncology Fellow
Fox Chase Cancer Center
Topic: Cell Death and Interferon: Exploring Augmentation of Direct Cytotoxicity
1 pm WRB 2-136

Cancer Center Research in Progress Seminar
Xia Liu, MD
Postdoctoral Scholar, Qu Lab
Topic: A Leukemia-Associated Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn 11 (Shp2)
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413

Case CCC Clinical Research Retreat
November 9
6-9pm Dively Building


Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH

Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16


Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants
Deadline: October 27

Pancreatic Cancer Action Network-AACR Fellowship:
Deadline: October 27

Pancreatic Cancer Action Network-AACR Career Development Awards
Deadline: October 27

AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research
Deadline: November 2

Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

SU2C Innovative Research Grants
LOI Deadline: November 15
Application Deadline: January 31, 2011

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Pre-Application Deadline: November 18
Application Deadline: December 2

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Pre-application Deadline: November 19
Application Deadline: December 7

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Sidney Kimmel Scholar Award
Deadline: December 1

Sidney Kimmel Translational Science Award
Deadline: December 1

DOD CDMRP Breast Cancer Postdoctoral Fellowship Award
Application Deadline: December 2

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

SU2C Innovative Research Grants
Application Deadline: January 31, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Revised NIH Term of Award on use of DUNS Number and New Term of Award on Maintaining an Active CCR Registration (NOT-OD-11-004)

Notice of New NIH Term of Award on Transparency Act Subaward and Executive Compensation Reporting Requirements (NOT-OD-11-005)

Notice of Revised Eligibility Requirements and Award Administration Information in NIH Funding Opportunity Announcements (NOT-OD-11-006)

Non-Competing Grant Awards under the Current Continuing Resolution (NOT-OD-11-015)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.