Case Comprehensive Cancer Center: Weekly Newsletter

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October 25, 2010
CANCER CENTER SEMINAR SERIES Rare Lung Diseases: From Mechanisms to Therapeutic Targeting Friday, October 29, 2010 12-1 pm Frohring Auditorium - BRB 105 Please join us Friday, October 29 at the Cancer Center Seminar Series and hear guest speaker Vera P. Krymskaya, PhD present Rare Lung Diseases: From Mechanisms to Therapeutic Targeting. Dr. Vera P. Krymskaya's research interests are in the signal transduction mechanisms of vascular and airway smooth muscle cell remodeling in pulmonary arterial hypertension (PAH), asthma, and COPD; and cellular and molecular mechanisms of rare lung diseases. Dr. Krymskaya has dedicated the last several years of her career to combating pulmonary lymphangioleiomyomatosis (LAM). Her lab was responsible for the breakthrough step of discovering the function of the Tuberous Sclerosis Complex 2 (TSC2) gene. Dr. Krymskaya's study linked mutational inactivation of TSC2 in human LAM cells to the constitutive activation of mTOR/S6K1 signaling pathway and abnormal LAM cell growth. Dr. Krymskaya has also dramatically advanced translational LAM research by demonstrating that rapamycin inhibits LAM cell growth. This discovery identified rapamycin as a promising therapeutic strategy for LAM patients, and paved the way for rapamycin clinical trials worldwide. For this achievement Dr. Krymskaya has honored by the Science Advancement Award from The LAM Foundation. CASE CCC IN THE NEWS New Clinical Trial Explores Role of Vitamin D in Preventing Esophageal Cancer EurekAlert - Oct 19, 2010 ...are exploring the role of Vitamin D in preventing esophageal cancer. Principal Investigator Linda Cummings, MD, along with Amitabh Chak, MD, and Gregory Cooper, MD, from the UH Digestive Health Institute... According to co-investigator Sanford Markowitz, MD, Ingalls Professor of Cancer Genetics at Case Western Reserve University School of Medicine and oncologist with UH Case Medical Center... FUNDING OPPORTUNITIES AACR-GlaxoSmithKline Outstanding Clinical Scholar Awards AACR-GlaxoSmithKline Outstanding Clinical Scholar Awards are presented to promising young cancer researchers who are the first authors and presenters of highly meritorious abstracts related to clinical cancer research. These Awards provide a $4,000 travel grant to be spent over two years to support the Scholar's attendance at the AACR 102nd Annual Meeting 2011 and future AACR meetings and conferences. Deadline: November 15 AACR Women in Cancer Research Scholar Awards AACR-Women in Cancer Research (WICR) Scholar Awards are awarded to ten members of Women in Cancer Research who are scientists-in-training and presenters of meritorious scientific papers at AACR Annual Meetings. Eligible candidates for these awards must fit the following criteria: Candidates must be members of WICR. Candidates must be full time scientists-in-training who are graduate students, medical students, residents, clinical fellows or equivalent, or postdoctoral fellows. Candidates may be traveling from within the United States or abroad. There are no citizenship or residency requirements. Candidates must be first authors on abstracts submitted for consideration for presentation at the AACR Annual Meeting. Deadline: November 30 CTSC Pilot Funding The Clinical and Translational Science Collaborative (CTSC) announces the December 1, 2010 quarterly competition for core utilization pilot funding of up to $10,000 to support activities provided by any of the CTSC Core facilities. This program is being supported by CWRU, UH, and MetroHealth Medical Center, and investigators whose primary appointments are based at these sites are eligible for this competition. Details and instructions will be posted on the CTSC website. Please contact the CTSC research concierge with any questions. Investigators at the Cleveland Clinic have access to internal pilot funds for clinical and translational research through the RPC Program. Information and details can be found on the Lerner Research Institute website. Click "Apply" on the right sidebar for the on-line application. Contact Charlotte Bhasin with any questions about the Cleveland Clinic program. National Center for Regenerative Medicine Stem Cell-related Pilot Projects The National Center for Regenerative Medicine (NCRM) is accepting proposals for funding of Stem Cell-related Pilot Projects (SCPP) for the period from February 1, 2011 – January 31, 2012. Current funds for this program come from the April 2009 award from the Research Commercialization Program (RCP) of $5 million which includes $200,000 annual funding for pilot projects. Additional funds of up to $50,000 from the CWRU Clinical and Translational Science Collaborative (CTSC) for Core Utilization Pilot Awards will be added into this year's funds. With CTSC Core Facility usage, NCRM can provide up to five $50,000 grants this year to promote new projects in stem cell research. In addition to providing seed money for new research ideas, priority will be given to projects that bring new researchers into the stem cell arena or provide funding to researchers not currently receiving NCRM research support. Projects must have a clinical and/or commercial direction though it may be more rudimentary than for a fully developed project. Deadline: November 22 Proposals must be submitted in electronic format using either Word or PDF files though the WebGrants portal ID number 1247 – National Center for Regenerative Medicine: Stem Cell Pilot. MAKR YOUR CALENDARS Oncomine Hands-On Workshop The first hands-on Oncomine workshop for registered users is scheduled for Wednesday, October 27 at 2 pm. The workshop will cover the basics of navigation in this valuable database. For access to the Oncomine database, visit http://www.oncomine.com and register using your Case.edu or CCF.org email address. You will then need to sign up for the limited space hands-on tutorial workshop on October 27 by emailing Patrick.Leahy@case.edu. Extra sessions will be run if necessary. Please contact Patrick Leahy with any questions. NCI CANCER BULLETIN News Featured Article: Cancer Screening Continues Even after Patients Are Diagnosed with Terminal Cancer Abiraterone Improves Survival in Metastatic Prostate Cancer Similar Early-phase Trials Prohibit Different Drugs, Undermining Outcomes Surgical Procedure Reduces Disability and Pain Caused by Spine Fractures in Cancer Patients Commentary Guest Commentary: Bringing Science to the Market In Depth Hormone Therapy Linked to Modest Increase in Breast Cancer Deaths Testing a "Smarter" Biopsy for Prostate Cancer Partners in Crime: Using Synthetic Lethality to Identify New Cancer Targets Featured Clinical Trial: Eliminating Hairy Cell Leukemia Minimal Residual Disease Updates FDA Update HHS Update Notes	EVENTS All events are open to anyone interested in attending October 25 Pathology Research Seminar Jonathan Stamler, MD Director, Institute for Transformative Molecular Medicine CWRU/ UH Topic:** S-nitrosylation in Health and Disease 12 pm WRB 1-413 SDIG Meeting Mark Adams, PhD Associate Professor, Genetics CWRU Topic: Exome Sequencing Identifies MLL2 Mutations as a Cause of Kabuki Syndrome 2:30 pm WRB 1-403 Allen H. and Constance C. Ford Distinguished Lecture Muthiah Manoharan, PhD Senior Vice President, Drug Discovery Alnylam Pharmaceuticals Topic: Making Drugs Out of siRNAs 4:30-5:00 pm WRB 1-413 October 26 Immunology Seminar Fabio Cominelli, MD Professor and Chief, Div. of Gastrointestinal and Liver Disease CWRU/ UH Topic: Role of Innate Immunity in Intestinal Inflammation 12 pm WRB 1-413 Taussig Cancer Institute Core Curriculum Series Brian Rini, MD Associate Professor, Hematology & Medical Oncology CWRU/ Cleveland Clinic Topic: Renal Cell Cancer 12 pm R3-002 Cleveland Clinic October 27 Hematology and Oncology Division Research Conference Clark Distelhorst, MD Professor, Medicine- Hem/Onc CWRU/ UH Topic: Novel Approach to Kill CLL Cells 8 am Lerner Tower B-151 Ribonucleotide Reductase Journal Club Charles Kunos, MD, PhD Director, Gynecologic Radiation Oncology CWRU/ UH Topic: Poly(ADP-ribose) Polymerase Inhibition Delays Repair of DNA Damage 1:30 pm SOM W331 Hands-on Oncomine Workshop 2 pm Pre-registration required Details October 28 Neurosciences Seminar Douglas McMahon, PhD Professor, Biological Sciences and Pharmacology Vanderbilt University Topic: Nature and Nurture in Rhythms and Blues: Genetic and Environmental Inputs Organizing the Brain's Biological Clock and Mood 12:10 pm BRB 105 October 29 Hematology and Oncology Special Seminar Charu Aggarwal, MD, MPH Medical Oncology Fellow Fox Chase Cancer Center Topic: Locally Advanced Non Small Cell Lung Cancer 8 am WRB 2-136 Taussig Cancer Institute Grand Rounds Michael Williams, MD Director, Hematologic Malignancy Program Div. of Hem/Onc University of Virginia Health System Topic: Mantle Cell Lymphoma: 20 Years of Progress 8 am R3/002-003 Cleveland Clinic Cancer Center Seminar Series Vera P. Krymskaya, PhD Associate Professor, Medicine- Pulmonary, Allergy & Critical Care Cardiovascular Institute Abramson Cancer Center University of Pennsylvania Topic: Rare Lung Disease: From Mechanisms to Therapeutic Targeting 12 pm BRB 105 Hematology and Oncology Special Seminar Sameer Gupta, MD, MPH Hematology and Oncology Fellow Fox Chase Cancer Center Topic: Cell Death and Interferon: Exploring Augmentation of Direct Cytotoxicity 1 pm WRB 2-136 Cancer Center Research in Progress Seminar Xia Liu, MD Postdoctoral Scholar, Qu Lab CWRU/ UH Topic: A Leukemia-Associated Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn 11 (Shp2) 4 pm WRB 3-136 Case CCC Calendar LRI Calendar UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS Cancer Center Scientific Series November 8 4-7 pm WRB 1-413 Case CCC Clinical Research Retreat November 9 6-9pm Dively Building ADDITIONAL UPCOMING SEMINARS & EVENTS Graft versus Host Disease Conference November 4 Corporate College East, Cleveland, OH Details Active Living Research Annual Conference February 22-24, 2011 San Diego, CA Call for Abstracts Deadline: August 6 Details Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals March 4-5, 2011 Las Vegas, Nevada Details 4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science March 28-29, 2011 Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland Details Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting April 27-29, 2011 Omni Shoreham, Washington, DC Abstract Deadline: December 16 Details

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES
Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants Deadline: October 27 Pancreatic Cancer Action Network-AACR Fellowship: Deadline: October 27 Pancreatic Cancer Action Network-AACR Career Development Awards Deadline: October 27 AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research Deadline: November 2 Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants Full Application Deadline: November 2 Susan G. Komen for the Cure Investigator-Initiated Research (IIR) Full Application Deadline: November 2 Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants Full Application Deadline: November 2 SU2C Innovative Research Grants LOI Deadline: November 15 Application Deadline: January 31, 2011 DOD CDMRP Breast Cancer Postdoctoral Fellowship Award Pre-Application Deadline: November 18 Application Deadline: December 2 DOD LCRP Lung Cancer Early Detection Clinical Consortium Pre-application Deadline: November 19 Application Deadline: December 7 International Clinical Research Fellows (ICRF) Program Deadline: December 1 Sidney Kimmel Scholar Award Deadline: December 1 Sidney Kimmel Translational Science Award Deadline: December 1	DOD CDMRP Breast Cancer Postdoctoral Fellowship Award Application Deadline: December 2 Susan G. Komen for the Cure Promise Grants Full Application Deadline: December 7 DOD LCRP Lung Cancer Early Detection Clinical Consortium Application Deadline: December 7 Susan G. Komen for the Cure Postdoctoral Fellowships Full Application Deadline: January 5, 2011 Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research Full Application Deadline: January 5, 2011 SU2C Innovative Research Grants Application Deadline: January 31, 2011 Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC) Deadline: Open AACR Scholar-in-Training Awards - Special Conferences Deadline: Open International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships Application Deadline: Open NCI Short-Term Scientist Exchange Program Application Deadline: Open James S. McDonnell Foundation Application Deadline: Open
NIH BULLETIN – Notices and Funding Opportunities Notice of Revised NIH Term of Award on use of DUNS Number and New Term of Award on Maintaining an Active CCR Registration (NOT-OD-11-004) Notice of New NIH Term of Award on Transparency Act Subaward and Executive Compensation Reporting Requirements (NOT-OD-11-005) Notice of Revised Eligibility Requirements and Award Administration Information in NIH Funding Opportunity Announcements (NOT-OD-11-006) Non-Competing Grant Awards under the Current Continuing Resolution (NOT-OD-11-015)
Produced by: Gillian Irwin Todd 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216-844-8317 phone 216-844-7832 fax gillian.irwin@case.edu	HELP US HELP YOU! If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu.