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Case Comprehensive Cancer Center Newsletter

October 18, 2010


Neurofibromatosis: Timing and Targets

Friday, October 22, 2010
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, October 22 at the Cancer Center Seminar Series and hear guest speaker Nancy Ratner, PhD present Neurofibromatosis: Timing and Targets.

Dr. Ratner's laboratory is interested in peripheral nerve glia known as Schwann cells. They study Schwann cells during normal development, and during abnormal development associated with tumor formation. The current focus of our research is genetic mutations in tumor suppressor genes and the effect of these mutations on Schwann cell development. These genes are thought to contribute to carcinogenesis when mutant or lost. Schwann cell tumors develop in humans who inherit mutations in two of these tumor supressor genes, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). Mechanistic analysis of Ras (a modulatoryNF1 activity) pathways and cytoskeleton- Rac (a member of the RhoGTPase family involved in NF2 signaling) intracellular signaling pathways in Schwann cells disrupted by mutations in these genes are being actively investigated. We are using transgenic mouse models, and cells from primary human tumors to define cellular changes that lead to Schwann cell tumor formation, secondary to mutations in the NF1 and NF2 genes.


Lack of Sleep Linked to Risky Colon Polyps
Post Chronicle - Oct 18, 2010
"Even if this is causal, it doesn't necessarily mean you'll get colon cancer," said Dr. Li Li, associate director of the Case Comprehensive Cancer Center at ...

First GvHD Symposium to Bring Nation's Leading Blood Cancer and Bone Marrow Transplant Specialists to Cleveland
PR Newswire (press release) - Oct 14, 2010
The Case Comprehensive Cancer Center, together with the Meredith A. Cowden Foundation, will bring the first ...


National Breast Cancer Awareness Month

For National Breast Cancer Awareness Month, the CWRU Bookstore will donate $1 for every fan on Facebook who changes his or her profile picture to the pink awareness ribbon (It's currently the Bookstores profile picture; you can save it to your desktop to use) and then comments on the Bookstores Facebook page so that the ribbon photo can be seen by all. You needn't keep the ribbon as your picture for the entire month, just until you leave the comment. Join the Bookstore at Facebook to help make a difference.


DOD CDMRP Breast Cancer Postdoctoral Fellowship Award

Applications are currently being accepted for the DOD Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Postdoctoral Fellowship Award. This Award supports exceptionally talented recent medical or other doctoral graduates performing innovative, high-impact breast cancer research during their postdoctoral training, and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research. Candidates for this award should exhibit a strong desire to pursue a career in breast cancer research.

As of the application submission deadline, all eligible PIs must have: been in the laboratory, in which the proposed research is to be performed, for no more than 2 years; a total of less than 4 years of postdoctoral research experience (excluding clinical residency or fellowship training); and successfully completed the requirements for a doctoral or medical degree.

Pre-Application Deadline: November 18
Application Deadline: December 2

National Center for Regenerative Medicine Stem Cell-related Pilot Projects

The National Center for Regenerative Medicine (NCRM) is accepting proposals for funding of Stem Cell-related Pilot Projects (SCPP) for the period from February 1, 2011 – January 31, 2012. Current funds for this program come from the April 2009 award from the Research Commercialization Program (RCP) of $5 million which includes $200,000 annual funding for pilot projects. Additional funds of up to $50,000 from the CWRU Clinical and Translational Science Collaborative (CTSC) for Core Utilization Pilot Awards will be added into this year's funds. With CTSC Core Facility usage, NCRM can provide up to five $50,000 grants this year to promote new projects in stem cell research. In addition to providing seed money for new research ideas, priority will be given to projects that bring new researchers into the stem cell arena or provide funding to researchers not currently receiving NCRM research support. Projects must have a clinical and/or commercial direction though it may be more rudimentary than for a fully developed project.

Deadline: November 22

Proposals must be submitted in electronic format using either Word or PDF files though the WebGrants portal ID number 1247 – National Center for Regenerative Medicine: Stem Cell Pilot.

SU2C Innovative Research Grants

The SU2C Innovative Research Grants are an effort to support the next generation of extraordinary leaders in their quest to conquer cancer. These grants will provide substantial funding to scientists whose novel, high-risk, high-reward cancer research proposals have significant potential for translational application, and hold great promise for advancing SU2C's overarching goal of improving and saving the lives of patients. It is the hope that ideas for new Stand Up To Cancer Dream Teams will emerge from these Innovative Research Grants, and this criterion will be given a high priority in the evaluation of the Letters of Intent. Research projects that are already being supported by the National Institutes of Health (NIH) R01 grants or the equivalent will not be accepted.

LOI Deadline: November 15
Application Deadline: January 31, 2011

2011 Pancreatic Cancer Action Network-AACR Grants Program

The Pancreatic Cancer Action Network, in partnership with AACR, is accepting applications for the following opportunities:

Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants: Represent a joint effort to ensure the future leadership of pancreatic cancer research by supporting outstanding early career investigators beginning in their postdoctoral research positions and continuing through their successful transition to independence. Applicants must have started their postdoctoral or clinical research fellowship on or after July 2, 2006, and not already have a full-time tenure track assistant professor position (or equivalent).

Pancreatic Cancer Action Network-AACR Fellowship: Represents a joint effort to encourage and support postdoctoral and clinical research fellows who are in the first three years of their fellowship training (at the start of the grant term) to conduct pancreatic cancer research and establish successful career paths in this field. The research proposed for funding may be basic, translational, clinical or epidemiological in nature and must have direct applicability and relevance to pancreatic cancer.

Pancreatic Cancer Action Network-AACR Career Development Awards: Represent a joint effort to encourage and support junior faculty who are in the first 4 years of a faculty appointment (at the start of the grant term) to conduct pancreatic cancer research and establish successful career paths in this field. The research proposed for funding may be basic, translational, clinical or epidemiological in nature and must have direct applicability and relevance to pancreatic cancer.

Deadline for all opportunities: October 27


2010 Conference on Clinical Cancer Research

Registration is still open for the 2010 Conference on Clinical Cancer Research, October 20 at Westin City Center in Washington, DC. Hosted by the Engelberg Center for Health Care Reform at Brookings and Friends of Cancer Research, and supported by the American Association for Cancer Research, the American Society of Clinical Oncology, and Susan G. Komen for the Cure, conference participants will join together to address specific challenges in clinical cancer research and discuss potential solutions proposed by expert panels. Panelists and participants represent the range of stakeholders in the cancer community, including senior officials from the U.S. Food and Drug Administration (FDA) and National Cancer Institute (NCI), as well as thought leaders from academia, patient advocacy organizations, and the life sciences industry.

Conference highlights include keynote addresses from FDA Commissioner Dr. Margaret Hamburg and NCI Director Dr. Harold Varmus, as well as four interactive panel discussions on:

  • Expanding the use of adaptive clinical trial design in oncology
  • Innovative and efficient pre-clinical testing
  • Incorporating pain metrics into oncology clinical trials
  • Using patient-generated data and samples to develop evidence for targeting approved treatments

Register today!

Oncomine Hands-On Workshop

The first hands-on Oncomine workshop for registered users is scheduled for Wednesday, October 27 at 2 pm. The workshop will cover the basics of navigation in this valuable database. For access to the Oncomine database, visit http://www.oncomine.com and register using your Case.edu or CCF.org email address. You will then need to sign up for the limited space hands-on tutorial workshop on October 27 by emailing Patrick.Leahy@case.edu. Extra sessions will be run if necessary. Please contact Patrick Leahy with any questions.



**All events are open to anyone interested in attending

October 18

Pathology Research Seminar
Brendan Manning, PhD
Associate Professor, Genetics & Complex Diseases
Harvard University, School of Public Health
Topic: mTOR Signaling in Metabolism and Cancer
12 pm WRB 1-413

Physiology and Biophysics Seminar
Michelle Puchowicz, PhD
Assistant Professor, Nutrition
Analytical Core Director, MMPC
Topic: Neuroprotection by Ketosis
4 pm SOM E501

October 19

Immunology Seminar
Amy Hise, MD
Assistant Professor, Center for Global Health and Diseases
Topic: The Role of the Inflammasome in Anti-Fungal Host Defense
12 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
Robert Dean, MD
Associate Staff, Hematologic Oncology & Blood Disorders
Cleveland Clinic
Topic: Hodgkin Lymphoma
12 pm R3-002 Cleveland Clinic

Special Seminar
Henri Brunengraber, MD, PhD
Professor and Chair, Nutrition
Topic: Uncovering the Metabolism of 4-Hydroxyacids: Drugs of Abuse and Products of Lipid Peroxidation
1pm NE1-205 Cleveland Clinic

October 20

Developmental Therapeutics Program Meeting canceled

Hematology/Oncology Special Seminar
Bryan P. Schneider, MD
Assistant Professor, Medicine and Medical/Molecular Genetics- Hem/Onc & Clinical Pharmacology
Indiana University Melvin and Bren Simon Cancer Center
Topic: Personalized Medicine for Triple Negative Breast Cancer - New Dimensions in Therapeutic Individualization
8 am Lerner Tower B-151

Pathology Graduate Student Seminar
Yeritza Hernandez
Boom Lab, Pathology
Topic: Differentiation of Tregs and Th17 Cells by Lung APCs: Role for Retinoic Acid
12 pm WRB 1-413

LRI Showcase Seminar
Candece Gladson, MD
Professor, Cancer Biology
CWRU/ Cleveland Clinic
Topic: New Anti-Angiogenic Therapy for Glioblastoma Tumors
4:30 pm NE1-205 Cleveland Clinic

October 21

Neurosciences Seminar
Robert Gordon Kalb, MD
Associate Professor, Neurology
University of Pennsylvania
Topic: From Molecular Machines to Locomotor Behavior
12:10 pm BRB 105

Cell Death Regulation Meeting
Donna Hansel, MD, PhD, Matt Summers and Alex Almasan
Topic: DNA Damage and Checkpoints (Part II)
Clark Distelhorst, MD
Topic: EAB Follow-up
4-6 pm NA2-30 Cleveland Clinic

October 22

Cancer Center Research in Progress Seminar canceled

Hematology and Oncology Fellows
Alvin Schmaier, MD
Professor, Medicine- Hem/Onc
Topic: Thrombocytopenia
8 am Wearn 137

Cancer Center Seminar Series
Nancy Ratner, PhD
Professor, Division of Experimental Hematology and Cancer Biology
Cincinnati Children's Hospital
Topic: Neurofibromatosis: Timing and Targets
12 pm BRB 105


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413

Case CCC Clinical Research Retreat
November 9
6-9pm Dively Building


2010 Cleveland Nanomedicine Summit
October 18-19
InterContinental Hotel, Cleveland, OH

International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
October 18-19
Purdue University, West Lafayette, IN

ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
October 18-20
Hollywood, FL
Call for Abstracts

Conference on Clinical Cancer Research
Wednesday, October 20
Westin City Center, Washington DC

2010 Regional RNA Meeting of the Midwest (aka Rustbelt Meeting)
October 22-23
Cleveland, OH
Contact Saba Valadkhan and David Rueda for more information

2010 International Conference of RNA Nanotechnology and Therapeutics
October 23- 25
Crowne Plaza Hotel, Cleveland

Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH

Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16


DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Awards
Application Deadline: October 20

DOD Peer Reviewed Cancer Research Program (PRCRP) Translational New Investigator Awards
Application Deadline: October 20

AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research
Deadline: November 2

Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Pre-application Deadline: November 19
Application Deadline: December 7

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Sidney Kimmel Scholar Award
Deadline: December 1

Sidney Kimmel Translational Science Award
Deadline: December 1

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Comprehensive Partnerships to Reduce Cancer Health Disparities (U54) (RFA-CA-11-001)

Translational Scholar Career Awards in Pharmacogenomics and Personalized Medicine (K23) (PA-11-009)

Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30) (PAR-11-005)

Reminder: Submission of the PHS 416-7 Termination Notice Not Required for Kirschstein-NRSA T34 Pre-baccalaureate Trainees (NOT-OD-11-001)

Proposal Preparation Costs Allowable as a Direct Charge for Mentored Career Development Awards (NOT-OD-11-002)

Publication of the Revised NIH Grants Policy Statement (Rev. 10/1/2010): Policy Changes, Clarifications and Document Enhancements (NOT-OD-11-003)

PD/PI Verification No Longer Necessary to Submit Final Invention Statements in eRA Commons Closeout Feature (NOT-OD-11-012)

Correction to the Eligibility Window for the NIH Directors Early Independence Awards (DP5) (NOT-OD-11-013)

NIH Response to Grants.gov System Problems: Deadline Extended for Electronic Applications Due on October 15, 2010 (RFA-GM-11-004) (NOT-OD-11-014)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.