October 11, 2010
CASE CCC IN THE NEWS
Health Care Costs for College Students Could Make You Sick; Know Your Options
Scientists Create Stem Cells That Don't Age
MESSAGE FROM THE DIRECTOR: Dr. James A. Levine Appointed as Chief of the Division of Endocrinology
Dear Cancer Center Members: Below is an announcement from Drs. Fred Rothstein and Richard Walsh announcing the appointment of Dr. James A. Levine as Chief of the Division of Endocrinology at University Hospitals. Please note this is an important recruit for the Aging and Energetics in Cancer Program.
We are pleased to announce the appointment of James A. Levine, MD, PhD, as Chief of the Division of Endocrinology in the Department of Medicine at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine. Dr. Levine will assume his duties as chief starting Nov. 1.
Dr. Levine comes to UH from Mayo Clinic in Rochester, Minn., where he has been Professor of Medicine, Professor of Physiology and Bioengineering and the Richard Emslander Chair in Nutrition and in Metabolism.
Dr. Levine is an internationally renowned expert in obesity, undernutrition and human energy requirements. He has developed practical solutions to help people lose weight in settings such as businesses, schools and metropolitan areas. He is board certified in internal medicine; and endocrinology, diabetes and metabolism.
In the laboratory, Dr. Levine's research has focused on understanding "non-exercise activity thermogenesis" (NEAT), obesity and body weight regulation. NEAT refers to the idea that expending calories through the activities of daily living is more important for calorie burning than exercise is.
More than 150 of his manuscripts have been published in peer-reviewed journals, including Science, Nature, The New England Journal of Medicine and The Lancet. He authored the non-fiction book, Move A Little Lose a Lot (Random House, 2009).
Dr. Levine has received more than 50 national and international awards in science, including the Judson Daland Prize from the American Philosophical Society. He holds several NIH and other federal grants. His "treadmill desk" is now produced as "The Walkstation" by Steelcase Inc. The company he founded with business partner John Montague, Muve Inc., which builds the calorie-counting "Gruve" device, won the Minnesota Cup Award for most innovative business idea of 2007.
CTSC Core Utilization Awards
Congratulations to the following Cancer Center members who were recently awarded CTSC Core Utilization Awards:
Mark Smith, PhD: Mass Spectrometry Analysis of Neurofilament Protein
Researchers Discover Novel Method to Identify Metastatic Breast Cancer Cells from their Nonmetastatic Counterparts
Excerpt from the School of Medicine Dean's October 2010 Newsletter
The development of metastatic phenotypes in cancer patients is devastating and underlies the deaths of 90 percent of patients with solid tumors, including those originating in the breast. Information as to how metastases arise during breast cancer progression remains incomplete, as does the ability to readily distinguish metastatic cells from their nonmetastatic counterparts. In a study appearing in Oncogene, researchers from the Case Comprehensive Cancer Center developed a unique and simple assay that marks and differentiates lethal metastatic breast cancer cells from indolent forms of the disease. In doing so, William P. Schiemann, PhD, co-director, Breast Cancer Program and associate professor, general medical sciences-oncology and Michael K. Wendt, PhD, American Cancer Society Postdoctoral Fellow at the School of Medicine, found that late-stage breast cancer cells form compact and dense spheroid structures in 3-dimensional culture systems, while nonmetastatic cells form intricate branched structures. The researchers went on to show that the process of epithelial-mesenchymal transition was sufficient to drive spheroid development and metastasis in breast cancer cells. The study delineates new mechanistic insights into how breast cancer cells become metastatic, as well as provides new methodologies that may improve the detection of metastatic disease in clinical settings.
AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research
Applications are currently being accepted for the AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research. Research projects are restricted to translational pancreatic cancer research that includes the use of human tissue and has implications for therapeutic application and individualized medicine. Proposed research must have implications for individualized cancer treatment and must make use of human biopsies or samples, such as needle biopsies or circulating cancer cells. In vivo primary tumor explants meet these criteria, but xenografts from established cell lines do not. One grant will be awarded this cycle.
Deadline: November 2
Center for Cancer Research Clinical Investigator Development Program
The Center for Cancer Research (CCR) announces a training opportunity for physicians interested in dedicating their careers to clinical oncology research. The Clinical Investigator Development Program will link eligible clinicians to a vibrant, multidisciplinary research community of more than 250 talented CCR intramural scientists conducting cutting-edge research on the campuses of the NIH in Bethesda and Frederick, Maryland. The CCR is nationally recognized as a premier training ground for clinical research, which is conducted in the state-of-the-art Clinical Research Center in Bethesda.
Deadline: October 15
Sidney Kimmel Scholar and Translational Science Awards
The Sidney Kimmel Foundation for Cancer Research is accepting applications for the following awards:
Kimmel Scholar Award
The Kimmel Translational Science Award
Deadline for both awards: December 1
MARK YOUR CALENDARS
Cell Death Regulation Program Meetings
As a follow-up to the Cell Death Regulation (Program 2) mini-retreat in June, the Program will be hosting a series of monthly meetings to examine topics in DNA damage response. The second meeting will Thursday, October 21 from 4-6 pm in Lerner Research Building NA2-30 at the Cleveland Clinic. Drs. Donna Hansel, Matt Summers, and Alex Almasan will present on DNA Damage and Checkpoints, Part 2. Drs. Clark Distelhorst and Nancy Oleinick will give a follow-up on the EAB visit. Light refreshments will be provided. Please contact Kristin Waite with any questions.
Case CCC Clinical Research Retreat
The next Case CCC Clinical Research Retreat will be held on Tuesday, November 9 from 6-9pm in the Dively Building at CWRU. We will provide an update on current trial accrual and initiatives to increase recruitment to our trials, as well as a discussion of integrating biomarkers into patient selection, response evaluation and target validation and novel statistical design for early phase clinical trials. A detailed program will follow shortly.
NCI CANCER BULLETIN
October 5, 2010
**All events are open to anyone interested in attending
Harvey Werber Memorial Lecture
Cleveland Clinic Seminar
Harvey Werber Memorial Lecture
Science Café Cleveland
Taussig Cancer Institute Core Curriculum Series
ICC Grand Rounds
Pathology Graduate Student Seminar
UCSC Genome Browser Hands-On Tutorial and User Workshop
Ribonucleotide Reductase Journal Club
Cancer Center Seminar Series canceled
Hematology and Oncology Fellows
Taussig Cancer Institute Grand Rounds
Cancer Center Research in Progress Seminar
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS
Cancer Center Scientific Series
ADDITIONAL UPCOMING SEMINARS & EVENTS
Third Annual Personalized Health Care National Conference
2010 Cleveland Nanomedicine Summit
International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
Conference on Clinical Cancer Research
2010 International Conference of RNA Nanotechnology and Therapeutics
Graft versus Host Disease Conference
Active Living Research Annual Conference
Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES
AACR GHA Clowes Memorial Award
International Clinical Research Fellows (ICRF) Program
NIH BULLETIN – Notices and Funding Opportunities
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
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