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Case Comprehensive Cancer Center Newsletter

October 11, 2010


Health Care Costs for College Students Could Make You Sick; Know Your Options
WKYC-TV - Oct 11, 2010
"Much like anything else, you have to read between the lines and look at the fine print," says Dr. George Kikano is in the Family Medicine Department at ...

Scientists Create Stem Cells That Don't Age
AOL Health - Oct 4, 2010
Dr. Hillard M. Lazarus, a stem cell expert at University Hospitals Case Medical Center, said that while he and his colleagues have worked with mesenchymal ...


MESSAGE FROM THE DIRECTOR: Dr. James A. Levine Appointed as Chief of the Division of Endocrinology

Dear Cancer Center Members: Below is an announcement from Drs. Fred Rothstein and Richard Walsh announcing the appointment of Dr. James A. Levine as Chief of the Division of Endocrinology at University Hospitals. Please note this is an important recruit for the Aging and Energetics in Cancer Program.

We are pleased to announce the appointment of James A. Levine, MD, PhD, as Chief of the Division of Endocrinology in the Department of Medicine at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine. Dr. Levine will assume his duties as chief starting Nov. 1.

Dr. Levine comes to UH from Mayo Clinic in Rochester, Minn., where he has been Professor of Medicine, Professor of Physiology and Bioengineering and the Richard Emslander Chair in Nutrition and in Metabolism.

Dr. Levine is an internationally renowned expert in obesity, undernutrition and human energy requirements. He has developed practical solutions to help people lose weight in settings such as businesses, schools and metropolitan areas. He is board certified in internal medicine; and endocrinology, diabetes and metabolism.

In the laboratory, Dr. Levine's research has focused on understanding "non-exercise activity thermogenesis" (NEAT), obesity and body weight regulation. NEAT refers to the idea that expending calories through the activities of daily living is more important for calorie burning than exercise is.

More than 150 of his manuscripts have been published in peer-reviewed journals, including Science, Nature, The New England Journal of Medicine and The Lancet. He authored the non-fiction book, Move A Little Lose a Lot (Random House, 2009).

Dr. Levine has received more than 50 national and international awards in science, including the Judson Daland Prize from the American Philosophical Society. He holds several NIH and other federal grants. His "treadmill desk" is now produced as "The Walkstation" by Steelcase Inc. The company he founded with business partner John Montague, Muve Inc., which builds the calorie-counting "Gruve" device, won the Minnesota Cup Award for most innovative business idea of 2007.

CTSC Core Utilization Awards

Congratulations to the following Cancer Center members who were recently awarded CTSC Core Utilization Awards:

Mark Smith, PhD: Mass Spectrometry Analysis of Neurofilament Protein
Kingman Strohl, MD: Novel Role for Apolipoprotein a2 in the Respiratory Neuroaxis

Researchers Discover Novel Method to Identify Metastatic Breast Cancer Cells from their Nonmetastatic Counterparts

Excerpt from the School of Medicine Dean's October 2010 Newsletter

The development of metastatic phenotypes in cancer patients is devastating and underlies the deaths of 90 percent of patients with solid tumors, including those originating in the breast. Information as to how metastases arise during breast cancer progression remains incomplete, as does the ability to readily distinguish metastatic cells from their nonmetastatic counterparts. In a study appearing in Oncogene, researchers from the Case Comprehensive Cancer Center developed a unique and simple assay that marks and differentiates lethal metastatic breast cancer cells from indolent forms of the disease. In doing so, William P. Schiemann, PhD, co-director, Breast Cancer Program and associate professor, general medical sciences-oncology and Michael K. Wendt, PhD, American Cancer Society Postdoctoral Fellow at the School of Medicine, found that late-stage breast cancer cells form compact and dense spheroid structures in 3-dimensional culture systems, while nonmetastatic cells form intricate branched structures. The researchers went on to show that the process of epithelial-mesenchymal transition was sufficient to drive spheroid development and metastasis in breast cancer cells. The study delineates new mechanistic insights into how breast cancer cells become metastatic, as well as provides new methodologies that may improve the detection of metastatic disease in clinical settings.


AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research

Applications are currently being accepted for the AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research. Research projects are restricted to translational pancreatic cancer research that includes the use of human tissue and has implications for therapeutic application and individualized medicine. Proposed research must have implications for individualized cancer treatment and must make use of human biopsies or samples, such as needle biopsies or circulating cancer cells. In vivo primary tumor explants meet these criteria, but xenografts from established cell lines do not. One grant will be awarded this cycle.

Deadline: November 2

Center for Cancer Research Clinical Investigator Development Program

The Center for Cancer Research (CCR) announces a training opportunity for physicians interested in dedicating their careers to clinical oncology research. The Clinical Investigator Development Program will link eligible clinicians to a vibrant, multidisciplinary research community of more than 250 talented CCR intramural scientists conducting cutting-edge research on the campuses of the NIH in Bethesda and Frederick, Maryland. The CCR is nationally recognized as a premier training ground for clinical research, which is conducted in the state-of-the-art Clinical Research Center in Bethesda.

Deadline: October 15

Sidney Kimmel Scholar and Translational Science Awards

The Sidney Kimmel Foundation for Cancer Research is accepting applications for the following awards:

Kimmel Scholar Award
The Kimmel Foundation is seeking accomplished young investigators dedicated to a career in cancer research. Applications are limited to those who achieved the equivalent rank of Assistant Professor on or after July, 2007. However, physicians who have both clinical and research responsibility are eligible if appointed on or after July, 2006. These awards are designed for researchers who do not yet have their own R01 funding. Applicants will be judged on the basis of quality of prior work, research proposed and letters of support. Funding of awards will be subject to execution of binding agreements setting forth terms and conditions under which scholarships will be provided. Applicants for 2011 awards will be notified by mid-April, 2011.

The Kimmel Translational Science Award
The Foundation provides up to five additional awards specifically for physicians engaged in translational science. Eligibility includes those with M.D. or equivalent degrees, who have achieved the rank of Assistant Professor on or after July, 2006. Candidates must not hold R01 funding for the laboratory component of their cancer research. Applicants must demonstrate a significant personal involvement in the laboratory component of the translational project described. The translational research may involve primarily animal studies but must include reasonable application to subsequent human investigation.

Deadline for both awards: December 1


Cell Death Regulation Program Meetings

As a follow-up to the Cell Death Regulation (Program 2) mini-retreat in June, the Program will be hosting a series of monthly meetings to examine topics in DNA damage response. The second meeting will Thursday, October 21 from 4-6 pm in Lerner Research Building NA2-30 at the Cleveland Clinic. Drs. Donna Hansel, Matt Summers, and Alex Almasan will present on DNA Damage and Checkpoints, Part 2. Drs. Clark Distelhorst and Nancy Oleinick will give a follow-up on the EAB visit. Light refreshments will be provided. Please contact Kristin Waite with any questions.

Case CCC Clinical Research Retreat

The next Case CCC Clinical Research Retreat will be held on Tuesday, November 9 from 6-9pm in the Dively Building at CWRU. We will provide an update on current trial accrual and initiatives to increase recruitment to our trials, as well as a discussion of integrating biomarkers into patient selection, response evaluation and target validation and novel statistical design for early phase clinical trials. A detailed program will follow shortly.


October 5, 2010

Featured Article: Experts Urge Further Research on Nicotine Reduction to Decrease Tobacco Addiction

Less-invasive Lymph Node Surgery Safe for Women with Breast Cancer

HPV Screen-and-Treat Methods Prevent Cervical Cancer Precursors in Low-resource Settings

Black Patients with Advanced Cancer Are More Likely to Receive Unwanted Care at End of Life

Genetic Study Finds Clue to Gastrointestinal Stromal Tumors

In Depth
Studies Provide New Data on Mammography and Breast Cancer Mortality

Turning the Immune System against a Childhood Cancer

Featured Clinical Trial: Preventing Chemotherapy-related Hearing Loss in Young Cancer Patients

Profiles in Cancer Research: Dr. Pier Paolo Pandolfi

Physician Assistants Valued for Patient Care and Research Support at NCI





**All events are open to anyone interested in attending

October 11

Harvey Werber Memorial Lecture
Bruce Beutler, MD
Professor and Chair, Genetics
Scripps Research Institute
Topic: Forward Genetics in the Mouse: Some Recent Discoveries
12 pm WRB 1-413

Cleveland Clinic Seminar
Bela Anand-Apte, MD, PhD
Associate Professor, Ophthalmology/Cell Biology
CWRU/ Cleveland Clinic
Topic: Regulation of Neovascularization by Tissue Inhibitor of Metalloproteinases-3 (TIMP-3)
12 pm NC1-202 Cleveland Clinic

SDIG Meeting
Ernest Chan, PhD
Postdoctoral Fellow
Cleveland Clinic
Topic: Determining Microflora Composition Using 16S rRNA Deep Sequencing Data
2:30 pm WRB 1-403

Harvey Werber Memorial Lecture
Bruce Beutler, MD
Professor and Chair, Genetics
Scripps Research Institute
Topic: How We Sense Infection and Initiate an Inflammatory Response
4-5:15 pm WRB 5-136

Science Café Cleveland
Ruth Keri, PhD
Associate Professor, Pharmacology
Agata Exner, PhD
Associate Professor, Radiology
Topic: Pills and Needles are so 20th Century: How Advancements in Drug Target Discovery and Drug Delivery are Shifting the Strategy in the Battle Against Cancer
6:30 pm Great Lakes Brewing Co.

October 12

Immunology Seminar
John Nedrud, PhD
Professor, Pathology
Topic: What are the Mechanisms of Immunity to Helicobacter Pylori Infection?
12 pm BRB 105

Taussig Cancer Institute Core Curriculum Series
Topic: Bioethics
12 pm R3-002 Cleveland Clinic

October 13

ICC Grand Rounds
Sanford Markowitz, MD, PhD
Professor, Medicine- Hem/Onc
Topic: Colon Cancer Genetics
8 am Lerner Tower B-151

Pathology Graduate Student Seminar
Jill Marinis
Abbott Lab, Pathology
Topic: Negative Regulation of NOD2 Signaling
12 pm WRB 1-413

UCSC Genome Browser Hands-On Tutorial and User Workshop
Robert Kuhn, PhD
Associate Director, Genome Browser Project, Center for Biomolecular Science and Engineering
University of California, Santa Cruz
1-4 pm SOM E401

Ribonucleotide Reductase Journal Club
Tomas Radivoyevitch, PhD
Assistant Professor, Epidemiology and Biostatistics
Topic: Activity of Ribonucleotide Reductase Helps Determine How Cells Repair DNA Double Strand Breaks; DNA Repair 8 (2009) 1258–1263
2 pm SOM W331

October 14

Neurosciences Seminar
Qiufu Ma, PhD
Associate Professor, Neurobiology
Harvard University
Topic: Generation of Somatic Sensory Neuron Diversity and the Coding of Pain Versus Itch
12:10 pm SOM E501

October 15

Cancer Center Seminar Series canceled

Hematology and Oncology Fellows
Lan Zhou, MD
Assistant Professor, Pathology
Topic: Introduction to Transfusion Medicine
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Sanford Markowitz, MD, PhD
Professor, Medicine-Hematology/Oncology
Topic: Genetic Opportunities to Prevent Deaths from Colon Cancer
8 am R3/002-003 Cleveland Clinic

Cancer Center Research in Progress Seminar
Nermeen Barakat, PhD
Postdoctoral Scholar, Koon Lab
Topic: ALK Signaling in Lung Cancer
4 pm WRB WRB 3-136


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413


Third Annual Personalized Health Care National Conference
October 14-15
The Ohio State University, Columbus, OH

Oncology Congress
October 15-17
San Francisco, CA

2010 Cleveland Nanomedicine Summit
October 18-19
InterContinental Hotel, Cleveland, OH
Clinical and research abstracts will be accepted through October 1 (please note new deadline)

International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
October 18-19
Purdue University, West Lafayette, IN

ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
October 18-20
Hollywood, FL
Call for Abstracts

Conference on Clinical Cancer Research
Wednesday, October 20
Westin City Center, Washington DC

2010 Regional RNA Meeting of the Midwest (aka Rustbelt Meeting)
October 22-23
Cleveland, OH
Contact Saba Valadkhan and David Rueda for more information

2010 International Conference of RNA Nanotechnology and Therapeutics
October 23- 25
Crowne Plaza Hotel, Cleveland

Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH

Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16


AACR GHA Clowes Memorial Award
Deadline: October 15

ACS Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families:
Deadline: October 15

ACS Area of Special Interest: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: October 15

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Nomination Deadline: October 15

AACR Richard and Hinda Rosenthal Memorial Award
Nomination Deadline: October 15

DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Awards
Application Deadline: October 20

DOD Peer Reviewed Cancer Research Program (PRCRP) Translational New Investigator Awards
Application Deadline: October 20

Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Pre-application Deadline: November 19
Application Deadline: December 7

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

NIH Director's Early Independence Awards (DP5) (RFA-RM-10-019)

New Procedures and Instructions for Submitting Annual Progress Reports for Multi-Year Funded (MYF) Awards (NOT-OD-11-010)

Notice to Correct NSF's Participation in the Joint Agency SBIR Funding Opportunity Announcement for Robotics, PAR-10-279 (R43) (NOT-OD-11-011)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.