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Case Comprehensive Cancer Center Newsletter

October 4, 2010


Evolutionary Dynamics in Carcinogenesis and Cancer Treatment

This week's Cancer Center Seminar Series is co-sponsored by the Case Comprehensive Cancer Center and the CWRU Institute for Science of Origins. Please join us Friday, October 8 to hear guest speaker Robert A. Gatenby, MD present Evolutionary Dynamics in Carcinogenesis and Cancer Treatment.

Robert A. Gatenby, MD is the Chairman of the departments of Radiology and codirector of the Integrated Mathematical Oncology at H. Lee Moffitt Cancer Center. He joined Moffitt in 2008 from the University of Arizona where he was Professor, Department Radiology and Professor, Department of Applied Mathematics since 2000. He received a BSE in Bioengineering and Mechanical Sciences from Princeton University and an MD from the University of Pennsylvania in 1977. He completed his residency in radiology at the University of Pennsylvania where he served as chief resident. Dr. Gatenby remains an active clinical radiologist specializing in body imaging. While working at the Fox Chase Cancer Center after residency, Dr. Gatenby perceived that cancer biology and oncology were awash in data but lacked coherent frameworks of understanding to organize this information and integrate new results. Since 1990, most of Dr. Gatenby's research has focused on exploring mathematical methods to generate theoretical models for cancer biology and oncology. His current modeling interests include: 1. the tumor microenvironment and its role in tumor biology. 2. evolutionary dynamics in carcinogenesis, tumor progression and therapy. 3. information flow in living systems and its role in maintaining thermodynamic stability.

Please join us for this important seminar Friday, October 8 at 12 pm in BRB 105. Refreshments will be served.


Genes Correlate with RCC Recurrence Risk
Renal and Urology News - Sep 30, 2010
... advance," said principal study investigator Brian I. Rini, MD, Associate Professor of Medicine at the Cleveland Clinic Taussig Cancer Institute in Ohio. ...

Cleveland Physicians and Scientists Focus on Skin Cancer Research, Treatment
Plain Dealer - Sep 27, 2010
"It came together spontaneously," Dr. Kevin Cooper, chairman of the dermatology department at CWRU and University Hospitals Case Medical Center, ...

Case Western Reserve School of Medicine Researcher Discovers New "Anti-pathogenic" Drugs to Treat MRSA
CWRU SOM - Sep 16, 2010
Menachem Shoham, PhD, associate professor and researcher in the department of biochemistry at the Case Western Reserve University School of Medicine, has identified new anti-pathogenic drugs that...

New Dual Recognition Mechanism Discovered in Tuberculosis
CWRU SOM - Sep 9, 2010
For the past 15 years, Drs. Clifford Harding and W. Henry Boom of Case Western Reserve have been seeking the answer to this question....


Please join us in welcoming the newest members of the Case CCC:

Manmeet Ahluwalia, MD
Section Head, Brain Tumor and Neuro-Oncology Center
Developmental Therapeutics Program

Kimberly Resnick, MD
Assistant Professor, Gynecologic Oncology
Developmental Therapeutics Program


Patrick Ma Receives DOD Award

Patrick Ma, MD recently received the Department of Defense CDMRP - Lung Cancer Research Program, Lung Cancer Promising Clinician Research Grant Award (2010-13) for his project: "Optimizing MET-Targeted Therapy for Lung Cancer Personalized Treatment".


AACR GHA Clowes Memorial Award

Nominations are being accepted for the AACR GHA Clowes Memorial Award, which recognizes an individual with outstanding recent accomplishments in basic cancer research. The winner of thsi award will receive a $10,000 honorarium, give a 50-minute lecture during the AACR Annual Meeting 2011 in Orlando, FL, and be given support for the winner and a guest to attend the Annual Meeting. The winner will also speak at the Eli Lilly and Company headquarters in Indianapolis, Indiana, at the invitation of the company later in 2011.

Deadline: October 15


Survivorship Workshop

The Gathering Place is presenting a special program, The Cancer is Over, Now What, scheduled for Thursday, October 7 from 6:30 pm - 8:30 pm at The Gathering Place East. Speaker Kevin Oeffinger, MD, a nationally known expert on cancer survivorship and the Director of the Adult Long-Term Follow-Up Program at Memorial Sloan-Kettering Hospital in New York. Dr. Oeffinger will be speaking about late effects and risks following cancer treatment and the benefits of having a survivorship health care plan. Program includes a panel of cancer survivors sharing strategies they used to cope. Advance registration is required.

UCSC Genome Browser Hands-On Tutorial and User Workshop

The Center for Human Genetics Laboratory, UH, Department of Genetics, and CWRU welcome Robert Kuhn, PhD, Associate Director of the Genome Browser Project, Center for Biomolecular Science and Engineering at University of California, Santa Cruz for a UCSC Genome Browser Hands-On Tutorial and User Workshop, Wednesday, October 13 from 1-4 pm in SOM E401. Bring your laptop for real-time practice.

Cancer Survivorship: Bridging the Gap Between Primary Care and Oncology

Taussig Cancer Institute is presenting Cancer Survivorship: Bridging the Gap Between Primary Care and Oncology on Friday, October 8 from 7:30 am - 4 pm. This program will provide intensive multidisciplinary review of cutting-edge topics on providing care for cancer survivors. visit the Cleveland Clinic website for registration information and to view the agenda.

2010 Regional RNA Meeting of the Midwest

The Center for RNA Molecular Biology in Cleveland is hosting the 2010 Regional RNA Meeting of the Midwest, aka the Rustbelt Meeting, in Cleveland on October 22-23. The meeting provides an excellent opportunity to meet the RNA scientists from Ohio and neighboring states, start new collaborations and also for our student and postdoctoral scientist colleagues to hone their presentation skills. The registration deadline for Cleveland area scientists is extended to October 1. Please contact the organizers of the meeting, Saba Valadkhan and David Rueda if you have any questions.

2010 Cleveland Nanomedicine Summit

Registration is open for the 2010 Cleveland NanoMedicine Summit, October 18-19 at the InterContinental Hotel. Co-hosted by the Cleveland Clinic and CWRU, this event will continue its incredibly successful format that brings together scientists, clinicians, business professionals, investors, and others to investigate sustainable solutions of multidisciplinary methodologies to further advance the use of nanomedicine in clinical practice. Clinical and research abstracts on the topic of nanoparticles for diagnostics, imaging, and therapeutics will be accepted through October 1. Cancer Center members Drs. Vinod Labhasetwar, James Basilion and Maciej Zborowski are on the Organizing Committee.

Graft versus Host Disease Conference

Together with the Case CCC, the Meredith A. Cowden Foundation presents the 2010 National GVHD Symposium to be held at Corporate College East on Thursday, November 4. This unique one-day program will be a two-track conference (one for physicians and one for patients) focusing on cutting edge research and new treatments. Continuing medical education credits will be offered for attending and participating medical providers.

Featured Case CCC presenters include: Drs. Stan Gerson, Ken Cooke, Matt Kalaycio and Jeff Auletta.



**All events are open to anyone interested in attending

October 4

Pathology Research Seminar
Walter Boron, MD, PhD
Professor and Chairman, Physiology and Biophysics
Topic: Sniffing CO2 and HCO3: How the Kidney Senses Acidosis
12 pm WRB 1413

Physiology and Biophysics Seminar
Kodi Ravichandran, PhD
Professor, Microbiology
University of Virginia
Topic: Signals for Apoptotoc Cell Clearance: The Begininnigs of a Good Meal
4 pm SOM E501

October 5

Immunology Seminar
Susan Pierce, PhD
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Topic: It's All About Change: The Antigen-Driven Initiation of B Cell Receptor Signaling
12 pm BRB 105

Taussig Cancer Institute Core Curriculum Series
Mikkael Sekeres, MD
Associate Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: MDS
12 pm R3-002 Cleveland Clinic

Cleveland Clinic Seminar
Jonathan Stamler, MD
Professor, Medicine and Biochemistry
Director for the Institute for Transformative Molecular Medicine
Topic: Transforming NO bioactivity through protein S-nitrosylation
1 pm NE1-205

October 6

ICC Grand Rounds
Polly Mazanec, PhD, MSN
Assistant Professor, Nursing
Topic: Palliative Care and Pain Management in Oncology
8 am Lerner Tower B-151

Cleveland Clinic Seminar
Jeong-Su Do, PhD
Postdoctoral Fellow, Min Lab, Immunology
Cleveland Clinic
Topic: CD4 T Cells Enhance IL-17 Expression in gamma delta T cells
12 pm NC1-202

October 7

Neurosciences Seminar
Lynn Landmesser, PhD
Professor, Neurosciences
Topic: Making Effective Synapses: Roles of NCAM Isoforms and MLCK/myosin II
12:10 pm BRB 105

Special Seminar
Kevin Oeffinger, MD
Director, Adult Long-Term Follow-Up Program
Memorial Sloan- Kettering Hospital
Topic: The Cancer is Over- Now What
6:30 pm - 8:30 pm Gathering Place East

October 8

Hematology and Oncology Fellows
Lalitha Nayak, MD
Fellow, Medicine- Hem/Onc
Topic: Overview of Anticoagulation
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Robert Timmerman, MD
Professor, Radiation Oncology
University of Texas Southwestern
Topic: Curing Cancer Quickly with Image Guided and Stereotactic Radiotherapy
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Robert Gatenby, MD
Chair, Diagnostic Imaging and Integrative Mathematical Oncology
H. Lee Moffitt Cancer Center
Topic: Evolutionary Dynamics in Carcinogenesis and Cancer Treatment
12 pm BRB 105

Cancer Center Research in Progress Seminar
Shigemi Matsuyama, DVM, PhD
Assistant Professor, Medicine-Hem/Onc
Topic: Role of Cell Death and Cellular Senescence in Organismal Aging
4 pm WRB WRB 3-136


Case CCC Calendar

LRI Calendar


Cancer Center Scientific Series
November 8
4-7 pm WRB 1-413


Science Café Cleveland
October 11
Great Lakes Brewing Company
Drs. Ruth Keri and Agata Exner
Topic: Pills and needles are so 20th century: How advancements in drug target discovery and drug delivery are shifting the strategy in the battle against cancer.

Third Annual Personalized Health Care National Conference
October 14-15
The Ohio State University, Columbus, OH

Oncology Congress
October 15-17
San Francisco, CA

2010 Cleveland Nanomedicine Summit
October 18-19
InterContinental Hotel, Cleveland, OH
Clinical and research abstracts will be accepted through October 1 (please note new deadline)

International Symposium on Breast Cancer Prevention: Nutrition, Communication and Public Policy
October 18-19
Purdue University, West Lafayette, IN

ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer
October 18-20
Hollywood, FL
Call for Abstracts

Conference on Clinical Cancer Research
Wednesday, October 20
Westin City Center, Washington DC

2010 Regional RNA Meeting of the Midwest (aka Rustbelt Meeting)
October 22-23
Cleveland, OH
Contact Saba Valadkhan and David Rueda for more information

2010 International Conference of RNA Nanotechnology and Therapeutics
October 23- 25
Crowne Plaza Hotel, Cleveland

Graft versus Host Disease Conference
November 4
Corporate College East, Cleveland, OH

Active Living Research Annual Conference
February 22-24, 2011
San Diego, CA
Call for Abstracts Deadline: August 6

Multilevel Interventions in Health Care: Building the Foundation for Future Research Goals
March 4-5, 2011
Las Vegas, Nevada

4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29, 2011
Bethesda North Marriot Hotel & Conference Center in Bethesda, Maryland

Call for Abstracts: 2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29, 2011
Omni Shoreham, Washington, DC
Abstract Deadline: December 16


ACS Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families:
Deadline: October 15

ACS Area of Special Interest: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: October 15

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Nomination Deadline: October 15

AACR Richard and Hinda Rosenthal Memorial Award
Nomination Deadline: October 15

DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Awards
Application Deadline: October 20

DOD Peer Reviewed Cancer Research Program (PRCRP) Translational New Investigator Awards
Application Deadline: October 20

Susan G. Komen for the Cure Post-Baccalaureate Training in Disparities Research Grants
Full Application Deadline: November 2

Susan G. Komen for the Cure Investigator-Initiated Research (IIR)
Full Application Deadline: November 2

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: November 2

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Pre-application Deadline: November 19
Application Deadline: December 7

International Clinical Research Fellows (ICRF) Program
Deadline: December 1

Susan G. Komen for the Cure Promise Grants
Full Application Deadline: December 7

DOD LCRP Lung Cancer Early Detection Clinical Consortium
Application Deadline: December 7

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: January 5, 2011

Susan G. Komen for the Cure Post Baccalaureate Training in Disparities Research
Full Application Deadline: January 5, 2011

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Special Conferences
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

New Time Limit for NIH Resubmission Applications (NOT-OD-10-140)

NIH, AHRQ, CDC, FDA & NIOSH to Require Use of Updated Electronic Application Forms in 2011 (NOT-OD-11-007)

Updated Electronic Application Forms Required for F, K, T and D Submissions with Due Dates of January 25, 2011 and Beyond (NOT-OD-11-008)

Electronic Submission Reminders for Those Considering Submitting in Response to the SBIR Joint Agency Announcement on Robotics, PAR-10-279 (R43) (NOT-OD-11-009)

Notice of Pre-application Meeting and Correction for Request for Applications (RFA-RM-10-011, RFA-RM-10-012, and RFA-RM-10-013) for the Knockout Mouse Phenotyping (U54), Project Database (U54), and Production and Cryopreservation (U42) (NOT-RM-10-015)

Research on Malignancies in the Context of HIV/AIDS (R01) (PA-10-290)

Research on Malignancies in the Context of HIV/AIDS (R21) (PA-10-291)

Resource Related Research Projects for Development of Animal Models and Related Materials (R24) (PAR-10-289)

Animal and Biological Material Resource Centers (P40) (PAR-11-001)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.