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Case Comprehensive Cancer Center Newsletter

January 19, 2010


Green Tea May Cut Smokers' Lung Cancer Risk
WebMD - Jan 12, 2010
Nathan Pennell, MD, PhD, a doctor at the Taussig Cancer Institute at Cleveland Clinic in Ohio, expressed caution at the findings. He notes that "only seven ...

Drug Shows Promise as New Treatment for Gut Tumor
Science Daily (press release) - Jan 11, 2010
A drug that is already an approved therapy for some cancers also might be an effective secondary treatment for a rare tumor of the gastrointestinal tract, ... The research team includes...Brian P. Rubin, MD, PhD, Lerner Research Institute and Taussig Cancer Center, Cleveland; ...


Bing-Cheng Wang, PhD has been invited to speak at the 2010 Molecular Medicine Workshop, May 6-9 in Camogli-Portofino Vetta, Italy. Dr. Wang will present Akt-EphA2 Crosstalk in Invasive Tumor Progression. The workshop will focus on the role of guidance molecules (such as ephrins,semaphorins, netrins, etc.) in different functional contexts related to cancer. The deadline for registration and abstract submission is February 1.


The Cancer Center's 19 core facilities were highlighted at the recent Case CCC Core Facilities Fair, held the afternoon of Wednesday, January 13 in Wolstein Atrium and Auditorium. The purpose of the event was to raise awareness of the shared resources that are available to members and others within the cancer research community. The afternoon included presentations by two Cancer Center core facility directors: James Jacobberger, PhD, Director of the Cytometry and Imaging Microscopy Core, and Christopher Flask, PhD, Director of the Imaging Research Core. Following the presentations, attendees viewed posters and recent work of all Case CCC core facilities and had the opportunity to talk with core directors, managers and staff.

Both speakers presented the capabilities of their facilities and encouraged attendees to consider how the services could be further applied to research taking place in Cancer Center scientific programs. They also invited investigators to suggest new applications that would be helpful to them.

During his talk, Dr. Jacobberger explained the different qualities of cytometry and confocal microscopy, two methods of cell data collection that often are used as complements to provide a more complete analysis of a single cell. Images illustrated the strengths of each approach: cytometry's ability to capture live cell cycles and microscopy's capacity to measure a cell's changes. He also discussed the importance of laser scanning cytometry, which allows for the subcellular localization analysis. He said cell cycling models are complex and difficult to show, and that platform integration is a key to understanding biochemical systems.

In the subsequent presentation, Dr. Flask noted the important capability of in vivo imaging as an element of the Imaging Research Core. As an example, it allows tracking the effect of contrast agents' uptake pre- and post-therapy, showing whether status is being maintained or is being modulated, and targeting low amounts of radiotracers. The Imaging Core focuses on physiologic/biologic questions that are not yet being addressed in medicine. Dr. Flask added that the core aids in proof of concept experiments, and can house and maintain animals that investigators are studying for up to three months. He also said that because of the broad scope of imaging research in many clinical fields, the core already has demonstrated its potential to bring together disciplines and strengthen collaboration among the Cancer Center's diverse programs.

Wednesday's program is the first in a series of Case CCC Core Facilities Fairs planned for 2010 by Cancer Center Director Stan Gerson, MD. Dr. Gerson believes that there is much to be gained when directors explain the roles each core has in cancer research. Mark Schluchter, PhD, Director of the Biostatistics Core, concurs, saying, "One of the challenges that the Biostatistics Shared Resource and other Cancer Center cores face is that not all Cancer Center investigators are aware of our existence or of the kinds of services we can provide. We are always interested in reaching new members and this fair and other events like it help showcase the cores and what we do."

Watch the newsletter and the Cancer Center website for information on future presentations.

Pat Faller and Kristin Waite contributed to this story.

CALL FOR APPLICATIONS– 2010 NASA Space Radiation Summer School

Applications are now being accepted for the 2010 NASA Space Radiation Summer School. Up to 15 students will be selected for the course to be held this summer at the Brookhaven National Laboratory (BNL) in Long Island, NY from May 20 – June 11. The goal of the course is to provide scientific and practical information to students and scientists who are either new to the NASA program or to charged particle radiobiology. At the completion of the summer school, students will have received the full complement of training required to conduct their own experiments at BNL.

Both foreign nationals and US citizens may apply to the program. All selected students must satisfy BNL and Department of Energy safety and security requirements in order to be admitted. Due to the intense nature of the course, applicants must demonstrate oral and written proficiency in the English language.

Deadline: February 28

For more information, please click here.


Featured Article
Physicians Urged to Consider Active Surveillance in Prostate Cancer

Cancer Research Highlights
Study Weighs Comparative Effectiveness of Low-risk Prostate Cancer Treatments

Lenalidomide Helps Delay Progression of Multiple Myeloma

Genetic Study of Lymphoma Tumors Points to Possible Therapies

Vaccine Kills Residual Leukemia Cells in Patients Treated with Imatinib

Cancer Cells Use Stored Fats to Fuel Aggressive Growth and Spread

Guest Director's Update: Andrea M. Denicoff and Dr. Jeffrey S. Abrams
Targeting Barriers, including Insurance Coverage, to Improve Clinical Trial Participation

FUNDING OPPORTUNITY— Title Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4)

NIH is accepting applications for the "Title Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas" (RC4) (RFA-OD-10-005).

This program will support projects that address research endeavors in specific areas that will benefit from significant three-year funds without the expectation of continued NIH funding beyond this period. The research supported by the program should have high short-term impact, and a high likelihood of enabling growth and investment in biomedical research and development, public health, and health care delivery.

This FOA solicits applications proposing to develop and implement critical research innovations in one or more of the following five thematic areas:

  1. Applying Genomics and Other High Throughput Technologies
  2. Translating Basic Science Discoveries into New and Better Treatments
  3. Using Science to Enable Health Care Reform
  4. Focusing on Global Health
  5. Reinvigorating the Biomedical Research Community

Only applications for projects that require $500,000 or more in total costs per year are expected to be considered for funding.

LOI Deadline: February 15 (requested, not required)
Proposal Deadline: March 15

For details, please click here.

Case CCC Leadership would like to review potential responses, and can assist in developing themes as responsive to the RFA.


**All events are open to anyone interested in attending

January 18

January 19

Immunology Seminar
Kate Fitzgerald, PhD
Associate Professor, Medicine
University of Massachusetts
Molecular Mechanisms Underlying the Sensing of Microbial DNA
12:00 pm WRB 1413

Taussig Cancer Institute Core Curriculum Series
Pierre Triozzi, MD
Staff, Solid Tumor Oncology
Cleveland Clinic
Topic: Melanoma
12:00 pm R3-002 Cleveland Clinic

CTSC Seminar Series
Michael Simonson, MS
Associate Professor, Medicine
Topic: Endothelin as a Novel Therapeutic Target for Fibrosis and the Complications of Diabetes
4:30 pm BRB 105

January 20

Grand Rounds
Mitchell Machtay, MD
Professor and Chairman, Radiation Oncology
Topic: RTOG Update
8:00 am Lerner B-151

CSCRM Seminar and Poster Presentation
Stan Gerson, MD
Director, Case CCC
Director, CSCRM
Professor, Medicine- Hem/Onc
Topic: CSCRM Stem Cell Innovations in 2010 and Beyond
4:30 pm WRB 1413

Lerner Research Institute Showcase Seminar
Claudio Fiocchio, MD
Professor, Pathobiology, Gastroenterology
CWRU/ Cleveland Clinic
Topic: Inflammatory Bowel Disease: Immune and Non-Immune Causes and Mechanisms
4:30 pm NE1-205 Cleveland Clinic

January 21

Developmental Therapeutics Meeting cancelled

Cancer Trainee Seminar Series
Ashley Rettew
PhD Candidate, Pathology
Topic: Novel Receptor Tyrosine Kinases in Osteosarcoma Identified by Phosphoproteomic and Functional Genomic Screening
Cecilia Choi, MD
Fellow, Div. of Hem/Onc
Topic: Osteosarcoma
12:00 pm WRB 3-136

Taussig Cancer Institute Core Curriculum Series
Topic: ASH Review
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
Anthony Jack, PhD
Assistant Professor, Cognitive Science, Philosophy & Psychology
Topic: Two Domains of Human Higher Cognition
12:10 pm BRB 105

January 22

Hem/Onc Fellows Seminar
Nabila Rasool, MD
Fellow, Div. of Gynecologic Oncology
Topic: Management of Cervical Cancer
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
John Niederhuber, MD
Director, National Cancer Institute
Topic: Cancer as an Organ System: The Tumor Microenvironment
8:00 am R3/002-003 Cleveland Clinic

Cell Biology Seminar
Joseph Nadeau, PhD
Professor, Genetics
Topic: Transgenerational Genetic Effects on Cancer, Metabolic Disease and Behavior
10:00 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Cynthia Kenyon, PhD
Director, Hillblom Center for the Biology of Aging
University of California, San Francisco
Topic: Evolutionary-Conserved Pathways that Affect Lifespan
12:00 pm BRB 105

Cancer Center Research in Progress Seminar
Dorjee Shola
Graduate Student, Danielpour Lab, General Medical Sciences (Oncology)
Topic: Investigating the Role of Hic-5 in Prostate Cancer
4:00 pm WRB 3-136


For a complete listing of LRI seminars click here.


Case CCC Scientific Series- TREC
January 28
4:00 pm - 7:00 pm WRB 1-413
Stephanie Doerner, PhD
Cheryl Thompson, PhD
Ofer Reizes, PhD
Sanjay Patel, MD

Olof Pearson Lecture
February 5
12:00 pm WRB 1-413
Speaker: V. Craig Jordan, PhD
Scientific Director, Lombardi Cancer Center
Vincent T. Lombardi Chair of Translational Cancer Research
Georgetown University
Topic: Estrogen in the Life and Death of Breast Cancer

Case CCC Scientific Retreat
July 9-10
The Lodge at Sawmill Creek Resort


12th International Symposium on Anti-Angiogenic Agents: Angio 2010 Recent Advances and Future Directions in Basic and Clinical Cancer Research
February 4-6
Hyatt Regency La Jolla, San Diego, CA

AACR-JCA 8th Joint Conference on Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9
Hilton Waikoloa Village, Waikoloa, HI

13th Annual Meeting of the Translational Research Cancer Centers Consortium
March 1-2
Blackwell Inn, Columbus, OH

AACR 101st Annual Meeting
April 17-21
Washington, DC


Please mark your calendars for the next installment of the Case CCC Scientific Series and reception on January 28 from 4:00-7:00 pm in Wolstein Auditorium (WRB 1413). Presentations will be related to the Case Transdisciplinary Research on Energetics and Cancer (TREC) Center, led by Dr. Nathan Berger:

Stephanie Doerner: Diet, Obesity and Susceptibility to Colon Cancer

Cheryl Thompson, PhD: Activation of the PI3K pathway in colon and breast cancer

Ofer Reizes, PhD: Role of Leptin in Mammary Tumorigenesis

Sanjay Patel, MD: The Effect of Sleep Disturbances on Adipose Tissue Gene Expression

Everyone is welcome and encouraged to attend.

FUNDING OPPORTUNITY– Damon Runyon Cancer Research Foundation Clinical Investigator Award

CWRU SOM has been invited to nominate up to three individuals for the Damon Runyon Cancer Research Foundation Clinical Investigator Award. This award supports young physician-scientists conducting patient-oriented cancer research, with a goal of increasing the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments.

If you are interested in applying for this award, please submit the following materials to gillian.irwin@case.edu by Wednesday, January 20: biosketch and a one-paragraph description of how your research fits the description of "Clinical Research" as described by the Damon Runyon Foundation.

Internal Deadline: January 20
External Deadline: March 1

For details, please click here.


We are always trying to foster communication and collaboration across the cancer center community any way that we can. The Case CCC has set up a page on Facebook and LinkedIn, so please become a fan of us on Facebook or join our group on LinkedIn, and encourage others to do so as well. Please help us spread the word.

We encourage you to post events, relevant news articles, items of discussion, etc… Your feedback is appreciated!

CALL FOR APPLICATIONS– K12 Clinical Oncology Research Training Program

The Case CCC invites applications for its two-year NCI-funded K12 Clinical Oncology Research Training Program, led by Stanton Gerson, MD, Director, and Alvin Schmaier, MD, Co-Director.

This career development program provides interdisciplinary training in clinical and translational oncology research for clinical oncologist who are interested in pursuing academic research careers as oncology physician scientists.

Application Deadline: February 28
Start Date: July 1

For more information and application materials, please click here.

MARK YOUR CALENDARS– NCI 3rd Annual Biospecimen Research Network Symposium

Registration is now open and abstracts are being accepted for NCI's 3rd Annual Biospecimen Research Network Symposium, Advancing Cancer Research Through Biospecimen Science, March 24-25 in Bethesda, Maryland. The symposium will address the significant impact of pre-analytical biospecimen variables on cancer research and molecular medicine. Hosted by NCI's Office of Biorepositories and Biospecimen Research, the meeting will bring together leaders in the fields of biospecimen research, genomics, proteomics, oncology, pathology, biobanking, hospital administration and pharmaceutics as well as patient advocates.

For details, please click here.

FACULTY CANDIDATE SEARCH– Associate Director for Basic Research

The Case CCC is currently accepting applications for the position of Associate Director for Basic Research. As we continue our search, we ask that people in the Cancer Center community encourage any qualified candidate to apply for the position. If you would like to nominate someone for the position, please contact Tracy Rehl (tracy.rehl@case.edu).

Click here to view the job description.


Landon Foundation-AACR INNOVATOR Grant for Research in Personalized Cancer Medicine
Deadline: January 20

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research
Deadline: January 20

Landon Foundation-AACR INNOVATOR Award for International Collaboration
Deadline: January 20

Prostate Cancer Foundation Creativity Awards
Deadline: January 31

IOTF Clinical Oncology Product Research/Review for Oncology Fellows
Deadline: January 31

IOTF Clinical Oncology Product Research/Review for Board Certified (BC) Oncologists
Deadline: January 31

ACS Ohio Division Joseph S. Silber Student Summer Fellowship
Deadline: February 3

Multiple Myeloma Research Foundation 2009 Seniors Award Program
Deadline: February 3

Leukemia Research Foundation Hollis Brownstein Research Grants Program
Deadline: February 15

Ohio Cancer Research Associates
Deadline: February 19

AICR Investigator Initiated Grants
Deadline: February 19

AICR Matching Grants
Deadline: February 19

AICR Postdoctoral Awards
Deadline: February 19

Hope Street Kids
Deadline: March 1

IOTF Oncology Product Research/Review Fellows
Deadline: May 30

IOTF Cancer Prevention Fellows
Deadline: September 1

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Exploratory Grants for Behavioral Research in Cancer Control (R21) (PA-09-130)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01) (PA-08-131)

Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R03) (PA-09-168)

Ruth L. Kirschstein National Research Service Award (NRSA) Stipends, Tuition/Fees and Other Budgetary Levels Effective for Fiscal Year 2010 (NOT-OD-10-047)

Administrative Supplements for Special Research Priority on U.S. Food and Drug Administration (FDA) Tobacco Product Regulation (NOT-CA-10-007)

Participation of NCI in RFA-OD-10-001, ARRAOS: Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Clinical Trials (RC4) (NOT-CA-10-012)

Participation of NCI in RFA-OD-10-002, ARRAOS: Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Pilot Research (RC4) (NOT-CA-10-013)

Participation of NCI in RFA-OD-10-008, Recovery Act Limited Competition: Comparative Effectiveness Research on Upper Endoscopy in Gastroesophageal Reflux Disease (GERD), Eradication Methods for Methicillin Resistant Staphylococcus aureus (MRSA), and Dementia Detection and Management Strategies (RC4) (NOT-CA-10-014)

Recovery Act Limited Competition: Institutional Comparative Effectiveness Research Mentored Career Development Award (KM1) (RFA-OD-10-011)

PHS 2010-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) (PA-10-050)

PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) (PA-10-051)

Shared Instrumentation Grant Program (S10) (PAR-10-082)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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