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Case Comprehensive Cancer Center Newsletter

January 4, 2010


MyoD Helps Stem Cells Proliferate in Response to Muscle Injury
EurekAlert (press release) - January 4, 2010
Senior author Nikki Harter now wants to investigate how the transcription factors cooperate to control Cdc6 expression–initial results suggest that MyoD ...


Please join us in welcoming the newest members of the Case CCC:

Barbara Bedogni, PhD
Assistant Professor, Biochemistry
Cancer Cell Signaling Program

Candece L. Gladson, MD
Staff, Cancer Biology
Cancer Cell Signaling Program

Abdo S. Haddad, MD
Assistant Professor, Solid Tumor Oncology
Aging-Cancer Research Program

Yogen Saunthararajah, PhD
Associate Professor, Hematologic Oncology and Blood Disorders
Developmental Therapeutics Program

Duncan Stearns, MD
Assistant Professor, Pediatrics-Hematology/Oncology
Cancer Cell Signaling Program

Scott Welford, PhD
Visiting Assistant Professor, Radiation Oncology
Aging-Cancer Research Program

MARK YOUR CALENDARS– Olof Pearson Lecture

The Case CCC and Division of Hematology/Oncology are pleased to present the Olof Pearson Lecture, featuring V. Craig Jordan, PhD, Scientific Director of the Lombardi Cancer Center and the Vincent T. Lombardi Chair of Translational Cancer Research at Georgetown University. Dr. Jordan will present Estrogen in the Life and Death of Breast Cancer on Friday, February 5 at 12:00 pm in Wolstein Auditorium. Reception to follow.

MARK YOUR CALENDARS– 12th International Symposium on Anti-Angiogenic Agents

Drs. Brian Rini and Neal Meropol are scheduled presenters at the 12th International Symposium on Anti-Angiogenic Agents, Angio 2010 Recent Advances and Future Directions in Basic and Clinical Cancer Research, February 4-6 at the Hyatt Regency La Jolla in San Diego, California. Both of their presentations are scheduled during the "Controversies in Anti-Angiogenic Therapy" session on February 5. Dr. Rini will discuss Development of Hypertension is a BioMarker of Clinical Efficacy for VEGF Inhibiting Agents in Metastatic RCC, and Dr. Meropol will talk about Pharmacoeconomics of Anti-VEGF Therapy.

This symposium is designed for medical, surgical, and radiation oncologists, pharmacists, other providers of cancer care (PAs, RNs, etc.), and research scientists who have an interest in the biology, diagnosis, and treatment of cancer, as well as those who diagnose and treat patients with nonmalignant vascular diseases, such as arthritis and retinal neovascularization. As new and emerging data on anti-angiogenic therapy is presented at this symposium every year, it is necessary for this audience to be made aware of these findings so they can be utilized in their clinical practice.

For more information, please click here.

MARK YOUR CALENDARS– 13th Annual Meeting of the Translational Research Cancer Centers Consortium

The Ohio State University will host the 13th Annual Meeting of the Translational Research Cancer Centers Consortium: Immune Suppression and The Tumor Microenvironment, March 1-2 at the Blackwell Inn in Columbus.

Abstract submission is now open. All pre- and post-doctoral trainees are encouraged to submit their work. Posters will be judged by a panel of faculty from multiple institutions, and awards will be given to the top two posters in each category (post-doc and pre-doc).

For more information, please click here.

CALL FOR APPLICATIONS– K12 Clinical Oncology Research Training Program

The Case CCC invites applications for its two-year NCI-funded K12 Clinical Oncology Research Training Program, led by Stanton Gerson, MD, Director, and Alvin Schmaier, MD, Co-Director.

This career development program provides interdisciplinary training in clinical and translational oncology research for clinical oncologist who are interested in pursuing academic research careers as oncology physician scientists.

Application Deadline: February 28
Start Date: July 1

For more information and application materials, please click here.

FUNDING OPPORTUNITY— Title Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4)

NIH is accepting applications for the "Title Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas" (RC4) (RFA-OD-10-005).

This program will support projects that address research endeavors in specific areas that will benefit from significant three-year funds without the expectation of continued NIH funding beyond this period. The research supported by the program should have high short-term impact, and a high likelihood of enabling growth and investment in biomedical research and development, public health, and health care delivery.

This FOA solicits applications proposing to develop and implement critical research innovations in one or more of the following five thematic areas:
1. Applying Genomics and Other High Throughput Technologies
2. Translating Basic Science Discoveries into New and Better Treatments
3. Using Science to Enable Health Care Reform
4. Focusing on Global Health
5. Reinvigorating the Biomedical Research Community

Only applications for projects that require $500,000 or more in total costs per year are expected to be considered for funding.

LOI Deadline: February 15 (requested, not required)
Proposal Deadline: March 15

For details, please click here.

Case CCC Leadership would like to review potential responses, and can assist in developing themes as responsive to the RFA.


**All events are open to anyone interested in attending

January 4

Physiology & Biophysics Seminar
Ernest Wright, PhD, DSc
Professor, Physiology
University of California, Los Angeles
Topic: The Human Biology of Sodium Glucose Symporters
4:00 pm SOM E501

January 5

Taussig Cancer Institute Core Curriculum Series
Ernest Borden, MD
Professor, Hematology & Medical Oncology, Cancer Biology
CWRU/ Cleveland Clinic
Topic: Sarcomas: 40 Years of Progress
12:00 pm R3-002 Cleveland Clinic

January 6

Grand Rounds cancelled

January 7

Taussig Cancer Institute Core Curriculum Series
Kandice Marchant, MD, PhD
Professor & Chairperson, Pathology, Cleveland Clinic Lerner College of Medicine
CWRU/ Cleveland Clinic
Topic: Coagulation Physiology and Basic Coagulation Tests
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
Timothy Kern, PhD
Professor, Endocrinology
Topic: Inflammatory Basis of Diabetic Retinopathy
12:10 pm BRB 105

January 8

Hem/Onc Fellows Seminar
Jennifer Eads, MD
Fellow, Div. of Hem/Onc
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Timothy Spiro, MD
Assistant Professor, Hematologic Oncology and Blood Disorders
CWRU/ Cleveland Clinic
Hamed Daw, MD
Associate Staff, Regional Oncology
Cleveland Clinic
Topic: Triple Negative Breast Cancer
8:00 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Sanford Markowitz, MD, PhD
Professor, Medicine-Hematology/Oncology
Topic: Colon Cancer
12:00 pm BRB 105

Neurosciences Thesis Defense
Christi Wylie
Graduate Student, Neurosciences
Topic: Distinct Transcriptomes Define Rostral and Caudal Serotonin Neurons
12:00 pm SOM E646


For a complete listing of LRI seminars click here.


Case CCC Core Facility Fair
January 13, 2010
3:00 pm - 6:00 pm Wolstein Atrium and Auditorium

Case CCC Scientific Series- TREC
January 28, 2010
4:00 pm - 7:00 pm WRB 1-413
Stephanie Doerner, PhD
Cheryl Thompson, PhD
Ofer Reizes, PhD
Sanjay Patel, MD

Case CCC Scientific Retreat
July 9-10, 2010
Location TBA


Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, AZ

AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy
January 11-14, 2010
Loews Coronado Bay Resort, Coronado, CA

AACR-JCA 8th Joint Conference on Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9, 2010
Hilton Waikoloa Village, Waikoloa, HI

AACR 101st Annual Meeting
April 17-21, 2010
Washington, DC


The Mary Kay Foundation has released a Call for Applications for their Cancer Research Grant Program. This non-profit public foundation focuses on funding research for innovative grants for translational research in ovarian, uterine, breast or cervical cancer. Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer.

Only ONE application per institution is allowed. Investigators interested in applying must submit their biosketch and a one-paragraph description to gillian.irwin@case.edu by Monday, January 11.

Internal Deadline: January 11
External Deadline: February 12

For details, please click here.

FUNDING OPPORTUNITY– Landon Foundation-AACR Awards

Deadline for all awards: January 20

Landon Foundation-AACR INNOVATOR Grant for Research in Personalized Cancer Medicine
This award represents a joint effort between the Landon Foundation and the AACR to accelerate progress in the area of personalized medicine by providing support for physician-scientists who conduct meritorious studies that hold promise for near-patient benefit.

Principal Investigators must be working in a multi-disciplinary environment where collaborations are strongly encouraged, have evidence of an established research program, and plan to contribute significant time, effort, and leadership to this project. This grant to physician-scientists is intended to have an impact on the field of personalized cancer medicine as a whole.

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research
The goals of the program are to:
–Encourage younger investigators to pursue novel, high-risk, high-reward cancer prevention research;
– Provide the support necessary to sustain and enhance highly meritorious cancer prevention research;
–Foster interactions between and among cancer scientists of various disciplines; and
–Disseminate scientific knowledge about cancer prevention research throughout the field.

Landon Foundation-AACR INNOVATOR Award for International Collaboration
This Award will support highly meritorious research that is being conducted collaboratively by investigators in different countries around the world. The goals of the program are to:
–Overcome barriers to international collaboration by providing funding for costs traditional grant mechanisms may not support;
–Raise the profile of the importance of collaboration to conquering the cancer problem; and
–Provide the means to facilitate travel and the sharing of knowledge that otherwise may have been difficult to achieve.

FUNDING OPPORTUNITY– Goldhirsh Foundation Brain Tumor Research Awards Program

The Goldhirsh Foundation provides strategic investment in brain tumor research to accelerate progress toward more effective treatment for malignant diffuse glioma tumors. Applications are encouraged from investigators working in the continuum between basic research and clinical application, integrating and translating knowledge in various disciplines into meaningful progress for patients. Examples of funding areas include but are not limited to oncogenomics and proteomics, genetically engineered models, the discovery and testing of small molecule therapies, unusual drug delivery systems, or improved brain imaging techniques. Research projects at the interface of developmental biology and cancer along the stem cell to glial axis are eligible.

Deadline: January 7

For details, please click here.


Please mark your calendars for the next installment of the Case CCC Scientific Series and reception on January 28 from 4:00-7:00 pm in Wolstein Auditorium (WRB 1413). Presentations will be related to the Case Transdisciplinary Research on Energetics and Cancer (TREC) Center, led by Dr. Nathan Berger:

Stephanie Doerner: Diet, Obesity and Susceptibility to Colon Cancer

Cheryl Thompson, PhD: Activation of the PI3K pathway in colon and breast cancer

Ofer Reizes, PhD: Role of Leptin in Mammary Tumorigenesis

Sanjay Patel, MD: The Effect of Sleep Disturbances on Adipose Tissue Gene Expression

Everyone is welcome and encouraged to attend.

MARK YOUR CALENDARS– Case CCC Core Facilities Fair

The Case CCC Core Facilities Fair is scheduled for Wednesday, January 13 from 3:00 pm - 6:00 pm in Wolstein Atrium and Auditorium.

Featured speakers are Dr. James Jacobberger, Professor, General Medical Sciences (Oncology), who will present Cell Cycle and Cell Signaling Cytometry, and Dr. Christopher Flask, Assistant Professor, Radiology, who will discuss Cancer Imaging Research and the Case Center for Imaging Research.

Core directors and managers will be present to discuss how their facilities are available to support your research. The afternoon will be filled with core facility related presentations, posters, food and more! We are hoping all members will attend; please encourage your graduate students and lab staff to drop by also.

FUNDING OPPORTUNITY– ACS Ohio Division Joseph S. Silber Student Summer Fellowship

ACS Ohio Division is accepting applications for the Joseph S. Silber Student Summer Fellowship.The purpose of the fellowship is to provide talented undergraduate and first-year graduate and medical students with exposure to hypothesis-driven laboratory science working with a sponsor on a cancer research project at an institution in the Cleveland area. The expectation is that a positive research experience may encourage students to consider future study in research or pursue a career in cancer research.

Deadline: February 3

For more information, please click here.

FUNDING OPPORTUNITY– Leukemia Research Foundation Hollis Brownstein Research Grants Program

Leukemia Research Foundation is accepting applications for the Hollis Brownstein Research Grants Program, which is open to new investigators. New Investigators are considered to be within seven years of their first independent position. Years as a resident physician, fellow physician, or post-doctoral fellow are considered to be training years. Preference will be given to proposals that focus on leukemia, lymphoma and MDS.

Deadline: February 15

For details, please click here.

FUNDING OPPORTUNITY– Damon Runyon Cancer Research Foundation Clinical Investigator Award

CWRU SOM has been invited to nominate up to three individuals for the Damon Runyon Cancer Research Foundation Clinical Investigator Award. This award supports young physician-scientists conducting patient-oriented cancer research, with a goal of increasing the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments.

If you are interested in being nominated for this award, please send your biosketch to gillian.irwin@case.edu. External application deadline is March 1, 2010.

For details, please click here.

FACULTY CANDIDATE SEARCH– Associate Director for Basic Research

The Case CCC is currently accepting applications for the position of Associate Director for Basic Research. As we continue our search, we ask that people in the Cancer Center community encourage any qualified candidate to apply for the position. If you would like to nominate someone for the position, please contact Tracy Rehl (tracy.rehl@case.edu).

Click here to view the job description.


We are always trying to foster communication and collaboration across the cancer center community any way that we can. The Case CCC has set up a page on Facebook and LinkedIn, so please become a fan of us on Facebook or join our group on LinkedIn, and encourage others to do so as well. Please help us spread the word.

We encourage you to post events, relevant news articles, items of discussion, etc… Your feedback is appreciated!


International Society for Stem Cell Research (ISSCR)
Deadline: January 14

Prostate Cancer Foundation Creativity Awards
Deadline: January 31

IOTF Clinical Oncology Product Research/Review for Oncology Fellows
Deadline: January 31

IOTF Clinical Oncology Product Research/Review for Board Certified (BC) Oncologists
Deadline: January 31

Multiple Myeloma Research Foundation 2009 Seniors Award Program
Deadline: February 3

AICR Investigator Initiated Grants
Deadline: February 19

AICR Matching Grants
Deadline: February 19

AICR Postdoctoral Awards
Deadline: February 19

IOTF Oncology Product Research/Review Fellows
Deadline: May 30

IOTF Cancer Prevention Fellows
Deadline: September 1

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4) (RFA-OD-10-005)

Recovery Act Limited Competition: Methodology Development in Comparative Effectiveness Research (RC4) (RFA-OD-10-009)

Cancellation of Notice NOT-CA-09-017, Clarification of Page Limitations for Research Plan in PAR-09-026 Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01) (NOT-CA-10-011)

AIDS Malignancy Clinical Trials Consortium (Limited Competition U01) (RFA-CA-10-502)

Academic Research Enhancement Award (Parent R15) (PA-10-070)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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