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Case Comprehensive Cancer Center Newsletter

September 28, 2009

CASE CCC IN THE NEWS

New Treatment is Showing Potential for Acute Myeloid Leukemia Patients
The Plain Dealer - Sept 24, 2009
But new, encouraging research being published in today's New England Journal of Medicine has begun to change the standard of care for some patients. ...that in patients with AML, there is an improvement in survival," said Dr. Hillard Lazarus, who helped design the study and is one of its authors. ...

Cleveland Clinic Researchers Secure Federal Grants Totaling $6 million
Crain's Cleveland Business - Sept 24, 2009
Dr. Jaroslaw Maciejewski, chairman of the Translational Hematology and Oncology Research Department, received a $1.9 million, five-year grant to continue ...

Case Western Reserve Researcher Wins $4.9M Grant for Colon Cancer Work
Crain's Business Cleveland - Sept 24, 2009
The five-year grant will enable Dr. Sanford Markowitz, the study's principal investigator and the Markowitz-Ingalls Professor of Cancer Genetics, to identify these susceptibility gene markers...

The Future of Colonoscopy
90.3 WCPN ideastream - Sep 22, 2009
Sanford Markowitz and his team at Case are developing new screening tests that detect the DNA of cancer cells in a person's stool or blood. ...


MEMBER PUBLICATIONS

A study by Dr. Sanford Markowitz, Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells, was published in the September 18 issue of "Science". This study suggests that glucose deprivation increases the activity of the KRAS oncogene in colon cancer.

An article by Dr. Hillard Lazarus, Anthracycline Dose Intensification in Acute Myeloid Leukemia, was published in the September 24 issue of the "New England Journal of Medicine". Research found that patients with AML who were given twice the standard dosage of chemotherapy had a higher complete remission rate than patients who received the standard dosage.


NEW MEMBERS CORNER

Please join us in welcoming the following new members of the Case CCC:

Anton V. Gorbachev, PhD
Instructor, Immunology
Molecular Basis of Cancer Program

Derek J. Taylor, PhD
Assistant Professor, Pharmacology
Molecular Basis of Cancer Program

Youwei Zhang, PhD
Assistant Professor, Pharmacology
Cell Death Regulation Program


MARK YOUR CALENDARS– Breast Cancer Spotlight Series

Mark your calendars for the next Breast Cancer Spotlight Series seminar, featuring Dr. William J. Muller, Professor of Biochemistry at McGill University. Dr. Muller will present Oncogene-Mediated Signaling in Transgenic Mouse Models of Human Breast Cancer. The seminar is scheduled for Tuesday, October 27 at 12:00 pm in SOM W331.


NCI CANCER BULLETIN

Featured Article
Modified Chemo Regimen Effective in Advanced Ovarian Cancer

Cancer Research Highlights
Diabetes Drug Metformin Shows Promise as a Breast Cancer Treatment

Hormone Therapy Linked to Risk of Death from Lung Cancer

Recently Discovered Virus Linked to Aggressive Prostate Tumors

Fat Cells Interfere with Chemotherapy for Leukemia

Hepatitis B Vaccine Lowers Risk of Liver Cancer

Director's Update
Using ARRA Funds to Advance Cancer Research


FUNDING OPPORTUNITY– Clinical Investigator Development Program

The Center for Cancer Research (CCR) announces a training opportunity for physicians interested in dedicating their careers to clinical oncology research. The Clinical Investigator Development Program will link eligible clinicians to a vibrant, multidisciplinary research community of more than 250 talented CCR intramural scientists conducting cutting-edge research on the campuses of the National Institutes of Health (NIH) in Bethesda and Frederick, Maryland. The CCR is nationally recognized as a premier training ground for clinical research, which is conducted in the state-of-the-art Clinical Research Center.

Application Deadline: October 15

Please click here for more information.


FUNDING OPPORTUNITY– Sidney Kimmel Foundation for Cancer Research

Kimmel Scholar Award
Qualified applicants must hold an MD, PhD or equivalent graduate degree and must perform research in an American not-for-profit institution during the period of Kimmel Foundation support. The Kimmel Foundation is seeking accomplished young investigators dedicated to a career in cancer research. Applications are limited to those who achieved the equivalent rank of Assistant Professor on or after July, 2006. However, physicians who have both clinical and research responsibility are eligible if appointed on or after July, 2005. These awards are designed for researchers who do not yet have their own R01 funding. Applicants will be judged on the basis of quality of prior work, research proposed and letters of support.

Kimmel Translational Science Award
The Foundation provides up to five additional awards specifically for physicians engaged in translational science. Eligibility includes those with M.D. or equivalent degrees, who have achieved the rank of Assistant Professor on or after July, 2005. Candidates must not hold R01 funding for the laboratory component of their cancer research. Applicants must demonstrate a significant personal involvement in the laboratory component of the translational project described. The translational research may involve primarily animal studies but must include reasonable application to subsequent human investigation.

Deadline: December 2

For more information, please click here.


MARK YOUR CALENDARS– Sequencing Data Interest Group (SDIG) Meeting

The Cancer Center is organizing a biweekly Sequencing Data Interest Group (SDIG) meeting. The aim is to bring all colleagues' effort and expertise together, so they can learn and benefit from each other to DIG out more from the huge data sets since this area is new and moving very fast. Anyone who has an interest in generating sequencing data and data analysis are welcome to attend.

The first SDIG meeting is scheduled for Monday, September 28 at 2:30 pm in WRB 1-402. Dr. Mark Adams is scheduled to present. For a list of additional meetings, please click here.

Please contact Dr. Shuying Sun for more information.


FUNDING OPPORTUNITY– Clinical Research Scholar Career Development Training Program

The Multidisciplinary Clinical Research Training Program seeks outstanding candidates to fill 5 Clinical Research (CR) Scholar positions available in July 2010. The training program is funded by the NIH and it is a component of the Cleveland Clinical and Translational Science Collaborative. This innovative program is a collaboration involving CWRU, Cleveland Clinic, UH and MetroHealth. Each CR Scholar will embark on a 4-year program of intensive training in multidisciplinary team-based, patient-oriented research, combining a novel educational program with mentored research experiences.

Interested applicants should contact Beth Spyke at spykeb@ccf.org or click here for further information and application instructions.

Deadline: October 23


FUNDING OPPORTUNITY– 2010 Szent-Györgyi Prize for Progress in Cancer Research

The National Foundation for Cancer Research is accepting nominations for the 2010 Szent-Györgyi Prize for Progress in Cancer Research. This annual prize, which includes a $25,000 cash award, is presented to a distinguished individual who has helped advance the field of cancer research and whose basic science research accomplishments have helped improve treatment options for patients. Recipients will be recognized and featured in major public media and press, national Prize designations, and ceremonies of the National Foundation for Cancer Research, an international charity supported by more than 4 million donors including hundreds of private foundations and corporations.

Deadline: September 30

For more information, please click here.


FUNDING OPPORTUNITY– Susan G. Komen for the Cure

Susan G. Komen for the Cure has announced the release of Postdoctoral Fellowship (basic, translational, clinical) Research grants and Post-Baccalaureate Training in Disparities Research for the 2009-2010 Research Program.

Postdoctoral Fellowship Research (PDF) Grants – Komen is committed to training across the research continuum and therefore has developed 3 types of PDF training awards: Basic Research, Translational Research and Clinical Research. Clinical Fellowships are designed to attract outstanding physicians who wish to pursue a career path that blends patient care with high impact, clinical and/or translation breast cancer research.

Post-Baccalaureate Training in Disparities Research (PBT-DR) Grants – PBT-DR Grants are intended to establish a training program headed by a mentor(s) to support qualified students who are dedicated to pursuing research in breast cancer disparities.

Pre-Application Deadline: October 1
Full Application Deadline: November 17

For details, please click here.

EVENTS

**All events are open to anyone interested in attending

September 28

Hem/Onc Research in Progress Seminar
Kristy Miskimen, PhD
Postdoc, Bunting Lab, Div. of Hem/Onc
CWRU/ UH
Topic: Role of Gab Adapter Proteins in Normal and Leukemic Hematopoiesis
12:00 pm WRB 2-136

Pathology Seminar
Reuben Shaw, PhD
Assistant Professor, Molecular and Cell Biology Laboratory
Salk Institute of Biological Studies
Topic: The LKB1/AMPK Pathway: Connecting Glucose Metabolism to Growth Control
12:00 pm WRB 1-413

Sequencing Data Interest Group (SDIG) Meeting
Mark Adams, PhD
Associate Professor, Genetics
CWRU
Topic: An Introduction to Illumina Sequencing at CWRU
2:30 pm WRB 1-402

Physiology & Biophysics Seminar
Chou-Long Huang, MD, PhD
Professor, Medicine- Nephrology
University of Texas Southwestern University
Topic: Regulation of Ion Transport and Blood Pressure by WNK Kinases
4:00 pm SOM E501


September 29

Cancer Biology Seminar
Jianfeng Xu, MD, DrPH
Professor, Public Health and Cancer Biology
Wake Forest University
Topic: TBA
11:00 am NCI-202

Immunology Seminar
Pavan Reddy, MD
Associate Professor, Internal Medicine
University of Michigan
Topic: Deacetylase Inhibition Mediated Regulation of DCs
12:00 pm WRB 1-413

Taussig Cancer Institute Core Curriculum Series
Brian Bolwell, MD
Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Bone Marrow Transplantation
12:00 pm R3-002 Cleveland Clinic

Case CCC Clinical Research Retreat
5:30 pm - 8:45 pm Dively Building
Agenda


September 30

Grand Rounds
Hillard Lazarus, MD
Professor, Medicine- Hem/Onc
CWRU/ UH
Topic: Introduction to Stem Cell Transplant
8:00 am Lerner Tower B-151

Immunology Seminar
Xiaoxia Li, PhD
Professor, Immunology
CWRU/ Cleveland Clinic
Topic: Th17 Cells in Autoimmunity
12:00 pm NC1-202 Cleveland Clinic


October 1

Neurosciences Seminar
Jeffrey D. Schall, PhD
Professor, Neuroscience
Vanderbilt University
Topic: Selection & Control of Visually Guided Saccades
12:10 pm BRB105

Inflammation, Infection and Cancer Focus Group Meeting
Alan Levine, PhD
Professor, Medicine-Gastroenterology
CWRU/ UH
AND
Ge Jin
Assistant Professor, Biological Sciences
CWRU
Topic: TBA
4:30 pm - 6:00 pm WRB 2-136


October 2

Taussig Cancer Institute Grand Rounds
Garrett Brodeur, MD
Professor, Pediatrics
Chief, Div. of Oncology
Abramson Cancer Center
Topic: Genetics and Genomics of Neuroblastoma
8:00 am R3/002-003 Cleveland Clinic

Oscar D. Ratnoff Symposium
8:30 am – 5:00 pm WRB 1-413
Details

Neurosciences Thesis Defense
Yuan Gao
Doctoral Student, Neurosciences
CWRU
Topic: Mechanisms of Synaptic Plasticity in the Rat Olfactory Bulb
10:00 am SOM E646

more

For a complete listing of LRI seminars click here.


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Breast Cancer Retreat
October 5
Sheep Barn, Squire Valleevue Farm
Details

Case CCC Scientific Series
November 5
4:00 pm - 7:00 pm WRB 1-413


ADDITIONAL UPCOMING SEMINARS & EVENTS

AACR Seminar: Frontiers in Basic Cancer Research
October 8-11
Boston, MA
Details

AACR Seminar: Advances in Breast Cancer Research
October 13-16
Hyatt Regency Mission Bay Spa and Marina, San Diego, CA
Details

International Association for Comparative Research on Leukemia and Related Diseases (IACRLRD) Symposium XXIV
October 14-16
Ohio State University Comprehensive Cancer Center, Columbus, OH
Details

Case Center for Proteomics and Bioinformatics Symposium
October 19
WRB 1-413
CPB-Registration@case.edu

ICMS-AACR-INCa Fifth International Conference on Tumor Microenvironment: Progression, Therapy and Prevention
October 20-24
Palais des Congres de Versailles, Versailles, France
Details

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
November 15-19 John B. Hynes Veterans Memorial Convention Center, Boston, MA Details

AACR Seminar: Frontiers in Cancer Prevention Research
December 6-9
Houston, TX
Details

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, AZ
Details

AACR Eighth Annual International Conference on Frontiers in Cancer Prevention Research
December 6-9
Hilton Americas, Houston, TX
Details

32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium
December 10-13
Henry B. Gonzalez Convention Center, San Antonio, TX
Details

AACR Seminar: Genetics and Biology of Brain Cancers
December 13-15
Omni San Diego Hotel, San Diego, CA
Details

AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy
January 11-14, 2010
Loews Coronado Bay Resort, Coronado, CA
Details

AACR-JCA 8th Joint Conference on Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9, 2010
Hilton Waikoloa Village, Waikoloa, HI
Details

AACR 101st Annual Meeting
April 17-21, 2010
Washington, DC
Details



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

2010 Szent-Györgyi Prize for Progress in Cancer Research
Deadline: September 30

Komen Postdoctoral Fellowship Research (PDF) Grants
Pre-Application Deadline: October 1
Full Application Deadline: November 17

Komen Post-Baccalaureate Training in Disparities Research (PBT-DR) Grants
Pre-Application Deadline: October 1
Full Application Deadline: November 17

ASCO Advanced Clinical Research Award (ACRA)
Full Application Deadline: October 1

World Cancer Research Fund International
Deadline: October 5

Pancreatic Cancer Action Network-AACR Innovative Grants
LOI Deadline: October 5

Clinical Investigator Development Program
Application Deadline: October 15

ACS Postdoctoral Fellowships
Deadline: October 15

NIH Director's Pioneer Awards
Deadline: October 20

Clinical Research Scholar Career Development Training Program
Deadline: October 23

NIH Director's New Innovator Awards
Deadline: October 27

Pancreatic Cancer Action Network-AACR Career Development Awards
Application Deadline: October 28

Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant
Application Deadline: October 28

Pancreatic Cancer Action Network-AACR Research Fellowship
Application Deadline: October 28

ED Thomas Post Doctoral Fellowship 2009
Deadline: November 2

Komen Postdoctoral Fellowship Research (PDF) Grants
Full Application Deadline: November 17

Komen Post-Baccalaureate Training in Disparities Research (PBT-DR) Grants
Full Application Deadline: November 17

DOD Lung Cancer Research Program Clinical Fellow Research Award
Pre-Application Deadline: November 19
Application Deadline: December 3


DOD Lung Cancer Research Program Collaborative Translational Research Award
Pre-Application Deadline: November 19
Application Deadline: December 3

DOD Lung Cancer Research Program Lung Cancer Promising Clinician Research Award
Pre-Application Deadline: November 19
Application Deadline: December 3

DOD OCRP Ovarian Cancer Academy Dean Award
Proposal Deadline: December 2

ASCO Improving Cancer Care Grant Improving Cancer Care Grant (ICCG)
Full Application Deadline: December 3

DOD Lung Cancer Research Program Clinical Fellow Research Award
Application Deadline: December 3

DOD Lung Cancer Research Program Collaborative Translational Research Award
Application Deadline: December 3

DOD Lung Cancer Research Program Lung Cancer Promising Clinician Research Award
Application Deadline: December 3

DOD PRCRP Synergistic Idea Awards
Proposal Deadline: December 9

DOD PRCRP Collaborative Translational Science Awards
Proposal Deadline: December 9

DOD PRCRP Idea Awards
Proposal Deadline: December 9

DOD PRCRP Mentor-Predoctoral Fellow Research Awards
Proposal Deadline: December 9

DOD PRCRP New Investigator Awards
Proposal Deadline: December 9

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Change of Expiration Date for PAR-08-135: Exploratory/Developmental Grant for Complementary and Alternative Medicine (CAM) Studies of Humans (R21) (NOT-AT-09-007)

Developing Research Capacity in Africa for Studies on HIV-Associated Malignancies (D43) (RFA-CA-09-016)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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