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Case Comprehensive Cancer Center Newsletter

August 10, 2009

MESSAGE FROM THE DIRECTOR–New Initiatives for the Case Comprehensive Cancer Center

I would like to follow up on a number of topics that emerged from our July 10-11 retreat. At individual sessions and during the executive session that followed, the Cancer Center leadership reviewed a number of opportunities to prioritize over the next few months. I would like to share this list with you.

Recruitment of the Associate Director for Basic Research
With the support of Dr. Pam Davis, Dean of the School of Medicine, we have assembled a group of 14 cancer center members to begin a national search for the next Associate Director for Basic Research. This is an important recruitment opportunity for our institutions and our Center. Our goal is to identify a strong investigator knowledgeable about NCI-designated cancer centers and interested in the interdisciplinary collaborative research in cancer. We will issue a formal announcement in the next few weeks. In the mean time, I and the committee welcome your suggestions of possible candidates. Please forward names to me and I will bring them to the committee. You may also notify your colleagues of the opportunity.

Drug Discovery and Development
Dr. Milton Brown from Georgetown provided us with a presentation of a very accomplished program in drug discovery. At our Center, we have decided to pursue collaborative programs with other cancer centers with established programs. The NCI has embarked on a broadly expanded program for drug screening and evaluation. Termed the Chemical Biology Consortium, this program has emerged from the RAID and represents an important initiative and opportunity for cancer investigators. The NCI chemical discovery program will work with investigators to analyze novel pathways and targets, help develop screens, and provide drug "hits". The consortium is holding its first meeting August 10 for the NCI campus and grantees. Please click here for the details of this important meeting. Please click here to view the overview of the CBC. Instructions on submitting requests for drug discovery and development can be found there.

There are also active shared resources at a number of other cancer centers. The centers we are currently discussing potential for collaborations with Drs. John Lazo at the University of Pittsburgh Cancer Center, Andre Gudkov at Roswell Cancer Institute, Milton Brown at Georgetown, as well as expanding a current collaboration led by Sandy Markowitz with the drug high throughput screening facility at UT Southwestern. We are also investigating a potential interaction with the drug screening program at the University of Cincinnati. We will shortly provide contact information for the core facilities at each of these institutions. Meanwhile, we plan to expand our capabilities in cell based screening efforts, currently ongoing in Dr. David Wald's laboratory and in the Small Molecule Screening Core at Lerner Research Institute.

Multi-investigator research efforts
I applaud the investigators who have established and are working with teams that will lead to program project and SPORE applications over the next few years. The Cancer Center has supported these and will continue to do so as a Center priority. At the risk of leaving someone out, I will simply mention the group leader of each these efforts and the subject matter, again, as discussed at the retreat:
Kevin Bunting, PhD – Stem Cell Biology
Ruth Keri, PhD – Breast Cancer
Ernest Borden, MD – Melanoma
Candece Gladson, MD – Angiogenesis and brain tumors
Gene Barnett, MD and Andy Sloan, MD – Glioma
Jeff Duerk, PhD and Jim Basilion, PhD – Cancer Imaging
Barb Daly, RN, PhD, FAAN and Li Li, MD, PhD - Survivorship

If you are interested in these topical areas, please contact the group leader!

The Cancer Center continues to develop the IRB protocol for exempt studies to facilitate access to tissue and to formalize the honest broker role of data collectors. The honest broker will be able to collect clinical information critical to annotate tissue samples for investigators while preserving personal health information in a secure setting. I thank Drs. Ruth Keri, Patrick Ma and Jill Barnholtz-Sloan for sharing their approach and use of tissue samples in their research, effectively illustrating the value for our entire Center in establishing improved biorepository services and capabilities. We continue to expand our efforts in biorepository informatics to facilitate retrieval of information and samples for specific investigation. To become fully operational, we also need to establish principles for review of research. This will be especially important when tissue samples are scarce and there is a need to prioritize sample distribution. Dr. Amitabh Chak has agreed to chair the scientific review committee for tissue distribution. Finally, we are discussing with UH administration a broader opt out universal consent for the use of discarded tissue and annotation with clinical information under HIPAA guidelines. Note also that while these efforts are focused at UHCMC, the infrastructure and principles, including the database, can be applicable to any affiliate hospital.

Stan Gerson, MD
Director, Case CCC


**All events are open to anyone interested in attending

August 10

August 11

August 12

Grand Rounds
Panos Savvides, MD
Assistant Professor, Medicine- Hem/Onc
Topic: Head and Neck Cancer Overview
8:00 am Lerner Tower B-151

August 13

Physiology & Biophysics Seminar
Jeonga Kim, PhD
Research Assistant Professor, Internal Medicine
University of Missouri- Columbia
Topic: Insulin Resistance and Endothelial Dysfunction: Role of Pro-Inflammatory Signaling
4:00 pm SOM E501

August 14

Hematology/ Oncology Fellows Seminar
Keith McCrae, MD
Professor, Medicine-Hematology/Oncology
Topic: Platelets and Thrombocytopenia
8:00 am Wearn 137


For a complete listing of LRI seminars click here.


Management of Lung Cancer in the Emphysema Patient: From Surgery to Cyberknife and Beyond
September 11
Embassy Suites, Independence

Paradigms in Lymphoma Management: A Case Based Approach
September 25
Marriott Downtown Cleveland at Key Center

Breast Cancer Retreat
October 5
Sheep Barn, Squire Valleevue Farm

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

**For more information on these symposiums, please contact Christine Rhoads.


MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

International Association for Comparative Research on Leukemia and Related Diseases (IACRLRD) Symposium XXIV
October 14-16
Ohio State University Comprehensive Cancer Center

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona


Please join us in welcoming the following new members of the Case CCC:

Anne L. Flamm, JD
Assistant Professor, Bioethics (pending)
Aging-Cancer Research Program

Zheng-Rong Lu, PhD
Professor, Biomedical Engineering
Cancer Imaging Program

Neal Meropol, MD
Professor, Medicine- Hematology/ Oncology
Cancer Prevention, Control and Population Research Program

Cheryl Thompson, PhD
Senior Instructor, Family Medicine
Cancer Prevention, Control and Population Research Program


To Fight Cancer, Know the Enemy
New York Times - James D. Watson - Aug 5, 2009
THE National Cancer Institute, which has overseen American efforts on researching and combating cancers since 1971, should take on an ambitious new goal for the next decade: the development of new drugs that will provide lifelong cures for many, if not all, major cancers. Beating cancer now is a realistic ambition because, at long last, we largely know its true genetic and chemical characteristics...

REQUEST FOR PROPOSALS– Pilot Grant Funding for Cancer Survivorship Related Research

As part of the Case Comprehensive Cancer Center Survivorship Research Initiative, the goal of this RFP is to foster collaborations, and to promote and increase institution-wide capacity and competitiveness in comprehensive and transdisciplinary survivorship research in the areas of basic, clinical, prevention & control, psychosocial, behavioral, health services/outcomes, and epidemiology. Multi-investigator efforts are encouraged.

Deadline: August 17

For more details and to view instructions, please click here.

FUNDING OPPORTUNITY– Clinical Investigator Development Program

The Center for Cancer Research (CCR) announces a training opportunity for physicians interested in dedicating their careers to clinical oncology research. The Clinical Investigator Development Program will link eligible clinicians to a vibrant, multidisciplinary research community of more than 250 talented CCR intramural scientists conducting cutting-edge research on the campuses of the National Institutes of Health (NIH) in Bethesda and Frederick, Maryland. The CCR is nationally recognized as a premier training ground for clinical research, which is conducted in the state-of-the-art Clinical Research Center.

Application Deadline: October 15

Please click here for more information.

FUNDING OPPORTUNITY– Acceleration Grant Opportunities in Cellular Molecular Imaging of Cancer, Cancer Biology, Therapeutics

Acceleration funding is available for investigative interdisciplinary teams with broad expertise in cancer biology, molecular imaging/imaging, pharmacology, genetics for opportunities to explore aspects of cancer biology with non-invasive imaging technologies.

This funding is designed to specifically provide the resources to fully develop ongoing projects for inclusion in ICMIC application, and is open to eligible faculty members with cancer focused funded research

Selected projects that will be used as the basis for a Summer 2010 P50 In-vivo Cellular and Molecular Imaging Center (ICMIC) grant and other future independent grants.

Deadline: September 15

Contact Marianne Sperk at Marianne.sperk@case.edu for more information and application instructions.

FUNDING OPPORTUNITY– Clinical Research Scholar Career Development Training Program

The Multidisciplinary Clinical Research Training Program seeks outstanding candidates to fill 5 Clinical Research (CR) Scholar positions available in July 2010. The training program is funded by the NIH and it is a component of the Cleveland Clinical and Translational Science Collaborative. This innovative program is a collaboration involving CWRU, Cleveland Clinic, UH and MetroHealth. Each CR Scholar will embark on a 4-year program of intensive training in multidisciplinary team-based, patient-oriented research, combining a novel educational program with mentored research experiences.

Interested applicants should contact Beth Spyke at spykeb@ccf.org or click here for further information and application instructions.

Deadline: October 23

MARK YOUR CALENDARS– Breast Cancer Metastasis Faculty Candidate

The Case CCC is pleased to announce two Breast Cancer Metastasis Faculty Candidate symposiums:

August 17
Pilar Blancafort, PhD
Assistant Professor, Pharmacology
University of North Carolina at Chapel Hill
Topic: TBA
10:00 am WRB 3-136

August 26
Danny Welch, PhD
Professor, Pathology
University of Alabama at Birmingham
Topic: Molecular Regulation of Metastasis: Mechanistic Insights and Therapeutic Opportunities
4:00 pm WRB 3-136

MARK YOUR CALENDARS– 2009 Case CCC Breast Cancer Retreat

The Case Comprehensive Cancer Center is planning a one-day Breast Cancer Research Retreat for October 5 at the Sheep Barn, and is inviting all members of the Cancer Center community to attend.

Please contact Retreat Co-Directors, Ruth Keri, PhD or Mark Jackson, PhD with any questions.

If you are interested in attending but have not yet registered, please email Gillian Irwin (gillian.irwin@case.edu) ASAP.

FUNDING OPPORTUNUTY– World Cancer Research Fund International

World Cancer Research Fund (WCRF) International is now inviting applications for grants worldwide to fund research into the effects of food, nutrition and physical activity on cancer. Preference will be given to applications that have direct relevance to human cancer - consider diets or foods as a whole and/or use whole body systems, and use foods or dietary constituents in physiological amounts.

Deadline: October 5

For more information, please click here.

FUNDING OPPORTUNITY– Avon Foundation Breast Care Fund

The Avon Foundation Breast Care Fund (AFBCF) is accepting applications for 2010 funding. The mission of the AFBCF is to link medically underserved women to breast health education and screening services. Medically underserved women need targeted, customized approaches to enable them to obtain regular mammograms and clinical breast exams. Successful programs have: culturally-competent educational strategies; dedicated staff with specialized language and communications skills; and participation from members of the targeted community who can reach women where they live, work and worship, and who offer personalized assistance to women for whom it is often difficult to access health care.

Application Deadline: August 28

For more information, please click here.

If you are interested in submitting a proposal, please email gillian.irwin@case.edu ASAP, as only one application per institution is allowed.

MARK YOUR CALENDARS– Case Center for Proteomics and Bioinformatics Symposium

The Center for Proteomics and Bioinformatics is proud to present the symposium, "Understanding Protein Complexes, Networks and the Interactome", on Monday, October 19. This event will be held in the Wolstein Research Building Auditorium 1413. For this symposium, the Center has invited speakers from distinguished institutions to discuss current developments and applications of computational and wet-lab approaches toward interactome mapping.

Further information on the symposium program schedule will be available within the next few weeks. Registration is free. To register, please send your name and institution/department to CPB-Registration@case.edu.


AACR–National Brain Tumor Society Fellowship, in memory of Bonnie Brooks
Deadline: August 10

Mesothelioma Applied Research Foundation
Deadline: August 15

Damon Runyon Cancer Research Foundation Fellowships
Deadline: August 17

DOD Lung Cancer Research Program Concept Award
Pre-Application Deadline: August 20
Application Deadline: September 3

International Myeloma Foundation 2010 Brian D. Novis Junior Research Award
Deadline: August 31

PhRMA Foundation Pharmacology/Toxicology
Pre Doctoral Fellowship
Post Doctoral Fellowship
Sabbatical Fellowship
Research Starter Grant
Deadline: September 1

PhRMA Foundation Informatics
Pre Doctoral Fellowship
Post Doctoral Fellowship
Sabbatical Fellowship
Research Starter Grant
Deadline: September 1

ASCO Cancer Foundation Improving Cancer Care Grant, funded by Susan G. Komen for the Cure
LOI Deadline: September 1

ASCO Improving Cancer Care Grant Improving Cancer Care Grant (ICCG)
LOI Deadline: September 1
Full Application Deadline: December 3

DOD Lung Cancer Research Program Concept Award
Pre-Application Deadline: August 20
Application Deadline: September 3

International Myeloma Foundation 2010 Brian D. Novis Senior Research Award
Deadline: September 4

ASCO Career Development Award
Full Application Deadline: September 9

ASCO Young Investigator Award
Application Deadline: September 9

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

ASCO Advanced Clinical Research Award (ACRA)
Full Application Deadline: October 1

ED Thomas Post Doctoral Fellowship 2009
Deadline: November 2

DOD Lung Cancer Research Program Clinical Fellow Research Award
Pre-Application Deadline: November 19
Application Deadline: December 3

DOD Lung Cancer Research Program Collaborative Translational Research Award
Pre-Application Deadline: November 19
Application Deadline: December 3

DOD Lung Cancer Research Program Lung Cancer Promising Clinician Research Award
Pre-Application Deadline: November 19
Application Deadline: December 3

ASCO Improving Cancer Care Grant Improving Cancer Care Grant (ICCG)
Full Application Deadline: December 3

DOD Lung Cancer Research Program Clinical Fellow Research Award
Application Deadline: December 3

DOD Lung Cancer Research Program Collaborative Translational Research Award
Application Deadline: December 3

DOD Lung Cancer Research Program Lung Cancer Promising Clinician Research Award
Application Deadline: December 3

DOD PRCRP Synergistic Idea Awards
Proposal Deadline: December 9

DOD PRCRP Collaborative Translational Science Awards
Proposal Deadline: December 9

DOD PRCRP Idea Awards
Proposal Deadline: December 9

DOD PRCRP Mentor-Predoctoral Fellow Research Awards
Proposal Deadline: December 9

DOD PRCRP New Investigator Awards
Proposal Deadline: December 9

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Innovations in Biomedical Computational Science and Technology (R01) (PAR-09-218)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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