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Case Comprehensive Cancer Center Newsletter

July 13, 2009

MESSAGE FROM THE DIRECTOR–Comments on Case CCC Scientific Retreat

On July 10-11, 2009, 170 faculty members of the Case Comprehensive Cancer Center met for our annual retreat at the Bertram Inn, where we covered basic translational and clinical research.

Following an extensive presentation on drug discovery and development by Milton Brown from the Lombardi Comprehensive Cancer Center and Georgetown University Medical Center, we reviewed our approach to developing cell-based assays, chemical synthesis, and use of throughput capabilities at the excellent facilities of our collaborators at partnering institutions. Examples include Milton Brown at Georgetown University, John Lazo at the University of Pittsburgh, and Andrei Gudkov at the Roswell Park Cancer Institute. We would like to promote these efforts to support investigators developing compelling new targets.

The stem cell, melanoma and brain tumor groups presented projects that will be developed into PPG applications, while the GI group met on Monday to discuss their SPORE application. These projects represent an important strategic priority for the Center.

Likewise, we heard from Jill Barnholtz-Sloan, Ruth Keri and Patrick Ma on biorepository-based research. I indicated that the IRB will review our biorepository access proposal to facilitate investigator research using human tumor samples, including access to paraffin blocks, fresh frozen tissue, and annotation about patient outcome. This effort will be promoted by a center-wide RFA for use of the Center biorepository in research.

The cancer imaging program met to review scientific priorities and to shape the RFA to be developed this fall between BME and the Cancer Center.

Another highlight of the day were the breakout sessions that allowed members to participate in cross-program initiatives.

On Saturday, we discussed survivorship research starting with a patient registry that includes behavioral and psychosocial data, which will also lead to an RFA in this area this fall.

At the end of the retreat, Mitch Machtay, recently recruited as chair of the Department of Radiation Oncology at UHCMC, discussed his interest in combined treatment research and the new trials from RTOG of which he serves as co-chairman.

Next, Neal Meropol, newly appointed Associate Director for Clinical Research, gave us his terrific vision to clinical and translational research and its links to his research interests in therapeutics, decision-making by patients in clinical trials, and cost-effectiveness research.

Next week, I will report on the senior leader executive session discussion, which will help refine our strategic priorities.

Thank you all for participating. It speaks volumes for the health of the Center that so many of us were able to join in the discussion!

Stan Gerson MD
Director, Case CCC


CASE CCC IN THE NEWS

MetroHealth researcher learns a key secret about a two-faced ...
The Plain Dealer - cleveland.com - July 6, 2009
Take Bingcheng Wang, a cancer researcher at MetroHealth Medical Center and Case Western Reserve University. Wang is intrigued by the conversion of normal ...

Study finds 60% rise in cancer for eating charred meat
The Plain Dealer - cleveland.com July 6, 2009
When consumed, HCAs can attack and damage DNA, causing the cancer snowball to begin rolling, says Dr. Li Li, associate director of the Ireland Cancer Center ...


KUDOS...

Dr. Nathan Berger was an invited speaker at the NCI/NINDS Cancer Cell Metabolism Workshop, July 9-10, 2009 at the Bethesda North Conference Center, Rockville, Maryland. Dr. Berger presented "Impact of Enhanced Exercise Phenotype on Colon Cancer in PEPCK-Cmus Transgenic Mice".


FUNDING OPPORTUNITY– ASCO Cancer Foundation

The ASCO Cancer Foundation is currently accepting applications for the following funding opportunities:

Improving Cancer Care Grant Improving Cancer Care Grant (ICCG)
The ASCO Cancer Foundation® Improving Cancer Care Grant, funded by Susan G. Komen for the Cure®, will provide extramural research funding to address important issues regarding access to healthcare, quality of care, and delivery of care, with general applicability to breast cancer. The goal of this program is to encourage multi-disciplinary research that will have a major impact on cancer care, with general applicability in the breast cancer arena.

LOI Deadline: September 1
Full Application Deadline: December 3

Advanced Clinical Research Award (ACRA)
The Advanced Clinical Research Award (ACRA) is designed to fund investigators who are committed to clinical cancer research and who wish to conduct original research not currently funded. Preference will be given to proposals involving therapeutic vaccine or immunotherapeutic approaches for sarcoma.

Deadline: LOI Deadline: August 6
Full Application Deadline: October 1

Career Development Award
The Career Development Award (CDA) provides funding to clinical investigators who have received their initial faculty appointment to establish an independent clinical cancer research program. The ASCO Cancer Foundation welcomes application submissions in all oncology subspecialties.

Full Applications Deadline: September 9

Young Investigator Award
The Young Investigator Award (YIA) provides funding to promising investigators to encourage and promote quality research in clinical oncology. The purpose of this award is to fund physicians during the transition from a fellowship program to a faculty appointment.

Full Application Deadline: September 9

EVENTS

**All events are open to anyone interested in attending

July 13


July 14


July 15

Grand Rounds
Balazs Halmos, MD
Assistant Professor, Medicine- Hem/Onc
CWRU/ UH
Topic: Gastroesophageal Cancer
8:00 am Lerner Tower B-151


July 16

Cancer Biology Seminar
John Isaacs, PhD
Professor, Oncology and Urology
Johns Hopkins Medical Institutions
James Buchanan Brady Urological Institute
Topic: TBA
10:00 am NE1-205 Cleveland Clinic

Taussig Cancer Institute Core Curriculum Series
Paul Elson, DSc
Associate Staff, Quantitative Health Sciences
Cleveland Clinic
Topic: Statistical Considerations for Cancer Research
12:00 pm R3-002 Cleveland Clinic

Case CCC Breast Cancer Metastasis Faculty Candidate Seminar
William P. Schiemann, PhD
Associate Professor, Pharmacology
University of Colorado Denver
Topic: Oncogenic TGF-â Signaling in Breast Cancer
3:00 pm WRB 3-136


July 17

Hematology/ Oncology Fellows Seminar
Brenda Cooper, MD
Associate Professor, Medicine-Hematology/Oncology
CWRU/ UH
Topic: Introduction to Stem Cell Transplant
8:00 am Wearn 137

more

For a complete listing of LRI seminars click here.


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Management of Lung Cancer in the Emphysema Patient: From Surgery to Cyberknife and Beyond
September 11
Embassy Suites, Independence

Paradigms in Lymphoma Management: A Case Based Approach
September 25
Marriott Downtown Cleveland at Key Center

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

**For more information on these symposiums, please contact Christine Rhoads.


ADDITIONAL UPCOMING SEMINARS & EVENTS

2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place
July 13-16
George S. Dively Building, CWRU Campus
Details

2009 caBIG® Annual Meeting: Solving Basic and Clinical Research Challenges in Cancer and Beyond
July 20 – 22
Marriott Wardman Park, Washington, DC
Details

VASCULATA Summer Course
July 28 - July 31
Cleveland Clinic Lerner Research Institute
Details

ACS Pan Ohio Hope Ride
July 30 - August 2
Details

MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center
Details

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA
Details

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona
Details


FUNDING OPPORTUNITY– Avon Foundation Breast Care Fund

The Avon Foundation Breast Care Fund (AFBCF) is accepting applications for 2010 funding. The mission of the AFBCF is to link medically underserved women to breast health education and screening services. Medically underserved women need targeted, customized approaches to enable them to obtain regular mammograms and clinical breast exams. Successful programs have: culturally-competent educational strategies; dedicated staff with specialized language and communications skills; and participation from members of the targeted community who can reach women where they live, work and worship, and who offer personalized assistance to women for whom it is often difficult to access health care.

Application Deadline: August 28

For more information, please click here.

If you are interested in submitting a proposal, please email gillian.irwin@case.edu ASAP, as only one application per institution is allowed.


MARK YOUR CALENDARS– International Association for Comparative Research on Leukemia and Related Diseases (IACRLRD) Symposium XXIV

On October 14-16, the Ohio State University Comprehensive Cancer Center will be hosting The IACRLRD Symposium XXIV: Molecular Approaches to Leukemia in the 21st Century: Biology, Outcome Prediction and Personalized Therapy including a mini-symposium - "Comparative Models of Leukemia" on October 14.

Junior faculty interested in leukemia and related diseases are encouraged to apply for one of several travel awards available. The travel awards were created to encourage junior faculty from around the world to participate in this symposium which will feature a distinguished group of internationally renowned presenters, oncologists, scientists and veterinarians. During the Symposium, junior faculty will have unique opportunities for informal gatherings with renowned leukemia experts to exchange ideas and research relating to hematologic malignancies.

Travel Award Deadline: July 15

For more information, please click here.



MARK YOUR CALENDARS– Fifth Biennial Cancer Survivorship Research Conference: Recovery and Beyond

The Fifth Biennial Cancer Survivorship Research Conference: Recovery and Beyond Conference is scheduled for June 17-19, 2010 at the Marriott Wardman Park Hotel in Washington, DC. This conference is co-sponsored by NCI Office of Cancer Survivorship, ACS Behavioral Research Center, Lance Armstrong Foundation and the Centers for Disease Control and Prevention's Division of Cancer Prevention and Control.

The conference will feature cutting edge research addressing what we know about the post-treatment health and function of cancer survivors and their families, and new directions in reducing morbidity and promoting well-being. More information will be available later this summer. A small number of abstracts will be selected for oral presentations during break-out.


CALL FOR ABSTRACTS– 2009 Case CCC Breast Cancer Retreat

The Case Comprehensive Cancer Center is planning a one-day Breast Cancer Research Retreat for late September, and is inviting all members of the Cancer Center community to attend.

All PIs currently examining topics related to all aspects of breast development and cancer are encouraged to submit abstracts. The abstracts that are chosen will be incorporated into the agenda either by giving a short talk or presenting a poster.

Abstracts should include title, authors and affiliation. Body of the abstract should be 300 words or less.

We look forward to a stimulating and informative retreat.

Please contact Retreat Co-Directors, Ruth Keri, PhD or Mark Jackson, PhD with any questions.

Please send abstracts by August 1, 2009 via email to: Gillian Irwin.

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

DOD PCRP Prostate Cancer Pathology Resource Network Award
Pre-Application Deadline: July 15
Proposal Deadline: August 5

DOD PRCRP Concept Awards
LOI Deadline: July 15
Proposal Deadline: July 30

Susan G. Komen for the Cure Promise Grants: Special Focus on Prevention
Deadline: July 15

Lustgarten Foundation
LOI Deadline: July 24
Application Deadline: August 7

Bone Marrow Failure Hypothesis Development Awards (BMFRP)
Application Deadline: July 30

Susan G. Komen for the Cure Investigator-Initiated Research (IIR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst in Disparities Research (CCDR) Grants
Full Application Deadline: July 31

Nancy R. Gelman Foundation Breast Cancer Seed Grants
Deadline: August 5

DOD PCRP Prostate Cancer Pathology Resource Network Award
Proposal Deadline: August 5

DOD PRCRP Synergistic Idea Awards
Pre-proposal Deadline: August 5
Proposal Deadline: December 9

DOD PRCRP Collaborative Translational Science Awards
Pre-proposal Deadline: August 5
Proposal Deadline: December 9

DOD PRCRP Idea Awards
Pre-proposal Deadline: August 5
Proposal Deadline: December 9

DOD PRCRP Mentor-Predoctoral Fellow Research Awards
Pre-proposal Deadline: August 5
Proposal Deadline: December 9

DOD PRCRP New Investigator Awards
Pre-proposal Deadline: August 5
Proposal Deadline: December 9

Lustgarten Foundation
Application Deadline: August 7


AACR–National Brain Tumor Society Fellowship, in memory of Bonnie Brooks
Deadline: August 10

Mesothelioma Applied Research Foundation
Deadline: August 15

Damon Runyon Cancer Research Foundation Fellowships
Deadline: August 17

International Myeloma Foundation 2010 Brian D. Novis Junior Research Award
Deadline: August 31

ASCO Cancer Foundation Improving Cancer Care Grant, funded by Susan G. Komen for the Cure
LOI Deadline: September 1

International Myeloma Foundation 2010 Brian D. Novis Senior Research Award
Deadline: September 4

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

ED Thomas Post Doctoral Fellowship 2009
Deadline: November 2

DOD PRCRP Synergistic Idea Awards
Proposal Deadline: December 9

DOD PRCRP Collaborative Translational Science Awards
Proposal Deadline: December 9

DOD PRCRP Idea Awards
Proposal Deadline: December 9

DOD PRCRP Mentor-Predoctoral Fellow Research Awards
Proposal Deadline: December 9

DOD PRCRP New Investigator Awards
Proposal Deadline: December 9

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

NIH Guidelines for Human Stem Cell Research (NOT-OD-09-116)

Amendment: Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research (PA-09-209) (NOT-OD-09-117)

Extension of Expiration Date for PAR-06-449: Paul Calabresi Award in Clinical Oncology (K12) (NOT-CA-09-030)

Mechanisms Underlying the Links between Psychosocial Stress, Aging, the Brain and the Body (R01) (PA-09-216)

Improving Diet and Physical Activity Assessment (R01)(PAR-09-224)

Research on Malignancies in the Context of HIV/AIDS (R21) (PA-07-454)

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R01) (PA-08-243)

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R21) (PA-08-244)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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