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Case Comprehensive Cancer Center Newsletter

June 29, 2009

MESSAGE FROM THE DIRECTOR– Case Comprehensive Cancer Center Annual Scientific Retreat, July 10-11, 2009, Bertram Inn, Aurora

This year's scientific retreat brings together Cancer Center scientific and clinical research programs at a new site, the Bertram Inn in Aurora, Ohio.

The retreat will emphasize topics of great interest to members, including recent stem cell biology, disease-based initiatives in breast, brain cancers and melanoma, and new scientific efforts in angiogenesis, high throughput sequencing, and drug discovery.

Since many of these topics cut across scientific programs, this year we have emphasized the science and not the programs, in an effort to promote interprogrammatic efforts. We will also review the current RFA for survivorship research, will announce the new RFA in biorepository-based research, and review the newest advances in technology available through our shared resources.

In addition, we will have introductory presentations by two recent senior recruits to the institutions: Dr. Neal Meropol, Associate Director of Clinical Research, and Dr. Mitch Machtay, Chair of Radiation Oncology at UH, who will develop a translational program in radiation biology and treatments.

Our special guest speaker is Dr. Milton Brown, who runs the drug discovery program at the Lombardi Comprehensive Cancer Center at Georgetown University. He has been asked to help us develop our drug discovery effort.

Overall, more than 55 members have helped organize the retreat and are presenting! This should be a terrific review of progress, a wonderful opportunity to update yourself about recent scientific advances, and a time to consider new collaborations. Further, this is the retreat that will help us frame priorities in the year prior to the renewal application for our core grant.

Thank you for attending and for your support of our cancer research efforts.

Stan Gerson, MD
Director, Case CCC


Farrah Fawcett's Struggle With Anal Cancer
FOXNews - June 25, 2009
... is usually successful, but can be disfiguring, said Dr. Stan Gerson, director of the Ireland Cancer Center of University Hospitals Case Medical Center ...

Ohio's Third Frontier Commission awards $5 million to stem cell ...
The Plain Dealer - cleveland.com - June 25, 2009
... using our strong background in pre-clinical models," said Stan Gerson, director of the Center for Stem Cell & Regenerative Medicine. ...

More than 70 people–including CBS Evening News anchor Katie Couric–attended a recent School of Medicine Research Event in New York City
Case Daily - June 26, 2009
Evening News anchor Katie Couric–attended a recent School of Medicine Research Event in New York City. The reception presented Sanford Markowitz's quest ...


An article by Dr. Alan Tartakoff, titled, Nuclear Fusion and Genome Encounter During Yeast Zygote Formation, was recently published in the April 2009 issue of "Molecular Biology of the Cell". This article has been selected for special mention by the American Society for Cell and Developmental Biology, and is summarized and discussed in the recent newsletter of the Society among their "InCytes." The journal subsequently selects an "article of the year" among those that appear in "InCytes."

FUNDING OPPORTUNITY– AACR–National Brain Tumor Society Fellowship, in memory of Bonnie Brooks

The AACR– National Brain Tumor Society Fellowship, in memory of Bonnie Brooks, is open to Postdoctoral Fellows and Clinical Research Fellows at an academic facility, teaching hospital, or research institution. This fellowship provides a one–year grant of $40,000 to support the salary and benefits of Fellows engaged in Glioblastoma multiforme (GBM) research. A partial amount of funds may be designated for direct research support.

Applicants must hold the title of Postdoctoral Fellow or Clinical Research Fellow at an academic facility, teaching hospital, or research institution within the United States. There are no citizenship requirements. Applicants must hold this title at the start of the fellowship term on December 1, 2009, and continue to hold it during the entire fellowship term. Applicants must have started their postdoctoral training no earlier than December 2, 2004 at the start of the fellowship term on December 1, 2009. That is, applicants must have started their fellowship no earlier than December 2, 2004 and no later than December 1, 2009.

Deadline: August 10

For more information, please click here.

CALL FOR ABSTRACTS– 2009 Case CCC Breast Cancer Retreat

The Case Comprehensive Cancer Center is planning a one-day Breast Cancer Research Retreat for Monday, September 28, and is inviting all members of the Cancer Center community to attend.

The abstracts that are chosen will be incorporated into the agenda either by giving a short talk or presenting a poster.

We look forward to a stimulating and informative retreat.

Please contact Retreat Co-Directors, Ruth Keri, PhD or Mark Jackson, PhD with any questions.

Please send abstracts by August 1, 2009 via email to: Gillian Irwin.


**All events are open to anyone interested in attending

June 29

Systems Biology Seminar
Chin-Rang Yang, PhD
Assistant Professor, Simmons Comprehensive Cancer Center and Radiation Oncology
University of Texas Southwestern Medical Center
Topic: Quantitative Proteomic Analysis for Cellular Signaling Modeling
11:00 am Olin 408

June 30

Department of Stem Cell Biology and Regenerative Medicine
Andre Machado, MD, PhD
Associate Staff, Center for Neurological Restoration
Cleveland Clinic
Topic: Stimulation of the Lateral Cerebellar Nucleus for Post-Stroke Motor Rehabilitation in a Rodent Model
9:00 am NC1-202 Cleveland Clinic

July 1

Grand Rounds
Rom Leidner, MD
Fellow, Div. of Hem/Onc
Topic: Testing a Genomic Strategy in Treatment of African American Non-small Cell Lung Cancer Patients
8:00 am Lerner Tower B-151

July 2

July 3

Hematology/ Oncology Fellows Seminar cancelled


For a complete listing of LRI seminars click here.


Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora

Management of Lung Cancer in the Emphysema Patient: From Surgery to Cyberknife and Beyond
September 11
Embassy Suites, Independence

Paradigms in Lymphoma Management: A Case Based Approach
September 25
Marriott Downtown Cleveland at Key Center

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

**For more information on these symposiums, please contact Christine Rhoads.


2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place
July 13-16
George S. Dively Building, CWRU Campus

2009 caBIG® Annual Meeting: Solving Basic and Clinical Research Challenges in Cancer and Beyond
July 20 – 22
Marriott Wardman Park, Washington, DC

ACS Pan Ohio Hope Ride
July 30 - August 2

MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona

FUNDING OPPORTUNITY– ED Thomas Post Doctoral Fellowship 2009

The José Carreras International Leukemia Foundation, which raises money for the support of research into the diagnosis, prevention and cure of leukemia and related hematological malignancies, is accepting applications for the ED Thomas Post Doctoral Fellowship 2009.

Candidates must hold an MD or PhD degree and have completed at least three years postdoctoral training but must be less than ten years post their first doctoral degree* when the award begins. There are no restrictions based on nationality, but only one application will be considered from each sponsoring institution. Candidates must be committed to the research goals of the Foundation, must be able to devote at least 80% of their time to the project and must have a sponsoring institution with the academic environment to provide adequate support for the proposed project.

Deadline: November 2

For details, please click here.


VASCULATA is a national summer course that promotes the study of vascular biology, and will be held July 28 - July 31 at the Cleveland Clinic Lerner Research Institute. Sponsored by the Cleveland Clinic and North American Vascular Biology Organization (NAVBO), this workshop is designed to present an overview of the field and future areas of active research. New for 2009, VASCULATA is offering a practical workshop where students can learn technically challenging laboratory techniques. Individuals with little or no background in vascular biology are encouraged to attend, and current trainees in the field and all interested individuals are invited to participate. This includes students (undergraduates, graduate students, medical students), trainees (postdocs, research fellows, residents) and others (junior and senior faculty).

Registration fees are inexpensive and vary depending on education level.

For details, please click here.

FUNDING OPPORTUNITY– DOD Peer Reviewed Cancer Research Program (PRCRP)

The Fiscal Year 2009 (FY09) Defense Appropriation Act provides for $16 million (M) to the Department of Defense (DOD) Peer Reviewed Cancer Research Program (PRCRP) to research cancers not addressed in the breast, prostate, and ovarian cancer research programs currently executed by the DOD U.S. Army Medical Research and Materiel Command (USAMRMC). The following program announcements were recently released:

Concept Awards will be awarded in Genetic Cancer Research or Non-invasive Cancer Ablation Research only. The PRCRP Concept Awards support the exploration of a highly innovative new concept or untested theory.
LOI Deadline: July 15

Idea Awards are promote the exploration of ideas that are still in the early stages of development yet have the potential to yield high-impact results and open new avenues of investigation in genetic cancer research and its relation to exposure to the various environments that are unique to a military lifestyle. This mechanism supports conceptually innovative, high-risk/high-reward research that could ultimately lead to critical discoveries or major advancements.
Pre-proposal Deadline: August 5

Mentor-Predoctoral Fellow Research Awards are designed to promote new ideas that are still in the early stages of development while training outstanding candidates in the topic area of noninvasive cancer ablation treatment research including selective targeting with nanoparticles. The research should have the potential to yield highly impactful data and new avenues of investigation. Mentored training of an outstanding Predoctoral fellow is an important aspect of this award, and inclusion of a Predoctoral Fellow is a requirement.
Pre-Proposal Deadline: August 5

New Investigator Awards support the career transition and/or continued development of promising PIs who have innovative, high-impact ideas or new technologies applicable to genetic cancer research and its relation to exposures to the various environments that are unique to a military lifestyle. This award supports independent PIs in the early stages of their careers, and it strongly encourages a designated collaborator.
Pre-proposal Deadline: August 5

Synergistic Idea Awards must address pediatric brain tumors within the field of childhood cancer, and the study of rare pediatric brain tumors is especially encouraged. Studies should include comprehensive methods for tumor data collection and host data collection. This award supports innovative approaches to pediatric brain tumor research involving two to four independent, faculty-level (or equivalent) PIs. These investigators should use synergistic and complementary perspectives to address a central problem or question in pediatric brain tumor research. This award is designed to encourage and support both new and pre-existing partnerships. This award requires that investigators jointly design a single project. However, each partner will be recognized as a PI, must submit a separate application, and will receive an individual award.
Pre-proposal Deadline: August 5

Collaborative Translational Science Awards support the development of translational research collaborations among two or three independent investigators (known as partners) to address one of the two Focus Areas in melanoma and other skin cancers in a manner relevant to military service that would be less readily achievable through separate efforts. At least one partner must have experience either in melanoma/other skin cancer research or in melanoma/other skin cancer patient care. It should be clear that all partners have equal intellectual input into the design of the research project. This award requests applications from these Focus Areas only: Research into melanoma and other skin cancers related to deployments of service members to areas of high exposure by: A) Understanding molecular and immunological effects of UV at the level of the cell and at the level of the human host, and B) The genetic epidemiology and increased susceptibility to melanoma and other skin cancers. Correlative clinical research studies are allowed under this mechanism.
Pre-Proposal Deadline: August 5


Clinical and Translational Science Collaborative (CTSC) Pilot Funds
Deadline: July 1
CWRU, UH, MetroHealth
Cleveland Clinic

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
Proposal Deadline: July 8

Bone Marrow Failure Hypothesis Development Awards (BMFRP)
Pre-Application Deadline: July 9
Application Deadline: July 30

National Breast Cancer Coalition Fund Advocacy in Action Grants
Deadline: July 10

NCRR Competitive Revision Application
Deadline: July 10

DOD PCRP Prostate Cancer Pathology Resource Network Award
Pre-Application Deadline: July 15
Proposal Deadline: August 5

Susan G. Komen for the Cure Promise Grants: Special Focus on Prevention
Deadline: July 15

Lustgarten Foundation
LOI Deadline: July 24
Application Deadline: August 7

Bone Marrow Failure Hypothesis Development Awards (BMFRP)
Application Deadline: July 30

Susan G. Komen for the Cure Investigator-Initiated Research (IIR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst in Disparities Research (CCDR) Grants
Full Application Deadline: July 31

DOD PCRP Prostate Cancer Pathology Resource Network Award
Proposal Deadline: August 5

Lustgarten Foundation
Application Deadline: August 7

Mesothelioma Applied Research Foundation
Deadline: August 15

Damon Runyon Cancer Research Foundation Fellowships
Deadline: August 17

International Myeloma Foundation 2010 Brian D. Novis Junior Research Award
Deadline: August 31

ASCO Cancer Foundation Improving Cancer Care Grant, funded by Susan G. Komen for the Cure
LOI Deadline: September 1

International Myeloma Foundation 2010 Brian D. Novis Senior Research Award
Deadline: September 4

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Modification to RFA-CA-09-012 to Increase Applicants Flexibility in Selecting the Research Focus for the Proposed Nanotechnology Centers (NOT-CA-09-029)

The Early Detection Research Network: Biomarker Developmental Laboratories (U01) (RFA-CA-09-017)

Cancer Intervention and Surveillance Modeling Network (CISNET) (U01) (RFA-CA-09-025)

Feasibility Studies for Collaborative Interaction for Minority Institution/Cancer Center Partnership (P20) PAR-09-201

Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21) (PAR-09-162)

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research (PA-09-209)

Administrative Supplements for Research on HIV/AIDS-Related Cancers Among Racial/Ethnic Minority and Underserved Persons in the United States

Minority Institutional Research Training Program (T32) (RFA-HL-10-014)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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