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Case Comprehensive Cancer Center Newsletter

June 15, 2009


Dear Cancer Center Members:

The 2009 scientific retreat of the Cancer Center will be July 10-11, 2009 at the Bertram Inn and Conference Center in Aurora, Ohio. This annual gathering is always an important event for the Cancer Center, giving us an opportunity to exchange ideas, evaluate current initiatives, and reorient our development and scientific priorities as needed. This year's program was developed with the assistance of the Cancer Center Retreat Program Committee, whose members are Drs. Alex Almasan, Ruth Keri, Mary Step, and John Wang.

Our program committee recommended some new approaches to the development of the agenda; members noted that they wished to highlight the scientific interests of new members and learning more about specific attributes of the core facilities. Thus, scientific presentations will feature some new members, and include capabilities of the most relevant core facilities to the specific topic. Rather than the traditional program-based breakout sessions, this year will include special topics that encourage interprogrammatic participation around selected themes.

The retreat will be anchored by a keynote address on drug discovery delivered by Milton Brown, MD, PhD. Dr. Brown is the Director of the Drug Discovery Program and the Edwin H. Richard and Elisabeth Richard von Matsch Endowed Chair in Experimental Therapeutics at Georgetown University. He is a medicinal chemist with a major interest in the design, synthesis, and evaluation of new drugs. He is also program leader for the Lombardi Comprehensive Cancer Center's Drug Discovery and Developmental Therapeutics Program. Dr. Brown's laboratory has evaluated over 1000 compounds for possible use as therapeutics to treat prostate cancer, leukemia, and epilepsy.

The breakout sessions will follow Dr. Brown's presentation, and Dr. Brown will participate in the session that will continue to explore topics of interest in drug development and discovery. Program leaders are encouraged to review the proposed topics and in turn note those of particular interest to their program themes and members.

Our emphasis on multi-investigator efforts and disease based initiatives will continue with presentations and discussions on lung cancer and melanoma, and will bring the membership up to date on activities and developments in support of our survivorship initiative. Dinner on Friday evening will be preceded by core facility poster presentations accompanied by beer, wine, and cocktails to ease the transition to social activities for the remainder of the evening. While we have elected not to have a formal scientific presentation after dinner, this would be an ideal time for small group discussions.

At the core facility poster session, we will also present the new large equipment coming into the Cancer Center through large instrumentation grants, institutional resources, cancer center commitments, and Howard Hughes Medical Institute. Among these items are: Solexa (high throughput sequencing), Amnis Image Stream Analyzer in Cytometry, Fluorescence Micro Tomography equipment in the Imaging Core, Upgrade ABI TaqMan Based Genotyping and the Gene Titan Affymetrix Analysis equipment in Gene Expression and Genotyping Core, and Veridex (Immunicon) equipment at Taussig.

Saturday morning, the program will focus on transdisciplinary research efforts. We will open with presentations on topics related to the Cancer Prevention, Control and Population Research and Aging-Cancer Research Programs, including Survivorship. Our retreat will conclude with presentations from our newest recruits: Neal Meropol, MD as Associate Director for Clinical Research at the Case CCC, and Mitchell Machtay, MD, as Chair of Radiation Oncology at CWRU and UHCMC.

After dismissal of the general, group, Cancer Center senior leadership and program leaders will meet to assess priorities, plan new initiatives, and to allocate funds for new pilot grant RFAs and core facility equipment purchases. Their discussions will begin the pre-renewal assessment of individual programs, which will come in useful in the spring of 2010 when the Cancer Center will begin the process of assembling our competitive renewal, which is due mid-2011.

The retreat will end after lunch, and we hope you will stay in the area and enjoy some local attractions surrounding the Bertram Inn and Conference Center, including Wildwater Kingdom, Aurora Farms Premium Outlets, and Thorncreek Winery & Gardens. The Barrington Golf Club, a Jack Nicklaus Signature Course, is nearby, as well as Boulder Creek and Aurora Country Club. If you are interested in playing golf on Saturday afternoon, please indicate this when you register and we will inform the staff at the Bertram Inn who will assist in making these arrangements.

Please fill out the Registration Form and let us know whether or not you are able to attend. Please return the form to gillian.irwin@case.edu as soon as possible so we can plan rooms for the break out sessions and plan meets and rooms.

Thank you for the time commitment that you have already made to the Cancer Center.

If you would like to add a topic to the list of presentations, have a comment about the schedule of events, or would like to provide input, please email me at slg5@case.edu.

I want to thank you in advance for taking the time out of your busy schedules to participate in this important event and showing your support for the Cancer Center. I look forward to seeing you on July 10-11.

Stan Gerson, MD
Director, Case CCC


Low-fat Diet Helps Genetically Predisposed Animals Avoid Liver Cancer
Science Daily (press release) - June 11, 2009
... humans," says senior co-author Joseph Nadeau, Professor and Chair of the Department of Genetics at Case Western Reserve University School of Medicine. ...Co-authors ...Nathan A. Berger,...from Case Western Reserve University.


Please join us in welcoming the following new members of the Case CCC:

Samuel Chao, MD
Associate Staff, Brain Tumor and Neuro-oncology Center and Radiation Oncology
Assistant Professor, CCLCM
developing program in Cancer Imaging

Neetu Gupta, PhD
Assistant Staff, Immunology
Assistant Professor, CCLCM
Stem Cells and Hematologic Malignancies Program

Nathan Pennell, MD, PhD
Associate Staff, Solid Tumor Oncology
Assistant Professor, CCLCM
Developmental Therapeutics Program

MARK YOUR CALENDARS– Drug Discovery and Developmental Therapeutics Retreat

Join your colleagues on Saturday, June 20 from 8:30 am - 1:00 pm at the Squire Valleevue Farm Sheep Barn for a broad scientific discussion of new drug targets, screening approaches, and examples of successful pathways towards clinical development.

Our goal is to develop a more cohesive scientific initiative in drug discovery leading to therapeutic development of new agents and combinations in cancer. The emphasis of the retreat will be on aligning our programmatic strengths in targets, disease-based research, study design and laboratory correlatives, and exploring potential new directions in drug discovery.

Please RSVP to gillian.irwin@case.edu as soon as possible.

For more information and to view the retreat agenda, please click here.


**All events are open to anyone interested in attending

June 15

Research in Progress Seminar cancelled

Physiology & Biophysics Seminar
Darren Boehning, PhD
Associate Professor, Neuroscience and Cell Biology
University of Texas Medical Branch
Topic: Regulation of Apoptosis by IP3R Calcium Channels
4:00 pm SOM E501

June 16

Taussig Cancer Institute Core Curriculum Series
Ann Tan, MD
Taussig Cancer Institute
Cleveland Clinic
Topic: TBA
12:00 pm R3-002 Cleveland Clinic

June 17

Grand Rounds
Ken Cooke, MD
Associate Professor, Pediatric Hematology/Oncology
Topic: TBA
8:00 am Lerner Tower B-151

June 18

Taussig Cancer Institute Core Curriculum Series
Courtney Jones, MD
Taussig Cancer Institute
Cleveland Clinic
Topic: TBA
12:00 pm R3-002 Cleveland Clinic

June 19

Hematology/ Oncology Fellows Seminar
Haydar Frangoul, MD
Associate Professor, Pediatric Hematology/Oncology
Vanderbilt University
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Monica Bertagnolli, MD
Associate Professor, Surgery
Harvard Medical School
Topic: Inflammation and Colon Cancer Risk: Realistic Chemopreventative Strategies
8:00 am R3/002-003 Cleveland Clinic


For a complete listing of LRI seminars click here.


Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Brochure and Registration

Developmental Therapeutics Programs Retreat
8:30 am - 1:00 pm
Squire Valleevue Sheep Barn

ASCO Review
June 25
InterContinental Hotel

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora

Management of Lung Cancer in the Emphysema Patient: From Surgery to Cyberknife and Beyond
September 11
Embassy Suites, Independence

Paradigms in Lymphoma Management: A Case Based Approach
September 25
Marriott Downtown Cleveland at Key Center

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

**For more information on these symposiums, please contact Christine Rhoads.


Prostate Cancer Forum: A Pathway to Support, Education and Empowerment
June 20
8:30 am - 5:00 pm Corporate College East, 4400 Richmond Rd, Warrensville Heights
Advance registration required: 216-595-9546

2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place
July 13-16
George S. Dively Building, CWRU Campus

2009 caBIG® Annual Meeting: Solving Basic and Clinical Research Challenges in Cancer and Beyond
July 20 – 22
Marriott Wardman Park, Washington, DC

ACS Pan Ohio Hope Ride
July 30 - August 2

MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona

CALL FOR ABSTRACTS– 2009 Case CCC Breast Cancer Retreat

The Case Comprehensive Cancer Center is planning a one-day Breast Cancer Research Retreat for mid-September, and is inviting all members of the Cancer Center community to attend.

The abstracts that are chosen will be incorporated into the agenda either by giving a short talk or presenting a poster.

We look forward to a stimulating and informative retreat.

Please contact Retreat Co-Directors, Ruth Keri, PhD or Mark Jackson, PhD with any questions.

Please send abstracts by August 1, 2009 via email to: Gillian Irwin.

NCI NEWS– Approved Oncology Drugs Now Available from DCTD in Plated Sets

The NCI Division of Cancer Treatment and Diagnosis can now bring a new, important resource to drug discovery efforts. Oncology drugs that have been approved by the Food and Drug Administration are being offered in plated sets. A collection of more than 50 oncology drugs is currently available and approximately 30 other drugs will become obtainable soon. The compounds are provided as 20 microliters at 10mM in 100% DMSO.

For more information, please click here.


The Case CCC was well represented at the ASCO Annual Meeting, held May 29 - June 2 in Orlando, Florida.

The following people were involved in the general meeting program as session co-chairs, or session/discussion participants: Drs. Robert Dreicer, Jorge Garcia, Timothy Gilligan, Eric Klein, Eric Kodish, Smitha Krishnamurthi, Derek Raghavan, Brian Rini, and Vivien von Gruenigen.

Also, the following abstracts were presented by Cancer Center Members:
3566Ganapathi, Mekhail
5043Elson, Garcia, Dreicer, Rini
5073Garcia, Dreicer
5096Garcia, Elson, Klein, Stephenson, Dreicer, Campbell, Rini
5594von Gruenigen, Waggoner
6058Fu, Cooney, Dowlati, Lavertu, Bokar, Savvides
7016Advani, Sekeres, Maciejewski
7036Barr, B. Cooper, Kindwall-Keller, Laughlin, Gerson, Fu, Lazarus
7557Mekhail, Pennell
9013Averbook, Rao
9571Brell, Stellato, Schluchter, Pink
9579Owusu, Koroukian
e16006Ponsky, Wessels, Einstein
e16503P. Rose, Zanotti

CALL FOR PARTICIPATION– Ohio Collaborative Conference on Bioinformatics

The Ohio Bioinformatics Consortium will hold the 4th Annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) on June 15-17 at Case Western Reserve University.

The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Keynote Speakers:
Igor Jurisica, Canada Research Chair in Integrative Computational Biology, University of Toronto
Integrative Network Analysis of Prognostic Markers in Lung Cancer (in collaboration with M. S. Tsao, F. Shepherd, D. Strumpf, C.Q. Zhang)

Tao Jiang, Presidential Chair Professor, University of California - Riverside
Searching and Predicting Active Chemical Compounds Using Maximum Common Substructure

Daniel R. Schoenberg, Center for RNA Biology and Department of Molecular and Cellular Biochemistry, The Ohio State University
Cytoplasmic Capping: A New Post-Transcriptional Step That May Expand the Transcriptome and the Proteome

For more information about this event, please click here.

FUNDING OPPORTUNITY– Susan G. Komen for the Cure Promise Grants: Special Focus on Prevention

Susan G. Komen for the Cure is accepting pre-applications for Prevention Promise Grants. These grants seek to support integrated programs of collaborative and cross-disciplinary research projects leading to the aggressive translation of scientific discoveries into interventions and strategies that have the greatest potential to significantly reduce breast cancer incidence, defined here in terms of the prevention of primary breast cancers in previously asymptomatic women or prevention of second primary breast cancers in women with a previous history of cancer. Proposals seeking to prevent breast cancer recurrence would not be within the scope of this RFA. These grants seek to remove current roadblocks to development and clinical translation of effective prevention interventions. Awards will provide up to $5million over 3-5 years.

Pre-application Deadline: July 15

For more information, please click here.

FUNDING OPPORTUNITY– International Myeloma Foundation 2010 Brian D. Novis Research Awards

The International Myeloma Foundation funds several research grants including the Brian D. Novis Research Award. These grants are provided through donations from private individuals, and are presented annually by the International Myeloma Foundation. These awards go to doctors/researchers doing work in the field of multiple myeloma. The Brian D. Novis Award honors the IMF's founder Brian Novis, who died of multiple myeloma in July of 1992. The International Myeloma Foundation is a non-profit organization whose mission is to improve the quality of life for myeloma patients while working toward prevention and a cure.

Junior Research Award
Candidates for this award will have completed postdoctoral studies or clinical fellowships not later than August 1 of the application year. They also must be able to devote a minimum of 50% of his or her time to the research project during the award year, and have the ability to provide a completed application with evidence of a meritorious research project.
Deadline: August 31

Senior Research Award
These awards are targeted to established investigators with a track record in myeloma or related research, and are designed for projects which represent a different focus, direction or area of research from those in which they are currently funded. In most cases, these awards will be for pilot projects to obtain sufficient funding for larger applications from NIH or similar larger funding agencies.
Deadline: September 4

CALL FOR INTEREST– NCI 2009 Translational Science Meeting (TSM2)

The National Cancer Institute is sponsoring the 2009 Translational Science Meeting (TSM2) on November 5-7, 2009 at the Sheraton Premiere in Vienna, VA. The purpose of the meeting is to enhance collaborations and interactions among investigators supported across all NCI funding mechanisms that support translational research. In addition, it will assist in the identification of Translational Research Opportunities as a part of NCI's new Process to Accelerate Translational Science initiative to advance the most promising translational research projects. Additional information on the 2009 NCI Translational Science Meeting can be found at http://ncitranslates.nci.nih.gov.

The Case CCC has been invited to select one investigator to represent our Center and submit an abstract on their translational work. In addition, we have reserved one non-presenting position so a second member of our Center can attend the meeting and actively participate in the discussion sessions. Our center will need to register and submit our abstract by July 1, 2009.

If you would like to be considered for this opportunity to represent the Case CCC, please send your abstract to gillian.irwin@case.edu by Monday, June 22.


Brain Tumor Funders' Collaborative
Deadline: June 15

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

Fanconi Anemia Research Fund Call for Abstracts
Deadline: June 19

Clinical and Translational Science Collaborative (CTSC) Pilot Funds
Deadline: July 1
CWRU, UH, MetroHealth
Cleveland Clinic

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
Proposal Deadline: July 8

Bone Marrow Failure Hypothesis Development Awards (BMFRP)
Pre-Application Deadline: July 9
Application Deadline: July 30

NCRR Competitive Revision Application
Deadline: July 10

DOD PCRP Prostate Cancer Pathology Resource Network Award
Pre-Application Deadline: July 15
Proposal Deadline: August 5

Lustgarten Foundation
LOI Deadline: July 24
Application Deadline: August 7

Bone Marrow Failure Hypothesis Development Awards (BMFRP)
Application Deadline: July 30

Susan G. Komen for the Cure Investigator-Initiated Research (IIR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst in Disparities Research (CCDR) Grants
Full Application Deadline: July 31

DOD PCRP Prostate Cancer Pathology Resource Network Award
Proposal Deadline: August 5

Lustgarten Foundation
Application Deadline: August 7

Mesothelioma Applied Research Foundation
Deadline: August 15

Damon Runyon Cancer Research Foundation Fellowships
Deadline: August 17

ASCO Cancer Foundation Improving Cancer Care Grant, funded by Susan G. Komen for the Cure
LOI Deadline: September 1

William Lawrence & Blanche Hughes Foundation
Deadline: September 16

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research (PA-09-209)

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32) (PA-09-210)

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (F33) (PA-09-211)

Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21) (PAR-09-162)

Feasibility Studies for Collaborative Interaction for Minority Institution/Cancer Center Partnership (P20) (PAR-09-201)

Translational Research at the Aging/Cancer Interface (TRACI) (R01) (PA-08-230)

Diet-Induced Changes in Inflammation as Determinants of Colon Cancer (R01) (PA-08-210)

Millennium Promise Awards: Non-communicable Chronic Diseases Research Training Program (NCoD) (D43) (PAR-08-175)

Biomarkers for Early Detection of Hematopoietic Malignancies (R01) (PA-09-197)

Biomarkers for Early Detection of Hematopoietic Malignancies (R21) (PA-09-198)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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