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Case Comprehensive Cancer Center Newsletter

May 4, 2009


Minorities to Bear Brunt of Rise in US Cancer Cases
Atlanta Journal Constitution - Apr 29, 2009
"Disparities facing minority patients are now reaching crisis proportions," said Dr. Derek Raghavan, director of the Cleveland Clinic Taussig Cancer ...

Study Bolsters Hopes for Prostate Cancer Vaccine Rejected by FDA
Los Angeles Times - Apr 28, 2009
"This will be much easier for patients than going through chemotherapy because there are no side effects," added Dr. Stanton Gerson, director of the ...

MARK YOUR CALENDARS– Drug Discovery and Developmental Therapeutics Retreat

Join your colleagues on Saturday, June 20 from 9:00 am - 2:00 pm at the Squire Valleevue Farm Sheep Barn for a broad scientific discussion of new drug targets, screening approaches, and examples of successful pathways towards clinical development.

Our goal is to develop a more cohesive scientific initiative in drug discovery leading to therapeutic development of new agents and combinations in cancer. The emphasis of the retreat will be on aligning our programmatic strengths in targets, disease-based research, study design and laboratory correlatives, and exploring potential new directions in drug discovery.

Agenda will be released soon. Please RSVP to gillian.irwin@case.edu by Friday, June 5.

FUNDING OPPORTUNITY– Susan G. Komen for the Cure

Susan G. Komen for the Cure is currently accepting pre-applications for Investigator Initiated and Career Catalyst Research grants for the 2009-2010 Research Program.

Investigator-Initiated Research (IIR) Grants
IIR Grants provide up to $600,000 over three years to stimulate exploration of new ideas and novel approaches in breast cancer research and clinical practice that will lead to reductions in breast cancer incidence and mortality within the next decade. Special emphasis will be given to studies seeking to understand the basis for difference in breast cancer outcomes and translating research discoveries into clinical and public health practice to eliminate breast cancer disparities. Pre-applications are required prior to starting a full application.

Career Catalyst Research (CCR) Grants
CCR Grants provide unique opportunities for scientists in the early stages of their career to achieve research independence with an independent award of up to $450,000 over three years. CCR investigators lead a research project addressing an important question in breast cancer research and complete a self-defined career development plan with support from a mentor committee. Pre-applications are required prior to starting a full application.

Career Catalyst in Disparities Research (CCDR) Grants
These awards provide a unique opportunity for scientists in the early stages of their career to achieve research independence. This award provides up to $450,000 over 3 years for research exploring the basis for differences in breast cancer outcomes and the translation of this research into clinical and public health practice interventions. Pre-applications are required prior to starting a full application.

Pre-Application Deadline: June 1
Full Application Deadline: July 31

For more information, please click here.

FUNDING OPPORTUNITY– DOD PCRP Prostate Cancer Pathology Resource Network Award

The Prostate Cancer Research Program (PCRP) is accepting applications for the Prostate Cancer Pathology Resource Network Award. This award is intended to provide infrastructure support for the development of a prostate cancer biorepository consortium that will facilitate the collection, processing, annotation, storage, and distribution of high-quality human prostate cancer biospecimens through a collaborative network across multiple institutions. The Network will also collect, store, and manage data derived from the distributed biospecimens. The initial, pilot Network will consist of a Coordinating Center and two additional Pathology Resource Sites that will be jointly responsible for developing the biospecimen repository for prostate cancer research. Additionally, Pathology Resource Network Sites should possess the ability to derivatize DNA, RNA, and proteins, and utilize both standard and state-of-the-art technologies (e.g., laser capture microdissection, tissue microarrays) to provide the necessary biospecimen processing for a large range of prostate cancer research studies.

Pre-Application Deadline: July 15
Proposal Deadline: August 5

For more information, please click here.


The American Cancer Society's Pan Ohio Hope Ride is a bicycling tour that enables you to take an incredible bicycle journey and to support ACS Hope Lodges and other vital patient services. The Pan Ohio Hope Ride will take cyclists from Cleveland to Cincinnati in a four-day tour through Ohio's scenic countryside from July 30-August 2. Challenge yourself to hit the road and make the road smoother for those battling cancer.

For more information, please click here.

MARK YOUR CALENDARS– Pan Ohio Hope Ride Research Rally

On May 30, the American Cancer Society will be sponsoring the Pan Ohio Hope Ride Research Rally to celebrate the cancer research going on in the Cleveland area and to raise awareness of the Third Annual ACS Pan Ohio Hope Ride to be held July 30 - August 2.

The Research Rally will begin at 9:00 a.m. in front of the ACS Hope Lodge at 11432 Mayfield Rd. After a brief program, the riders will proceed down Euclid Avenue to Public Square and loop around back at the Hope Lodge.

Everyone in the local oncology community is encouraged to participate in the approximately 10-mile bike ride.

Anyone interested in participating should contact Paul Purdy, ACS Pan Ohio Staff, at Paul.purdy@cancer.org or 888-227-6446, ext. 1208.

MARK YOUR CALENDARS– Case CCC Scientific Series

The next installment of the Case CCC Scientific Series and reception is planned for Monday, May 11 4:30 pm - 6:00 pm in Wolstein Auditorium. Presentations will be made by the following ACS Pilot Project Awardees:
Alex Huang, MD, PhDRole of Tumor Microenvironment on Immune Cell Trafficking and Function in situ
Alan Zhu, PhDProtein Phosphatase 2A Dephosphorylates Smoothened to Inhibit Hedgehog Signaling
Patrick Ma, MDEGFR Mutations and Differential Response to Inhibitors in Leptomeningeal Metastases: Opportunities for Individualized Targeted Therapy in Lung Cancer

Everyone is welcome and encouraged to attend.

MARK YOUR CALENDARS– Cancer Survivor/ Cancer Caregiver Photo Exhibition

Dr. Maghboeba Mosavel from the Case Center for Reducing Health Disparities and Kimberly Sanders from NorthEast Ohio Neighborhood (NEON) Health Services, are pleased to invite you to attend the Cancer Survivor/ Cancer Caregiver Photo Exhibition on Wednesday, May 13 from 10:00 am - 12:00 pm at MetroHealth Medical Center, Rammelkamp R170. This photo exhibit tells the story of the journey, triumphs and challenges of Cancer Survivors in Cleveland. Refreshments will be served.

This exhibit is sponsored by the Case Comprehensive Cancer Center and the Lance Armstrong Foundation. For more information, please contact Meia Jones at (216)778-8456.

MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins.

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required.

For details, please click here.

MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics (OCCBIO)

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.


**All events are open to anyone interested in attending

May 4

Hematology/Oncology Research in Progress Seminar
Zhengqi Wang, PhD
Research Associate, Bunting Lab, Div. of Hem/Onc
Topic Toward Defining STAT5 Target Genes in Hematopoietic Stem Cells
12:00 pm WRB 2-136

Biochemistry Seminar
Chawnshang Chang, PhD
Professor, Pathology, Urology and Radiation Oncology
University of Rochester
Topic: Differential Androgen Receptor Signals Explains Why Androgen Deprivation Therapy of Prostate Cancer Fails
12:00 pm SOM W428

Gastroenterology Seminar
Shrikant Anant, PhD
Associate Professor, Medicine and Cell Biology
University of Oklahoma
Topic: Posttranscriptional Regulation and Tumorigenesis: Novel Paradigms for Therapeutic Interventions
12:00 pm BRB 433

Pathology Graduate Student Dissertation Defense
Joshua Rosenblum
Fairchild Lab, Pathology
Topic: Novel Roles for Chemokines in Acute Cardiac Allograft Rejection
12:00 pm WRB 1-413

May 5

Taussig Cancer Institute Core Curriculum Series
Robert Wesolowski, MD
Taussig Cancer Institute
Cleveland Clinic
Topic: Human Epidermal Growth Factor Receptor Specific Therapy for Breast Cancer
12:00 pm R3-002 Cleveland Clinic

May 6

Grand Rounds
Cecilia Choi, MD
Fellow, Division of Hematology/Oncology
Topic: Hepatocellular Carcinoma: Diagnosis and Management
8:00 am Lerner Tower B-151

May 7

Taussig Cancer Institute Core Curriculum Series
Anuj Mahindra, MD
Taussig Cancer Institute
Cleveland Clinic
Topic: Amyloidosis
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
Michael Zigmond, PhD
Professor, Neurology
University of Pittsburgh
Topic: The Value of Exercise and Neurotrophic Factors in Neurodegenerative Disease: Studies with Models of Parkinsons's Disease
12:10 pm BRB 105

Aging-Cancer Seminar
Beth O'Toole, MD
Professor, Medicine-Geriatrics and Bioethics
CWRU/ MetroHealth
Topic: TBA
4:00 pm BRB 732

May 8

Hematology/ Oncology Special Conference
Fadi Braiteh, MD
Clinical Fellow, Medical Oncology
University of Texas MD Anderson Cancer Center
Topic: Half a Century of Anti-Cancer Drug Approval in the USA: Lessons Learned from the FDA Approval Process
8:00 am Wearn 137

Cancer Center Seminar Series/ Blood Club
Eva Grunfeld, MD, MSc, DPhil
Professor, Family and Community Medicine
University of Toronto
Topic: Cancer Survivorship
12:00 pm BRB 105

Taussig Cancer Institute Grand Rounds
Nathan Pennell, MD, PhD
Solid Tumor Oncology
Cleveland Clinic
Topic: Targeting the Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
8:00 am R3/002-003 Cleveland Clinic


For a complete listing of LRI seminars click here.


Case CCC Scientific Series- ACS Pilot Project Awardees
May 11
4:30 pm - 6:00 pm WRB 1-413

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Brochure and Registration

ASCO Review
June 25
InterContinental Hotel

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1

CTTE 2009 Short Course: Cell-Based Therapies & Tissue Engineering
May 18-21
Clapp and Millis Hall, CWRU Campus

Center for Mind-Body Medicine CancerGuides® II
June 11 - 14
Washington, DC

2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place
July 13-16
George S. Dively Building, CWRU Campus

MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona


OCRP Ovarian Cancer Academy Award
Pre-App Deadline: May 8
Proposal Deadline: May 22

AACR Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen for the Cure Nomination Deadline: May 15

Breast Cancer Research Foundation-AACR Grants for Translational Breast Cancer Research
LOI Deadline: May 20

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
LOI Deadline: May 20
Proposal Deadline: July 8

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

Damon Runyon-Rachleff Innovation Award
Pre-proposal Deadline: June 1

Brain Tumor Funders' Collaborative
Deadline: June 15

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
Proposal Deadline: July 8

NCRR Competitive Revision Application
Deadline: July 10

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R21) (PA-09-167)

Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R03) (PA-09-168)

Administrative Supplements to Study Economic Impact of Interventions Targeting Cancer Survivors and/or their Families (NOT-CA-09-023)

Minority-Based Community Clinical Oncology Program (U10) (RFA-CA-09-023)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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