May 11, 2009

CASE CCC IN THE NEWS

University Hospitals' Cancer Hospital Taking Shape With Promise to ...
The Plain Dealer - cleveland.com - May 8, 2009
Dr. Stanton Gerson, Ireland's director, talked to the crowd about his hope that the Cancer Hospital will become a nationally recognized destination for ...

Case Western Reserve Med School Wins $3 Million-plus Grant
Crain's Cleveland Business - May 7, 2009
and Hepatitis C co-infection affect the progression of HIV and treatments, said Mark Chance, director of the Center for Proteomics and Bioinformatics. ...

Cancer: Minorities Report More Pain
WebMD - May 7, 2009
Cleveland Clinic oncologist Derek Raghavan, MD, tells WebMD that the study was too small, with far too few minority participants to allow for meaningful ...

Investigating Therapeutic Lung Cancer Vaccine
eMaxHealth.com - May 4, 2009
"New treatments are urgently needed for patients with advanced non-small cell lung cancer," said Balazs Halmos, MD, Ireland Cancer Center of University ...

MARK YOUR CALENDARS– Case CCC Scientific Series

The next installment of the Case CCC Scientific Series and reception is planned for TODAY, May 11 4:30 pm - 6:00 pm in Wolstein Auditorium (WRB 1-413). Presentations will be made by the following ACS Pilot Project Awardees:
• Alex Huang, MD, PhD– Role of Tumor Microenvironment on Immune Cell Trafficking and Function in situ
• Alan Zhu, PhD– Protein Phosphatase 2A Dephosphorylates Smoothened to Inhibit Hedgehog Signaling
• Patrick Ma, MD– EGFR Mutations and Differential Response to Inhibitors in Leptomeningeal Metastases: Opportunities for Individualized Targeted Therapy in Lung Cancer

Everyone is welcome and encouraged to attend.

AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO) ANNUAL MEETING PRESENTATIONS & POSTERS

The Cancer Center is attempting to track members who are part of the formal program or presenting a poster at the ASCO Annual Meeting, May 29 - June 2 in Orlando, Florida. Please send information to gillian.irwin@case.edu.

MARK YOUR CALENDARS– Race for the Place

Join The Gathering Place on Sunday, June 7, National Cancer Survivors Day, for the 9th Annual Race for the Place, a 5k run/walk and 1-mile walk. The race starts at 9:15 am at Beachwood Mall on the upper level parking lot between Dillards and Nordstrom with several pre-race activities beginning at 8:00 am. All proceeds from Race for the Place help keep programs and services free of charge for individuals and families touched by cancer.

For details and registration information, please click here.

NCI NEWS– Approved Oncology Drugs Now Available from DCTD in Plated Sets

The NCI Division of Cancer Treatment and Diagnosis can now bring a new, important resource to drug discovery efforts. Oncology drugs that have been approved by the Food and Drug Administration are being offered in plated sets. A collection of more than 50 oncology drugs is currently available and approximately 30 other drugs will become obtainable soon. The compounds are provided as 20 microliters at 10mM in 100% DMSO.

For more information about the sets and how to obtain them, please click here.

MARK YOUR CALENDARS– Drug Discovery and Developmental Therapeutics Retreat

Join your colleagues on Saturday, June 20 from 9:00 am - 2:00 pm at the Squire Valleevue Farm Sheep Barn for a broad scientific discussion of new drug targets, screening approaches, and examples of successful pathways towards clinical development.

Our goal is to develop a more cohesive scientific initiative in drug discovery leading to therapeutic development of new agents and combinations in cancer. The emphasis of the retreat will be on aligning our programmatic strengths in targets, disease-based research, study design and laboratory correlatives, and exploring potential new directions in drug discovery.

Anyone with a poster related to this theme is encouraged to present it at the retreat. Please let us know if you plan on bringing one so we can make arrangements.

Agenda will be released soon. Please RSVP to gillian.irwin@case.edu by Friday, June 5.

MARK YOUR CALENDARS– 2009 caBIG® Annual Meeting: Solving Basic and Clinical Research Challenges in Cancer and Beyond

Registration is now open for the 2009 caBIG® Annual Meeting: Solving Basic and Clinical Research Challenges in Cancer and Beyond, July 20 – 22 at the Marriott Wardman Park, Washington, DC. Registration is free and open to the public.

The meeting will feature:
•Resources to enhance capabilities in the areas of clinical trials management, in vivo imaging, molecular analysis, biospecimen banking and pathology, and data-sharing and security

•Case studies and best practices from the cancer community

•Tips on implementing and customizing caBIG® tools and infrastructure, or adapting existing tools and systems to achieve caBIG® compatibility, to solve challenges at your organization

•Descriptions of caBIG®-enabled translational research projects in cancer and beyond

•Opportunities for future collaborations and partnerships

For more information and to register, please click here.

CALL FOR ABSTRACTS– Fanconi Anemia Research Fund

The Fanconi Anemia Research Fund has released a Call for Abstracts for the 21st Annual Fanconi Anemia Research Fund Scientific Symposium, schedule for October 1-4, 2009 at the Baltimore Marriott Waterfront in Baltimore, Maryland. Abstracts may be submitted online at http://www.fanconi.org May 11- June 19.

MARK YOUR CALENDARS– ACS Pan Ohio Hope Ride

The American Cancer Society's Pan Ohio Hope Ride is a bicycling tour that enables you to take an incredible bicycle journey and to support ACS Hope Lodges and other vital patient services. The Pan Ohio Hope Ride will take cyclists from Cleveland to Cincinnati in a four-day tour through Ohio's scenic countryside from July 30 - August 2. Challenge yourself to hit the road and make the road smoother for those battling cancer.

For more information, please click here.

MARK YOUR CALENDARS– Pan Ohio Hope Ride Research Rally

On May 30, the American Cancer Society will be sponsoring the Pan Ohio Hope Ride Research Rally to celebrate the cancer research going on in the Cleveland area and to raise awareness of the Third Annual ACS Pan Ohio Hope Ride to be held July 30 - August 2.

The Research Rally will begin at 9:00 a.m. in front of the ACS Hope Lodge at 11432 Mayfield Rd. After a brief program, the riders will proceed down Euclid Avenue to Public Square and loop around back at the Hope Lodge.

Everyone in the local oncology community is encouraged to participate in the approximately 10-mile bike ride.

Anyone interested in participating should contact Paul Purdy, ACS Pan Ohio Staff, at Paul.purdy@cancer.org or 888-227-6446, ext. 1208.

MARK YOUR CALENDARS– Cancer Survivor/ Cancer Caregiver Photo Exhibition

Dr. Maghboeba Mosavel from the Case Center for Reducing Health Disparities and Kimberly Sanders from NorthEast Ohio Neighborhood (NEON) Health Services, are pleased to invite you to attend the Cancer Survivor/ Cancer Caregiver Photo Exhibition on Wednesday, May 13 from 10:00 am - 12:00 pm at MetroHealth Medical Center, Rammelkamp R170. This photo exhibit tells the story of the journey, triumphs and challenges of Cancer Survivors in Cleveland. Refreshments will be served.

This exhibit is sponsored by the Case Comprehensive Cancer Center and the Lance Armstrong Foundation. For more information, please contact Meia Jones at (216)778-8456.

NCI CANCER BULLETIN– Special Issue: Bioinformatics

Commentary
Director's Update: Enabling the Evolution of Oncology

A Conversation with Dr. Kenneth Buetow

caBIG Tools®

News
Recovery Act Boosts Bioinformatics

Cancer Genomics: Building Haystacks, Finding Needles

Electronic Health Records Emerging as Important Care, Research Tool

Computational Modeling Paints a Picture of the Future

Learn More

Highlights
Mutant Protein Implicated in Diffuse Large B-cell Lymphoma

Testing Breast Tumors May Predict Response to Chemotherapy

More Gene Mutations Found in Childhood Leukemia

Dutasteride May Reduce Prostate Cancer Risk

Cancer Incidence Could Rise Sharply in Coming Decades

Immunotherapy Improves Survival in Metastatic Prostate Cancer

EVENTS

**All events are open to anyone interested in attending

May 11

Hematology/Oncology Research in Progress Seminar
Dan Xu
Graduate Student, Qu Lab, Div. of Hem/ Onc
CWRU/ UH
Topic Effects of Activating Mutations on SHP-2 Phosphatase in Hematopoietic Cell Development and Leukemogenesis
12:00 pm WRB 2-136

Case CCC Scientific Series and Reception- ACS Pilot Project Awardees
Alex Huang, MD, PhD
Assistant Professor, Pediatric Hem/Onc
CWRU/ UH
Topic: Role of Tumor Microenvironment on Immune Cell Trafficking and Function in situ
AND
Alan Zhu, PhD
Assistant Professor, Cell Biology, Genetics
CWRU
Topic: Protein Phosphatase 2A Dephosphorylates Smoothened to Inhibit Hedgehog Signaling
AND
Patrick Ma, MD
Assistant Professor, Medicine-Hematology/Oncology
CWRU/ UH
Topic EGFR Mutations and Differential Response to Inhibitors in Leptomeningeal Metastases: Opportunities for Individualized Targeted Therapy in Lung Cancer
4:30 pm - 6:00 pm WRB 1-413

May 12

CSCRM Special Seminar
Jan Rosocha, PhD
Vice Dean of the Medical Faculty
Teaching Hospital of Louis Pasteur in Kosice
University of Pavol Jozef Safarik - Faculty of Medicine, Kosice, Slovak Republic
Topic: Experience with Autologous and Allogeneic Approach in Large Size Bone Lesion Regeneration
12:00 pm WRB 2-136

May 13

Grand Rounds
David Vesole, MD, PhD
Div. of Hem/Onc
Cardinal Bernardin Cancer Center
Loyola University Hospital
Topic Multiple Myeloma: Control vs. Cure
8:00 am Lerner Tower B-151

Lerner Research Institute Seminar
Brent Reynolds, PhD
Associate Professor, Neurosurgery
University of Florida
Topic: Cancer Stem Cells?
9:00 am NC1-202 Cleveland Clinic

Taussig Cancer Institute Core Curriculum Series
Dale Shepard, MD
Taussig Cancer Institute
Cleveland Clinic
Topic: Pharmacology Part I
12:00 pm R3/002-003 Cleveland Clinic

CSCRM Seminar
Gordana Vunjak-Novakovic, PhD
Associate Director, Tissue Engineering Resource Center
Biomedical Engineering
Columbia University
Topic: Advanced Technologies for Human Stem Cells and Tissue Engineering
4:30 pm WRB 1-413

May 14

TREC Seminar cancelled

Taussig Cancer Institute Core Curriculum Series
Dale Shepard, MD
Taussig Cancer Institute
Cleveland Clinic
Topic: Pharmacology Part II
12:00 pm R3/002-003 Cleveland Clinic

Neurosciences Seminar
Charles Stevens, PhD
Professor and Chair, Molecular Neurobiology
Salk Institute
Topic A General Principle Governing the Design of Neural Circuits
12:10 pm SOM E501

May 15

Hematology/ Oncology Fellows Seminar
Cecilia Choi, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic Waldenstrom's Macroglobulinemia
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Kaled Alektiar, MD
Radiation Oncology
Memorial Sloan Kettering Cancer Center
Topic Adjuvant RT in Endometrial Cancer: A Matter of Survival
8:00 am R3/002-003 Cleveland Clinic

Cell Biology
Erik Andrulis, PhD
Assistant Professor, Molecular Biology & Microbiology
CWRU
Topic: On Ribonucleases, RNA Metabolism, and the Regulation and Organization of Eukaryotic Cells
10:00 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Cheng Kui, Qu, MD, PhD
Assistant Professor, Medicine- Hem/Onc
CWRU/ UH
Topic SHP-2 Tyrosine Phosphatase in Leukemogenesis
12:00 pm BRB 105

Genomic Medicine Institute
Robert Elston, PhD
Professor, Epidemiology & Biostatistics
CWRU
Topic: Multistage Sampling for Genomic Studies
2:00 pm NA5-08 Cleveland Clinic

more

For a complete listing of LRI seminars click here.

UPCOMING CANCER CENTER SYMPOSIUMS AND EVENTS

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)
Brochure

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus
Details

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Brochure and Registration

ASCO Review
June 25
InterContinental Hotel
Details

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

**For more information on these symposiums, please contact Christine Rhoads.

ADDITIONAL UPCOMING SEMINARS & EVENTS

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1
Details

CTTE 2009 Short Course: Cell-Based Therapies & Tissue Engineering
May 18-21
Clapp and Millis Hall, CWRU Campus
Details

Center for Mind-Body Medicine CancerGuides® II
June 11 - 14
Washington, DC
Details

2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place
July 13-16
George S. Dively Building, CWRU Campus
Details

MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center
Details

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA
Details

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona
Details

MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins.

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required.

For details, please click here.

MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics (OCCBIO)

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

AACR Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen for the Cure Nomination Deadline: May 15

Breast Cancer Research Foundation-AACR Grants for Translational Breast Cancer Research
LOI Deadline: May 20

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
LOI Deadline: May 20
Proposal Deadline: July 8

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

Damon Runyon-Rachleff Innovation Award
Pre-proposal Deadline: June 1

Susan G. Komen for the Cure Investigator-Initiated Research (IIR) Grants
Pre-Application Deadline: June 1
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Pre-Application Deadline: June 1
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst in Disparities Research (CCDR) Grants
Pre-Application Deadline: June 1
Full Application Deadline: July 31

Brain Tumor Funders' Collaborative
Deadline: June 15

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
Proposal Deadline: July 8

NCRR Competitive Revision Application
Deadline: July 10

DOD PCRP Prostate Cancer Pathology Resource Network Award
Pre-Application Deadline: July 15
Proposal Deadline: August 5

Susan G. Komen for the Cure Investigator-Initiated Research (IIR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst Research (CCR) Grants
Full Application Deadline: July 31

Susan G. Komen for the Cure Career Catalyst in Disparities Research (CCDR) Grants
Full Application Deadline: July 31

DOD PCRP Prostate Cancer Pathology Resource Network Award
Pre-Application Deadline: July 15
Proposal Deadline: August 5

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Community Clinical Oncology Program (U10) (RFA-CA-09-022)

Announcing a new business process for submitting revised abstracts, specific aims, and/or public health relevance statements when changing the scope of proposed research projects (NOT-OD-09-088)

Revision of PA-08-190: Research Supplements to Promote Diversity in Health-Related Research (NOT-OD-09-093)

Revision of PA-08-191: Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (NOT-OD-09-094)

NIH Requests Comments on Proposed Amendment of Regulations on the Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors (NOT-OD-09-099)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.