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Case Comprehensive Cancer Center Newsletter

April 20, 2009


Dendreon Corp. says new approach to fighting prostate cancer ...
The Plain Dealer - cleveland.com - Apr 15, 2009
... the data is robust and real, this is a big deal," said Dr. Robert Dreicer, who heads up the department of solid tumor oncology at the Cleveland Clinic. ...

CWRU receives $1.7 million grant
Crain's Cleveland Business - Apr 14
Dr. Qing Yin Zheng, an assistant professor of head and neck surgery and genetics at CWRU, will lead the study funded by the five-year grant. ...
Full Press Release


Case Daily - Apr 17, 2009
The Centers for Disease Control and Prevention has funded Case Western Reserve University as its newest Prevention Research Center (PRC). The PRC will be a university-level center co-directed by Elaine Borawski, associate professor of epidemiology and biostatistics, and Sue Flocke, associate professor of family medicine and epidemiology and biostatistics. Accompanying the PRC is a five-year core research project; Jessica Kelley-Moore, associate professor of sociology, is the principal investigator. The funding will support graduate student stipends and provide research opportunities for undergraduates. The project is a neighborhood-level intervention that will alter the food environment of disadvantaged and under-served neighborhoods in Cleveland.

MESSAGE FROM DR. ALAN TARTAKOFF- Breast Cancer Study Collaboration

Dear Colleagues,

I am formulating a Grand Opportunity proposal which will be centered on breast cancer. If you might be interested in participating, let me know soon. If you might be interested in using this technology in the future, please tell me so, regardless of whether your interest would relate to cancer. This will make it possible for me to tell the NIH that there is a large interested public that will want to see this approach succeed and be extended into the future.

Our strategy should identify single cDNAs that augment or oppose any of a broad range of cellular phenotypes. To do so, my lab will package high complexity human retroviral cDNA libraries and use them to infect cells at low multiplicity. The cells will then be subject to a challenge (e.g. a nutritional change, addition of a drug, irradiation etc.) so that only some cells survive (or turn green, or migrate etc.). This subset of cells will be recovered, and after extraction of genomic DNA, my lab will copy the cDNA inserts and have them quantitated on microarrays at the Gene Expression and Genomics Core. Samples of DNA will also be recovered at t = 0. Data analysis will be coordinated through the Computer Science Department.

The prediction is that that cDNAs that become enriched or depleted do so for a reason. The differential evolution of the spectrum of inserts that persist therefore informs as to how to steer the behavior of the cells. The result will be a closely interrelated data set which should both make a general advertisement for this approach and also answer several important biological questions. Later experiments could be performed using xenografts.

Do let me know,

Alan Tartakoff
cell: 216-347-2024

FUNDING OPPORTUNITY– Brain Tumor Funders' Collaborative

The Brain Tumor Funders' Collaborative (BTFC) announced a new funding initiative aimed at accelerating development of non- or minimally- invasive methods for monitoring if, when, and how human brain tumors are responding to investigational therapies. This represents the second round of funding offered by a unique collaborative funding effort representing private foundations and patient advocacy groups. The BTFC inaugurated its funding program in 2005, awarding grants to three multi-institutional, collaborative research projects. The BTFC's primary goal is bridging the "translational gap" that can prevent promising laboratory findings from yielding new medical treatments.

The eight members of the BTFC are: American Brain Tumor Association, Brain Tumour Foundation of Canada, Children's Brain Tumor Foundation, Goldhirsh Foundation, Ivy Foundation, James S. McDonnell Foundation, National Brain Tumor Society, and Sontag Foundation.

Deadline: June 15

For more information, please click here.


The Cancer Center would like to draw your attention to the Protein Expression Purification Crystallization Core (PEPCC). The PEPCC is led by Dr. Harry Gill, and located in the Department of Physiology & Biophysics at Case. Their aim is to foster interdisciplinary collaborations among scientists in the Cancer Center by making available "high end" technology.

The PEPCC can train personnel to perform protein work, or it can perform the work itself. The equipment and the expertise should be attractive to those who might not have either. The two major goals of the PEPCC are (1) to produce high quantities (mg) of high-quality protein, and (2) to use high-throughput approaches for protein crystallization. To obtain large quantities of protein, we have set up large-scale protein expression in bacteria and Sf9 insect cells. Currently, we can grow 18-liter batches of bacteria in refrigerated shakers and up to 40 liters of Sf9 insect cells for expression. (In the future, we hope to add a 150-liter fermentor for very large growths of bacteria or yeast.) We are purchasing a high-pressure cell disruptor.

The PEPCC has an AKTA explorer for protein separation, as well as other equipment (e.g., dynamic and/or multiangle light scattering devices to measure monodispersity or molecular mass) for characterizing the purified proteins. The protein thus obtained can be used in several applications, including: (1) the creation of antibodies; (2) assays for experimental screening of drugs; (3) biophysical techniques (e.g., Biacore, isothermal calorimetry), (4) determining crystallographic structures (particularly applications in drug design). A particular strength of the PEPCC is its robotic infrastructure for protein crystallization. A robotic solution handler ("Hydra") transfers solutions in a 96-well format. Another robotic device ("Mosquito") sets up nano-liter volumes of protein for crystallization trials in a 96-well format, the small volumes saving the researcher considerable time and significantly reduce costs for protein work. The crystallization trials themselves take place in another robotic unit ("RockImager") that regulates the temperature to 22oC or 4oC (in two separate units), and uses an integral microscope-based camera to monitor the crystallization drops. Thus, users can remotely follow the progress of crystallization from anywhere in the world. Once a 'hit' (i.e., crystallization under a particular set of conditions) is found, another robotic unit ("Formulator") automatically dispenses the solutions for the next set of crystallization trials to optimize the crystal condition for the user. Finally, after a crystal is in hand, the PEPCC offers a UV-light microscope to distinguish salt from protein crystals, and a high-end stereo-microscope for mounting crystals.

For additional information on the PEPCC, please click here.

MARK YOUR CALENDARS– 2009 Ovarian Cancer Survivors Course

The Gynecologic Cancer Foundation is pleased to present the 2009 Ovarian Cancer Survivors Course on Saturday, April 25 at the Wolstein Research Building. This FREE full day course is open to all cancer survivors, friends, family members, professionals, and all others interested in attending. Additional support for this event was provided by University Hospitals MacDonald Women's Hospitals, Ireland Cancer Center, OutRun Ovarian Cancer (OROC), and an anonymous donor.

Cancer Center Members Drs. Vivian von Gruenigen, Steven Waggoner, and Kristine Zanotti will be presenting.

To view the entire agenda and for registration information, please click here.

MARK YOUR CALENDARS– Cancer Survivor/ Cancer Caregiver Photo Exhibition

Dr. Maghboeba Mosavel from the Case Center for Reducing Health Disparities and Kimberly Sanders from NorthEast Ohio Neighborhood (NEON) Health Services, are pleased to invite you to attend the Cancer Survivor/ Cancer Caregiver Photo Exhibition on Wednesday, May 13 from 10:00 am - 12:00 pm at MetroHealth Medical Center, Rammelkamp R170. This photo exhibit tells the story of the journey, triumphs and challenges of Cancer Survivors in Cleveland. Refreshments will be served.

This exhibit is sponsored by the Case Comprehensive Cancer Center and the Lance Armstrong Foundation. For more information, please contact Meia Jones at (216)778-8456.


**All events are open to anyone interested in attending

April 20

Hematology/Oncology Research in Progress Seminar cancelled

Pathology Research Seminar
Neil Greenspan, MD, PhD
Professor, Pathology
Topic: Against Medical Utopianism: An Evolutionary Perspective
12:00 pm WRB 1413

April 21

April 22

Grand Rounds cancelled

April 23

Neurosciences Seminar
Rachel Wong, PhD
Professor, Biological Structure
University of Washington
Topic: Imaging Circuit Assembly in the Vertebrate Retina
12:10 pm BRB 105

Case CCC Faculty Candidate Seminar
Scott Welford, PhD
Postdoc Fellow, Radiation Oncology
Stanford University
Topic: The Regulation of Senescence by Hypoxia
1:30 pm WRB 3-136

TREC Seminar
Ofer Reizes, PhD
Associate Staff, Cell Biology
Cleveland Clinic
Topic: The Fat Secreted Hormone Leptin Tips the Scales on WNT-1 Mammary Tumors
4:00 pm BRB 732

April 24

Hematology/ Oncology Fellows Seminar
Scott Sommers, MD
Fellow, Div. of Hem/Onc
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Shetal Shah, MD
Diagnostic Radiology
Cleveland Clinic
Topic: Oncology PET and PET/CT: Integration in Clinical Management
8:00 am R3/002-003 Cleveland Clinic

Case CCC Faculty Candidate Chalk Talk
Scott Welford, PhD
Postdoc Fellow, Radiation Oncology
Stanford University
Topic: Hypoxia, Senescence and Radioresistance
10:00 am WRB 3-136

Cell Biology Seminar
Scott Tenenbaum, PhD
Assistant Professor, Cancer Genomics
University of Albany- SUNY
Topic: RIP-Chip: Using RNA-Binding Proteins and microRNA Targeting to Study the Human Regulatory Code
10:00 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Hongtao Yu, PhD
Professor, Pharmacology
Investigator, Howard Hughes Medical Institute
University of Texas Southwestern Medical Center
Topic: Molecular Mechanisms of the Spindle Checkpoint
12:00 pm BRB 105


For a complete listing of LRI seminars click here.


Case CCC Scientific Series- ACS Pilot Project Awardees
May 11
4:30 pm - 6:00 pm WRB 1-413

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Hts
Brochure and Registration

ASCO Review
June 25
InterContinental Hotel
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


AACR Annual Meeting
April 18 - 22
Colorado Convention Center
Denver, CO

Neuropathic Cancer Pain Symposium
April 27
Bethesda Marriott Pooks Hill
Bethesda, MD

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1

CTTE 2009 Short Course: Cell-Based Therapies & Tissue Engineering
May 18-21
Clapp and Millis Hall, CWRU Campus

2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place
July 13-16
George S. Dively Building, CWRU Campus

MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference
August 17-19
Cleveland Marriott Downtown at Key Center

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, Arizona

MARK YOUR CALENDARS– Case CCC Scientific Series

The next installment of the Case CCC Scientific Series and reception is planned for Monday, May 11 4:30 pm - 6:00 pm in Wolstein Auditorium. Presentations will be made by the following ACS Pilot Project Awardees:
Alex Huang, MD, PhDRole of Tumor Microenvironment on Immune Cell Trafficking and Function in situ
Alan Zhu, PhDProtein Phosphatase 2A Dephosphorylates Smoothened to Inhibit Hedgehog Signaling
Patrick Ma, MDEGFR Mutations and Differential Response to Inhibitors in Leptomeningeal Metastases: Opportunities for Individualized Targeted Therapy in Lung Cancer

Everyone is welcome and encouraged to attend.

MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins.

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.

For details, please click here.

For registration information, please click here.

FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.

MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics (OCCBIO)

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.

MARK YOUR CALENDARS– Center for Mind-Body Medicine CancerGuides® II

The Center for Mind-Body Medicine is pleased to announce CancerGuides® II, June 11 - 14 in Washington, DC. This is an in-depth training program in cutting-edge integrative cancer care, combining inspiring and informative plenary sessions with two-hour breakout workshops on specific modalities of cancer care. Please note: 10 full scholarships are available for leaders in cancer care in the US, generously funded by the George Family Foundation.

For more information, please click here.

FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. They will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Applications will be accepted April 1-24.

For details, please click here.


NCRR Competitive Revision Application
Deadline: April 21 and July 10

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Pre-Application Deadline: April 29
Proposal Deadline: May 20

Paul Marks Prize for Cancer Research
Nominations Deadline: April 30

Proteomics and Bioinformatics Pilot Research Award
Deadline: May 1

OCRP Ovarian Cancer Academy Award
Pre-App Deadline: May 8
Proposal Deadline: May 22

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
LOI Deadline: May 20
Proposal Deadline: July 8

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

Damon Runyon-Rachleff Innovation Award
Pre-proposal Deadline: June 1

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition
Proposal Deadline: July 8

NCRR Competitive Revision Application
Deadline: July 10

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Implementation of Executive Order on Removing Barriers to Responsible Scientific Research Involving Human Stem Cells (NOT-OD-09-085)

Developmental Research in Cancer Prognosis and Prediction (R21) (PA-09-158)

Developmental Research in Cancer Prognosis and Prediction (R33) (PA-09-159)

Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R21) (PA-09-167)

In vivo Cellular and Molecular Imaging Centers (ICMICs) (P50) (PAR-09-157)

Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R03) (PA-09-168)

Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21) (PAR-09-160)

Basic Cancer Research in Cancer Health Disparities (U01) (PAR-09-161)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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