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April 20, 2009 |
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CASE CCC IN THE NEWSDendreon Corp. says new approach to fighting prostate cancer ... CWRU receives $1.7 million grant CWRU PREVENTION RESEARCH CENTER FUNDED BY THE CENTERS FOR DISEASE CONTROL AND PREVENTIONCase Daily - Apr 17, 2009 MESSAGE FROM DR. ALAN TARTAKOFF- Breast Cancer Study CollaborationDear Colleagues, Our strategy should identify single cDNAs that augment or oppose any of a broad range of cellular phenotypes. To do so, my lab will package high complexity human retroviral cDNA libraries and use them to infect cells at low multiplicity. The cells will then be subject to a challenge (e.g. a nutritional change, addition of a drug, irradiation etc.) so that only some cells survive (or turn green, or migrate etc.). This subset of cells will be recovered, and after extraction of genomic DNA, my lab will copy the cDNA inserts and have them quantitated on microarrays at the Gene Expression and Genomics Core. Samples of DNA will also be recovered at t = 0. Data analysis will be coordinated through the Computer Science Department. The prediction is that that cDNAs that become enriched or depleted do so for a reason. The differential evolution of the spectrum of inserts that persist therefore informs as to how to steer the behavior of the cells. The result will be a closely interrelated data set which should both make a general advertisement for this approach and also answer several important biological questions. Later experiments could be performed using xenografts. Do let me know, FUNDING OPPORTUNITY– Brain Tumor Funders' CollaborativeThe Brain Tumor Funders' Collaborative (BTFC) announced a new funding initiative aimed at accelerating development of non- or minimally- invasive methods for monitoring if, when, and how human brain tumors are responding to investigational therapies. This represents the second round of funding offered by a unique collaborative funding effort representing private foundations and patient advocacy groups. The BTFC inaugurated its funding program in 2005, awarding grants to three multi-institutional, collaborative research projects. The BTFC's primary goal is bridging the "translational gap" that can prevent promising laboratory findings from yielding new medical treatments. The eight members of the BTFC are: American Brain Tumor Association, Brain Tumour Foundation of Canada, Children's Brain Tumor Foundation, Goldhirsh Foundation, Ivy Foundation, James S. McDonnell Foundation, National Brain Tumor Society, and Sontag Foundation. Deadline: June 15 For more information, please click here. PROTEIN EXPRESSION PURIFICATION CRYSTALLIZATION CORE (PEPCC)The Cancer Center would like to draw your attention to the Protein Expression Purification Crystallization Core (PEPCC). The PEPCC is led by Dr. Harry Gill, and located in the Department of Physiology & Biophysics at Case. Their aim is to foster interdisciplinary collaborations among scientists in the Cancer Center by making available "high end" technology. The PEPCC can train personnel to perform protein work, or it can perform the work itself. The equipment and the expertise should be attractive to those who might not have either. The two major goals of the PEPCC are (1) to produce high quantities (mg) of high-quality protein, and (2) to use high-throughput approaches for protein crystallization. To obtain large quantities of protein, we have set up large-scale protein expression in bacteria and Sf9 insect cells. Currently, we can grow 18-liter batches of bacteria in refrigerated shakers and up to 40 liters of Sf9 insect cells for expression. (In the future, we hope to add a 150-liter fermentor for very large growths of bacteria or yeast.) We are purchasing a high-pressure cell disruptor. The PEPCC has an AKTA explorer for protein separation, as well as other equipment (e.g., dynamic and/or multiangle light scattering devices to measure monodispersity or molecular mass) for characterizing the purified proteins. The protein thus obtained can be used in several applications, including: (1) the creation of antibodies; (2) assays for experimental screening of drugs; (3) biophysical techniques (e.g., Biacore, isothermal calorimetry), (4) determining crystallographic structures (particularly applications in drug design). A particular strength of the PEPCC is its robotic infrastructure for protein crystallization. A robotic solution handler ("Hydra") transfers solutions in a 96-well format. Another robotic device ("Mosquito") sets up nano-liter volumes of protein for crystallization trials in a 96-well format, the small volumes saving the researcher considerable time and significantly reduce costs for protein work. The crystallization trials themselves take place in another robotic unit ("RockImager") that regulates the temperature to 22oC or 4oC (in two separate units), and uses an integral microscope-based camera to monitor the crystallization drops. Thus, users can remotely follow the progress of crystallization from anywhere in the world. Once a 'hit' (i.e., crystallization under a particular set of conditions) is found, another robotic unit ("Formulator") automatically dispenses the solutions for the next set of crystallization trials to optimize the crystal condition for the user. Finally, after a crystal is in hand, the PEPCC offers a UV-light microscope to distinguish salt from protein crystals, and a high-end stereo-microscope for mounting crystals. For additional information on the PEPCC, please click here. MARK YOUR CALENDARS– 2009 Ovarian Cancer Survivors CourseThe Gynecologic Cancer Foundation is pleased to present the 2009 Ovarian Cancer Survivors Course on Saturday, April 25 at the Wolstein Research Building. This FREE full day course is open to all cancer survivors, friends, family members, professionals, and all others interested in attending. Additional support for this event was provided by University Hospitals MacDonald Women's Hospitals, Ireland Cancer Center, OutRun Ovarian Cancer (OROC), and an anonymous donor. Cancer Center Members Drs. Vivian von Gruenigen, Steven Waggoner, and Kristine Zanotti will be presenting. To view the entire agenda and for registration information, please click here. MARK YOUR CALENDARS– Cancer Survivor/ Cancer Caregiver Photo ExhibitionDr. Maghboeba Mosavel from the Case Center for Reducing Health Disparities and Kimberly Sanders from NorthEast Ohio Neighborhood (NEON) Health Services, are pleased to invite you to attend the Cancer Survivor/ Cancer Caregiver Photo Exhibition on Wednesday, May 13 from 10:00 am - 12:00 pm at MetroHealth Medical Center, Rammelkamp R170. This photo exhibit tells the story of the journey, triumphs and challenges of Cancer Survivors in Cleveland. Refreshments will be served. This exhibit is sponsored by the Case Comprehensive Cancer Center and the Lance Armstrong Foundation. For more information, please contact Meia Jones at (216)778-8456. |
EVENTS**All events are open to anyone interested in attending April 20Hematology/Oncology Research in Progress Seminar cancelled Pathology Research Seminar April 21April 22Grand Rounds cancelled April 23Neurosciences Seminar Case CCC Faculty Candidate Seminar TREC Seminar April 24Hematology/ Oncology Fellows Seminar Taussig Cancer Institute Grand Rounds Case CCC Faculty Candidate Chalk Talk Cell Biology Seminar Cancer Center Seminar Series/ Blood Club more UPCOMING CANCER CENTER SYMPOSIUMS AND EVENTSCase CCC Scientific Series- ACS Pilot Project Awardees Case CCC Scientific Series Signaling in Cancer Ohio Collaborative Conference on Bioinformatics (OCCBIO) Annual Breast Cancer Update: Highlights of the National Meetings ASCO Review Case CCC Scientific Retreat 2009 **For more information on these symposiums, please contact Christine Rhoads. ADDITIONAL UPCOMING SEMINARSAACR Annual Meeting Neuropathic Cancer Pain Symposium 11th Annual Midwest DNA Repair Symposium CTTE 2009 Short Course: Cell-Based Therapies & Tissue Engineering 2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference ASCO Breast Cancer Symposium Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop |
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MARK YOUR CALENDARS– Case CCC Scientific SeriesThe next installment of the Case CCC Scientific Series and reception is planned for Monday, May 11 4:30 pm - 6:00 pm in Wolstein Auditorium. Presentations will be made by the following ACS Pilot Project Awardees: Everyone is welcome and encouraged to attend. MARK YOUR CALENDARS– Signaling in Cancer SymposiumThe Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins. Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24. For details, please click here. For registration information, please click here. FUNDING OPPORTUNITY– James S. McDonnell FoundationThe Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems. In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas: Applications are continuously accepted for these awards. For more information, please click here. |
MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics (OCCBIO)The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio. Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated. For more information, please click here. MARK YOUR CALENDARS– Center for Mind-Body Medicine CancerGuides® IIThe Center for Mind-Body Medicine is pleased to announce CancerGuides® II, June 11 - 14 in Washington, DC. This is an in-depth training program in cutting-edge integrative cancer care, combining inspiring and informative plenary sessions with two-hour breakout workshops on specific modalities of cancer care. Please note: 10 full scholarships are available for leaders in cancer care in the US, generously funded by the George Family Foundation. For more information, please click here. FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. They will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR. Applications will be accepted April 1-24. For details, please click here. |
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PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES |
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NCRR Competitive Revision Application |
OCRP Ovarian Cancer Academy Award |
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NIH Bulletin – Notices and Funding OpportunitiesDevelopmental Research in Cancer Prognosis and Prediction (R21) (PA-09-158) Developmental Research in Cancer Prognosis and Prediction (R33) (PA-09-159) Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R21) (PA-09-167) In vivo Cellular and Molecular Imaging Centers (ICMICs) (P50) (PAR-09-157) Developmental Projects in Complementary Approaches to Cancer Care and Treatment (R03) (PA-09-168) Basic Cancer Research in Cancer Health Disparities (U01) (PAR-09-161) |
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| Produced by: Gillian Irwin 11100 Euclid Avenue, Wearn 152 Cleveland, Ohio 44106-5065 216-844-8317 phone 216-844-7832 fax gillian.irwin@case.edu Janice Hassinger 11100 Euclid Avenue, Wearn 149 Cleveland, Ohio 44106-5065 216-844-1862 phone 216-844-7832 fax janice.hassinger@uhhospitals.org |
HELP US HELP YOU!If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to gillian.irwin@case.edu. |
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