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Case Comprehensive Cancer Center Newsletter

April 13, 2009


New Kidney Cancer Drug Afinitor Offers Hope
The Plain Dealer - cleveland.com - Apr 7, 2009
"Before these new medications, survival was generally less than one year," said Dr. Matthew Cooney, an oncologist at the Ireland Cancer Center at University ...

UF Researcher Identifies Stem Cell Marker for Possible "Root" of ...
University of Florida - Apr 7, 2009
Dr. Sanford Markowitz, the Markowitz-Ingalls professor of cancer genetics in the department of medicine at Case Western Reserve University in Cleveland, ...

Could Stem Cell Therapy Help Farrah Fawcett Fight Cancer?
FOXNews - Apr 6, 2009
... but it can be disfiguring, said Dr. Stan Gerson,director of the Ireland Cancer Center of University Hospitals Case Medical Center and the director of ...


Everyone is encouraged to attend Research ShowCASE this Thursday, April 16 from 9:00 am - 5:00 pm in the Veale Convocation Center on the CWRU campus. Research ShowCASE is a free event open to the public where hundreds of scientists and scholars gather to celebrate the broad range of research currently being conducted at CWRU and its affiliates. Please be sure to stop by the Case CCC booth and the Tissue Procurement and Histology Core Facility booth.

Congratulations to the following Cancer Center members who were selected to present posters at Research ShowCASE: Drs. Louise Acheson, Mark Adams, Arnold Caplan, Sanjay Gupta, Shirley Moore, and Elizabeth O'Toole.

For more information, including a complete program schedule, registration, parking, directions, maps and lodging, please visit showcase.case.edu or call (216) 368-2932.


The AACR 100th Annual Meeting 2009 is scheduled for Monday, April 20, at the Colorado Convention Center. If you are presenting at the meeting, please email gillian.irwin@case.edu.

MARK YOUR CALENDARS– Case CCC Scientific Series

The next installment of the Case CCC Scientific Series and reception is planned for Monday, May 11 4:30 pm - 6:00 pm in Wolstein Auditorium. Presentations will be made by the following ACS Pilot Project Awardees:
Alex Huang, MD, PhDRole of Tumor Microenvironment on Immune Cell Trafficking and Function in situ
Alan Zhu, PhDProtein Phosphatase 2A Dephosphorylates Smoothened to Inhibit Hedgehog Signaling
Patrick Ma, MDEGFR Mutations and Differential Response to Inhibitors in Leptomeningeal Metastases: Opportunities for Individualized Targeted Therapy in Lung Cancer

Everyone is welcome and encouraged to attend.


Featured Article
Cancer Survivors and Their Doctors Have Different Expectations about Care

Cancer Research Highlights
Ovarian Cancer Screening Resulted in Many Unnecessary Surgeries

Racial Disparity in Colon Cancer Linked to p53 Gene

Multifocal Lung Tumors May Arise from a Single Cell

Alcohol-induced Flush Warns of Esophageal Cancer Risk

Director's Update
New Resources for a Bright Future

FUNDING OPPORTUNITY– Doris Duke Charitable Foundation Innovation in Clinical Research Award Competition

The Doris Duke Charitable Foundation invites Letters of Intent for clinical research that have the potential to catalyze innovative breakthroughs in the treatment of sickle cell disease (SCD).

The Doris Duke Charitable Foundation encourages investigators proposing the following types of sickle cell disease research to apply:
–Early translational phase testing of novel therapeutic approaches
–Development of new treatments or cures drawing from innovations in other fields such as cancer research, and
–Genetic and genomic approaches to study variability in the severity of SCD
–Innovative research projects that take advantage of existing tissue repositories and clinical trials already being supported by other sources such as grants from the NIH/ NHLBI.

LOI Deadline: May 20
Proposal Deadline: July 8

For more information, please click here.

MARK YOUR CALENDARS– Case CCC Clinical Trials Faculty Retreat

The Case Comprehensive Cancer Center is hosting a Clinical Trials Faculty Retreat on Monday, April 13 from 5:30 pm - 8:30 pm at the InterContinental Hotel.

This retreat will give clinical researchers from Ireland Cancer Center and Taussig Cancer Institute main campuses and regional networks the chance to interact.

The program will include:
• Overview of the Case Comprehensive Cancer Center research program

• Update of some featured trials from the GU and Lung groups

• Opportunity for exchange of ideas on how to improve our joint clinical research efforts and accrual to trials across our network.

Please RSVP to Christine Rhoads, cmr4@case.edu, 844-1675.

MARK YOUR CALENDARS– CTTE 2009 Short Course: Cell-Based Therapies & Tissue Engineering

The Skeletal Research Center will offer the 8th Annual short course Cell-Based Therapies & Tissue Engineering May 18-21 in Clapp and Millis Hall. This four day course will involve lectures by eminent scholars; laboratories and lectures on the HOW TO of adult stem cell cultures and cell-scaffold interactions. The course is intended for graduate students, post-graduate students and health science professionals who are interested in Tissue Engineering with emphasis on the principles and detailed protocols used or being modeled for direct clinical use. A syllabus from lectures and labs will be available to all registered participants.

For details including registration information, please click here.

MARK YOUR CALENDARS– 2nd Annual Business Education Course The Business of Regenerative Medicine: From Stem Cells to the Market Place

Registration is now open for The Business of Regenerative Medicine: From Stem Cells to the Market Place, which will take place in the George S. Dively Building, July 13-16. This program will bring together an International Faculty of business managers, government officials, scientists, engineers, physicians, and academicians in the field of Regenerative Medicine to focus on the key economic/business issues in this emerging healthcare niche. Focus will be on new business models, new leadership and financing strategies and legal/regulatory hurdles in Regenerative Medicine. The learning objectives will be to provide exposure to the new scientific and medical logics, the newest economic pricing and marketing models and investment logics that make the traditional big-pharma models obsolete. New leadership and initiatives in government, academia, venture capital and public policy will be discussed on the fabric of entrepreneurial principles.

For details including registration information, please click here.

MARK YOUR CALENDARS- Thoracic Malignancies 2009: Up For Debate

The Case CCC is pleased to announce the upcoming course, Thoracic Malignancies 2009: Up for Debate, on April 18 at the InterContinental Hotel & Bank of America Conference Center. This one day course will provide a topical, clinically based overview of the current therapy dilemmas faced by clinicians managing lung and esophagus cancers, and mesothelioma, with an emphasis on the opportunity for multidisciplinary management. Medical oncologists, radiation oncologists, pulmonologists, thoracic surgeons, and internists are encouraged to attend.

For more information, please click here.

MARK YOUR CALENDARS–MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference

Registration for MSC2009: The Regenerative Medicine and Adult Stem Cell Therapy Conference is now open. MSC2009, which will take place in Cleveland, August 17-19, will offer a forum for the exchange and discussion of research, ideas, and cutting-edge breakthroughs in translational regenerative medicine.

The breadth of topics from basic discovery through model validation, clinical product development, and therapeutic application, in addition to the links between academic and commercial labs, make this conference imperative for industrial researchers, academic investigators, and graduate and post-doctoral students.

For details including registration information, please click here.


**All events are open to anyone interested in attending

April 13

Hematology/Oncology Research in Progress Seminar
Andrew Chen
Postdoc Fellow, Schmaier Lab, Div. of Hem/Onc
Topic: Delineating the Two Mechanisms of Protection from Thrombosis in the Bradykinin B2 Receptor - KO Mouse
12:00 pm WRB 2-136

Pathology Graduate Student Dissertation Defense
Justine Tigno-Aranjuez
Graduate Student, Lehmann Lab
Topic: Aduvant Guided T cell Responses
12:00 pm WRB 5-136

HIV Clinical Research Seminar
Helen Piontkivska, PhD
Assistant Professor, Biological Sciences
Kent State University
Topic: Evolution of HIV: CTL and Antibody Epitopes
5:00 pm Foley Building 3rd Fl Conference Room

Case CCC Clinical Trials Faculty Retreat
5:30 pm - 8:30 pm InterContinental Hotel

April 14

Biomedical Engineering Seminar
Seulki Lee, PhD
Postdoc Fellow, Molecular Imaging Probe Laboratory
Stanford University
Topic: Cancer Theranostics: Combined Delivery of Diagnostic and Therapeutic
2:00 pm NA1-140 Cleveland Clinic

Visual Sciences Research Center/ Case CCC Special Seminar
Vincent Cryns, MD
Associate Professor, Medicine
Northwestern University
Topic: αB-Crystallin: Portrait of a Malignant Chaperone
3:00 pm WRB 1-413

April 15

Neurosurgery Grand Rounds
Candece Gladson, MD
Staff, Cancer Biology
Cleveland Clinic
Topic: New Inhibitors of Angiogenesis for Treating Malignant Glioma Tumors
7:30 am TT1-100 Cleveland Clinic

Grand Rounds
Lisa Arfons, MD
Fellow, Div. of Hem/Onc
Topic: Adult Acute Lymphoblastic Leukemia
8:00 am Lerner Tower B-151

Immunology Seminar
Thomas Egelhoff, PhD
Professor, Cell Biology
Topic Nonmuscle Myosin Mechanics in Cancer Cell Migration and Cytokinesis: (or you may be more like slime mold than you realize)
12:00 pm NC1-202

Pathology Graduate Student Seminar
Nicole Yonkers
Graduate Student, Pathology, Anthony Lab
Topic: Impact of HCV and HIV Infections on Dendritic Cell Maturation State and Function
12:00 pm WRB 1413

Developmental Therapeutics Program Meeting
5:00 pm WRB 2-136

April 16

Aging-Cancer Seminar cancelled

Research ShowCASE
9:00 am - 5:00 pm Veale Convocation Center

Neurosciences Seminar
Michael Bastiani, PhD
Professor, Biology
University of Utah
Topic: The DLK/ p38 MAPK Pathway is Essential for Axon Regeneration
12:10 pm BRB 105

April 17

Cancer Center Seminar Series/ Blood Club cancelled

Hematology/ Oncology Fellows Seminar
Shilen Patel, MD
Fellow, Div. of Hem/Onc
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Stephen Lutz, MD
Blanchard Valley Regional Cancer Center
Topic: The Role of Radiotherapy in the Management of Hospice and Palliative Care Patients
8:00 am R3/002-003 Cleveland Clinic


For a complete listing of LRI seminars click here.


Case CCC Faculty Candidate Seminar
April 23
Scott Welford, PhD
Postdoc Fellow, Radiation Oncology
Stanford University
Topic: The Regulation of Senescence by Hypoxia
1:30 pm WRB 3-136

Case CCC Faculty Candidate Chalk Talk
April 24
Scott Welford, PhD
Postdoc Fellow, Radiation Oncology
Stanford University
Topic: Hypoxia, Senescence and Radioresistance
10:00 am WRB 3-136

Case CCC Scientific Series
May 11
4:30 pm - 6:00 pm WRB 1-413

Case CCC Scientific Series
October 8
4:00 pm - 6:00 pm WRB 1-413

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Hts
Brochure and Registration

ASCO Review
June 25
InterContinental Hotel
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


AACR Annual Meeting
April 18 - 22
Colorado Convention Center
Denver, CO

Neuropathic Cancer Pain Symposium
April 27
Bethesda Marriott Pooks Hill
Bethesda, MD

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

MARK YOUR CALENDARS– Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop

The fifth annual Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop will be held January 9 -15, 2010 in Scottsdale, Arizona. This intensive six-day workshop is intended for faculty members and fellows in radiology, radiation oncology, and nuclear medicine academic departments. Investigators with an MD or PhD degree are eligible to apply. Applicants should be in, or plan to enter, a career track that will permit them to be a Principal Investigator on a clinical trial. Participants will learn how to develop protocols for the clinical evaluation of imaging modalities. Applicants will undergo a competitive selection process for entrance into the course.

Workshop trainees participate in didactic sessions, one-on-one mentoring, small discussion sessions, self study, and individual protocol development. Topics covered during the didactic portion of the Workshop include principles of clinical study design, statistical methods for imaging studies, design and conduct of multi-institutional studies, and regulatory processes. The focal point of each trainee's participation is the development of a protocol for a clinical study, ready for inclusion in an application for external funding.

Application Deadline: June 8

For more information, please click here.

FUNDING OPPORTUNITY– Proteomics and Bioinformatics Pilot Research Award

The Center for Proteomics and Bioinformatics is currently accepting applications for the Proteomics and Bioinformatics Pilot Research Award. This award seeks to support up to five research projects that will utilize the facilities of the Center. This program was designed with the understanding that the principal investigator will form a collaboration with the Center and subsequently apply for NIH or equivalent funding using preliminary data acquired during the project period. Funding priority will be given for the following criteria: (1) Applicants who have not yet attained tenure or promotion to the full professor level; (2) Projects with a high likelihood of subsequent national-level funding; (3) Research in the areas of expression proteomics, post-translational modifications, systems biology data analysis, structural mass spectrometry, protein crystallography, and interaction proteomics.

Deadline: May 1

For more information and to download the application, please visit http://proteomics.case.edu. For inquiries, please contact Joan Schenkel at joan.schenkel@case.edu.

FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.

MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins.

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.

For details, please click here.

For registration information, please click here.

MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.

FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. They will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Applications will be accepted April 1-24.

For details, please click here.


NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Proposal Deadline: April 14

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

NCRR Competitive Revision Application
Deadline: April 21 and July 10

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Pre-Application Deadline: April 29
Proposal Deadline: May 20

Paul Marks Prize for Cancer Research
Nominations Deadline: April 30

OCRP Ovarian Cancer Academy Award
Pre-App Deadline: May 8
Proposal Deadline: May 22

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

Damon Runyon-Rachleff Innovation Award
Pre-proposal Deadline: June 1

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

NCRR Competitive Revision Application
Deadline: July 10

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Notice Regarding Competitive Revisions Using Recovery Act Funds for Applications Still Requiring Paper Submission (NOT-OD-09-083)

Notice of Intent to Publish a Request for Applications for a Cancer Immunotherapy Trials Network (U01) (NOT-CA-09-016)

Notice of Intent to Publish a Request for Applications for Research Training Grants in Developing Research Capacity for HIV-Associated Malignancies in Africa (NOT-CA-09-021)

Studies of Energy Balance and Cancer in Humans (R01) (PA-09-148)

Studies of Energy Balance and Cancer in Humans (R21) (PA-09-149)

Pilot and Feasibility Clinical Research Studies in Digestive Diseases and Nutrition (R21) (PA-09-151)

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (P01)(PAR-09-147)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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