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Case Comprehensive Cancer Center Newsletter

March 9, 2009

MESSAGE FROM THE DIRECTOR– Challenge Grants in Health and Science Research RFA

The NIH Office of Extramural Research has released information about the RFA for the Challenge Grants in Health and Science Research, which will be funded by the the American Recovery and Reinvestment Act of 2009. To view general information about the RFA, please click here.

The earliest date an application can be submitted to grants.gov is March 27. Application Deadline: April 27

We have compiled a list of cancer-related topics based on those designated as high priority by NIH and NCI. To view this list, please click here.

I encourage you to talk to Program Leaders to coordinate efforts and to review ideas. Also, please feel free to contact any of the Senior Leaders for advice, review, or for collaboration facilitation: Drs. Stan Gerson, George Stark, Derek Raghavan, Janet Houghton, Li Li, Clark Distelhorst, Mark Schluchter, and James Jacobberger.

You can also contact the NIH Program Officer for currently funded grants to get better insight into the emphasis intended.

Please also remember the Cancer Center is always happy to provide administrative help as needed; in order to budget our time, a minimum of 3 weeks advanced notice is appreciated.

Stan Gerson, MD
Director, Case CCC


CASE CCC POSTDOCTORAL TRAINING OPPORTUNITIES

The Case CCC is currently accepting applications for the following training opportunities:

Computational Genomic Epidemiology of Cancer Funded Postdoctoral Fellowship
This 2-3 year NCI-funded postdoctoral training program, led by Program Director, Robert Elston, PhD and Associate Director, Li Li, MD, PhD, combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum. This program is designed to prepare fellows for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics, and computer science.

Cancer Prevention and Control Funded Postdoctoral Fellowship
This 2-year NCI-funded postdoctoral training program, led by Program Director, Julia H. Rose, PhD, combines a mentored cancer behavioral research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum. This program is designed to prepare fellows for careers as independent investigators engaged in research on behavioral aspects of cancer prevention, detection, and control.

Stipends and research funds are highly competitive.

Review of applications for both programs will begin March 30 for positions starting August 1. Applications will be accepted until all slots are filled. Please contact Margy Weinberg, Training Grants Manager, at margy.weinberg@case.edu with any questions.


FUNDING OPPORTUNITY– OCRP Ovarian Cancer Academy Award

The OCRP is currently accepting applications for the Ovarian Cancer Academy Award. This award is intended to develop a unique, interactive virtual academy that will provide intensive mentoring, national networking, and a peer group for junior faculty. The overarching goal of the Ovarian Cancer Academy is to develop successful, highly productive ovarian cancer researchers in a collaborative and interactive research training environment. The Ovarian Cancer Academy will be a virtual career development and research training platform consisting of up to five (5) Early-Career Investigator/Designated Mentor pairs from different institutions and one Academy Dean. Applications to this award mechanism must be submitted by each Early-Career Investigator of the Early-Career Investigator/Designated Mentor pair, or by an individual applying to serve as the Academy Dean.

Pre-Application Deadline: May 8
Proposal Deadline: May 22

For more information, please click here.


FUNDING OPPORTUNITY– William Guy Forbeck Research Foundation Forbeck Scholar Award

The William Guy Forbeck Research Foundation is accepting nominations for the Forbeck Scholar Award. This award recognizes promising young scientists working in the field of cancer research, and serves as a scholarship for them to attend the annual Foundation Forum on November 5-8 in Hilton Head, South Carolina. During the meeting, recipients of the award have an unrivaled opportunity to interact with international experts in a particular field of cancer research. In addition, award recipients will be invited to participate in the Foundation's new program, Scholar Retreats.

Scholars are selected by competitive application and have been consistently outstanding. Nomination must be made by a letter of recommendation from the applicant's director of studies. Applicants will be selected by our Scientific Advisory Board.

Deadline: April 2

For details, please click here.


FUNDING OPPORTUNITY– GI SPORE

All Faculty members are invited to submit outlines for pilot projects for potential inclusion in the GI SPORE (September 2009). Successful proposals will be included in the NCI SPORE Application and will be considered for Cancer Center funding beginning September 2009.

Proposals must conform to the following guidelines:
1. Cover page listing contact information for PI and faculty collaborators

2. Proposal (5 pages) in length (excluding references) as follows:
– Specific aims (1 page)
– Background and Significance (1-2 pages)
– Experimental Design (2-3 pages)

3. NIH biosketches for all faculty participants

4. Detailed budget in NIH Budget Format

Note that a SPORE project must be directed toward translational research of a GI cancer. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples. For more information and forms click here.

Deadline: March 27

Please email submissions by March 27th to: Terri Daso, Cancer Center Administration, 216-844-7252, tld6@case.edu.


FUNDING OPPORTUNITY– CTSC Pilot Projects

The CTSC has announced its quarterly competition for pilot funding of up to $10,000 which will be made available to support studies conducted through any of the CTSC Core facilities. This program is being supported by Case Western Reserve University, University Hospitals of Cleveland, and MetroHealth Medical Center, and investigators based at these sites are eligible for this competition. Investigators at the Cleveland Clinic have access to a separate pilot program and should access funds through this mechanism (contact Charlotte Bhasin at bhasinc@ccf.org).

The institutions supporting the CTSC have contributed funds to support investigators at their own institutions under the following terms:
– Support will be up to $10,000 and the costs must be justified.
– Funds can be spent only in a CTSC supported facility. Other costs associated with these projects cannot be paid.

Deadline: April 1

For details, please click here.


FUNDING OPPORTUNITY– American Cancer Society IRG Awards

The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Application Deadline: April 6

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu for more information.


MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present "Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins".

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.

For details and registration information, please click here.

EVENTS

**All events are open to anyone interested in attending

March 9

Hematology/Oncology Research In Progress Seminar
Alina Bulgar
Graduate Student, Liu Lab, Div. of Hem/Onc
CWRU/ UH
Topic: Identifying New Therapeutic Strategies for Chronic Lymphocytic Leukemia
12:00 pm WRB 2-136

Pathology Research Seminar
Surachai Supattapone, MD, PhD
Associate Professor, Biochemistry & Medicine
Dartmouth College
Topic: Mechanism of Prion Formation In Vitro
12:00 pm WRB 1-413


March 10

Pathobiology Seminar
Bela Anand-Apte, MD, PhD
Associate Professor, Ophthalmology/Cell Biology
CWRU/ Cleveland Clinic
Topic: Inhibition of Angiogenesis by Tissue Inhibitor of Metalloproteinases-3: Implications in Diseases with Ocular Neovascularization
1:00 pm NE1-205

Case CCC & Dept. of Biochemistry Faculty Candidate Seminar
Barbara Bedogni, PhD
Research Fellow, Radiation Oncology
Stanford University
Topic: The Role of Oncogenes and Microenvironment in Melanoma Development
3:00 pm SOM W428


March 11

Grand Rounds
Kristine Zanotti, MD
Assistant Professor, Gynecologic Oncology
CWRU/ UH
Topic: Challenging Traditional Paradigms in Endometrial Cancer
8:00 am Lerner Tower B-151

Clinical Research Scholars Master's Program (CRSP) Thesis Defense
Renee Salas
MD, MS Candidate, CRSP
CWRU
Topic: A Phase II Clinical Trial of Sunitinib in Unresectable Renal Cell Carcinoma
8:30 am Cleveland Clinic R3-002

Case CCC & Dept. of Biochemistry Faculty Candidate Chalk Talk
Barbara Bedogni, PhD
Research Fellow, Radiation Oncology
Stanford University
Topic: Oncogene-Hypoxia Interaction in Melanomagenesis: Effectors and Mouse Models
2:30 pm WRB 1-402

Physiology & Biophysics Faculty Candidate Seminar
Luke Wiseman, PhD
Postdoctoral Research Fellow, Skirball Institute of Biomolecular Medicine
New York University
Topic: The Role of Protein Folding Energetics in ER-Associated Protein Misfolding Disease
4:00 pm SOM E-501

CSCRM Seminar
Jeremy Rich, MD
Chair, Stem Cell Biology & Regenerative Medicine
Cleveland Clinic
Topic: How the Stem Cell Prospective Can Inform Cancer Biology
4:30 pm WRB 1-413


March 12

TREC Seminar
Henri Brunengraber, MD, PhD
Professor and Chair, Nutrition
CWRU
Topic: Use of Deuterated Water to Monitor the Synthesis of Biopolymers: The Glutathione-Ophthalmate System
4:00 pm BRB 732


March 13

Hematology/ Oncology Fellows Seminar
Greg Chipman, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: TBA
8:00 am Wearn 137

Cancer Center Seminar Series/ Blood Club
Mark Jackson, PhD
Assistant Professor, Pathology
CWRU
Topic: Forward Genetics and Cancer Signaling: Oncogene-tumor Suppressor Interactions in Mammary Epithelial Cell Transformation
12:00 pm BRB 105

Taussig Cancer Institute Grand Rounds
Alan Lichtin, MD
Taussig Cancer Center
Cleveland Clinic
Topic: New Developments in the Treatment of ITP
8:00 am R3/002-003

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

Case CCC Scientific Series
March 24
4:00 pm - 6:00 pm WRB 1-413

May 11
4:00 pm - 6:00 pm WRB 1-413

October 8
4:00 pm - 6:00 pm WRB 1-413

Family-Centered Care
March 21
Holiday Inn, Independence
Details

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)
Brochure and Registration

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus
Details

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


UPCOMING OUTSIDE SEMINARS

Second Annual David C. Hohn, MD Health Policy Lecture
March 30
Bruce C. Vladeck, PhD
Senior Health Policy Advisor/Executive Director
Health Sciences Advisory Services
Ernst & Young
Topic: Cancer Care as a Paradigm for Health Care Reform
5:00 pm, David C. Hohn, MD Lecture Hall, Roswell Park Cancer Institute
Details

Neuropathic Cancer Pain Symposium
April 27
Bethesda Marriott Pooks Hill
Bethesda, MD
Details

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1
Details


MARK YOUR CALENDARS– Case CCC Scientific Series: Transcriptional Regulatory Networks in Breast Cancer

Please mark your calendars for the next installment of the Case CCC Scientific Series, Transcriptional Regulatory Networks in Breast Cancer. Drs. Ruth Keri, Monica Montano, Noa Noy, Mukesh Jain, and Julian Kim will present on their pilot projects, which were funded by the Breast Cancer Working Group. This event is scheduled for Tuesday, March 24 in Wolstein Auditorium; the program will begin at 4:00 pm, with a reception immediately following. All are encouraged to attend.


MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Early registration opens March 14. Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.


FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. They will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Before submitting applications of a clinical or semi-clinical nature, potential applicants are strongly encouraged to seek advice by e-mailing a brief description of the proposed project to the Scientific Co-ordinator (matfield@aicr.org.uk).

Applications will be accepted April 1-24.

For details, please click here.


FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

ACS Joseph S. Silber Student Fellowship
Deadline: March 11

BCRP Postdoctoral Fellowship Awards
BCRP Predoctoral Traineeship Awards
Proposal Deadline: March 11

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

Lymphoma Society Translational Research Program
Full Applications Deadline: March 15

ASH Trainee Research Award
Deadline: March 16

James S. McDonnell Foundation 21st Century Science Initiative
Deadline: March 17

ACS Cancer Research Fellowship
Deadline: March 18

Peer Reviewed Medical Research Program (PRMRP)
Pre-Application LOI Deadline: March 19
Application Deadline: April 16

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

BCRP Idea Award
Pre-Application Deadline: March 25
Proposal Deadline: June 17

ACS Research Scholar Grants in Basic, Preclinical, Clinical, and Epidemiology Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention: Psychosocial and Behavioral Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention Health Services and Health Policy Research
Deadline: April 1

ACS Postdoctoral Fellowships
Deadline: April 1

ACS Mentored Research Scholar Grants in Applied and Clinical Research
Deadline: April 1

ACS Physician Training Awards in Preventive Medicine
Deadline: April 1

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Proposal Deadline: April 14

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Pre-Application Deadline: April 29
Proposal Deadline: May 20

Paul Marks Prize for Cancer Research
Nominations Deadline: April 30

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

NCI Short-Term Scientist Exchange Program
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Recovery Act of 2009: NIH Review Criteria, Scoring System, and Suspension of Appeals Process (NOT-OD-09-054)

Clarification to RFA-OD-09-003-Recovery Act Limited Competition: NIH Challenge Grants in Health and Science Research (RC1) (NOT-OD-09-061)

Addition of Recovery Funds to the Shared Instrumentation Grant Program (NOT-RR-09-008)

Announcement of Participation of NCI on PA-09-100, Energy Efficiency and Renewable Energy System Technology Research and Development (SBIR [R43/R44]) (NOT-CA-09-018)

The Integrative Cancer Biology Program (ICBP): Centers for Cancer Systems Biology (CCSB) (U54) (RFA-CA-09-011)

Recovery Act Limited Competition: NIH Challenge Grants in Health and Science Research (RC1) (RFA-OD-09-003)

Recovery Act Limited Competition: Extramural Research Facilities Improvement Program (C06) (RFA-RR-09-008

Recovery Act Limited Competition: Core Facility Renovation, Repair, and Improvement (G20) (RFA-RR-09-007

Recovery Act Limited Competition: High-End Instrumentation Grant Program (S10) (PAR-09-118)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.hassinger@uhhospitals.org

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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