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Case Comprehensive Cancer Center Newsletter

March 30, 2009


Studies Question PSA Screening
Cancer Letter - Mar 20, 2009 (page 3)
The Cancer Letter asked Barnett Kramer, director of NIH's Office .... the zealots who have proclaimed vast benefits of prostate cancer screening, using DRE and PSA, were simply wrong," said Derek Raghavan, director of the Cleveland Clinic Taussig Cancer ...


Recovery Act RFA OD-09-004, Research and Research Infrastructure "Grand Opportunities" has now been released. Click here to view both the announcement and specific NCI guidance relevant to applications.

As always, please remember that in addition to myself, the Senior Leaders and Program Leaders would be happy to assist in the development of grant ideas.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center


Featured Article
No Definitive Answers from Initial Results of Prostate Screening Trials

Cancer Research Highlights
Three-Drug Regimen May Preserve the Voice Box in Larynx Cancer

Obesity Worsens Survival after Pancreatic Cancer Surgery

In Talking about Prostate Cancer, Medical Language May Confuse Some Patients

Rare Genetic Disorder Reveals How UV Exposure May Cause Melanoma

Director's Update
Making Connections between Stem Cells and Cancer

A Conversation with... Dr. Jorge Gomez

In Depth
Spotlight: Discovering the Secrets of Brain Tumors

Spotlight: Treatment Approach Using Radiofrequency Waves Heats Up

A Closer Look: Delving Into Possible Mechanisms for Chemobrain

Featured Clinical Trial: Helping Survivors of Childhood Cancer Quit Smoking

FUNDING OPPORTUNITY–NCRR Competitive Revision Application Information Now Available

The National Center for Research Resources announced that investigators and U.S. institutions or organizations with active NIH-funded R01 awards originally reviewed by the Center for Scientific Review may submit revision applications (formerly termed competitive supplements). These revision applications are intended to leverage the resources, expertise and infrastructure of NCRR centers and center-like programs through significant expansion of the scope or research protocol of approved and funded projects.

Support for these revision applications will come from funds provided to NIH through the American Recovery and Reinvestment Act of 2009 (Recovery Act). Consistent with the intent of the Recovery Act, the purpose of the program is to promote job creation and economic development along with accelerating the pace and achievement of scientific research.

Application Due Date: April 21 or July 10

To learn more, click here.

FUNDING OPPORTUNITY– AACR Scholar-in-Training Awards - Special Conferences

The AACR offers Scholar-in-Training Awards to enhance the education and training of early career scientists by providing financial support for their attendance at AACR Special Conferences. These awards are provided to offset a portion of the registration, travel, and subsistence expenses incurred in attending these conferences.

These awards are open to all graduate and medical students, postdoctoral fellows, and physicians-in-training who submit abstracts. Individuals wishing to apply for one of these awards should check the appropriate box when submitting their abstract online. Applicants must be listed as the presenter of the abstract. To be considered for an award, applicants must also submit a letter of recommendation from their program supervisor or department head that describes the quality of their clinical and/or experimental work. Deadline varies depending on the conference applicant will be attending.

For more information, please click here.

MARK YOUR CALENDARS– Seventh Annual Cancer Survivorship Series: Living With, Through & Beyond Cancer

The Seventh Annual Cancer Survivorship Series: Living With, Through & Beyond Cancer, is a free three-part telephone education workshop program made possible by CancerCare and with support from the National Cancer Institute and Lance Armstrong Foundation, offers cancer survivors, their families, friends and health care professionals practical information to help them cope with concerns and issues that arise after treatment ends.

Part I: Managing the Stress of Survivorship, April 14 1:30 – 2:30 pm, ET.

Part II: The Importance of Nutrition and Physical Activity, May 19 1:30 – 2:30 pm, ET.

Part III: Survivors Too: Family, Friends and Loved Ones: Managing the Fatigue of Caregiving, June 23 1:30 – 2:30 pm, ET.

These workshops are free – no phone charges apply. However, pre-registration is required. To register simply go to the CancerCare website.


NCI announces the availability of two new patient education posters and a pin to increase awareness about clinical trials. Their purpose is to begin the discussion with cancer patients that a trial may be a reasonable option in the continuum of their cancer care.

There are many obstacles that face clinical trials today. In order to reduce some of these barriers, the NCI has developed promotional tools to increase clinical trials awareness and to further the effort to improve cancer treatments.

These new posters and pins will introduce patients to the concept of a clinical trial, complement education and recruitment efforts, and serve as conversation starters to discuss trials in a larger context before exploring specific trials with patients. The pins will also be available to patients participating in clinical trials including their family and friends so they can all help in the effort to increase awareness. In addition, these resources are particularly for clinical research staff at cancer centers, community oncology practices, cancer community oncology programs, NCI community cancer centers programs sites and other NCI-affiliated networks, and advocacy organizations.

For more information, call the NCI Cancer Information Service at 1-800-4-CANCER, or visit www.cancer.gov.

MARK YOUR CALENDARS– Visual Sciences Research Center/ Case CCC Special Seminar

The Visual Sciences Research Center and Case CCC are pleased to announce a special seminar, featuring Vincent Cryns, MD, Associate Professor of Medicine at Northwestern University. Dr. Cryns will present, αB-Crystallin: Portrait of a Malignant Chaperone, on Tuesday, April 14 at 3:00 pm in the Wolstein Auditorium (WRB 1-413). All are welcome to attend. For more information, please email jjk9@case.edu or call 368-4752.


**All events are open to anyone interested in attending

March 30

Hematology/Oncology Research in Progress Seminar cancelled

Pathology Research Seminar
Danny Manor, PhD
Associate Professor, Nutrition
Topic: Of GEFs and GTPases
12:00 pm WRB 1-413

Physiology & Biophysics Seminar
Roberto Galan, MD, PhD
Assistant Professor, Neurosciences
Topic: Neural Codes With Reliable Temporal Precision: Studies on the Underlying Biophysical Mechanisms
4:00 pm SOM E501

March 31

Orthopaedics Distinguished Visiting Professor Seminar
Thomas Einhorn, MD
Chairman, Orthopaedic Surgery
Professor, Orthopaedic Surgery, Biochemistry, and Biomedical Engineering
Boston University
Topic: The Cell and Molecular Biology of Bone Repair and Regeneration
5:00 pm RB&C Amphitheater (RBC 123)

April 1

Grand Rounds cancelled

Orthopaedics Distinguished Visiting Professor Seminar
Thomas Einhorn, MD
Chairman, Orthopaedic Surgery
Professor, Orthopaedic Surgery, Biochemistry, and Biomedical Engineering
Boston University
Topic: New Technologies for the Enhancement of Skeletal Repair
7:00 am WRB 1-413

April 2

Neurosciences Seminar
Steven Schiff
Professor, Engineering Science and Mechanics
Pennsylvania State University
Topic: Kalman Meets Neuron - the Emerging Intersection of Control Theory and Neuroscience
12:10 pm BRB 105

Aging-Cancer Seminar
Aloen Townsend, PhD
Associate Professor, Applied Social Sciences
Topic: Psychosocial Quality of Life in Older Married Cancer Survivors and Their Spouses
4:00 pm BRB 732

Physiology & Biophysics Seminar
Jennifer Pluznick, PhD
Postdoctoral Fellow, Cellular and Molecular Physiology
Yale University
Topic: Olfaction and the Kidney
4:00 pm SOM E501

April 3

Hematology/ Oncology Fellows Seminar cancelled

Cancer Center Seminar Series/ Blood Club
Keith McCrae, MD
Professor, Medicine-Hematology/Oncology
Topic: Regulation of Angiogenesis by Kininogen
12:00 pm BRB 105

Taussig Cancer Institute Grand Rounds
Ian F. Tannock, MD, PhD
Professor, Medical Oncology
Princess Margaret Hospital/ University of Toronto
Topic: Limited Drug Distribution and Repopulation as Important and Neglected Causes of Drug Resistance in Solid Tumors
8:00 am R3/002-003 Cleveland Clinic


For a complete listing of LRI seminars click here.



Case CCC Scientific Series
May 11
4:00 pm - 6:00 pm WRB 1-413

October 8
4:00 pm - 6:00 pm WRB 1-413

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Brochure and Registration

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


AACR Annual Meeting
April 18 - 22
Colorado Convention Center
Denver, CO

Neuropathic Cancer Pain Symposium
April 27
Bethesda Marriott Pooks Hill
Bethesda, MD

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA

FUNDING OPPORTUNITY– American Cancer Society IRG Awards

The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Application Deadline: April 6

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu for more information.

FUNDING OPPORTUNITY– Proteomics and Bioinformatics Pilot Research Award

The Center for Proteomics and Bioinformatics is currently accepting applications for the Proteomics and Bioinformatics Pilot Research Award. This award seeks to support up to five research projects that will utilize the facilities of the Center. This program was designed with the understanding that the principal investigator will form a collaboration with the Center and subsequently apply for NIH or equivalent funding using preliminary data acquired during the project period. Funding priority will be given for the following criteria: (1) Applicants who have not yet attained tenure or promotion to the full professor level; (2) Projects with a high likelihood of subsequent national-level funding; (3) Research in the areas of expression proteomics, post-translational modifications, systems biology data analysis, structural mass spectrometry, protein crystallography, and interaction proteomics.

Deadline: May 1

For more information and to download the application, please visit http://proteomics.case.edu. For inquiries, please contact Joan Schenkel at joan.schenkel@case.edu.

FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.

MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present "Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins".

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.

For details, please click here. For registration information, please click here.

MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Early registration opens March 14. Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.

FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. They will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Applications will be accepted April 1-24.

For details, please click here.


CTSC Pilot Projects
Deadline: April 1

ACS Research Scholar Grants in Basic, Preclinical, Clinical, and Epidemiology Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention: Psychosocial and Behavioral Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention Health Services and Health Policy Research
Deadline: April 1

ACS Postdoctoral Fellowships
Deadline: April 1

ACS Mentored Research Scholar Grants in Applied and Clinical Research
Deadline: April 1

ACS Physician Training Awards in Preventive Medicine
Deadline: April 1

William Guy Forbeck Research Foundation Forbeck Scholar Award
Deadline: April 2

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Proposal Deadline: April 14

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Pre-Application Deadline: April 29
Proposal Deadline: May 20

Paul Marks Prize for Cancer Research
Nominations Deadline: April 30

OCRP Ovarian Cancer Academy Award
Pre-App Deadline: May 8
Proposal Deadline: May 22

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

NCI Short-Term Scientist Exchange Program
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure Grand Opportunities (RC2) (RFA-OD-09-004)

Basic and Translational Research in Emotion (R01) (PA-09-137)

Ruth L. Kirschstein National Research Service Award (NRSA) Stipend and Other Budgetary Levels Effective for Fiscal Year 2009

Enhancing Peer Review: The NIH Announces Consolidation of Review Criteria for Institutional Research Training Grant Applications (T32) Submitted for FY 2010 Funding

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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