March 23, 2009
CASE CCC IN THE NEWS
PSA Testing: What Should Men Do?
NEW MEMBERS CORNER
Please join us in welcoming the following new members of the Case CCC:
Arie Horowitz, DSc
Minh Lam, PhD
A study conducted by Dr. David Danielpour, in collaboration with Drs. Jiayi Yang and Reema Wahdan-Alaswad of CWRU, was published in the March 15 issue of "Cancer Research". This study, Critical Role of Smad2 in Tumor Suppression and Transforming Growth Factor-β-Induced Apoptosis of Prostate Epithelial Cells, investigated Smad signaling in the NRP-154 rate prostate carcinoma cell line. It is the first report demonstrating that Smad2 is a critical mediator of TGF-beta-induced apoptosis and gene expression. The results suggest that Smad 2 may have a critical role as a tumor suppressor in the basal epithelial or stem cell compartment of the prostate.
MESSAGE TO CASE CCC MEMBERS– Angiogenesis in Brain Tumors Program Project Grant
We are interested in creating a close working group of investigators focused on the topic of angiogenesis in brain tumors who will work toward the submission of a Program Project Grant. I know that a number of you are definitely interested in being a part of such an effort. As advised by Dr. Paul DiCorleto and Dr. Janet Houghton, we will begin data presentation meetings every other week on Thursdays at 4 to 5 PM with the goal of each interested participant presenting their proposed specific aims and preliminary data for a program project grant more than one time. The first meeting will be on Thursday, April 2, 2009, at 4 PM in the Cancer Biology Conference Room, NB-409, Lerner Research Institute of the Cleveland Clinic.
I ask that each participant at this meeting bring one slide (or a transparency for an overhead) outlining your research interests as related to brain tumor angiogenesis, and be willing to present this in 2 minutes. At this meeting we will discuss the milestones necessary to reach the goal of a program project grant on brain tumor angiogenesis and how we can reach this goal. At this meeting, I ask that each interested participant sign up for two dates to present their proposed specific aims and preliminary data in 25 minutes, and that if at all possible they attend the other data presentation meetings so as to give input to others and to see how we can synergize our research efforts by working together. Please attend if you are interested.
Schedule of Data Presentation Meetings (NB409), Lerner Research Institute:
NOTICE FROM NCI– Information Regarding Stimulus Package for NCI K Awardees
Congress has awarded the NIH $10.4B dollars in stimulus funds. As such, the NIH has designated $200M to fund NIH Challenge Grants in Health and Science Research (RC1).
If you apply for a Challenge Grant as a PI or a multiple-PI, and receive it, you are no longer considered a NIH New Investigator (RFA-OD-09-003 Executive Summary).
If you are in the last two years of a mentored K award, and you receive a Challenge Grant for which you are the PI, you can reduce your effort on your K award to 50%.
If you are listed as a co-investigator on the Challenge Grant, and the grant is funded, you can receive research support from it. You cannot take salary support.
For further information and questions about NIH Challenge grants, please refer to the NIH Challenge Grants FAQ web page.
For NCI-specific information about the American Recovery and Reinvestment Act of 2009, please see the NCI Recovery Act web page.
MARK YOUR CALENDARS– Visual Sciences Research Center/ Case CCC Special Seminar
The Visual Sciences Research Center and Case CCC are pleased to announce a special seminar, featuring Vincent Cryns, MD, Associate Professor of Medicine at Northwestern University. Dr. Cryns will present, αB-Crystallin: Portrait of a Malignant Chaperone, on Tuesday, April 14 at 3:00 pm in the Wolstein Auditorium (WRB 1-413). All are welcome to attend. For more information, please email email@example.com or call 368-4752.
FUNDING OPPORTUNITY– Proteomics and Bioinformatics Pilot Research Award
The Center for Proteomics and Bioinformatics is currently accepting applications for the Proteomics and Bioinformatics Pilot Research Award. This award seeks to support up to five research projects that will utilize the facilities of the Center. This program was designed with the understanding that the principal investigator will form a collaboration with the Center and subsequently apply for NIH or equivalent funding using preliminary data acquired during the project period. Funding priority will be given for the following criteria: (1) Applicants who have not yet attained tenure or promotion to the full professor level; (2) Projects with a high likelihood of subsequent national-level funding; (3) Research in the areas of expression proteomics, post-translational modifications, systems biology data analysis, structural mass spectrometry, protein crystallography, and interaction proteomics.
Deadline: May 1
FUNDING OPPORTUNITY– GI SPORE
All faculty members are invited to submit outlines for pilot projects for potential inclusion in the GI SPORE (September 2009). Successful proposals will be included in the NCI SPORE Application and will be considered for Cancer Center funding beginning September 2009.
Note that a SPORE project must be directed toward translational research of a GI cancer. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples. For more information and forms click here.
Deadline: March 27
Please email submissions by March 27th to: Terri Daso, Cancer Center Administration, 216-844-7252, firstname.lastname@example.org.
MARK YOUR CALENDARS– Case CCC Scientific Series: Transcriptional Regulatory Networks in Breast Cancer
Please mark your calendars for the next installment of the Case CCC Scientific Series, Transcriptional Regulatory Networks in Breast Cancer. The following speakers will present on their pilot projects, which were funded by the Breast Cancer Working Group:
This event is scheduled for Tuesday, March 24 in Wolstein Auditorium; the program will begin at 4:00 pm, with a reception immediately following. All are encouraged to attend.
**All events are open to anyone interested in attending
Hematology/Oncology Special Conference
Pathology Research Seminar
Case CCC Scientific Series
Grand Rounds cancelled
Physiology & Biophysics Seminar
Aging-Cancer Research Seminar
Cancer Center Seminar Series/ Blood Club cancelled
Hematology/ Oncology Fellows Seminar
Taussig Cancer Institute Grand Rounds
Leaders in AIDS Research Seminar
Richard Ambinder, MD
MARK YOUR CALENDARS:
UPCOMING CANCER CENTER SYMPOSIUMS
Case CCC Scientific Series
Ohio Collaborative Conference on Bioinformatics (OCCBIO)
Annual Breast Cancer Update: Highlights of the National Meetings
Case CCC Scientific Retreat 2009
**For more information on these symposiums, please contact Christine Rhoads.
UPCOMING OUTSIDE SEMINARS
Second Annual David C. Hohn, MD Health Policy Lecture
AACR Annual Meeting
Neuropathic Cancer Pain Symposium
11th Annual Midwest DNA Repair Symposium
ASCO Breast Cancer Symposium
FUNDING OPPORTUNITY– American Cancer Society IRG Awards
The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.
Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.
Application Deadline: April 6
MARK YOUR CALENDARS– Signaling in Cancer Symposium
The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present "Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins".
Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.
MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics
The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.
Early registration opens March 14. Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.
For more information, please click here.
CASE CCC POSTDOCTORAL TRAINING OPPORTUNITIES
The Case CCC is currently accepting applications for the following training opportunities:
Computational Genomic Epidemiology of Cancer Funded Postdoctoral Fellowship
Cancer Prevention and Control Funded Postdoctoral Fellowship
Stipends and research funds are highly competitive.
Review of applications for both programs will begin March 30 for positions starting August 1. Applications will be accepted until all slots are filled. Please contact Margy Weinberg, Training Grants Manager, at email@example.com with any questions.
PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES
NFRP Clinical Trial Award
NIH Bulletin – Notices and Funding Opportunities
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
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