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Case Comprehensive Cancer Center Newsletter

March 23, 2009

CASE CCC IN THE NEWS

PSA Testing: What Should Men Do?
U.S. News & World Report - Mar 19, 2009
And PSA testing should certainly stop at age 70, said Dr. Derek Raghavan, chairman of the Cleveland Clinic's Taussig Cancer Institute -- but with one caveat ...


NEW MEMBERS CORNER

Please join us in welcoming the following new members of the Case CCC:

Arie Horowitz, DSc
Assistant Staff, Molecular Cardiology
Assistant Professor, CCLCM
Developing Program in Cancer-Vascular Biology

Minh Lam, PhD
Instructor, Dermatology
Cell Death Regulation Program


PUBLICATION NEWS

A study conducted by Dr. David Danielpour, in collaboration with Drs. Jiayi Yang and Reema Wahdan-Alaswad of CWRU, was published in the March 15 issue of "Cancer Research". This study, Critical Role of Smad2 in Tumor Suppression and Transforming Growth Factor-β-Induced Apoptosis of Prostate Epithelial Cells, investigated Smad signaling in the NRP-154 rate prostate carcinoma cell line. It is the first report demonstrating that Smad2 is a critical mediator of TGF-beta-induced apoptosis and gene expression. The results suggest that Smad 2 may have a critical role as a tumor suppressor in the basal epithelial or stem cell compartment of the prostate.


MESSAGE TO CASE CCC MEMBERS– Angiogenesis in Brain Tumors Program Project Grant

We are interested in creating a close working group of investigators focused on the topic of angiogenesis in brain tumors who will work toward the submission of a Program Project Grant. I know that a number of you are definitely interested in being a part of such an effort. As advised by Dr. Paul DiCorleto and Dr. Janet Houghton, we will begin data presentation meetings every other week on Thursdays at 4 to 5 PM with the goal of each interested participant presenting their proposed specific aims and preliminary data for a program project grant more than one time. The first meeting will be on Thursday, April 2, 2009, at 4 PM in the Cancer Biology Conference Room, NB-409, Lerner Research Institute of the Cleveland Clinic.

I ask that each participant at this meeting bring one slide (or a transparency for an overhead) outlining your research interests as related to brain tumor angiogenesis, and be willing to present this in 2 minutes. At this meeting we will discuss the milestones necessary to reach the goal of a program project grant on brain tumor angiogenesis and how we can reach this goal. At this meeting, I ask that each interested participant sign up for two dates to present their proposed specific aims and preliminary data in 25 minutes, and that if at all possible they attend the other data presentation meetings so as to give input to others and to see how we can synergize our research efforts by working together. Please attend if you are interested.

Schedule of Data Presentation Meetings (NB409), Lerner Research Institute:

• April 2, 2009, Thursday, 4:00 pm
• April 16, 2009, Thursday, 4:00 pm
• April 30, 2009, Thursday, 4:00 pm
• May 14, 2009, Thursday, 4:00 pm
• May 28, 2009, Thursday, 4:00 pm
• June 25, 2009, Thursday, 4:00 pm
• July 9, 2009, Thursday, 4:00 pm
• July 23, 2009, Thursday, 4:00 pm

Dates for the remainder of the year will be forthcoming.

Sincerely,
Candece Gladson, MD (gladsoc@ccf.org)
Department of Cancer Biology
Lerner Research Institute


NOTICE FROM NCI– Information Regarding Stimulus Package for NCI K Awardees

Congress has awarded the NIH $10.4B dollars in stimulus funds. As such, the NIH has designated $200M to fund NIH Challenge Grants in Health and Science Research (RC1).

If you apply for a Challenge Grant as a PI or a multiple-PI, and receive it, you are no longer considered a NIH New Investigator (RFA-OD-09-003 Executive Summary).

If you are in the last two years of a mentored K award, and you receive a Challenge Grant for which you are the PI, you can reduce your effort on your K award to 50%.

If you are listed as a co-investigator on the Challenge Grant, and the grant is funded, you can receive research support from it. You cannot take salary support.

For further information and questions about NIH Challenge grants, please refer to the NIH Challenge Grants FAQ web page.

For NCI-specific information about the American Recovery and Reinvestment Act of 2009, please see the NCI Recovery Act web page.


MARK YOUR CALENDARS– Visual Sciences Research Center/ Case CCC Special Seminar

The Visual Sciences Research Center and Case CCC are pleased to announce a special seminar, featuring Vincent Cryns, MD, Associate Professor of Medicine at Northwestern University. Dr. Cryns will present, αB-Crystallin: Portrait of a Malignant Chaperone, on Tuesday, April 14 at 3:00 pm in the Wolstein Auditorium (WRB 1-413). All are welcome to attend. For more information, please email jjk9@case.edu or call 368-4752.


FUNDING OPPORTUNITY– Proteomics and Bioinformatics Pilot Research Award

The Center for Proteomics and Bioinformatics is currently accepting applications for the Proteomics and Bioinformatics Pilot Research Award. This award seeks to support up to five research projects that will utilize the facilities of the Center. This program was designed with the understanding that the principal investigator will form a collaboration with the Center and subsequently apply for NIH or equivalent funding using preliminary data acquired during the project period. Funding priority will be given for the following criteria: (1) Applicants who have not yet attained tenure or promotion to the full professor level; (2) Projects with a high likelihood of subsequent national-level funding; (3) Research in the areas of expression proteomics, post-translational modifications, systems biology data analysis, structural mass spectrometry, protein crystallography, and interaction proteomics.

Deadline: May 1

For more information and to download the application, please visit http://proteomics.case.edu. For inquiries, please contact Joan Schenkel at joan.schenkel@case.edu.


FUNDING OPPORTUNITY– GI SPORE

All faculty members are invited to submit outlines for pilot projects for potential inclusion in the GI SPORE (September 2009). Successful proposals will be included in the NCI SPORE Application and will be considered for Cancer Center funding beginning September 2009.

Note that a SPORE project must be directed toward translational research of a GI cancer. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples. For more information and forms click here.

Deadline: March 27

Please email submissions by March 27th to: Terri Daso, Cancer Center Administration, 216-844-7252, tld6@case.edu.


MARK YOUR CALENDARS– Case CCC Scientific Series: Transcriptional Regulatory Networks in Breast Cancer

Please mark your calendars for the next installment of the Case CCC Scientific Series, Transcriptional Regulatory Networks in Breast Cancer. The following speakers will present on their pilot projects, which were funded by the Breast Cancer Working Group:
Ruth Keri, PhDForkhead Transcription Factors in Breast Development and Cancer
Monica Montano, PhDNegative Regulators of Mammary Carcinogenesis
Noa Noy, PhDRetinoic Acid Signaling in Breast Cancer Development
Mukesh Jain, MD– KLF2 – A Novel Inhibitor of Breast Cancer Development
Julian Kim, MDKLF-4 As a Regulator of Immunity

This event is scheduled for Tuesday, March 24 in Wolstein Auditorium; the program will begin at 4:00 pm, with a reception immediately following. All are encouraged to attend.

EVENTS

**All events are open to anyone interested in attending

March 23

Hematology/Oncology Special Conference
Erica Leigh Campagnaro, MD
Clinical Lecturer, Div. of Hem/Onc
University of Michigan
Topic: Moving Towards Individualized Therapy in Multiple Myeloma
12:00 pm WRB 2-136
*This conference will take the place of this week's Research in Progress Seminar

Pathology Research Seminar
Maria Hatzoglou, PhD
Professor, Nutrition
CWRU
Topic: Mechanisms of Osmotic Stress-Induced Apoptosis
12:00 pm WRB 1-413


March 24

Case CCC Scientific Series
Topic: Transcriptional Regulatory Networks in Breast Cancer
4:00 pm - 6:00 pm WRB 1-413


March 25

Grand Rounds cancelled

Immunology Seminar
Chenyang Xiao, PhD
Postdoctoral Fellow, Hamilton Lab
Cleveland Clinic
Topic: The Role of Tis7 in Cell Stress and Injury
AND
Li-Xin Wang, PhD
Project Scientist, Plautz Lab
Cleveland Clinic
Topic: Adoptive Transfer of Hyperexpanded Antigen-Sensitized T Cells for Immunotherapy of Cancer
12:00 pm NC1-202 Cleveland Clinic

Physiology & Biophysics Seminar
Jeffrey Garvin, PhD
Professor, Physiology
Wayne State University
Topic: Luminal Flow: A Regulator of Renal Nitric Oxide and Superoxide
4:00 pm SOM E501


March 26

Neurosciences Seminar
Stephen Maricich, MD, PhD
Assistant Professor, Pediatric Neurology
CWRU/ UH
Topic: The Function and Developmental Origin of Mammalian Merkel Cells- A Touching Story
12:10 pm BRB 105

Aging-Cancer Research Seminar
Siran Koroukian, PhD
Associate Professor, Epidemiology & Biostatistics
CWRU
Topic: Resilience and Vulnerability in Elders with Cancer (Work in Progress)
4:00 pm BRB 732


March 27

Cancer Center Seminar Series/ Blood Club cancelled

Hematology/ Oncology Fellows Seminar
Alecia Nero, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: Nitric Oxide in Sickle Cell Vasculopathy
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Joachim Yahalom, MD
Professor, Radiation Oncology
Weill Cornell Medical College/Memorial Sloan Kettering Cancer Center
Topic: Modern Treatment of Hodgkin Lymphoma: Is There Still a Role for Radiation Therapy?
8:00 am R3/002-003

Leaders in AIDS Research Seminar Richard Ambinder, MD
Professor, Oncology
Johns Hopkins University
Topic: Targeting Herpesvirus-Associated Cancers for Therapy
1:00 pm SOM W203

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

Case CCC Scientific Series
March 24
4:00 pm - 6:00 pm WRB 1-413
Flyer

May 11
4:00 pm - 6:00 pm WRB 1-413

October 8
4:00 pm - 6:00 pm WRB 1-413

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)
Brochure
Registration

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus
Details

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


UPCOMING OUTSIDE SEMINARS

Second Annual David C. Hohn, MD Health Policy Lecture
March 30
Bruce C. Vladeck, PhD
Senior Health Policy Advisor/Executive Director
Health Sciences Advisory Services
Ernst & Young
Topic: Cancer Care as a Paradigm for Health Care Reform
5:00 pm, David C. Hohn, MD Lecture Hall, Roswell Park Cancer Institute
Details

AACR Annual Meeting
April 18 - 22
Colorado Convention Center
Denver, CO
Details

Neuropathic Cancer Pain Symposium
April 27
Bethesda Marriott Pooks Hill
Bethesda, MD
Details

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1
Details

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA
Details


FUNDING OPPORTUNITY– American Cancer Society IRG Awards

The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Application Deadline: April 6

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu for more information.


MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present "Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins".

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.

For details, please click here. For registration information, please click here.


MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Early registration opens March 14. Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.


CASE CCC POSTDOCTORAL TRAINING OPPORTUNITIES

The Case CCC is currently accepting applications for the following training opportunities:

Computational Genomic Epidemiology of Cancer Funded Postdoctoral Fellowship
This 2-3 year NCI-funded postdoctoral training program, led by Program Director, Robert Elston, PhD and Associate Director, Li Li, MD, PhD, combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum. This program is designed to prepare fellows for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics, and computer science.

Cancer Prevention and Control Funded Postdoctoral Fellowship
This 2-year NCI-funded postdoctoral training program, led by Program Director, Julia H. Rose, PhD, combines a mentored cancer behavioral research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum. This program is designed to prepare fellows for careers as independent investigators engaged in research on behavioral aspects of cancer prevention, detection, and control.

Stipends and research funds are highly competitive.

Review of applications for both programs will begin March 30 for positions starting August 1. Applications will be accepted until all slots are filled. Please contact Margy Weinberg, Training Grants Manager, at margy.weinberg@case.edu with any questions.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

BCRP Idea Award
Pre-Application Deadline: March 25
Proposal Deadline: June 17

CTSC Pilot Projects
Deadline: April 1

ACS Research Scholar Grants in Basic, Preclinical, Clinical, and Epidemiology Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention: Psychosocial and Behavioral Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention Health Services and Health Policy Research
Deadline: April 1

ACS Postdoctoral Fellowships
Deadline: April 1

ACS Mentored Research Scholar Grants in Applied and Clinical Research
Deadline: April 1

ACS Physician Training Awards in Preventive Medicine
Deadline: April 1

William Guy Forbeck Research Foundation Forbeck Scholar Award
Deadline: April 2

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Proposal Deadline: April 14

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Pre-Application Deadline: April 29
Proposal Deadline: May 20

Paul Marks Prize for Cancer Research
Nominations Deadline: April 30

OCRP Ovarian Cancer Academy Award
Pre-App Deadline: May 8
Proposal Deadline: May 22

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

NCI Short-Term Scientist Exchange Program
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (NOT-OD-09-058)

NIH Announces the Availability of Recovery Act Funds for Administrative Supplements Providing Summer Research Experiences for Students and Science Educators (NOT-OD-09-060)

NIH Announces the Availability of Recovery Act Funds for Administrative Supplements (NOT-OD-09-056)

Incorporating Cost-Effectiveness Analysis Into Factors Affecting Quality-of-Life Health Related Research (R01) (RFA-NR-09-005)

Research on Clinical Decision Making in People with or at Risk for Life-Threatening Illness (R21) (PA-09-121)

Biomedical Research on the International Space Station (BioMed-ISS) (UH2/UH3) (PAR-09-120)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.hassinger@uhhospitals.org

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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