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Case Comprehensive Cancer Center Newsletter

March 16, 2009

CASE CCC IN THE NEWS

Selected Men With Low-risk Prostate Cancer Have Good Clinical Outcomes Without Immediate Treatment ...
Science Daily (press release) - Mar 16, 2009
A multi-center study of prostate cancer patients appearing in Journal of Urology... Additional authors include ... Eric Klein, Steven Jones, ...

Marvels ease patients' pain, boost NE Ohio's rep as innovator
Crain's Cleveland Business - Mar 16, 2009
Enter Dr. Stan Gerson, director of the Ireland Cancer Center at UH. He has developed a drug called methoxyamine that shows promise of reversing a cancer ...

Obama lifting of embryonic stem cell research ban to benefit local ...
The Plain Dealer - cleveland.com - Mar 10, 2009
... [private research] labs and countries, easily within the next three months at one of our three campuses," said Dr. Stan Gerson, the center's director, ...

Cleveland stem cell researchers celebrate Obama decision
WKYC-TV - Mar 10, 2009
Under the leadership of Dr. Stanton Gerson, the director of the National Center for Regenerative Medicine, the researchers at CWRU have already published ...

Obama lifts restriction on stem cell research
ABC12.com - Mar 10, 2009
"They have the scientific capability to bring us into every type of tissue that needs regenerative help and support," said Dr. Stanton Gerson with the ...


NEW RESEARCH ONCOLOGY PRE-DOCTORAL TRAINEES ANNOUNCED

The Case CCC is pleased to announce the newest trainees appointed to the Research Oncology Training Program:
•Brad Casali- Dr. Ruth Keri's lab
•Reema Wahdan- Dr. David Danielpour's lab
•Lachelle Weeks- Dr. Stan Gerson's lab

The primary goal of the Research Oncology Training Program is to prepare predoctoral and postdoctoral participants for investigative careers in cancer research. The predoctoral training program provides a forum within the Biomedical Sciences Training Program (BSTP) at Case Western Reserve University School of Medicine for graduate training that emphasizes cancer research. Trainees will conduct their thesis research under the guidance of Cancer Center faculty in the PhD degree-granting programs of Molecular Biology, Biochemistry, Cell Biology, Neuroscience, Genetics, Pathology, Pharmacology, Physiology and Biophysics. Predoctoral Trainees will participate in the Core Academic Program of the BSTP during the first year of training and then, during subsequent years of training, participate in didactic course work focused specifically on cancer research.


FUNDING OPPORTUNITY– Proteomics and Bioinformatics Pilot Research Award

The Center for Proteomics and Bioinformatics is currently accepting applications for the Proteomics and Bioinformatics Pilot Research Award. This award seeks to support up to five research projects that will utilize the facilities of the Center. This program was designed with the understanding that the principal investigator will form a collaboration with the Center and subsequently apply for NIH or equivalent funding using preliminary data acquired during the project period. Funding priority will be given for the following criteria: (1) Applicants who have not yet attained tenure or promotion to the full professor level; (2) Projects with a high likelihood of subsequent national-level funding; (3) Research in the areas of expression proteomics, post-translational modifications, systems biology data analysis, structural mass spectrometry, protein crystallography, and interaction proteomics.

Deadline: May 1

For more information and to download the application, please visit http://proteomics.case.edu. For inquiries, please contact Joan Schenkel at joan.schenkel@case.edu.


NCI CANCER BULLETIN

Featured Article
Potential New Target for Melanoma Treatment Identified

Cancer Research Highlights
Survival Benefit from Brain Cancer Regimen Persists over Time

Study Suggests Low, Moderate Alcohol Use Increases Cancer Risk

Chemoradiotherapy for Hodgkin Lymphoma Raises Mesothelioma Risk

Links between Genes and Smoking Confirmed

Guest Director's Update
Collaborative Initiative Will Tackle Obesity Among Youth


FUNDING OPPORTUNITY– GI SPORE

All faculty members are invited to submit outlines for pilot projects for potential inclusion in the GI SPORE (September 2009). Successful proposals will be included in the NCI SPORE Application and will be considered for Cancer Center funding beginning September 2009.

Proposals must conform to the following guidelines:
1. Cover page listing contact information for PI and faculty collaborators

2. Proposal (5 pages) in length (excluding references) as follows:
– Specific aims (1 page)
– Background and Significance (1-2 pages)
– Experimental Design (2-3 pages)

3. NIH biosketches for all faculty participants

4. Detailed budget in NIH Budget Format

Note that a SPORE project must be directed toward translational research of a GI cancer. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples. For more information and forms click here.

Deadline: March 27

Please email submissions by March 27th to: Terri Daso, Cancer Center Administration, 216-844-7252, tld6@case.edu.


MARK YOUR CALENDARS– Signaling in Cancer Symposium

The Case CCC is pleased the present the Signaling in Cancer Symposium, scheduled for May 18-19 in the Wolstein Research Building. This conference is intended for faculty, postdoctoral fellows and students interested in basic cancer research. The program is filled with many interesting presentations, including that of Keynote Speaker, Jerry E. Chipuk, PhD of St. Jude Children's Research Hospital, who will present "Mitochondrial Outer Membrane Permeabilization And Apoptosis Are Regulated By Collaborative Interactions Between Mitochondrial Physiology And BH3-Only Proteins".

Please note that students and postdoctoral fellows may attend this event for FREE. Registration is required. The deadline for registration and abstract submission is April 24.

For details and registration information, please click here.


MARK YOUR CALENDARS– Case CCC Scientific Series: Transcriptional Regulatory Networks in Breast Cancer

Please mark your calendars for the next installment of the Case CCC Scientific Series, Transcriptional Regulatory Networks in Breast Cancer. The following speakers will present on their pilot projects, which were funded by the Breast Cancer Working Group:
Ruth Keri, PhDForkhead Transcription Factors in Breast Development and Cancer
Monica Montano, PhDNegative Regulators of Mammary Carcinogenesis
Noa Noy, PhDRetinoic Acid Signaling in Breast Cancer Development
Mukesh Jain, MD– KLF2 – A Novel Inhibitor of Breast Cancer Development
Julian Kim, MDKLF-4 As a Regulator of Immunity

This event is scheduled for Tuesday, March 24 in Wolstein Auditorium; the program will begin at 4:00 pm, with a reception immediately following. All are encouraged to attend.


FUNDING OPPORTUNITY– American Cancer Society IRG Awards

The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Application Deadline: April 6

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu for more information.

EVENTS

**All events are open to anyone interested in attending

March 16

Hematology/Oncology Research In Progress Seminar
Patrick Weitzel
Graduate Student, Laughlin Lab, Div. of Hem/Onc
CWRU/ UH
Topic: Regulation of NFAT1 Protein in UCB CD4+ T-cells by microRNA-184: Implications for Graft-versus-Host Disease (GVHD)
12:00 pm WRB 2-136

Pathology Research Seminar
Mukesh Jain, MD
Professor, Medicine-Cardiology
CWRU/ UH
Topic: TBA
12:00 pm WRB 1-413

Physiology & Biophysics Seminar
Stanley Nattel, MD
Associate Professor, Pharmacology
University of Montreal/ Montreal Heart Institute
Topic: Changes in Cardiac Ion Channel Expression and Arrhythmia Susceptibility Resulting from Sustained Alteration in Heart Rate
4:00 pm SOM E501


March 17


March 18

Developmental Therapeutics Program Meeting cancelled

Neurosurgery Grand Rounds
Jose Valerio, MD
Brain Tumor Neuro-Oncology Center
Cleveland Clinic
Topic: Emerging Evidence for New Treatments in Neurosurgery Oncology
7:30 am Cleveland Clinic TT1-100

Grand Rounds
Nancy Oleinick, PhD
Professor, Radiation Oncology
CWRU/ UH
Topic: Photodynamic Therapy of Cancer: How it Works and Where it's Going
8:00 am Lerner Tower B-151

Immunology Seminar
Ganes Sen, PhD
Professor and Chair, Molecular Biology/ Molecular Genetics
CWRU/ Cleveland Clinic
Topic: New Branches of Double-Stranded RNA Signaling Pathways
12:00 pm NC1-202 Cleveland Clinic


March 19

Aging-Cancer Research Seminar
Tanyanika Phillips Towe, MD, MPH
Assistant Professor, Medicine- Hem/Onc
CWRU/ UH
Topic: Understanding Patient Preferences for Care at the Early Phase of Treatment in End Stage Lung Cancer: Beyond the Influence of Age and Race
4:00 pm BRB 732

Neurosciences Seminar
Kevin Daly, PhD
Assistant Professor, Biology
West Virginia University
Topic: Exploring Spatiotemporal Representations in Primary Olfactory Networks and Their Relationship to Olfactory Ability
12:10 pm BRB 105


March 20

Hematology/ Oncology Fellows Seminar
Himabindu Gaddipati, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: TBA
8:00 am Wearn 137

Cancer Center Seminar Series/ Blood Club
Anthony Letai, MD, PhD
Assistant Professor, Medical Oncology
Harvard University/ Dana-Farber Cancer Institute
Topic: Tuning Cancer Cells for Apoptotic Death
12:00 pm BRB 105

Taussig Cancer Institute Grand Rounds
Gottfried Konecny, MD
Assistant Professor, Hematology/Oncology
UCLA
Topic: Breast Cancer
8:00 am R3/002-003

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

Case CCC Scientific Series
March 24
4:00 pm - 6:00 pm WRB 1-413

May 11
4:00 pm - 6:00 pm WRB 1-413

October 8
4:00 pm - 6:00 pm WRB 1-413

Family-Centered Care
March 21
Holiday Inn, Independence
Details

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)
Brochure and Registration

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus
Details

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Bertram Inn & Conference Center, Aurora
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


UPCOMING OUTSIDE SEMINARS

Second Annual David C. Hohn, MD Health Policy Lecture
March 30
Bruce C. Vladeck, PhD
Senior Health Policy Advisor/Executive Director
Health Sciences Advisory Services
Ernst & Young
Topic: Cancer Care as a Paradigm for Health Care Reform
5:00 pm, David C. Hohn, MD Lecture Hall, Roswell Park Cancer Institute
Details

AACR Annual Meeting
April 18 - 22
Colorado Convention Center
Denver, CO
Details

Neuropathic Cancer Pain Symposium
April 27
Bethesda Marriott Pooks Hill
Bethesda, MD
Details

11th Annual Midwest DNA Repair Symposium
May 16-17
BSRB Auditorium, University of Michigan
Ann Arbor, MI
Abstract Deadline: May 1
Details

ASCO Breast Cancer Symposium
October 8-10
San Francisco Marriott
San Francisco, CA
Details


MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics

The fourth annual Ohio Collaborative Conference on Bioinformatics (OCCBIO) will be hosted by Case Western Reserve University on June 15-17. The conference provides an interdisciplinary forum for the discussion of methods, research findings, and experiences. An important goal for the conference is to foster long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology that benefit Ohio.

Early registration opens March 14. Poster Presentation Abstracts are due by May 11 for review by the OCCBIO '09 committee. All appropriate posters submitted will be accommodated.

For more information, please click here.


CASE CCC POSTDOCTORAL TRAINING OPPORTUNITIES

The Case CCC is currently accepting applications for the following training opportunities:

Computational Genomic Epidemiology of Cancer Funded Postdoctoral Fellowship
This 2-3 year NCI-funded postdoctoral training program, led by Program Director, Robert Elston, PhD and Associate Director, Li Li, MD, PhD, combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum. This program is designed to prepare fellows for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics, and computer science.

Cancer Prevention and Control Funded Postdoctoral Fellowship
This 2-year NCI-funded postdoctoral training program, led by Program Director, Julia H. Rose, PhD, combines a mentored cancer behavioral research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum. This program is designed to prepare fellows for careers as independent investigators engaged in research on behavioral aspects of cancer prevention, detection, and control.

Stipends and research funds are highly competitive.

Review of applications for both programs will begin March 30 for positions starting August 1. Applications will be accepted until all slots are filled. Please contact Margy Weinberg, Training Grants Manager, at margy.weinberg@case.edu with any questions.


FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. They will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Before submitting applications of a clinical or semi-clinical nature, potential applicants are strongly encouraged to seek advice by e-mailing a brief description of the proposed project to the Scientific Co-ordinator (matfield@aicr.org.uk).

Applications will be accepted April 1-24.

For details, please click here.


FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

ASH Trainee Research Award
Deadline: March 16

James S. McDonnell Foundation 21st Century Science Initiative
Deadline: March 17

ACS Cancer Research Fellowship
Deadline: March 18

Peer Reviewed Medical Research Program (PRMRP)
Pre-Application LOI Deadline: March 19
Application Deadline: April 16

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

BCRP Idea Award
Pre-Application Deadline: March 25
Proposal Deadline: June 17

CTSC Pilot Projects
Deadline: April 1

ACS Research Scholar Grants in Basic, Preclinical, Clinical, and Epidemiology Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention: Psychosocial and Behavioral Research
Deadline: April 1

ACS Research Scholar Grants in Cancer Control and Prevention Health Services and Health Policy Research
Deadline: April 1

ACS Postdoctoral Fellowships
Deadline: April 1

ACS Mentored Research Scholar Grants in Applied and Clinical Research
Deadline: April 1

ACS Physician Training Awards in Preventive Medicine
Deadline: April 1

William Guy Forbeck Research Foundation Forbeck Scholar Award
Deadline: April 2

NFRP Clinical Trial Award
NFRP Investigator-Initiated Research Award
NFRP Exploration-Hypothesis Development Award
NFRP New Investigator Award
NFRP Postdoctoral Traineeship Award
Proposal Deadline: April 14

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Pre-Application Deadline: April 29
Proposal Deadline: May 20

Paul Marks Prize for Cancer Research
Nominations Deadline: April 30

OCRP Ovarian Cancer Academy Award
Pre-App Deadline: May 8
Proposal Deadline: May 22

PCRP Population-Based Idea Development Award
PCRP New Investigator Award
PCRP Health Disparity Research Award
PCRP Health Disparity Training Award
PCRP Physician Research Training Award
PCRP Prostate Cancer Training Award
Proposal Deadline: May 20

OCRP Ovarian Cancer Academy Award
Proposal Deadline: May 22

BCRP Impact Awards
BCRP Multi-Team Awards
BCRP Era of Hope Scholar Awards
BCRP Innovator Awards
Application Deadline: June 17

NCI Short-Term Scientist Exchange Program
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Shared Instrumentation Grant Program (S10)(PAR-09-028)

Innovative and Applied Emerging Technologies in Biospecimen Science (R21) (RFA-CA-09-004)

Innovative and Applied Emerging Technologies in Biospecimen Science (R33) (RFA-CA-09-005)

Application and Use of Transformative Emerging Technologies in Cancer Research (R21) (RFA-CA-09-006)

Application and Use of Transformative Emerging Technologies in Cancer Research (R33) (RFA-CA-09-007)

Innovative Technology Development for Cancer Research (R21) (RFA-CA-09-008)

NIH Announces its 2009 SBIR/STTR Conference (June 30 July 1, 2009) (NOT-OD-09-063)

Research on Clinical Decision Making in People with or at Risk for Life-Threatening Illness (R01) (PA-09-122)

Exploratory/Developmental Clinical Research Grants in Obesity (R21) (PA-09-124)

Biobehavioral Methods to Improve Outcomes Research (R01) (PA-09-125)

Biobehavioral Methods to Improve Outcomes Research (R21) (PA-09-126)

Exploratory Grants for Behavioral Research in Cancer Control (R21) (PA-09-130)

Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03) (PAR-09-129)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.hassinger@uhhospitals.org

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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