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Case Comprehensive Cancer Center Newsletter

February 23, 2009

CASE CCC IN THE NEWS

Cancer death rates among blacks down, but not all news good ...
The Plain Dealer - cleveland.com, OH - Feb 18, 2009
Not much in the ACS report is a surprise, but that doesn't lessen the need to pay more attention to the problems, said Dr. Robert Dreicer, chairman of the ...

Northeast Ohio Health and Medical Consumer News
The Plain Dealer - cleveland.com, OH - Feb 16, 2009
"It can be extremely difficult to tell if you're making the impact that you really want," said Dr. Derek Raghavan, director of the Cleveland Clinic's ...

Scientists ready to jump-start embryonic stem-cell research
Columbus Dispatch, OH - Feb 7, 2009
"It's time to pursue embryonic stem-cell research," said Stanton Gerson, director of the Center for Stem Cell and Regenerative Medicine in Cleveland. ...

NIH awards Case Western Reserve University $1.33M
EurekAlert (press release), DC - Jan 26, 2009
The Case Western Reserve University project, headed by Susan Redline, MD, MPH, of the Case Western Reserve University School of Medicine and GQ Zhang, PhD...


THE STIMULUS PACKAGE AND NIH- Excerpts From an Announcement Made by Raynard S. Kington, MD, PhD, Acting Director, NIH

On Tuesday, February 17, 2009, President Barack Obama signed the American Recovery & Reinvestment Act of 2009 (ARRA), the economic stimulus, into law...

The stimulus bill provides a total of $10.4 billion, all available for two years--through September 2010. We expect to spend as much as possible in FY 2009 to support the goals of the ARRA and advance scientific priorities. (Note that none of these resources are added to the NIH's future base funding level). Below is a summary:

$8.2 billion in support of scientific research priorities
–$7.4 billion is transferred to the Institutes and Centers and Common Fund (CF), based on a percentage-based formula
–$800 million to the Office of the Director (OD) (not including CF) (For example, support for Challenge Grants), a program designed to focus on health and science problems where progress can be expected in two years.
–To support additional scientific research-related activities that also align with the overall purposes of the Act

$1 billion to support Extramural Construction, Repairs, and Alterations
–Allocated to the National Center for Research Resources (NCRR) in support of all NIH funded research institutions

$300 million for Shared Instrumentation and other capital equipment
–Allocated to NCRR to support all NIH activities

$500 million for NIH buildings and facilities
–To fund high priority repair, construction and improvement projects on NIH campuses that also align with the overall purpose of the Act

$400 million for Comparative Effectiveness Research (CER)

 

Many types of funding mechanisms will be supported, but, in general, NIH will focus scientific activities in several areas:

1) We will choose among recently peer reviewed, highly meritorious R01 and similar mechanisms capable of making significant advances in two years. R01 are projects proposed directly from scientists across the country.

2) We will also fund new R01 applications that have a reasonable expectation of making progress in two years. The adherence to this time frame is in direct response to the spirit of the law.

3) We will accelerate the tempo of ongoing science through targeted supplements to current grants. For example, we may competitively expand the scope of current research awards or supplement an existing award with additional support for infrastructure (e.g., equipment) that will be used in the two-year availability of these funds.

4) NIH anticipates supporting new types of activities that fit into the structure of the ARRA. For example, it will support a reasonable number of awards to jump start the new NIH Challenge Grant program. This program is designed to focus on health and science problems where progress can be expected in two years. The number of awards and amount of funds will be determined, based on the scientific merit and the quality of applications. I anticipate-out of the OD funds in the ARRA--NIH will support at least $100 to $200 million-but the science will drive the actual level.

5) We will also use other funding mechanisms as appropriate.

 

The impact of this stimulus to scientists cannot be overstated. The impact extends far beyond the current economic challenges and immediate scientists who will receive funds, to allied health workers, technicians, students, trade workers and others who will receive the leveraged benefits.

We understand to accomplish the goals of ARRA, it will take the help of the entire scientific community. Beyond the immediate economic stimulus, the long-term impact from the science funded by the ARRA will have a positive impact upon the health of the nation for years to come.

The ARRA is complex, with multi-layered reporting requirements. NIH is working with the Administration to ensure transparency and accountability. In the near future, NIH will post information about its role in the recovery and impact on RECOVERY.gov.

We are committed, with the outstanding support that has been given by the White House, the Department, and Congress, to make our decisions based on best scientific opportunity and public need. We will seek projects with the broadest impact, work that can be accomplished in two years, that relies heavily on our new streamlined, modernized peer review system. This is not a time for business as usual nor formulaic solutions; this is a time for true innovation, energy, and recovery.

To view the entire message from Dr. Kington, please click here.


MARK YOUR CALENDARS– Case Scientific Series: Transcriptional Regulatory Networks in Breast Cancer

Please mark your calendars for the next installment of the Case CCC Scientific Series, Transcriptional Regulatory Networks in Breast Cancer. Drs. Ruth Keri, Monica Montano, Noa Noy, Mukesh Jain, and Julian Kim will present on their pilot projects, which were funded by the Breast Cancer Working Group. This event is scheduled for Tuesday, March 24 in Wolstein Auditorium; the program will begin at 4:00 pm, with a reception immediately following. All are encouraged to attend.


MARK YOUR CALENDARS– 11th Annual Midwest DNA Repair Symposium

May 16-17, 2009
BSRB Auditorium, University of Michigan
Ann Arbor, MI

Please mark your calendars for the 11th Annual Midwest DNA Repair Symposium, which will be held on May 16-17, 2009 at the University of Michigan. The tradition of these symposia has always been to make them affordable, promote presentations by students and young investigators, and to stimulate interactions between DNA repair labs in the Midwest.

Topics to be covered include: DNA repair enzymology, DNA damage signaling, DNA repair and chromatin, transcription and replication "stress", DNA repair in stem cells, and DNA repair as a therapeutic target.

The abstract submission deadline is May 1. Students and postdocs are encouraged to present.

For details, please click here.


MARK YOUR CALENDARS– Neuropathic Cancer Pain Symposium

April 27, 2009
Bethesda Marriott Pooks Hill
Bethesda, MD

The National Cancer Institute and the NIH Pain Consortium will host a Neuropathic Cancer Pain Symposium, which will bring together a multi-disciplinary group of researchers, clinicians, and patient advocates to build upon our knowledge and understanding of the role of pain and pain management in cancer care. This symposium seeks to address the knowledge gap in the area of neuropathic pain associated with cancer, due to the underlying disease, as well as therapy. Planners aim to develop a symposium report, a synopsis of which could be published in a peer-review journal as a call-to-action to government, industry, clinicians, and others.

The symposium will include plenary sessions, panel discussions, and opportunities for networking. Participants will explore several focus areas, including:
–Defining pain through the patient's eyes
–Assessment and outcome measures of neuropathic pain
–Evidence-based treatments
–Behavioral research
–Emerging therapeutic models
–Future research directions

For details, please click here.


FUNDING OPPORTUNITY– Paul Marks Prize for Cancer Research

Memorial Sloan Kettering Cancer Center is accepting applications for the Paul Marks Prize for Cancer Research. This award recognizes outstanding young investigators who have made significant contributions to increase the understanding of cancer or improve the treatment of the disease through basic or clinical research.

The Paul Marks Prize is now awarded to up to three investigators every other year. The first recipients were named in 2001. The winners will present their work at a scientific symposium at Memorial Sloan-Kettering Cancer Center on December 3, 2009. They will share a cash award of $150,000.

Nominations must be received by April 30

For more information, please click here.

EVENTS

**All events are open to anyone interested in attending

February 23

Hematology/Oncology Research In Progress Seminar
Kristi Allen
Postdoc Fellow, McCrae Lab, Div. of Hem/Onc
CWRU/ UH
Topic: Modulation of KLF2 and KLF4 by Antiphospholipid Antibodies
12:00 pm WRB 2-136

Pathology Research Seminar
Mark Cookson, PhD
Investigator, National Institute on Aging
NIH
Topic: Pathways to Parkinsonism
12:00 pm WRB 1-413

Pediatric Hematology/Oncology Guest Lecture
Joe Matloub, MD
Director, Oncology Global Clinical Research
Bristol-Myers Squibb Company
Topic: Acute Lymphoblastic Leukemia in Children : A Perspective
4:00 pm RBC Amphitheater

Physiology & Biophysics Seminar
Daniela Calvetti, PhD
Professor and Chair, Mathematics
CWRU
Topic: Computational Cell Models and Statistical Frameworks
4:00 pm SOM E501


February 24

Taussig Cancer Institute Core Curriculum Series
Sanjay Mohan, MD
Taussig Cancer Center
Cleveland Clinic
Topic: TBA
12:00 pm R3/002 Cleveland Clinic


February 25

Grand Rounds
Kim Day, MSSA, LSW
AND
Lauren Garvey, MSSA, LSW
Psycho-Oncology
CWRU/ UH
Topic: Boundaries and Healthcare Professionals
8:00 am Lerner Tower B-151

Immunology Seminar
Gary Koski, PhD
Assistant Professor, Surgery
CWRU/ Cleveland Clinic
Topic: Functional Regulation of Dendritic Cells Through Integration of Multiple Danger Signals
12:00 pm NC1-202 Cleveland Clinic

Pathology Graduate Student Seminar
Colleen Lewis
Graduate Student, Cobb Lab, Pathology
CWRU/ UH
Topic: Regulation of Polysaccharide Antigen Processing
12:00 pm WRB 1-413


February 26

Neurosciences Seminar
Susann Brady-Kalnay, PhD
Associate Professor, Molecular Biology & Microbiology
CWRU
Topic: PTPµ Signaling in Retinal Development and Axon Guidance
12:10 pm BRB 105

TREC Seminar
Katarina Greer, MD
Fellow, Chak Lab, Gastroenterology
CWRU/ UH
Topic: Insulin/ IGF-1 in Barrett's Esophagus
4:00 pm BRB 732

Taussig Cancer Institute Core Curriculum Series
David Peereboom, MD
Associate Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Brain Metastasis
12:00 pm R3/002 Cleveland Clinic


February 27

Hematology/ Oncology Fellows Seminar cancelled

Pathology Faculty Candidate Seminar
Dian Feng, MD, PhD
Cytopathology Fellow, Pathology
University of Florida
Topic: The Unique Staining Pattern of CD10 in Primary and Metastatic Seminomas of the Testis
8:00 am IP Amphitheatre

Taussig Cancer Institute Grand Rounds
Robert Buckman, MD
Professor, Medicine
University of Toronto
Topic: It Ain't (Just) What You Say, It's (Also) The Way That You Say It-The C-L-A-S-S- Strategy
8:00 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
John T. Isaacs, PhD
Professor, Oncology and Urology
Johns Hopkins University
Topic: Translating Theory into Therapy for Prostate Cancer
12:00 pm BRB 105

Cancer Prevention and Control Seminar
Topic: Planning Meeting: Development of a Tobacco Working Group
12:30 pm Wearn 137

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

Case CCC Scientific Series
March 24
4:00 pm - 6:00 pm WRB 1-413

May 11
4:00 pm - 6:00 pm WRB 1-413

October 8
4:00 pm - 6:00 pm WRB 1-413

Family-Centered Care
March 21
Holiday Inn, Independence
Details

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)
Brochure and Registration

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus
Details

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


UPCOMING OUTSIDE SEMINARS

2nd Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 16–18
Bethesda North Marriott Hotel & Conference Center
Bethesda, MD
Abstract Deadline: February 9
Registration Deadline: February 17
Details

Second Annual David C. Hohn, MD Health Policy Lecture
March 30
Bruce C. Vladeck, PhD
Senior Health Policy Advisor/Executive Director
Health Sciences Advisory Services
Ernst & Young
Topic: Cancer Care as a Paradigm for Health Care Reform
5:00 pm, David C. Hohn, MD Lecture Hall, Roswell Park Cancer Institute
Details


FUNDING OPPORTUNITY– ASH Trainee Research Award

The American Society of Hematology (ASH) is accepting applications for the 2009 ASH Trainee Research Award. This award provides support for medical students, residents, and undergraduates for a three-month hematology-related research project and travel to the ASH annual meeting. This experience will expose the participants to hematology research early in their career and hopefully encourage them to continue research as a part of their future training.

Deadline: March 16

For more information, please click here.


FUNDING OPPORTUNITY– American Cancer Society IRG Awards

The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Application Deadline: April 6

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu for more information.


FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. We will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Before submitting applications of a clinical or semi-clinical nature, potential applicants are strongly encouraged to seek our advice by e-mailing a brief description of the proposed project to our Scientific Co-ordinator (matfield@aicr.org.uk).

Applications will be accepted April 1-24.

For details, please click here.


FUNDING OPPORTUNITY– Choose Ohio First Scholarship and Tomas – Evelyn James Fellowship in Bioinformatics, Computational Biology and Medical Informatics

The primary objective of the Choose Ohio First Scholarship (COF) Program is to support increased higher education participation and success of Ohio students in bioinformatics, computational biology and medical informatics, through the development and implementation of innovative curricular and programs, and in so doing, to advance the economic growth of the state. Bioinformatics, computational biology, imaging, clinical and translational informatics, cancer informatics are commonly cast as sub-domains within Biomedical Informatics, the broad discipline concerned with the study and application of computer science, information science, informatics, cognitive science and human-computer interaction in the practice of biological research, biomedical science, medicine and healthcare.

The deadline has been extended to February 27.

For details, please click here.


CSCRM NEWS

The CSCRM would like to draw your attention to some WaferGen microscope stage size hypoxia units, which may be useful in your research. WaferGen is willing to come to Cleveland and provide a demonstration provided there is sufficient investigator interest. If you are interested, please contact Susan Halloway.

Please click on the following links for more information:
SmartSlide 200

SmartSlide 50

SmartSlide 6

Comparison Chart


FUNDING OPPORTUNITY– Dana Foundation Program in Neuroimmunology of Brain Infections and Cancers

CWRU SOM has been invited to nominate ONE applicant for the Dana Foundation Program in Neuroimmunology of Brain Infections and Cancers. The Neuroimmunology Program was redesigned to focus on brain infections and cancers. The Foundation is inviting studies of 1) immune-based therapies for primary brain tumors and for metastases to the brain of other cancers; 2) immune responses to infections in the brain including but not limited to viral encephalitis, meningitis, cerebral malaria, and prion diseases; and 3) how immune functions are carried out and modified in the brain. The program focuses on clinical studies in humans or human tissues. Animal studies that are directly relevant to human disease but not ready for application to studies of humans or human tissues will also be considered.

This award is open to faculty tenure track researchers early in their career at the assistant professor level or early in their associate professor career. Established researchers pioneering efforts in brain infections and cancers are also eligible to apply. Postdoctoral fellows are not eligible. Projects involving collaborations with NIH intramural researchers or industry scientists are acceptable. Proposals for research that can be supported through clinical income should not be submitted.

Internal Deadline: March 2

For more information, please click here. Please contact Richard J. Sohn, PhD, Richard.Sohn@case.edu., (216)368-1158 with any questions.


FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

National Science Foundation Partnerships for International Research and Education (PIRE)
Deadline: February 26

AACR Gertrude B. Elion Cancer Research Award
Deadline: February 27

2009 NASA Space Radiation Summer School
Deadline: February 28

Cancer Research Institute Investigator Award Program
Deadline: March 1

Lymphoma Society Translational Research Program
LOI Deadline (mandatory): March 1
Full Applications Deadline: March 15

Lady Tata Memorial Trust International Awards for Research in Leukemia
Deadline: March 1

OCRP Idea Development Awards
Preproposal Deadline: March 2

OCRP Collaborative Translational Research Awards
Preproposal Deadline: March 2

PCRP Idea Development Program
Preproposal Deadline: March 3

PCRP Synergistic Idea Development Awards
Preproposal Deadline: March 3

ACS Joseph S. Silber Student Fellowship
Deadline: March 11

BCRP Postdoctoral Fellowship Awards
Proposal Deadline: March 11

BCRP Predoctoral Traineeship Awards
Proposal Deadline: March 11

BCRP Impact Awards
Preproposal Deadline: March 12

BCRP Multi-Team Awards
Preproposal Deadline: March 12

BCRP Era of Hope Scholar Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Innovator Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Impact Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Multi-team Research Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

Lymphoma Society Translational Research Program
Full Applications Deadline: March 15

James S. McDonnell Foundation 21st Century Science Initiative
Deadline: March 17

ACS Cancer Research Fellowship
Deadline: March 18

Peer Reviewed Medical Research Program (PRMRP)
Pre-Application LOI Deadline: March 19
Application Deadline: April 16

NFRP Clinical Trial Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

NFRP Investigator-Initiated Research Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

NFRP Exploration-Hypothesis Development Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

NFRP New Investigator Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

NFRP Postdoctoral Traineeship Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

NFRP Clinical Trial Award
Proposal Deadline: April 14

NFRP Investigator-Initiated Research Award
Proposal Deadline: April 14

NFRP Exploration-Hypothesis Development Award
Proposal Deadline: April 14

NFRP New Investigator Award
Proposal Deadline: April 14

NFRP Postdoctoral Traineeship Award
Proposal Deadline: April 14

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

BCRP Era of Hope Scholar Awards
Application Deadline: June 17

BCRP Innovator Awards
Application Deadline: June 17

BCRP Impact Awards
Application Deadline: June 17

BCRP Multi-team Research Awards
Application Deadline: June 17

NCI Short-Term Scientist Exchange Program
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Testing Tobacco Products Promoted to Reduce Harm (R01) (PA-09-046)

Testing Tobacco Products Promoted to Reduce Harm (R21) (PA-09-047)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.hassinger@uhhospitals.org

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