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Case Comprehensive Cancer Center Newsletter

February 16, 2009

MESSAGE FROM THE DIRECTOR– Impact of the Stimulus Package on Cancer Research

I am sure that you noticed the surprising finish to the federal stimulus bill in which Arlen Specter achieved his long-standing goal of increasing funding to the NIH. This will not be a one time event, and could well be transformational. The NIH will receive an additional $10B and this will reset the annual appropriation from $29B to $39B.

As Senator Specter stated in a recent New York Times article:
"Cancer could be cured, Mr. Specter said, if the government spent $335 billion for the research – a total he said he was 'working on' getting. But for now, he said, future budget discussions for N.I.H. will begin at $40 billion, not $30 billion – more fodder for complaints from House Republicans. And if the Republicans win back control of the Senate, he promised that that number would go considerably higher."

"I think it's scandalous that we haven't done more to cure cancer," Mr. Specter said.

The balance has tipped in terms of the priorities stated in the bill. Cancer and stem cell research will be prioritized.

What does this mean to you and to the Cancer Center:
1. You will not be funded if you don't write a grant. Please start now developing the concepts for at least 1 if not 2-4 grant applications.

2. Develop concepts for many different types of grants, not just the trusted R01. Think about an R21, R03, STTR, U01, equipment grant, clinical trials grant and a P01.

3. Line up collaborators here and elsewhere to support your grant.

4. Take advantage of our Cores including our new high throughput sequencing core.

5. Think about stem cells since this will be highlighted!

As information comes out about the format of grants for any and all new applications, we will keep you informed. But the word on the street is that within 60 days, there will be an RFA released for a short application with a few years duration (2-3), with a defined endpoint, not so speculative that it will fail or still be a concept in 3 years. This means a commercializable discovery, drug, or insight into cancer cause or treatment.

Finally, the cancer center administration will prioritize support to all investigators who respond to this new grant opportunity. Please call or email the Cancer Center if you need our help or support developing a grant idea, or need resources to help pursue a project. We will set aside other projects for this purpose.

Stan Gerson, MD
Director, Case CCC


FUNDING OPPORTUNITY– AACR Gertrude B. Elion Cancer Research Award

The AACR Gertrude B. Elion Cancer Research Award is open to tenure-track scientists at the level of Assistant Professor, who completed postdoctoral studies or clinical fellowships no more than five years prior to the start of the grant term. It provides a one-year grant of $50,000 for salary and benefits, laboratory supplies, and limited travel for the grant recipient. Projects may focus on research in cancer etiology, diagnosis, treatment, or prevention (basic, translational, or clinical cancer research). The recipient of the 2009 Award must attend the 2009 AACR Annual Meeting to accept the award, and is required to give a presentation of his or her research in a minisymposium at the 2010 AACR Annual Meeting.

Deadline: February 27

For more information, please click here.


FUNDING OPPORTUNITY– American Cancer Society IRG Awards

The Case CCC is accepting applications for American Cancer Society (ACS) IRG pilot funding for cancer-related research in basic, clinical, prevention & control, behavioral, health services and epidemiology. These pilot project grants are intended to support independent, self-directed investigators early in their careers (usually assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for independent national competitive research grants, but may not currently hold such a grant.

Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Application Deadline: April 6

Instructions, frequently asked questions, and applications available at http://cancer.case.edu. Contact Terri Daso, Cancer Center Administration, 844-7252, tld6@case.edu for more information.


FUNDING OPPORTUNITY– Choose Ohio First Scholarship and Tomas & Evelyn James Fellowship in Bioinformatics, Computational Biology and Medical Informatics

The primary objective of the Choose Ohio First Scholarship (COF) Program is to support increased higher education participation and success of Ohio students in bioinformatics, computational biology and medical informatics, through the development and implementation of innovative curricular and programs, and in so doing, to advance the economic growth of the state. Bioinformatics, computational biology, imaging, clinical and translational informatics, cancer informatics are commonly cast as sub-domains within Biomedical Informatics, the broad discipline concerned with the study and application of computer science, information science, informatics, cognitive science and human-computer interaction in the practice of biological research, biomedical science, medicine and healthcare.

James-COF scholars must be a resident of Ohio, with a minimum GPA of 3.0. They should have a background compatible with academic excellence and leadership development in Biomedical Informatics. Each COF scholar is required to find a faculty mentor who will be responsible for the direction of program of study and supervision of appropriate projects. In addition to weekly meetings with their respective faculty mentors, James-COF scholars will meet at least once a semester collectively to share their experiences and report progress. All scholars are required to be on campus during summer 2009 for research under the direction of their faculty mentor. Scholars are also expected to participate in Ohio Consortium for Bioinformatics (OCBIO) activities, especially its annual conference series OCCBIO09, which will take place on the Case campus from June 15- 17, 2009.

Deadline: February 20

For details, please click here.


FUNDING OPPORTUNITY– ACS Cancer Research Fellowship

ACS is currently accepting applications for Cancer Research Fellowships. The purpose of these fellowships is to strengthen the field of cancer research by encouraging outstanding clinicians and scientists to pursue careers in oncology and academic medicine and to engage in basic or clinical cancer research upon completion of their specialty training. The fellowship in not intended to support PhD candidates already on a research track. These awards are intended for MDs, DOs, DDSs, PhDs in Nursing and others not already on a research track. PhDs are ineligible. Candidates must be nominated by a sponsor or advisor who is actively engaged in cancer related research.

Application Deadline: March 18

For more information, please click here.


FUNDING OPPORTUNITY– Association for International Cancer Research (AICR)

AICR awards project grants of between one and three years to support fundamental and translational research into the causes, mechanisms, diagnosis, treatment and prevention of cancer. We will consider proposals in which a mixture of basic and clinical research is proposed. However, completely clinical applications, such as intervention studies, clinical trials or health care delivery research and many substantially clinical applications are beyond the remit of AICR.

Before submitting applications of a clinical or semi-clinical nature, potential applicants are strongly encouraged to seek our advice by e-mailing a brief description of the proposed project to our Scientific Co-ordinator (matfield@aicr.org.uk).

Applications will be accepted April 1-24.

For details, please click here.

EVENTS

**All events are open to anyone interested in attending

February 16

Hematology/Oncology Research In Progress Seminar cancelled


February 17

Taussig Cancer Institute Core Curriculum Series
David Peereboom, MD
Associate Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Overview of Brain Tumors
12:00 pm R3/002 Cleveland Clinic


February 18

Grand Rounds
Ajita Narayan, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: Leptomeningeal Metastases
8:00 am Lerner Tower B-151

Genetics/ Epidemiology & Biostatistics Seminar
David G. Hoel, PhD
Professor, Radiology
University of South Carolina
Topic: The Use of Epidemiological Studies in Low- Dose Radiation Risk Estimation
11:00 am BRB 105

Genetics Special Seminar
Martin Peifer, PhD
University of Cologne, Germany
Topic: Analyzing Copy Number Aberrations in Cancer
1:00 pm WRB 1-403

Developmental Therapeutics Program (DTP) Meeting
5:00 pm WRB 2-136


February 19

Aging-Cancer Research Seminar cancelled

Taussig Cancer Institute Core Curriculum Series
Frederic Reu, MD
Taussig Cancer Center
Cleveland Clinic
Topic: Multiple Myeloma
12:00 pm R3/002 Cleveland Clinic


February 20

Hematology/ Oncology Fellows Seminar
Paolo Caimi, MD
Fellow, Div. of Hem/Onc
CWRU/ UH
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Mary Carrington, PhD
Laboratory of Experimental Immunology
National Cancer Institute
Topic: The Influence of Variation at HLA and KIR Gene Loci on Human Disease
8:00 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Ann-Marie Broome, PhD
Assistant Professor, Biomedical Engineering, Radiology & Dermatology
CWRU/ UH
Topic: Imaging the Cancer Signature Through Enzymatic Complementation
12:00 pm BRB 105

Genomics Medicine Institute Seminar Series
Peter Scacheri, PhD
Assistant Professor, Genetics
CWRU
Topic: Genomic Studies of CHD7 Reveal Insights into Tissue Specific Gene Expression, ES Cell Pluripotency, and the Pathogenesis of CHARGE Syndrome
2:00 pm NA5-03/04 Cleveland Clinic

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

Case CCC Scientific Series
March 24
4:00 pm - 6:00 pm WRB 1-413

May 11
4:00 pm - 6:00 pm WRB 1-413

October 8
4:00 pm - 6:00 pm WRB 1-413

Emerging Trends in Cancer Immunotherapy
February 18
Holiday Inn, Independence
Course Directors: Drs. Henry Koon, Joseph Baar, Andrew Sloan
Brochure and Registration

Family-Centered Care
March 21
Holiday Inn, Independence
Details to follow

Signaling in Cancer
May 18-19
Wolstein Research Building (CWRU Campus)
Brochure and Registration

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17
CWRU campus
Details

Annual Breast Cancer Update: Highlights of the National Meetings
June 19
Marriott Cleveland East, Warrensville Heights
Details to follow

Case CCC Scientific Retreat 2009
July 10-11
Details to follow

**For more information on these symposiums, please contact Christine Rhoads.


UPCOMING OUTSIDE SEMINARS

2nd Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 16–18
Bethesda North Marriott Hotel & Conference Center
Bethesda, MD
Abstract Deadline: February 9
Registration Deadline: February 17
Details

Second Annual David C. Hohn, MD Health Policy Lecture
March 30
Bruce C. Vladeck, PhD
Senior Health Policy Advisor/Executive Director
Health Sciences Advisory Services
Ernst & Young
Topic: Cancer Care as a Paradigm for Health Care Reform
5:00 pm, David C. Hohn, MD Lecture Hall, Roswell Park Cancer Institute
Details


NCI CANCER BULLETIN

Note from Dr. Gerson:
Please be sure to read the NCI's annual plan and budget proposal for 2010, The Nation's Investment in Cancer Research: Connecting the Nation's Cancer Community. NCI Director John E. Niederhuber discusses this proposal in his update.

News
Health Groups Hail Increase in Federal Tobacco Taxes

Combining Targeted Drugs Is Worse in Colorectal Cancer

Preserving Ovaries May Be Safe for Some Endometrial Cancer Patients

Costs Force Some Cancer Survivors to Pass on Health Care

Engineered Immune Cells Shrink or Eradicate Large Tumors in Mice

Commentary
Director's Update: Budget Proposal Highlights Progress and Opportunities in Cancer Research

A Conversation with Dr. Joe Harford


FUNDING OPPORTUNITY– DOD Neurofibromatosis Research Program (NFRP)

The Department of Defense fiscal year 2009 Neurofibromatosis Research Program (NFRP) has released all program announcements related to the fiscal year 2009 Appropriation of $10 million. The following funding opportunities are open to all levels of PhD or MD investigators and clinicians interested in neurofibromatosis research funding:

Clinical Trial Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

Investigator-Initiated Research Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

Exploration-Hypothesis Development Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

New Investigator Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14

Postdoctoral Traineeship Award
Pre-Application Deadline: March 24
Proposal Deadline: April 14


FUNDING OPPORTUNITY– Dana Foundation Program in Neuroimmunology of Brain Infections and Cancers

CWRU SOM has been invited to nominate ONE applicant for the Dana Foundation Program in Neuroimmunology of Brain Infections and Cancers. The Neuroimmunology Program was redesigned to focus on brain infections and cancers. The Foundation is inviting studies of 1) immune-based therapies for primary brain tumors and for metastases to the brain of other cancers; 2) immune responses to infections in the brain including but not limited to viral encephalitis, meningitis, cerebral malaria, and prion diseases; and 3) how immune functions are carried out and modified in the brain. The program focuses on clinical studies in humans or human tissues. Animal studies that are directly relevant to human disease but not ready for application to studies of humans or human tissues will also be considered.

This award is open to faculty tenure track researchers early in their career at the assistant professor level or early in their associate professor career. Established researchers pioneering efforts in brain infections and cancers are also eligible to apply. Postdoctoral fellows are not eligible. Projects involving collaborations with NIH intramural researchers or industry scientists are acceptable. Proposals for research that can be supported through clinical income should not be submitted.

Internal Deadline: March 2

For more information, please click here. Please contact Richard J. Sohn, PhD, Richard.Sohn@case.edu., (216)368-1158 with any questions.


FUNDING OPPORTUNITY– James S. McDonnell Foundation

The Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems.

In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
–Bridging Brain, Mind, and Behavior
–Studying Complex Systems
–Brain Cancer Research

Applications are continuously accepted for these awards.

For more information, please click here.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Komen/ASCO Medical Student Rotation
Deadline: February 20

Komen/ASCO Resident Travel Award
Deadline: February 20

Ohio Cancer Research Associates
Deadline: February 20

BCRP Postdoctoral Fellowship Awards
Pre-Application Deadline: February 25
Proposal Deadline: March 11

BCRP Predoctoral Traineeship Awards
Pre-Application Deadline: February 25
Proposal Deadline: March 11

National Science Foundation Partnerships for International Research and Education (PIRE)
Deadline: February 26

2009 NASA Space Radiation Summer School
Deadline: February 28

Cancer Research Institute Investigator Award Program
Deadline: March 1

Lymphoma Society Translational Research Program
LOI Deadline (mandatory): March 1
Full Applications Deadline: March 15

Lady Tata Memorial Trust International Awards for Research in Leukemia
Deadline: March 1

OCRP Idea Development Awards
Preproposal Deadline: March 2

OCRP Collaborative Translational Research Awards
Preproposal Deadline: March 2

PCRP Idea Development Program
Preproposal Deadline: March 3

PCRP Synergistic Idea Development Awards
Preproposal Deadline: March 3

ACS Joseph S. Silber Student Fellowship
Deadline: March 11

BCRP Postdoctoral Fellowship Awards
Proposal Deadline: March 11

BCRP Predoctoral Traineeship Awards
Proposal Deadline: March 11

BCRP Impact Awards
Preproposal Deadline: March 12

BCRP Multi-Team Awards
Preproposal Deadline: March 12

BCRP Era of Hope Scholar Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Innovator Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Impact Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Multi-team Research Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

Lymphoma Society Translational Research Program
Full Applications Deadline: March 15

Peer Reviewed Medical Research Program (PRMRP)
Pre-Application LOI Deadline: March 19
Application Deadline: April 16

James S. McDonnell Foundation 21st Century Science Initiative
Deadline: March 17

Peer Reviewed Medical Research Program (PRMRP)
Application Deadline: April 16

BCRP Era of Hope Scholar Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Innovator Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Impact Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

BCRP Multi-team Research Awards
Pre-App/Nomination Deadline: March 12
Application Deadline: June 17

NCI Short-Term Scientist Exchange Program
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Correlative Studies with Specimens from Multi-Site Trials (R01) (PA-08-134)

In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01) (PA-08-140)

Improving Diet and Physical Activity Assessment (R21) (PAR-06-103)

Request for Information (RFI): Public Comment on Development of a Funding Opportunity Announcement on Translational Research on Minimizing Risks of ... (NOT-DA-09-006)

Revision: Notice of Re-issuance of Kirschstein-NRSA T32 (PA-08-226) and T35 (PA-08-227) Funding Opportunity Announcements (NOT-OD-09-049)

Update to PAR-09-091 Pre-Application for Dietary Supplement Research Centers: Botanicals (X02) and RFA-OD-09-001...(NOT-OD-09-050)

Allowable Salary Levels on Career Awards Supported by the National Cancer Institute (NOT-CA-09-013)

Correction to Review Criteria for RFA-CA-09-004, RFA-CA-09-006, and RFA-CA-09-008, the Innovative Molecular Analysis Technologies (IMAT) for Cancer Program (NOT-CA-09-015)

Clarification of Page Limitations for Research Plan in PAR-09-026 Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01) (NOT-CA-09-017)

New Technologies for Liver Disease STTR(R41/R42) (PA-09-094)

New Technologies for Liver Disease SBIR(R43/R44) (PA-09-095)

Centers for AIDS Research: D-CFAR, CFAR (P30) (PAR-09-103)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.hassinger@uhhospitals.org

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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