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Case Comprehensive Cancer Center Newsletter

December 7, 2009


Friend to Friend: University Hospitals Breast Cancer Vaccine Study
WKYC-TV - December 4, 2009
Joseph Baar, MD, PhD, Director of Breast Cancer Research at the Ireland Cancer Center, and colleagues analyzed 53 tumors and determined that 92 percent of ...

Brain Tumor Cells Made More Responsive to Radiation
Science Daily (press release) - Dec 2, 2009
The Duke researchers, in collaboration with a team led by Dr. Jeremy Rich at Cleveland Clinic, used drugs called gamma-secretase inhibitors that target a ...


Li Li, MD, PhD and Nathan Berger, MD were featured participants in the Fourth International Symposium on Community Health and Family Medicine in Shanghai, Zhabei, on November 11. The fourth in a series, the conference focused on changing and improving health and health management in Zhabei District Shanghai, which has a population of over 1.1 million residents. Please click here to read more.


The American Society of Hematology (ASH) Annual Meeting began December 5 and runs through December 8 in New Orleans. The Cancer Center is pleased to have many members participating: Education Programs and Oral Sessions and Posters. Please support your colleagues if you are attending the meeting. Congratulations to everyone!


The Case CCC recently purchased a Fluorescence Molecular Tomography (FMT) instrument that is available for use in the Case Center for Imaging Research. This second generation fluorescence imaging device uses tomography to detect and quantify fluorescence from anywhere within the body of a mouse. It is extremely sensitive and has equal to or greater resolution than microPET imaging devices, i.e. approximately 1-2 mm resolution. The instrument is able to detect wavelengths compatible with currently used fluorophores, making adaptation to ongoing fluorescent studies seamless.

The device is essentially an in vivo small animal imaging system that has great applicability to preclinical research use. It is designed to provide calibrated quantitative tomographic images and data of fluorescence signals within biological tissue through the depth of the subject. Ongoing studies such as stem cell tracking benefit from the quantitative tools provided by this system, which are far more precise than those previously available.

A training seminar on this device is scheduled for Tuesday, December 8 at 12:00 pm in Wearn B-37, and is sponsored by the NFCR Center for Molecular Imaging at Case. Representatives from VisEn Instruments, the machine's manufacturer, will present on Fluorescence Molecular Tomography: Quantitating Biology to the pmol. Lunch will be served. Case CCC members are urged to attend. Please contact Gopi Ramamurthy, PhD with any questions.


Please mark your calendars for the next installment of the Case CCC Scientific Series and reception on January 28, 2010 from 4:00 pm-7:00 pm in Wolstein Auditorium (WRB 1413). Presentations will be related to the Case Transdisciplinary Research on Energetics and Cancer (TREC) Center, led by Dr. Nathan Berger:

Stephanie Doerner: Diet, Obesity and Susceptibility to Colon Cancer

Cheryl Thompson, PhD: Activation of the PI3K pathway in colon and breast cancer

Ofer Reizes, PhD: Role of Leptin in Mammary Tumorigenesis

Sanjay Patel, MD: The Effect of Sleep Disturbances on Adipose Tissue Gene Expression

Everyone is welcome and encouraged to attend.

MARK YOUR CALENDARS– Weekly Seminar Series on Applied Biostatistics in Clinical Research

Dr. Mark Schluchter will be teaching a free nine-week course on applied biostatistics in clinical research. The course, which is sponsored by the William T. Dahms Clinical Research Unit and the CTSC, will be held Thursdays from 4:00 pm - 5:30 pm in SOM E501 starting January 14, 2010.

The course is targeted toward faculty, fellows, and others involved in clinical research at CWRU and its affiliated hospitals, and is meant to provide an introductory overview. Emphasis is non-mathematical, focusing on understanding what methods to use in what situations, and on how to interpret the results. This is a non-credit course with no formal examination. Individuals are welcome to attend some or all lectures depending on their particular interest.

To register online, please click here.

NCI CANCER BULLETIN– Special Issue: Cancer Research Training

Director's Update:Success Against Cancer Depends on a Vibrant, Well-trained Workforce

Inside NCI: A Conversation with Dr. Jonathan Wiest about Cancer Research Training

Academia and Beyond: Supporting the Biomedical Workforce of the Future

Intramural Training at NCI: A Wealth of Opportunities

Ensuring a Diverse Cancer Research Workforce

Catalyzing a National Shift toward Translational Research

NCI Trains Future International Research Leaders

Opportunities in a Nontraditional but Much-needed Science Workforce

Oncology Training Resources

Cancer Research Highlights
Cervical Cancer Screening Can Be Done Later and Less Often, According to ACOG

Long-term Follow-up Provides New Insights on Adjuvant Therapy for Lung Cancer

No Evidence that Hookah Smoking Is Less Harmful than Cigarette Smoking

No Significant Change in Smoking Rate from 2007 to 2008

Home Care Nursing Improves Cancer Symptom Management

FUNDING OPPORTUNITY– American Institute for Cancer Research

The American Institute for Cancer Research (AICR) recently released their updated grant application package. Applications are being accepted for the following grants:

Investigator Initiated Grants
Applicants must have an MD, PhD or equivalent degree, and be a research staff or faculty member at a non‐profit academic or research institution at the level of assistant professor (or its equivalent) or higher. Applications may be revised one time if not funded but receive a priority score between 1.0 and 2.5. Funded grants are eligible for one-time renewal.

Postdoctoral Awards
Applicants must have an MD, PhD or equivalent degree, awarded no more than four years prior to the date of application, and must be sponsored by a professor from the facility or laboratory in which the applicant is to perform the research. Awards may not be revised and are not eligible for renewal.

Matching Grants
Applicants must have an MD, PhD or equivalent degree, and be a research staff or faculty member at a non‐profit academic or research institution at the level of assistant professor (or its equivalent) or higher. AICR is interested in working with for-profit corporations and/or non-profit organizations in funding cancer research consistent with AICR's areas of interest. Applications are evaluated by peer-review process and are held to the same high and rigorous standards as all other AICR-funded grants.

Application Deadline: February 19, 2010

For details, please click here.

FUNDING OPPORTUNITY– Damon Runyon Cancer Research Foundation Clinical Investigator Award

CWRU SOM has been invited to nominate up to three individuals for the Damon Runyon Cancer Research Foundation Clinical Investigator Award. This award supports young physician-scientists conducting patient-oriented cancer research, with a goal of increasing the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments.

If you are interested in being nominated for this award, please send your biosketch to gillian.irwin@case.edu. External application deadline is March 1, 2010.

For details, please click here.


**All events are open to anyone interested in attending

December 7

Hem/Onc Research in Progress Seminar cancelled

Pathology Research Seminar
Jiri Safar, MD
Associate Professor, Pathology
Topic: A Journey from Laughing Cannibals and Mad Cows to Precarious Conformations of Prions
12:00 pm WRB 1413

Sequencing Data Interest Group (SDIG)
Yoon Soo Pyon, MS
PhD Candidate, Electrical Engineering and Computer Science
Topic: MAQ Alignment Algorithms
2:30 pm WRB 1413

Physiology & Biophysics Seminar
Bhanu Jena, PhD, DSc
Professor, Physiology
Wayne State University
Topic: Porosome: the Universal Secretory Machinery in Cells
4:00 pm SOM E501

Skeletal Research Center Seminar
Jean Welter, MD, PhD
Research Associate Professor, Biology
Topic: TBA
4:00 pm Millis 123

December 8

Fluorescence Molecular Tomography (FMT) Training Seminar
VisEn Instruments Staff
Topic: Fluorescence Molecular Tomography: Quantitating Biology to the pmol
12:00 pm Wearn B-37

Immunology Seminar
David Woodland, PhD
President and Director, Trudeau Institute
Topic: Regulation of T Cell Immunity to Respiratory Virus Infections
12:00 pm WRB 1413

Pathobiology Seminar
Jeremy Rich, MD
Chairman and Professor, Stem Cell Biology & Regenerative Medicine
CWRU/ Cleveland Clinic
Topic: Potential Implications of Cancer Stem Cells in Brain Tumor Biology
1:00 pm NE1-205 Cleveland Clinic

Inflammation, Infection and Cancer Focus Group Meeting
Xiaoxia Li, PhD
Professor, Immunology
Ganes Sen, PhD
Professor, Molecular Genetics
CWRU/ Cleveland Clinic
4:30 pm ND3-01 Cleveland Clinic

December 9

Grand Rounds
Paolo Caimi, MD
Fellow, Div. of Hem/Onc
Topic: Diffuse Large B Cell Lymphoma
in the Elderly

8:00 am Lerner Tower B-151

Genetics and Proteomics Seminar
Nathan Price, PhD
Assistant Professor, Chemical and Biomedical Engineering
University of Illinois at Urbana- Champaign
Topic: Systems Medicine Approaches to Diagnosis and Prognosis of Human Disease
11:00 am BRB 105

Pathology Special Seminar
Jessica Berg, JD
Professor, Law and Bioethics
Topic Conflict of Interest
12:00 pm WRB 1413

December 10

Molecular Genetics Seminar
Glenn Rall, PhD
Fox Chase Cancer Center
Topic: Interferon Signaling in Neurons: the Usual Suspects Result in Unusual Outcomes
9:30 am NE1-205 Cleveland Clinic

Taussig Cancer Institute Core Curriculum Series
Jaroslaw Maciejewski, MD, PhD
Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Aplastic Anemia
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
Stephen Jones, PhD
Professor, Physiology & Biophysics
Topic: Ions as Probes for Calcium Channels
12:10 pm BRB 105

Physiology and Biophysics Seminar
Sudha Chakrapani, PhD
Research Assistant Professor, Biochemistry & Molecular Biology
University of Chicago
Topic: Understanding Gating Mechanisms: A Structural, Functional and Dynamic Approach
4:00 pm SOM E501

December 11

Hematology/ Oncology Fellows Conference
Scott Sommers, MD
Fellow, Div. of Hem/ Onc
Topic: Spontaneous Autologous Graft-vs-Host Disease in Myeloma Autograft Recipients: A Syndrome Increasing in Incidence?
8:00 am Wearn 137

Cell Biology Seminar
Saikh Jaharul Haque, PhD
Assistant Professor, Cancer Biology
CWRU/ Cleveland Clinic
Topic: Redox Regulation of Interleukin-4 Signaling
10:00 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series/ Blood Club
Laxminarayana Devireddy, DVM, PhD
Assistant Professor, Pathology
Topic: TBA
12:00 pm BRB 105


For a complete listing of LRI seminars click here.


Case CCC Core Facility Fair
January 13, 2010
Wolstein Atrium and Auditorium

Case CCC Scientific Series- TREC
January 28, 2010
4:00 pm - 7:00 pm WRB 1-413
Stephanie Doerner, PhD
Cheryl Thompson, PhD
Ofer Reizes, PhD
Sanjay Patel, MD

Case CCC Scientific Retreat
July 9-10, 2010
Location TBA


32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium
December 10-13
Henry B. Gonzalez Convention Center, San Antonio, TX

AACR Seminar: Genetics and Biology of Brain Cancers
December 13-15
Omni San Diego Hotel, San Diego, CA

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, AZ

AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy
January 11-14, 2010
Loews Coronado Bay Resort, Coronado, CA

AACR-JCA 8th Joint Conference on Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9, 2010
Hilton Waikoloa Village, Waikoloa, HI

AACR 101st Annual Meeting
April 17-21, 2010
Washington, DC

CALL FOR NOMINATIONS– FDA-ODAC Call for Nominations 2010

The Food and Drug Administration (FDA) is requesting nominations for members to serve on the Oncologic Drugs Advisory Committee (ODAC) in the Center for Drug Evaluation and Research (CDER). The ODAC is a standing committee that reviews and evaluates data concerning the safety and effectiveness of marketed and investigational human drug products for use in the treatment of cancer and formulates recommendations to the FDA. Committee members generally serve terms of four years and are selected from authorities knowledgeable in general oncology, pediatric oncology, hematologic oncology, tumor immunology, biostatistics, and other related specialties. Candidates should have familiarity and experience in the conduct and interpretation of clinical trials. Candidates should also have minimal conflicts of interest.

The FDA will be accepting recommendations for ODAC members through December 23. Please forward CVs of candidates to Nicole Vesely, PharmD, Designated Federal Official for the ODAC. CVs must contain candidate contact information, including phone number and email address. Click here to view Dr. Vesely's contact information.

FACULTY CANDIDATE SEARCH– Associate Director for Basic Research

The Case CCC is currently accepting applications for the position of Associate Director for Basic Research. As we continue our search, we ask that people in the Cancer Center community encourage any qualified candidate to apply for the position. If you would like to nominate someone for the position, please contact Tracy Rehl (tracy.rehl@case.edu).

Click here to view the job description.


In the spirit of the holidays, the Case CCC is sponsoring two families in need.

The first family consists of a mother, father and two boys, ages 9 and 11. The father was diagnosed with melanoma several years ago, and was recently diagnosed with lymphoma. Co-pays have piled up from tests and doctors' appointments. The patient has developed foot neuropathy that makes it difficult for him to work at his job that requires long periods of standing. Also, he will not be able to work much while he is undergoing chemotherapy. The family has provided a small wish list of items; gift cards and cash are also greatly appreciated.

We are also adopting the family of a former Cancer Center employee who died of cancer in November. To view the family wish list, please click here. Gift cards and cash are greatly appreciated.

Please turn in all donations to Gillian Todd (Wearn 149) by Monday, December 14.

Please email Gillian.irwin@case.edu if you have any questions.


We are always trying to foster communication and collaboration across the cancer center community any way that we can. The Case CCC has set up a page on Facebook and LinkedIn, so please become a fan of us on Facebook or join our group on LinkedIn, and encourage others to do so as well. Please help us spread the word.

We encourage you to post events, relevant news articles, items of discussion, etc… Your feedback is appreciated!


AACR-AstraZeneca Fellowship for Translational Lung Cancer Research
Deadline: December 7

AACR Basic Cancer Research Fellowships: AACR Anna D. Barker Fellowship in Basic Cancer Research and AACR-Astellas USA Foundation Fellowships in Basic Cancer Research
Deadline: December 7

AACR Clinical and Translational Cancer Research Fellowships
Deadline: December 7

AACR Judah Folkman Fellowship for Anti-Angiogenesis Research
Deadline: December 7

DOD PRCRP Synergistic Idea Awards
Proposal Deadline: December 9

DOD PRCRP Collaborative Translational Science Awards
Proposal Deadline: December 9

DOD PRCRP Idea Awards
Proposal Deadline: December 9

DOD PRCRP Mentor-Predoctoral Fellow Research Awards
Proposal Deadline: December 9

DOD PRCRP New Investigator Awards
Proposal Deadline: December 9

International Society for Stem Cell Research (ISSCR)
Deadline: January 14, 2010

AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Clarification to RFA-CA-09-014 Cancer Nanotechnology Training Centers (CNTCs)(R25) Regarding Allowable Participant Salaries (NOT-CA-10-006)

Cancer Immunotherapy Trials Network (U01) (RFA-CA-10-007)

Coordination Center for Transdisciplinary Research in Energetics and Cancer (Limited Competition U01) (RFA-CA-10-501)

Dissemination and Implementation Research in Health (R01) (PAR-10-038)

Dissemination and Implementation Research in Health (R03) (PAR-10-039)

Dissemination and Implementation Research in Health (R21) (PAR-10-040)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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