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Case Comprehensive Cancer Center Newsletter

December 21, 2009

DRS. SUSANN BRADY-KALNAY AND GEORGE STARK HONORED FOR THEIR ROLES IN THE CANCER CENTER

SBK and Stark Dr. Stan Gerson recently recognized the significant contributions of two leaders who have been integral to the Case CCC over the past few years.

Dr. Susann Brady-Kalnay, co-leader of Cancer Cell Signaling Program (Program 3) was named Program Leader of the Year. In making this award, Dr. Gerson noted specifically her energy and enthusiasm as she worked with Drs. George Stark and Clark Distelhorst to invigorate the basic science programs by creating smaller focus groups to encourage collaborations. Over the past year, as these groups were realigned within the scientific programs, Dr. Brady Kalnay worked tirelessly to ensure the continued success of these new collaborations both within her own program and with the leadership of the other programs. This past fall, the Case CCC External Advisors lauded the success of these efforts, noting Dr. Brady-Kalnay's strong leadership and the overall strengthening of the basic science programs as a result of this initiative. Dr. Brady-Kalnay joins Dr. Kevin Bunting who was the inaugural recipient of this award.

Dr. George Stark has served as Associate Director for Basic Research for the Case CCC since 2005. Noting he was initially recruited to serve in this role as an interim Associate Director, Dr. Gerson expressed his gratitude for Dr. Stark's decision to remain in the position, from which he guided the reorganization and realignment of the basic science programs. Throughout his tenure Dr. Stark has advocated for resources and support to strengthen basic cancer research and encourage participation of clinical investigators to stimulate translational research. While Dr. Stark is stepping down as Associate Director, Dr. Gerson has persuaded him to assume an advisory role to the Director, in addition to his leadership of Program 3 together with Dr. Brady-Kalnay.


CASE CCC IN THE NEWS

Protein Link May Be Key to New Treatment for Aggressive Brain Tumor
University of Central Florida - Dec 21, 2009
... George A. Kyriazis and Kiminobu Sugaya from UCF; Sergey Bushnev from Florida Hospital Cancer Institute; and Justin D. Lathia and Jeremy N. Rich from the ...

US Panel Narrowly Backs Photocure Cancer Test Drug
Reuters - Dec 17, 2009
... outcome and that they wouldn't have been detected anyway by routine measures," said Dr. Mikkael Sekeres, a medical oncologist at the Cleveland Clinic. ...

Case Western's RNA Center Hiring Bioinformaticist, Non-Coding RNA Researcher
GenomeWeb Daily News - Dec 15, 2009
The center, according to its director, Timothy Nilsen, was originally established to "expand analyses of the molecular biology of parasites. ...

The Right Target: How Survival is Affected by Race/Ethnicity, Socioeconomic Status
HemOncToday - Dec 10, 2009
Derek Raghavan, MD, PhD, former chairman of ASCO's Health Disparities Advisory Group, said disparity research needs to be backed by action. ...


PUBLICATION HIGHLIGHTS

The December 17 issue of the "New England Journal of Medicine" features the article, Molecular Basis of Colorectal Cancer, by Dr. Sanford Markowitz. In the article, Dr. Markowitz reviews recent advances toward understanding the molecular basis of colorectal cancer. The hope is that this knowledge will result in the development of better cancer treatments and eventually prevention of the disease.

An article by Cancer Center members Drs. Shenandoah Robinson, Andrew Sloan, Michael Vogelbaum, Robert Miller, and Susann Brady-Kalnay, titled PTPµ Suppresses Glioma Cell Migration and Dispersal, was published in the December 2009 issue of "Neuro-Oncology". The cover of this issue features an image from the study, which examined the effect of the cell-surface receptor protein tyrosine phosphatase mu (PTPµ) on human glioblastomas (GBMs), and found a loss of PTPµ in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPµ in glioma progression.

EVENTS

**All events are open to anyone interested in attending

December 21

Hem/Onc Research in Progress Seminar cancelled

Physiology & Biophysics Seminar
Oleh Pochynyuk, PhD
Research Assistant Professor, Physiology
University of Texas Health Science Center
Topic: Paracrine Regulation of ENaC Activity by ATP/ Purinergic Tone in the Mammalian Collecting Duct
4:00 pm SOM E501


December 22


December 23

Grand Rounds cancelled


December 24


December 25

Merry Christmas!

more

For a complete listing of LRI seminars click here.


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case CCC Core Facility Fair
January 13, 2010
3:00 pm - 6:00 pm Wolstein Atrium and Auditorium

Case CCC Scientific Series- TREC
January 28, 2010
4:00 pm - 7:00 pm WRB 1-413
Speakers:
Stephanie Doerner
Cheryl Thompson, PhD
Ofer Reizes, PhD
Sanjay Patel, MD

Case CCC Scientific Retreat
July 9-10, 2010
Location TBA


ADDITIONAL UPCOMING SEMINARS & EVENTS

Radiological Society of North America (RSNA) Clinical Trials Methodology Workshop
January 9 -15, 2010
Scottsdale, AZ
Details

AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy
January 11-14, 2010
Loews Coronado Bay Resort, Coronado, CA
Details

AACR-JCA 8th Joint Conference on Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9, 2010
Hilton Waikoloa Village, Waikoloa, HI
Details

AACR 101st Annual Meeting
April 17-21, 2010
Washington, DC
Details


FUNDING OPPORTUNITY– Interagency Oncology Task Force Joint Fellowship Program

The Interagency Oncology Task Force (IOTF), a joint initiative between NCI and the FDA, has announced fellowship training opportunities for PhDs, MDs, and MD/PhDs or their equivalents in cancer-related scientific research and research-related regulatory review. Fellowship programs are available for various career levels and vary in length between one and four years.

Clinical Oncology Product Research/Review for Oncology Fellows
Application deadline: January 31

Clinical Oncology Product Research/Review for Board Certified (BC) Oncologists
Application deadline: January 31

Oncology Product Research/Review Fellows
Application deadline: May 30

Cancer Prevention Fellows
Application deadline: September 1


FUNDING OPPORTUNITY– Multiple Myeloma Research Foundation

The Multiple Myeloma Research Foundation (MMRF) seeks proposals for the 2009 Seniors Award Program, an initiative supporting researchers with more than five years experience in blood cancer research. The MMRF welcomes proposals to the MMRF 2009 Seniors Award on any and all multiple myeloma related topics. The goal of this initiative is to accelerate the development of therapeutic approaches for myeloma.

Deadline: February 3

For more information, please click here.


MARK YOUR CALENDARS– Case CCC Scientific Series: TREC

Please mark your calendars for the next installment of the Case CCC Scientific Series and reception on January 28, 2010 from 4:00 pm-7:00 pm in Wolstein Auditorium (WRB 1413). Presentations will be related to the Case Transdisciplinary Research on Energetics and Cancer (TREC) Center, led by Dr. Nathan Berger:

Stephanie Doerner: Diet, Obesity and Susceptibility to Colon Cancer

Cheryl Thompson, PhD: Activation of the PI3K pathway in colon and breast cancer

Ofer Reizes, PhD: Role of Leptin in Mammary Tumorigenesis

Sanjay Patel, MD: The Effect of Sleep Disturbances on Adipose Tissue Gene Expression

Everyone is welcome and encouraged to attend.


CALL FOR NOMINATIONS– FDA-ODAC Call for Nominations 2010

The Food and Drug Administration (FDA) is requesting nominations for members to serve on the Oncologic Drugs Advisory Committee (ODAC) in the Center for Drug Evaluation and Research (CDER). The ODAC is a standing committee that reviews and evaluates data concerning the safety and effectiveness of marketed and investigational human drug products for use in the treatment of cancer and formulates recommendations to the FDA. Committee members generally serve terms of four years and are selected from authorities knowledgeable in general oncology, pediatric oncology, hematologic oncology, tumor immunology, biostatistics, and other related specialties. Candidates should have familiarity and experience in the conduct and interpretation of clinical trials. Candidates should also have minimal conflicts of interest.

The FDA will be accepting recommendations for ODAC members through December 23. Please forward CVs of candidates to Nicole Vesely, PharmD, Designated Federal Official for the ODAC. CVs must contain candidate contact information, including phone number and email address. Click here to view Dr. Vesely's contact information.



NCI CANCER BULLETIN

Featured Article
Trial Suggests New First-line Treatment Option for Slow-growing Lymphomas

Cancer Research Highlights
Bone Drugs Linked to Fewer Cases of Breast Cancer

U.S. Cancer Cases and Deaths Continued to Decline in 2006

Nilotinib Effective and Safe in Initial Treatment of Chronic Leukemia

Androgen Deprivation Therapy Linked to Cardiovascular Disease, Diabetes

Antioxidant Supplement May Prevent Return of Precancerous Colorectal Growths

Director's Update
Modeling a Future without Cancer


MARK YOUR CALENDARS– Case CCC Core Facilities Fair

The Case CCC Core Facilities Fair is scheduled for Wednesday, January 13 from 3:00 pm - 6:00 pm in Wolstein Atrium and Auditorium. Core directors and managers will be present to discuss how their facilities are available to support your research. The afternoon will be filled with core facility related presentations, posters, food and more! We are hoping all members will attend; please encourage your graduate students and lab staff to drop by also.


FUNDING OPPORTUNITY– Damon Runyon Cancer Research Foundation Clinical Investigator Award

CWRU SOM has been invited to nominate up to three individuals for the Damon Runyon Cancer Research Foundation Clinical Investigator Award. This award supports young physician-scientists conducting patient-oriented cancer research, with a goal of increasing the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments.

If you are interested in being nominated for this award, please send your biosketch to gillian.irwin@case.edu. External application deadline is March 1, 2010.

For details, please click here.


FACULTY CANDIDATE SEARCH– Associate Director for Basic Research

The Case CCC is currently accepting applications for the position of Associate Director for Basic Research. As we continue our search, we ask that people in the Cancer Center community encourage any qualified candidate to apply for the position. If you would like to nominate someone for the position, please contact Tracy Rehl (tracy.rehl@case.edu).

Click here to view the job description.


CASE CCC ON FACEBOOK AND LINKEDIN– Join Us!

We are always trying to foster communication and collaboration across the cancer center community any way that we can. The Case CCC has set up a page on Facebook and LinkedIn, so please become a fan of us on Facebook or join our group on LinkedIn, and encourage others to do so as well. Please help us spread the word.

We encourage you to post events, relevant news articles, items of discussion, etc… Your feedback is appreciated!

PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

International Society for Stem Cell Research (ISSCR)
Deadline: January 14

Prostate Cancer Foundation
Deadline: January 31

AICR Investigator Initiated Grants
Deadline: February 19

AICR Matching Grants
Deadline: February 19

AICR Postdoctoral Awards
Deadline: February 19


AACR Scholar-in-Training Awards - Special Conferences
Deadline varies

NCI Short-Term Scientist Exchange Program
Deadline: Open

James S. McDonnell Foundation
Deadline: Open


NIH Bulletin – Notices and Funding Opportunities

Academic Career Award (Parent K07) (PA-10-058)

Mentored Clinical Scientist Research Career Development Award (Parent K08) (PA-10-059)

Mentored Patient-Oriented Research Career Development Award (Parent K23) (PA-10-060)

Midcareer Investigator Award in Patient-Oriented Research (Parent K24) (PA-10-061)

Mentored Quantitative Research Development Award (Parent K25) (PA-10-062)

NIH Pathway to Independence Award (Parent K99/R00) (PA-10-063)

Research Project Grant (Parent R01) (PA-10-067)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.

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