Case Comprehensive Cancer Center Newsletter

September 22, 2008

MESSAGE FROM THE DIRECTOR– Case CCC Annual Meeting of the External Advisory Board

On September 18 and 19, nine members of the Case CCC External Advisory Board met with program and senior leaders of the Cancer Center to review the progress and new developments of the past year.

The members of the EAB are:

  • Michael A. Caligiuri, MD, Director, OSU Comprehensive Cancer Center
  • William S. Dalton, MD, PhD, CEO & Director, H. Lee Moffitt Cancer Center & Research Institute
  • David L. DeMets, PhD, University of Wisconsin
  • Paul F. Engstrom, MD, Fox Chase Cancer Center
  • Beverly Ginsburg-Cooper, MBA, Dana-Farber/Harvard Cancer Institute
  • Jerome Ritz, MD, Dana-Farber Cancer Institute
  • Thomas A. Sellers, PhD, MPH, H. Lee Moffitt Cancer Center & Research Institute
  • Craig B. Thompson, MD, Director, Abramson Cancer Center,
  • Donald L. Trump, MD, President & CEO, Roswell Park Cancer Institute

The Board had the opportunity to meet with the following institutional leadership from Case Western Reserve University, the School of Medicine, University Hospitals Case Medical Center, and Cleveland Clinic:

  • Barbara Snyder, JD, President, Case Western Reserve University
  • Joseph Hahn, MD, Chief of Staff, Cleveland Clinic
  • Paul DiCorleto, PhD, Chair, Lerner Research Institute, Cleveland Clinic
  • Pamela Davis, MD, PhD, Dean and Vice President for Medical Affairs, Case Western Reserve University School of Medicine
  • Thomas F. Zenty, Chief Executive Officer, University Hospitals Health System
  • Fred Rothstein, MD, President, University Hospitals Case Medical Center

Topics of discussion at the EAB meeting included the developing Imaging and Cancer Program (Jeff Duerk, PhD & Jim Basilion, PhD), reviews of the Developmental Therapeutics (Afshin Dowlati, MD) and Stem Cells and Hematologic Malignancies Programs (Kevin Bunting, PhD & Hillard Lazarus, MD), and the disease-based initiatives in melanoma (Ernie Borden, MD), lung cancer (Afshin Dowlati, MD), and colon cancer (Sandy Markowitz, MD, PhD). Afshin Dowlati, MD and John Sweetenham, MD discussed progress in clinical trial development activation and accrual. We also discussed the reorganization of our basic science research programs into 11 scientific focus areas (coordinated by George Stark, PhD, Janet Houghton, PhD, Susann Brady-Kalnay, PhD, and Clark Distelhorst, MD), and the added value this has had in promoting interactions, collaborations, new grant submissions, and pilot grant awards. There was considerable constructive commentary that will help us guide our program development over the next year.

We will receive formal comments from the EAB in 4-6 weeks, and will share these with the senior and program leaders of the Center.

Stanton Gerson, MD
Director, Case CCC


Andrew Sloan, MD is the Project Leader of the CWRU SOM branch of the Ivy Genomics-Based Medicine Project. This project, made possible by a $3 million award from the Ben and Catherine Ivy Foundation, is a collaboration of nine US institutions working to discover better ways to treat brain tumors. Other institutions involved in the project are: Translational Genomics Research Institute (lead institution); Ohio State University; University of Texas MD Anderson Cancer Center; University of Alabama at Birmingham; University of California, San Francisco; Henry Ford Hospital; Mayo Clinic, Rochester, Minnesota; and Van Andel Research Institute.

For more information, please click here.

FUNDING OPPORTUNITY–Short-Term Scientist Exchange program

The Short-Term Scientist Exchange program promotes collaborative research between established US and foreign scientists from developing countries by supporting, in part, exchange visits of cancer researchers to foreign laboratories. Visits of US scientists to overseas laboratories in developing countries may also be considered for support. The visits may be from one week to six months in duration.

Candidates must have a minimum of three years postdoctoral experience in cancer research and have an invitation from a qualified sponsor. Sponsors or exchangees from the US must be NCI-supported PIs, in either the intramural or extramural research programs. Foreign sponsors must be established scientists recognized in the international peer reviewed literature. Foreign candidates must be proficient in spoken and written English. Persons holding US permanent resident status or any work visa are not eligible for this program.

For details, please click here.

CALL FOR NOMINATIONS– AACR Future Leaders Symposium

The AACR Associate Member Council seeks institutional nominations of outstanding and innovative young investigators as speakers for the third annual Future Leaders Special Symposium to be held during the AACR 100th Annual Meeting, April 18-22, 2009 in Denver, CO. This is an unprecedented opportunity, during the world's largest meeting for cancer researchers, to showcase how your institution is contributing to the future of cancer research!

Nominees will be evaluated on scientific merit, research design, innovation, and independent contributions through a highly competitive selection process. The nominees who are selected as speakers will be treated as Invited Speakers to the Annual Meeting: they will receive complimentary registration and support for their travel; they will present a 15-20 minute platform presentation for this Symposium; and they will be introduced by a prominent senior researcher within their field. Your institution may submit up to two nominations.

Nominees must be graduate students, medical students or residents, clinical fellows, or postdoctoral fellows. Those with Junior faculty status are not eligible for nomination, including trainees expected to advance to junior faculty status prior to the Symposium. Each institution may submit two nominations, but the nominees must represent different areas of cancer research (e.g., laboratory, clinical, or translational research, epidemiology, etc.)

If you would like to nominate someone for this opportunity, please contact Gillian Irwin ( by Wednesday, October 15.

For details, please click here.


November 16
Fort Lauderdale, FL

The purpose of this annual symposium is to engage promising young clinical investigators in cooperative group clinical research. Individuals who meet the criteria are invited to submit an abstract for presentation at the fall ECOG meeting, which will take place November 14-16 in Fort Lauderdale, Florida. The symposium will tentatively take place between 8:30-11:00 am on November 16.

Abstracts should be emailed or faxed no later than October 10. For details, please click here.

MARK YOUR CALENDARS– NanoMedicine Summit 2008

September 25-26
Ritz Carlton

The 2008 Cleveland NanoMedicine Summit, is the anchor event for Nano Week in Cleveland (in its fifth year) and will be co-hosted by NorTech's Nano-Network, the Cleveland Clinic Foundation and Case Western Reserve University. This conference has been incredibly successful in the past (as evidenced by national media attention and feedback from attendees) by bringing together scientists, clinicians, business professionals, investors and others to learn, discuss and interact under the umbrella of nanomedicine.

The 2008 Summit will focus on the use of nanoparticles for diagnostics and therapeutics. Session highlights include:
–Nanoparticles for Imaging Cancer and other Diseases
–Nanoparticles for Drug Delivery
–Nanoparticle Building Blocks
–Nanoparticles for Treatment of Disease
–Biological Investigation Using Nanoparticles

Many Cancer Center members are involved in this Summit. Drs. James Basilion, Vinod Labhasetwar, and Maciej Zborowski are on the Organizing Committee, and the following members are scheduled to speak: Drs. Stanton Gerson, Clemens Burda, Agata Exner, Vinod Labhasetwar, Horst von Recum, Pam Davis, Mark Cooper, and Thomas Budd.

For more information, please click here.


**All events are open to anyone interested in attending

September 22

Hematology/Oncology Research In Progress Seminar
Gregory Adams
Graduate Student- Schmaier Lab, Div of Hem/Onc
Topic: Prolylcarboxypeptidase Murine Hypomorphs Are Prothrombotic and Hypertensive
12:00 pm WRB 2-136

Pathology Research Seminar Series
Robert Mrak, MD, PhD
Professor and Chairman, Pathology
University of Toledo
Topic: Neuroinflammation and the New Neuropathology of Alzheimer's Disease
12:00 pm WRB 1-413

Case CCC and Biostatistics Seminar
Seongho Kim, PhD
Postdoc Fellow, Biostatistics
Indiana University School of Medicine
Topic: Markov-Chain Monte Carlo Methods for Pharmacokinetic Models
2:00 pm Wearn 137

Physiology & Biophysics Seminar
Marc Francois Pelletier, PhD
VP & Chief Scientific Officer
Aeromics, LLC
Topic: Towards Modulating Water and Gas Permeabilities in the CNS
4:00 pm SOM E501

Skeletal Research Center Seminar
Harihara Baskaran, PhD
Associate Professor, Chemical Engineering
Topic: TBA
4:00 pm Millis 123

September 23

Taussig Cancer Center Core Curriculum Series
Mikkael Sekeres, MD
Assistant Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Overview of Myelodysplastic Syndromes
12:00 pm R3-002 Cleveland Clinic

Case CCC Faculty Chalk Talk
Jeongwu Lee, PhD
Staff Scientist, Neuro-Oncology Branch
Topic: Tumor Stem Cells In Glioblastomas: New Model for Biology and Therapeutics
3:00 pm WRB 3-136

September 24

Grand Rounds
Alvin Schmaier, MD
Professor, Medicine- Hem/Onc
Topic: Anticoagulation
8:00 am Lerner B-151

Pathology Graduate Student Seminar
Zhenfeng Zhang
Halmos Lab, Division of Hem/Onc
Topic: Evaluation of Dual Specificity Phosphatase 6 as a Candidate Tumor Suppressor in Non-Small Cell Lung Cancer
12:00 pm WRB 1413

Developmental Therapeutics Program Meeting
5:00 pm WRB 2-136

September 25

Taussig Cancer Institute Core Curriculum Series
Halle Moore, MD
Staff, Solid Tumor Oncology
Cleveland Clinic
Topic: Metastatic Breast Cancer
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
Daniel Feldman, PhD
Associate Professor, Neurology
University of California, Berkeley
Topic: Processing and Plasticity in the Whisker Map in Somatosensory Cortex
12:10 pm SOM E501

TREC Seminar
Cheryl Thompson, PhD
Senior Research Associate, Family Medicine
Topic: Genetic Susceptibility Variants for Obesity and Type II Diabetes
4:00 pm BRB 732

Practice-Based Research Network Seminar
Topic: Sampling and Nested Analyses in PBRNs
6:00 pm Cuyahoga County Coroner's Office

September 26

Hematology/Oncology Fellows Seminar
Richard Creger, PharmD
Department of Medicine
Topic: Practical Supportive Pharmacotherapy-Antiemetics
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
David Steensma, MD
Associate Professor, Medicine- Oncology
Mayo Clinic
Topic: Rings of Fire: New Insights into Sideroblastic Anemias
8:00 am R3/002-003 Cleveland Clinic

Prevention & Control Meeting
12:30 pm Wearn 137


For a complete listing of LRI seminars click here.



**For more information on these symposiums, please contact Christine Rhoads.

Family-Centered Care
March 21, 2009
Holiday Inn, Independence
Details to follow

Head and Neck Conference
April 17, 2009
Holiday Inn, Independence
Details to follow


September 25-28
Hilton San Francisco

The Oncology Congress engages you in productive peer-to-peer discussions about cancer prevention, diagnosis, and treatment options, giving you the practical knowledge, tools, and insight needed to improve care and quality of life for your patients today.

The Case CCC has partnered with the Oncology Congress to offer a discounted registration rate for Case CCC members: $395 for physicians and $195 for nurses and physician assistants. To register, please click here, and use priority code COE8.

MARK YOUR CALENDARS– 61st Annual Symposium on Cancer Research: Systems Biology of Cancer

October 30-November 1
University of Texas MD Anderson Cancer Center
Houston, TX

The University of Texas MD Anderson Cancer Center is pleased to host the 61st Annual Symposium on Cancer Research: Systems Biology of Cancer. This symposium will bring together internationally-recognized scientists from academia, industry, regulatory agencies, and patient advocates to describe and discuss state-of-the art information about how systems biology is transforming cancer research. This symposium is directed towards scientists, scientists-in-training, physicians, physicians-in-training, students, and fellows interested in integrating large molecular data sets to generate information relevant to understanding the mechanism of cancer growth and ultimately diagnosing and treating it.

For details, please click here.

MARK YOUR CALENDARS– AFAR Conference on Cancer and Aging

October 6-7
Union League Club
New York, NY

The American Federation on Aging Research (AFAR) is pleased to present Aging and Cancer: Two Sides of the Same Coin?, October 6-7 in New York. This two-day conference will explore fundamental aspects of aging and cancer processes and their interactions. Speakers will examine: genetic and epigenetic changes, environmental influences, and host factors such as oxidative stress and cell death. The evolutionary, cellular and molecular relationships among aging, tumor suppressor mechanisms and the development of cancer as well as the interactions of normal aging cells, stem cells and differences in the manifestation of cancer in young and old will also be discussed. Speakers will report on topics such as telomere biology; nuclear processes such as DNA damage, repair, replication, recombination and transcription; and relevant aspects of mitochondrial structure and function. The goal will be to elucidate genetic and epigenetic alterations that lead to aging and cancer phenotypes.

For more information, please click here.


Susan G. Komen Promise Grants
Pre-Application Deadline: September 25

ACS Ohio Division Pilot Grants
Deadline: September 29

Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01)
Deadline: October 5

World Cancer Research Fund International
Deadline: October 13

Canary Foundation/ACS Postdoctoral Fellowship in the Early Detection of Cancer
Deadline: October 15

NCI Clinical Investigator Development Program
Deadline: October 15

ACS Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

AACR/American Cancer Society Award for Research Excellence in Cancer Epidemiology & Prevention
Nomination Deadline: October 15

AACR Award for Outstanding Achievement in Cancer Research Nomination Deadline: October 15

Multidisciplinary Clinical Research Training Program Clinical Research Scholars
Deadline: November 4

Susan G. Komen Promise Grants
Full Application Deadline: December 4

Sallie Rosen Kaplan Fellowship
Deadline: December 15

NIH Bulletin – Notices and Funding Opportunities

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (P01) (PAR-08-245)

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R21) (PA-08-244)

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R01) (PA-08-243)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Green
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
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