Case Comprehensive Cancer Center Newsletter

June 16, 2008

DR. OTIS W. BRAWLEY– Pfizer Visiting Professor in Oncology

We are pleased to welcome Otis W. Brawley, MD as the Pfizer Visiting Professor in Oncology. In connection with the professorship, Dr. Brawley will be giving several talks in Cleveland June 23-25, 2008. Dr. Brawley is a leader in health disparities research, and has spent much time highlighting the social and economic factors which create healthcare disparities in cancer care. Dr. Brawley's visit was made possible by a Pfizer Medical and Academic Partnerships (MAP) Grant.

Dr. Brawley is currently the Chief Medical Officer at the American Cancer Society. He attended the University of Chicago for his undergraduate degree as well as for medical school. Dr. Brawley was an intern and subsequently a resident at University Hospital of Cleveland, Case Western Reserve University. He was also a Medical Staff Fellow in the Division of Cancer Treatment at the National Cancer Institute.

Please mark your calendars for the following seminars featuring Dr. Brawley:

June 23
(Special) David Satcher Lecture
Topic: Highlighting Issues with Cancer in Underserved Populations
11:45 am - 1:00 pm Kulas Auditorium (Lakeside 5th Floor)
Lunch will be served

June 23
Town Hall Meeting
Topic: Opening New Doors in Cancer Communication in the 21st Century
6:00 pm - 8:00 pm Karamu House, 2355 East 89th Street, Cleveland
Refreshments will be served
For more information or to RSVP, call (216)844-5176, or email

June 25
Grand Rounds
Topic: Health Policy and Cancer Care Disparities
8:00 am - 9:00 am Lerner B-181


The 2008 scientific retreat of the Cancer Center will be July 11-12 at Sawmill Creek Resort and Conference Center in Huron, Ohio. This annual gathering is an important event for the Cancer Center, as it gives us the opportunity to evaluate our current initiatives and adjust our development and scientific priorities as needed. To view the agenda, please click here.

Please fill out the Registration Form and let us know whether or not you are able to attend. Please return the form to Gillian Irwin ( or fax 844-7832) as soon as possible.

FUNDING OPPORTUNITY– Breast Cancer Research Foundation- AACR Grant for Translational Breast Cancer Research

The BCRF-AACR Grants for Translational Breast Cancer Research are a joint effort of the Breast Cancer Research Foundation and the American Association for Cancer Research. The grants provide direct support for innovative cancer research projects designed to accelerate the discovery, development, and application of new agents to treat breast cancer and/or for pre-clinical research with direct therapeutic intent. Laboratory-based projects must present plans with clinical collaborators indicating how the work will be translated into the clinic. Similarly, clinical studies must show how the work was derived from basic preclinical work and how results will be channeled back to laboratory-based collaborators.

Application Deadline: July 9

For details, please click here.

FUNDING OPPORTUNITY– Komen-AACR Outstanding Investigator Award for Breast Cancer Research

The AACR is currently accepting nominations for the Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research. This award will recognize an investigator whose novel and significant work has had or may have a far-reaching impact on the etiology, detection, diagnosis, treatment, or prevention of breast cancer. Such work may involve any discipline across the continuum of biomedical research, including basic, translational, clinical, and epidemiological studies.

Candidates must be no older than 50 years of age at the time the award is received (December 2008). The Award will be presented to an individual investigator. Institutions or organizations are not eligible for the Award.

Nominations must be submitted electronically to no later than 4:00 p.m. EST, Thursday, July 10.

Paper nominations will not be accepted. Nominations may be made by any scientist, whether an AACR member or nonmember, who is now or has been affiliated with any institution involved in cancer research, cancer medicine, or cancer-related biomedical science. Candidates may not nominate themselves. Nominators are asked to maintain the confidentiality of the nomination process and to refrain from informing the candidate about the nomination. There is no restriction on the number of candidates that may be nominated by any institution or individual.

For more information, please click here.

MARK YOUR CALENDARS– Affymetrix Integrated Genomics Seminar

Please mark your calendars for the upcoming Affymetrix Integrated Genomics Seminar on Tuesday, June 24 from 10:30 am - 1:30 pm in the Wolstein 1st Floor Conference Room (Rm. 1413). The seminar will include talks from Affymetrix technical representatives and a seminar from Dr. Matthias Kretzler from the University of Michigan, who has successfully used this approach in his research.

This series of talks discussed how to employ both expression and SNP arrays in an integrated approach to comprehensively examine the genome. Lunch will be provided. To register, please click here.


Congratulations to Cancer Center Member Mark A. Smith, PhD, who was recently awarded the the 2008 Denham Harman Research Award from the American Aging Association. The honor is a lifetime achievement award in research. Dr. Smith is a Professor of Pathology at CWRU.


**All events are open to anyone interested in attending

June 16

Cancer Genetics/ Biology Journal Club
Ricardo Espinola, MD
Instructor, Medicine-Hem/Onc
Topic: Platelet CD36 Mediates Interactions with Endothelial Cell–derived Microparticles and Contributes to Thrombosis in Mice
12:00 pm WRB 2-136 Conference Room

Physiology & Biophysics Seminar
Masao Ikeda-Saito, PhD
Director, Hybrid Nano-Materials Research Center
Institute of Multidisciplinary Research for Advanced Materials
Tohoku University, Katahira, Japan
Topic: Structural Bioinorganic Chemistry to Unravel the Mechanism of Heme Catabolism by Heme Oxygenase
4:00 pm SOM W203

June 17

Cancer Biology Seminar
Barton Kamen, MD, PhD
Executive Vice President- Chief Medical Officer
Leukemia and Lymphoma Society
Topic: Folates and Anti-Folates: Good for What Ails You
2:00 pm NC1-202 Cleveland Clinic

June 18

Grand Rounds
Joseph Baar, MD, PhD
Associate Professor, Medicine- Hem/Onc
Topic: The Seed and the Soil: Bone Marrow Micrometastases in Early-Stage Breast Cancer
8:00 am Lerner B-151

Lerner Research Institute Showcase Seminar
Janet Houghton, PhD
Chair, Cancer Biology
Cleveland Clinic
Topic: Translational Research in Colorectal Cancer
4:30 pm NE1-205

Developmental Therapeutics Program Core Committee Meeting
5:00 pm WRB 2-136

June 19

Molecular Genetics Seminar
John Hiscott, PhD
Professor of Medicine, Microbiology and Oncology
McGill University
Topic: Chemical Targeting of the Innate Antiviral Response by Histone Deacetylase Inhibitors Renders Refractory Cancers Sensitive to Viral Oncolysis
9:30 am NE1-205 Cleveland Clinic

Neurosciences Thesis Defense
Ivy Samuels
Student, Landreth Lab
Dept. of Neurosciences
Topic: The Roles of ERK1 and ERK2 MAP Kinase in Neural Development and Disease
10:00 am SOM E609

22nd Annual Oscar Ratnoff, MD Lecture
James Bussel, MD
Professor, Pediatrics in Obstetrics & Gynecology and in Medicine
Weill Cornell Medical College
Topic: New Developments in the Investigation and Management of Refractory ITP
12:00 pm BRB 105

Aging-Cancer Research Seminar
4:00 pm BRB 732

Physiology & Biophysics Seminar
Luis G. Cuello, PhD
Research Assistant Professor, Biochemistry & Cell Biology
University of Chicago
Topic: Structural Basis of K+ Channel C-type Inactivation: Crystal Structure of KcsA in the Open/C-type Inactivated Conformation
4:00 pm SOM W428

June 20

Hematology/Oncology Fellows Seminar
Cecilia Choi, MD
Fellow, Division of Hem/Onc
Topic: Soft Tissue Carcinoma
8:00 am Wearn 137

Taussig Cancer Center Grand Rounds
John Tisdale, MD
Topic: Hematopoietic Stem Cells as Vehicles for the Treatment of Sickle Cell Disease
8:00 am R3/002-003 Cleveland Clinic


For a complete listing of LRI seminars click here.



**For more information on these symposiums, please contact Christine Rhoads.

ASCO Review 2008
June 27
InterContinental Hotel & Bank of America Conference Center
Course Directors: Robert Dreicer, MD and Hillard Lazarus, MD
Brochure and Registration

Faculty Positions Available Soon– K12 Clinical Oncology Research Career Development Award

The Case Comprehensive Cancer Center is accepting applications for its K12 Clinical Oncology Research Career Development Award (CORP). Positions are available for July 2008 and July 2009. If you are interested in applying, please contact Margy Weinberg ( or 216-844-5375). Application deadline: August 1, 2008.

Program Directors
Stanton L. Gerson, MD, Director, Case Comprehensive Cancer Center, and
Alvin H. Schmaier, MD, Chief, Division of Hematology/Oncology

Career Development
Junior faculty appointment in medical, surgical, radiation, or pediatric departments at CWRU and UHCMC. Clinical oncology research that is focused on laboratory-based translational research and includes therapeutic clinical research.

MD with clinical training in an oncologic discipline. May be completing a residency and/or fellowship, depending on discipline. Interest and training in clinical trials and/or laboratory-based research. Intent to focus on translational research leading to a clinical trial. Willingness to participate in didactic training in clinical and translational research, to publish and author clinical trials. Minimum two-year commitment required.

Mentoring Faculty
Mentoring provided by nationally recognized basic, clinical, and translational faculty at CWRU and UHCMC.

The Case CCC has 9 multidisciplinary programs and 17 shared resources that promote focused cancer research and provide unique training opportunities.

Salaries and Research Seed Funds
Salary support at $75,000 for 75% effort plus generous annual research seed money provided through NCI-funded K12 CORP Award. Additional salary for 25% effort provided for clinical responsibilities.


Featured Article
Colorectal Cancer Drugs Require Careful Patient Selection

Cancer Research Highlights
Gemcitabine after Pancreatic Cancer Surgery Improves Survival

Cetuximab Plus Chemotherapy Extends Survival for Advanced Lung Cancer

Zoledronic Acid Improves Early Breast Cancer Treatment

Acupuncture Tested in Cancer Patients after Neck Surgery

Protein Biomarkers Point to Early Stage Pancreatic Cancer

Initial Costs of Cancer Treatment on the Rise

Director's Update
Dr. Niederhuber's Remarks at the ASCO Opening Session

MARK YOUR CALENDARS– Cancer Health Disparities Summit

July 14-16
Bethesda North Marriott Hotel and Conference Center
Bethesda, MD

The National Cancer Institute (NCI) Center to Reduce Cancer Health Disparities (CRCHD) is pleased to present the Cancer Health Disparities Summit 2008, July 14–16, at the Bethesda North Marriott Hotel and Conference Center, Bethesda, Maryland. The overall theme for this year's Summit is Eliminating Cancer Health Disparities Through Science, Training, and Community. The Cancer Health Disparities 2008 will highlight the science of the programs and grantees funded through the CRCHD.

For more information, please click here.

MARK YOUR CALENDARS– AACR Centennial Conference

July 20-23
Hyatt Regency Monterey
Monterey, California

The AACR Centennial Conference on Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine is the second in the AACR Centennial Conference series on Translational Cancer Medicine and the first to be held in the United States. Translational research is a key programmatic priority of the AACR, and this meeting will showcase the latest scientific discoveries from the laboratory and their clinical applications.

For more information, please click here.

MARK YOUR CALENDARS– Cancer Immunology and Immunotherapy: Realizing the Promise

September 11-12
National Institutes of Health
Bethesda, MD

The Center for Cancer Research (CCR) at the National Cancer Institute will be hosting a two-day, national symposium entitled Cancer Immunology and Immunotherapy: Realizing the Promise. This meeting will host leaders in the field of cancer immunology and immunotherapy, include recent advances in both translational and clinical research, and should provide an exciting forum for discussion and debate on promising immunologic approaches to prevent and treat cancer.

Registration is free, but seating is limited so be sure to register early! Abstracts are being accepted for the poster session. Deadline for abstract submission is July 15.

For more information, please click here.


Susan G. Komen for the Cure: Post-Baccalaureate Training in Disparities Research
Pre-Application Deadline: June 19

DOD OCRP Consortium Development Award
Pre-Application Deadline: June 25

DOD PCRP Laboratory-Clinical Transition Award: Stage 1
LOI Deadline: June 30

DOD PRMRP Investigator-Initiated Research Award
Proposal Deadline: July 2

DOD PRMRP Investigator-Initiated Research Award (Specific appropriation for bone marrow failure disorder research)
Proposal Deadline: July 2

DOD PRMRP Translational Research Award
Proposal Deadline: July 2

DOD PRMRP Advanced Technology/Therapeutic Development Award
Proposal Deadline: July 2

DOD PRMRP Clinical Trial Award
Proposal Deadline: July 2

DOD OCRP Consortium Development Award
Proposal Deadline: July 9

Cleveland Clinical and Translational Sciences Collaborative (CTSC)
Deadline: July 15

Susan G. Komen for the Cure: Career Catalyst in Disparities Research
Full Application Deadline: July 31

Susan G. Komen for the Cure: Post-Baccalaureate Training in Disparities Research
Full Application Deadline: July 31

Doris Duke CSDA Bridge Grant
Deadline: September 1

Mesothelioma Applied Research Foundation
Deadline: September 15

NIH Bulletin – Notices and Funding Opportunities

Continuation of the NCI Program for Rapid, Independent Diagnostic Evaluation (PRIDE) of Cancer Biomarkers (NOT-CA-08-023)

Letters of Intent Not Required for "Quick-Trials for Imaging and Image-Guided Interventions: Exploratory Grants (R21)"(NOT-CA-08-025)

Millennium Promise Awards: Non-communicable Chronic Diseases Research Training Program (NCoD)(D43)(PAR-08-175)

OLAW Institutional Official (IO) Outreach Program (NOT-OD-08-076)

OLAW IACUC Staff Outreach Program (NOT-OD-08-077) National Institutes of Health

Transforming Medicine Through Innovation: 10th Annual NIH SBIR/STTR Conference (July 22-23, 2008) (NOT-OD-08-079)

Delays in Grant Application Submission due to Floods – June 2008 (NOT-OD-08-080)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Green
11100 Euclid Avenue
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
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