Case Comprehensive Cancer Center Newsletter

May 5, 2008

JOURNAL OF CLINICAL ONCOLOGY: Multi-Institutional Phase I Trials of Anticancer Agents

One of the most difficult roadblocks to curing cancer is the time and delay associated with evaluating new cancer treatments. Afshin Dowlati, MD, Director of Early Drug Development at the Ireland Cancer Center at University Hospitals of Cleveland and the Case Comprehensive Cancer Center, recently published an international study entitled "Multi-Institutional Phase I Trials of Anticancer Agents" in the Journal of Clinical Oncology (April 20, 2008), assessing the multi-institutional approach taken by many cancer centers evaluating new cancer treatments during clinical trials of these agents. An editorial accompanying the article found the findings of Dowlati et al surprising, and predicted this study will change the approach taken by most centers in the years to come.

Contrary to what most would assume as true, Dr. Dowlati's article shows multi-institutional phase I studies as less effective than studies performed at a single institution. Performing such studies at a single institution resulted in faster results and more consistent data than studying the new treatment at multiple institutions simultaneously. When all of the patients on a trial are cared for by a small group of physicians, a more consistent evaluation of the new treatment is possible.

"We were somewhat surprised by the clear differences we observed. It reinforces our approach at the Ireland Cancer Center, to emphasize clinical trials in which we take the lead and conduct the evaluation of new treatments in a focused and dedicated manner. In the end this will help patients more than simply adding one or two patients to a study conducted elsewhere," stated Dr. Dowlati.

To view the full article text, click here.


FUNDING OPPORTUNITY– Susan G. Komen for the Cure: Career Catalyst in Disparities Research

Susan G. Komen for the Cure is currently accepting applications for Career Catalyst in Disparities Research (CCDR) awards. These awards provide a unique opportunity for scientists in the early stages of their career, particularly scientists from populations affected by disparities in breast cancer outcomes, to achieve research independence.

Pre-applications Deadline: June 10
Full Application Deadline: July 31

For more information, please click here.


FUNDING OPPORTUNITY– Susan G. Komen for the Cure: Post-Baccalaureate Training in Disparities Research

Susan G. Komen for the Cure has released an RFA for Post-Baccalaureate Training in Disparities Research (PBT-DR) awards. These awards provide an opportunity for individuals early in their education, particularly those from populations affected by disparities in breast cancer outcomes, and encourages them to seek careers focused on understanding and eliminating these disparities. This award provides individual support of $45,000 annually for 3 years for up to three trainees. Training programs provided with these funds are to supply the tools and environment in which students very early in their career can begin to define meaningful career paths focused on addressing disparities in breast cancer. The goal is to empower these students with the analytical, research, scientific, clinical, and public health skills necessary to effectively explore the basis for differences in breast cancer outcomes and to translate research discoveries into clinical and public health practice to eliminate breast cancer disparities.

Pre-application Deadline: June 19
Full application Deadline: July 31

For details, click here.


NCI CANCER BULLETIN

Featured Article
Costs of Cancer Care Estimated for Elderly Patients

Cancer Research Highlights
Cisplatin No Better than Standard Therapy for Anal Canal Cancer

Ovarian Epithelial Tumors Traced to Fallopian Tubes

Prognostic Test for Breast Cancer Profiles the Tumor Environment

Pesticide Linked to Testicular Cancer Risk

Director's Update: Guest Update by Dr. Lynn Matrisian
Accelerating Translational Research at NCI: The Next Steps


MARK YOUR CALENDARS– Cancer Health Disparities Summit

July 14-16
Bethesda North Marriott Hotel and Conference Center
Bethesda, MD

The National Cancer Institute (NCI) Center to Reduce Cancer Health Disparities (CRCHD) is pleased to present the Cancer Health Disparities Summit 2008, July 14–16, at the Bethesda North Marriott Hotel and Conference Center, Bethesda, Maryland. The overall theme for this year's Summit is Eliminating Cancer Health Disparities Through Science, Training, and Community. The Cancer Health Disparities 2008 will highlight the science of the programs and grantees funded through the CRCHD.

For more information, please click here.


MARK YOUR CALENDARS– Ohio Collaborative Conference on Bioinformatics

June 2-4, 2008
University of Toledo
Toledo, Ohio

The Third Annual Ohio Collaborative Conference on Bioinformatics will be held at the University of Toledo June 2-4. This conference will provide an interdisciplinary forum for discussing approaches, research findings, and experiences regarding computational investigations of biological problems. An important goal of the conference continues to be the fostering of long-term collaborative relationships among informatics and life sciences researchers from academia, government and industry, spanning Ohio and adjacent states. This meeting is not only for experts in bioinformatics, but also for those who make substantial use of bioinformatic tools in their research/development work, or would like to expand such use.

For more information, please click here.

EVENTS

**All events are open to anyone interested in attending

May 5

Cancer Genetics/ Biology Journal Club
Patrick Ma, MD
Assistant Professor, Medicine- Hem/Onc
CWRU/ UH
Topic: Targeted Inhibition in Lung Cancer: Studies in EGFR and MET
12:00 pm WRB 2-136


May 6


May 7

Grand Rounds
Shanmuga Subbiah, MD
Fellow, Division of Hem/Onc
CWRU/ UH
Topic: TBA
8:00 am Lerner B-151


May 8

Biochemistry Seminar
Chih-Cheng Tsai, PhD
Assistant Professor, Physiology & Biophysics
Robert Wood Johnson Medical School
Topic: Atrophin Recruits Chromatin Modifying Factors to Silence Gene Transcription and to Determine Cell Fates
12:00 pm SOM W428

Taussig Cancer Center Core Curriculum Series
Christina Rodriguez, MD
Taussig Cancer Center
Cleveland Clinic
Topic: Nasopharyngeal Carcinoma
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
John Stahl, MD
Associate Professor, Neurology
CWRU/ UH
Topic: Through the Eyes of Mice: Exploring Cerebellar Function Via the Eye Movements of P/Q Calcium Channel Mutants
12:10 pm BRB 105

Aging-Cancer Research Seminar
Kathleen Smyth, PhD
Associate Professor, Center for Memory and Aging
CWRU
AND
Siran Koroukian, PhD
Assistant Professor, Epidemiology & Biostatistics
CWRU
Topic: Examining the Impact of Antecedent Dementia on Breast Cancer Screening, Diagnosis and Treatment Decisions: Qualitative and Quantitative Methods and Results
4:00 pm BRB 732


May 9

Hematology/Oncology Fellows
Alan Sandler, MD
Associate Professor of Medicine- Hematology/Oncology
Vanderbilt-Ingram Cancer Center
Topic: Complex Cases in NSCLC
8:00 am Wearn 137

Taussig Cancer Center Grand Rounds
Anjali Advani, MD
Assistant Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Acute Lymphocyctic Leukemia: New Therapeutic Strategies
8:00am Cleveland Clinic R3/002-003

Cell Biology Seminar
Kathleen Boris-Lawrie, PhD
Professor, Veterinary Biosciences
Ohio State University
Topic: Translation of Complex mRNAs: Lessons from Study of Retroviruses
10:00am Cleveland Clinic NC1-202

Cancer Center Seminar Series/ Blood Club
Benjamin Neel, MD, PhD
Director, Ontario Cancer Institute
Princess Margaret Hospital
Topic: Shp2 in Hematopoiesis and Leukemia
12:00 pm BRB 105

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

**For more information on these symposiums, please contact Christine Rhoads.

Annual Update on Breast Cancer: Highlights of the National Meetings
June 13
Hilton Cleveland East, Beachwood
Course Directors: Janice Lyons, MD, Halle Moore, MD, and Paula Silverman, MD
Brochure and Registration

ASCO Review 2008
June 27
InterContinental Hotel & Bank of America Conference Center
Course Directors: Robert Dreicer, MD and Hillard Lazarus, MD
Brochure and Registration

Head and Neck Conference
October 31
Holiday Inn, Independence
Details to follow


MARK YOUR CALENDARS– ASCO Annual Meeting

May 30 - June 3
McCormick Place
Chicago, IL

The American Society of Clinical Oncology (ASCO) Annual Meeting is scheduled for May 30- June 3 in Chicago. This meeting is the premier scientific and educational event in oncology, drawing 30,000 attendees worldwide. As a forum for collaboration and communication, the ASCO Annual Meeting brings together oncologists of all disciplines, researchers, nurses, and patient advocates in the fight against cancer. The 2008 Meeting will unite the global oncology community with the common goals of delivering the highest quality patient care and innovating treatment advances.

For details, please click here.

If anyone is presenting at the Meeting, please let us know. As always, we are happy to publicize any news you have, such as major presentations, publications, awards, etc.


FUNDING OPPORTUNITY– Case CCC Request for Pilot Project Applications

The Case CCC is currently accepting applications for a "Multi-Investigator Grant Initiative to Promote the Basic Science Scientific Focus Group Areas of the Cancer Center". Awards of up to $50,000 for 1 year are available.

Principal Investigators must be full-time members of the faculty at Case Western Reserve University or Cleveland Clinic Lerner College of Medicine and members of the Case Comprehensive Cancer Center.

Application Deadline: May 27

To view the RFA, please click here. RFA, Instructions and Cover Sheet are also available on the Cancer Center homepage.


CASE CCC 2008 RETREAT

The Case CCC 2008 Retreat is scheduled for July 11-12 at Sawmill Creek Resort in Huron, Ohio. The 235-acre resort has many features, including an 18-hole golf course, charter fishing on a Lake Erie marina, restaurants, shops, indoor/outdoor pools, exercise room and tennis courts. Nearby is Cedar Point, wineries, the Lake Erie Islands, and Maritime Museums.

Details and an agenda will be circulated soon.


RACE FOR THE PLACE- Join Our Team!

The Case Comprehensive Cancer Center has created a team for the Race for the Place, a fundraiser that benefits The Gathering Place in Beachwood, Ohio.

For those of you that are not familiar with the Gathering Place, it is a support center providing programs and services free of charge for individuals and families touched by cancer.

Each year, the first Sunday in June (June 1, 2008) is National Cancer Survivors' Day. On this day, The Gathering Place hosts a 5K / 1 Mile event called Race for the Place. This event helps to raise the money that allows The Gathering Place to offer all of their services free of charge.

If you want to join the Case CCC team, please click here or email gillian.irwin@case.edu. Family and friends are also welcome to join our team! It really is a great experience for everyone who is involved.

If cannot run the race, but would still like to help, please consider making a small donation to sponsor our team. Every little bit helps. To sponsor us, please click here.


MARK YOUR CALENDARS– AACR Conference: Cancer Epigenetics

May 28-31
Boston Park Plaza Hotel
Boston, Massachusetts

This AACR special conference on cancer epigenetics will assemble prominent investigators in the field to discuss recent advances in this rapidly moving area. Sessions will review mechanisms and recent advances in whole genome epigenetic analysis of cancer. Several sessions will examine specific clinical applications such as diagnostics and therapeutics, and workshops will discuss practical research and translational issues such as methods of whole genome epigenetic analysis and definition of hypermethylator phenotypes. Ample time has been reserved for discussion, oral presentation of selected submitted abstracts, and late breaking research. This conference will provide a unique forum to review the remarkable progress in this area over the past few years, and provide a glimpse of where the field is moving, with a strong emphasis on translational epigenetics research.

For details and registration information, please click here.


MARK YOUR CALENDARS–AACR Accelerating Anticancer Agent Development and Validation Workshop

June 18-20, 2008
North Bethesda, MD

This is a postgraduate workshop for clinical and translational investigations focused on strategic planning to develop and validate new anticancer and cancer prevention agents and pathways. This is an intensive and interactive workshop in how to design effective strategies– from clinical trial initiative, to enabling trials, to pivotal efficacy trials– to develop new anticancer and prevention agents, taught by a distinguished faculty from across the academic, industry, consumer, and government (FDA) sectors.

For more information, click here.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

DOD PCRP Idea Development Award
Pre-App/LOI Deadline: May 22

DOD PCRP New Investigator Award
Pre-App/LOI Deadline: May 22

DOD PCRP Prostate Cancer Training Award
Pre-App/LOI Deadline: May 22

DOD PCRP Physician Research Training Award
Pre-App/LOI Deadline: May 22

DOD PCRP Collaborative Undergraduate HBCU Student Summer Training Program Award Award
Pre-App/LOI Deadline: May 22

DOD PCRP Synergistic Idea Development Award
Pre-App/LOI Deadline: May 22

Administrative Supplements for Making Knockout Mice
Deadline: June 1

Damon Runyon-Rachleff Innovation Award
Pre-Proposal Deadline: June 2

DOD PRMRP Investigator-Initiated Research Award
Pre-App Deadline: June 4

DOD PRMRP Investigator-Initiated Research Award (Specific appropriation for bone marrow failure disorder research)
Pre-App Deadline: June 4

DOD PRMRP Translational Research Award
Pre-App Deadline: June 4

DOD PRMRP Advanced Technology/Therapeutic Development Award
Pre-App Deadline: June 4

DOD PRMRP Clinical Trial Award
Pre-App Deadline: June 4

DOD PCRP Clinical Consortium Agreement
Pre-App/LOI Deadline: June 11

DOD PCRP Clinical Trial Award
Pre-App/LOI Deadline: June 11

DOD PCRP Health Disparity Research Award
Pre-App/LOI Deadline: June 11

DOD PCRP Health Disparity Training Award
Pre-App/LOI Deadline: June 11

DOD PCRP Laboratory-Clinical Transition Award: Stage 1
Pre-App/LOI Deadline: June 11

DOD OCRP Consortium Development Award
Pre-Application Deadline: June 25

DOD PCRP Laboratory-Clinical Transition Award: Stage 1
LOI Deadline: June 30

DOD PRMRP Investigator-Initiated Research Award
Proposal Deadline: July 2

DOD PRMRP Investigator-Initiated Research Award (Specific appropriation for bone marrow failure disorder research)
Proposal Deadline: July 2

DOD PRMRP Translational Research Award
Proposal Deadline: July 2

DOD PRMRP Advanced Technology/Therapeutic Development Award
Proposal Deadline: July 2

DOD PRMRP Clinical Trial Award
Proposal Deadline: July 2

DOD OCRP Consortium Development Award
Proposal Deadline: July 9

Doris Duke CSDA Bridge Grant
Deadline: September 1


NIH Bulletin – Notices and Funding Opportunities

Request for Information (RFI): Priorities for Cancer-oriented Research and Development by Small Businesses (NOT-CA-08-015)

Change In the Implementation of Expanded Authority For PAR 08-120 Titled "Cancer Education Grants Program (R25)"(NOT-CA-08-016)

Change in Scientific Contact for PA-08-156 and PA-08-157, Biomarkers of Infection-Associated Cancers (R01 and R21, respectively)(NOT-CA-08-021)

Community Clinical Oncology Program (U10) (RFA-CA-08-015) National Cancer Institute

Minority-Based Community Clinical Oncology Program (U10) (RFA-CA-08-016)

Stem Cells and Cancer (R21) (PA-08-165)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Green
11100 Euclid Avenue
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.green@uhhospitals.org
 
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