Case Comprehensive Cancer Center Newsletter

April 14, 2008

FUNDING OPPORTUNITY– Case CCC Request for Pilot Project Applications

The Case CCC is currently accepting applications for a "Multi-Investigator Grant Initiative to Promote the Basic Science Scientific Focus Group Areas of the Cancer Center". Awards of up to $50,000 for 1 year are available.

Principal Investigators must be full-time members of the faculty at Case Western Reserve University or Cleveland Clinic Lerner College of Medicine and members of the Case Comprehensive Cancer Center.

Application Deadline: May 27

To view the RFA, please click here. RFA, Instructions and Cover Sheet are also available on the Cancer Center homepage.


FUNDING OPPORTUNITY– Dana Foundation Brain and Immuno-Imaging Grant Program

CWRU SOM has been invited to submit TWO applications (one per Track A and Track B) to the Dana Foundation Brain and Immuno-Imaging Grant Program- Round 2 2008 (Using Brain and Immune Imaging Innovations to Improve Human Health).

The Dana Foundation supports research on imaging innovations that help reveal how the human brain functions normally, how disorders and injuries alter these functions, and how various therapies affect these conditions. Since immune cells are often integrally involved in the development of, protection against, or responses to brain diseases and injuries, funded research also can focus on immune cell interactions with brain cells. The Program is designed to enable investigators to obtain pilot data more quickly than is possible through other funding processes. Investigations must be applicable to human brain or brain-immune functioning or malfunctioning to be considered for funding.
Track A: Conventional imaging of anatomical or physiological brain functioning and should involve patient-oriented clinical research.
Track B: Cellular and molecular imaging and should have direct clinical relevance--should focus on the biological activities of human brain cells, or their interactions with immune cells in health and disease. These studies may involve human tissues or animal models.

Internal Deadline: April 24
External Deadline: May 20

Internal Contact: Richard Sohn, PhD richard.sohn@case.edu; 368-1158

If you are interested in applying, the following documents required:
1. Full CV with funding history
2. 1-2 page proposal with specific aims, and
3. Letter of support from your Chair
Send materials electronically to Richard.sohn@case.edu (please ONE document if feasible)

For details including eligibility requirements, please click here.


PRMC TEMPLATES

Any Case CCC Member submitting a member-initiated trial to the PRMC should use the templates provided on the PRMC webpage, accessible from the Clinical Research Portal. Please note that this area is password protected. Please contact David Goldblatt with any questions.


MARK YOUR CALENDARS– Research ShowCASE

Come and support your colleagues at the Research ShowCASE, April 16-17 in the Veale Convocation Center. Make sure you visit the Case CCC booth, which will feature the Case CCC Core Facilities and Training Programs. The Tissue Procurement & Histology Facility and the Transgenic & Targeting Facility will also have separate booths.

The following Cancer Center members will also be presenting their research: Drs. Elaine Borawski, Arnold Caplan, Shelley Francis, Marion Good, Neil Greenspan, Sanjay Gupta, Damir Janigro, Eric Juengst, Michael Lederman, Tomas Radivoyevitch, Christian Simon, Mark Smith, and Xiongwei Zhu.

Research ShowCASE features hundreds of Case faculty, staff, and students presenting their latest research and scholarship. For more information, please click here.


FUNDING OPPORTUNITY– V Foundation

The Case CCC has been invited to submit ONE application for the V Foundation Translational Grant. The purpose of this grant is to develop novel approaches to the prevention, detection and treatment of human cancer that requires collaboration of investigators from both the lab and the clinic.

If you are interested in applying, please submit abstract, biosketch and budget to Gillian Irwin (gmi@case.edu) by tomorrow, Tuesday, April 15. The full application of the selected team is due to the V Foundation by June 16.


FUNDING OPPORTUNITY– TREC

The Case Center for Transdisciplinary Research on Energetics and Cancer and the Case Comprehensive Cancer Center invite investigators to submit developmental projects in the area of nutrition, energetics, energy balance, obesity, physical activity and cancer. These projects should provide an avenue for introducing and integrating new investigators and innovative technologies, methodologies, and/or research in the TREC infrastructure.

Pilot projects can be funded though a maximum of $50,000 per year, direct cost and should be planned to lead to independent research funding preferably of the NIH R01 type.

Please send original application via e-mail to lcc3@case.edu by Thursday, May 1.

To view the RFA, please click here. To view the Application Facepage, please click here.


MARK YOUR CALENDARS– Cancer Immunology and Immunotherapy: Realizing the Promise

September 11-12
National Institutes of Health
Bethesda, MD

The Center for Cancer Research (CCR) at the National Cancer Institute will be hosting a two-day, national symposium entitled Cancer Immunology and Immunotherapy: Realizing the Promise. This meeting will host leaders in the field of cancer immunology and immunotherapy, include recent advances in both translational and clinical research, and should provide an exciting forum for discussion and debate on promising immunologic approaches to prevent and treat cancer.

Registration is free, but seating is limited so be sure to register early! Abstracts are being accepted for the poster session. Deadline for abstract submission is July 15.

For more information, please click here.


MARK YOUR CALENDARS– AACR Conference: Cancer Epigenetics

May 28-31
Boston Park Plaza Hotel
Boston, Massachusetts

This AACR special conference on cancer epigenetics will assemble prominent investigators in the field to discuss recent advances in this rapidly moving area. Sessions will review mechanisms and recent advances in whole genome epigenetic analysis of cancer. Several sessions will examine specific clinical applications such as diagnostics and therapeutics, and workshops will discuss practical research and translational issues such as methods of whole genome epigenetic analysis and definition of hypermethylator phenotypes. Ample time has been reserved for discussion, oral presentation of selected submitted abstracts, and late breaking research. This conference will provide a unique forum to review the remarkable progress in this area over the past few years, and provide a glimpse of where the field is moving, with a strong emphasis on translational epigenetics research.

Advance Registration Deadline: April 21

For details and registration information, please click here.


CANCER RELATED ARTICLE– "Meditations on a Cure"

Dr. Stan Gerson thought you may be interested in an article entitled, "Meditations on a Cure", that ran in the April 6 edition of the New York Times. In this article, the author, Tim Guertin, Chief Executive of Varian Medical Systems Instruments, reflects on the effect of cancer in his life and his role in finding a cure. To view the article, please click here.

EVENTS

**All events are open to anyone interested in attending

April 14

Cell Biology Seminar
Kerry-Anne Rye, PhD
Head, Lipid Research Group
Heart Research Institute
Topic: ApoA-I, ApoA-II and the Anti-Inflammatory Properties of HDL
10:00 am NC1-202 Cleveland Clinic

Cancer Genetics/ Biology Journal Club
Sergei Merkoulov, PhD
Research Associate, McCrae Lab
Division of Hem/Onc
CWRU/ UH
Topic: Defective Angiogenesis, Endothelial Migration, Proliferation, and MAPK Signaling in Rap1b-deficient Mice
AND
Matt Lesniewski, PhD
Research Associate, Laughlin Lab
Division of Hem/Onc
CWRU/UH
Topic: Smad3 and NFAT Cooperate to Induce Foxp3 Expression Through Its Enhancer
12:00 pm WRB 2-136

Physiology & Biophysics Seminar
Colleen Clancy, PhD
Assistant Professor, Physiology & Biophysics
Institute for Computational Biomedicine
Weill College of Cornell University
Topic: Math Instead of Mice: Insights into Electrically Based Disease
4:00 pm SOM E301


April 15

Taussig Cancer Center Core Curriculum Series
Ramon Tiu, MD
Taussig Cancer Center
Cleveland Clinic
Topic: The Philadelphia Chromosome Negative Myeloproliferative Disorders
12:00 pm R3-002 Cleveland Clinic


April 16

Neurosurgery Grand Rounds
Lilyanna Angelov, MD
Staff, Brain Tumor and Neuro-Oncology Center
Cleveland Clinic
Topic: Primary CNS Lymphoma An Update: The Internal Brain Barrier Disruption Experience
7:30 am TT1-100 Cleveland Clinic

Grand Rounds
Alvin H. Schmaier, MD
Professor, Medicine- Hem/Onc
CWRU/ UH
Topic: The Influence of the Plasma Kallikrein Kinin System on Vascular Biology
8:00 am Lerner B-151

Developmental Therapeutics Meeting
5:00 pm WRB 2-136


April 17

Neurosciences Seminar
Roberta Diaz Brinton, PhD
Professor, Molecular Pharmacology & Toxicology
University of Southern California
Topic: Estrogen Mechanisms of Action in the Brain: Translational Pathway to Novel Therapeutics to Prevent Neurodegenerative Disease
12:10 pm BRB 105

Cancer Prevention & Control Seminar
Elaine Borawski, PhD
Associate Professor, Epidemiology & Biostatistics
CWRU
Topic: Developing a Neighborhood-Level and Community-Driven Intervention to Increase Healthy Food Options and Decrease Youth Exposure to Tobacco and Alcohol: A Proposal
3:30 pm Wearn 137

Physiology & Biophysics Seminar
Michaela Jansen, PhD
Physiology & Biophysics
Akabas Laboratory
Albert Einstein College of Medicine of Yeshiva University
Topic: Investigating the Structure and Function of Cys Loop Receptors
4:00 pm SOM W203

TREC Seminar
Joseph Nadeau, PhD
Professor, Genetics
CWRU/ UH
Topic: Interacting Genes in Different Generations, the "Missing Heritability"?
4:00 pm BRB 732


April 18

Update on Cervical Cancer Prevention: New Technology, New Evidence, and New Recommendations
April 18
Ritz Carlton Cleveland
Course Directors: Steven Waggoner, MD and Kristine Zanotti, MD
Brochure and Registration

Hematology/Oncology Fellows
Shan Subbiah, MD
Fellow, Division of Hem/Onc
CWRU/ UH
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Center Grand Rounds
Mark Socinski, MD
Associate Professor, Clinical Research- Hem/Onc
University of North Carolina
Topic: Lung Cancer
8:00 am Cleveland Clinic R3/002-003

Cancer Center Seminar Series/ Blood Club
Ken Cooke, MD
Associate Professor, Medicine-Hem/Onc
CWRU/ UH
Topic: Mechanisms of Pulmonary Dysfunction After Allogeneic Bone Marrow Transplantation
12:00 pm BRB 105

Genomic Medicine Institute
Joseph Testa, PhD
Director, Human Genetics Program
Fox Chase Cancer Center
Topic: Molecular Pathways in Malignant Mesothelioma Pathogenesis: Lessons from Human Cell Lines and Mouse Models
2:00 pm NE1-205 Cleveland Clinic

more

For a complete listing of LRI seminars click here.


MARK YOUR CALENDARS:

UPCOMING CANCER CENTER SYMPOSIUMS

**For more information on these symposiums, please contact Christine Rhoads.

Annual Update on Breast Cancer: Highlights of the National Meetings
June 13
Hilton Cleveland East, Beachwood
Course Directors: Janice Lyons, MD, Halle Moore, MD, and Paula Silverman, MD
Brochure and Registration

Head and Neck Conference
October 31
Holiday Inn, Independence
Details to follow


MARK YOUR CALENDARS– AACR Centennial Conference

July 20-23
Hyatt Regency Monterey
Monterey, California

The AACR Centennial Conference on Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine is the second in the AACR Centennial Conference series on Translational Cancer Medicine and the first to be held in the United States. Translational research is a key programmatic priority of the AACR, and this meeting will showcase the latest scientific discoveries from the laboratory and their clinical applications.

Deadline for abstract submission, award opportunities, and early registration is May 2.

For more information, please click here.


MARK YOUR CALENDAR– AACR Annual Meeting 2008

The Case CCC has 62 members participating in 57 presentations at the American Association for Cancer Research (AACR) Annual Meeting scheduled for April 12-16 in San Diego, CA. In addition, Dr. Balazs Halmos is Chairperson of the Minisymposium, Molecular Markers for Cancer Diagnosis and Determination of Patient Outcomes on April 15. To view the Meeting Program, please click here.


CASE CCC 2008 RETREAT

The Case CCC 2008 Retreat is scheduled for July 11-12 at Sawmill Creek Resort in Huron, Ohio. The 235-acre resort has many features, including an 18-hole golf course, charter fishing on a Lake Erie marina, restaurants, shops, indoor/outdoor pools, exercise room and tennis courts. Nearby is Cedar Point, wineries, the Lake Erie Islands, and Maritime Museums.

Details and an agenda will be circulated soon.


RACE FOR THE PLACE- Join Our Team!

The Case Comprehensive Cancer Center has created a team for the Race for the Place, a fundraiser that benefits The Gathering Place in Beachwood, Ohio.

For those of you that are not familiar with the Gathering Place, it is a support center providing programs and services free of charge for individuals and families touched by cancer.

Each year, the first Sunday in June (June 1, 2008) is National Cancer Survivors' Day. On this day, The Gathering Place hosts a 5K / 1 Mile event called Race for the Place. This event helps to raise the money that allows The Gathering Place to offer all of their services free of charge.

If you want to join the Case CCC team, please click here or email gillian.irwin@case.edu. Family and friends are also welcome to join our team! It really is a great experience for everyone who is involved.

If cannot run the race, but would still like to help, please consider making a small donation to sponsor our team. Every little bit helps. To sponsor us, please click here.


MARK YOUR CALENDARS– NIH Symposium: Challenges & Promise of Cell-Based Therapies

May 6, 2008
Natcher Conference Center, NIH
Bethesda, MD

Mark your calendars for the upcoming NIH Symposium: Challenges & Promise of Cell-Based Therapies on May 6. A small group of outstanding scientists will discuss productive new directions for research in regenerative medicine and highlight the state-of-the-science, notable milestones, and general impediments to cell-based therapies. Don't miss out on this opportunity to learn from and network with some of the best experts in the field of regenerative medicine.

Please register by April 18, 2008, as a large number of attendees is expected and seating is limited. There is a $30 registration fee to attend. For more information and to register, please click here.


MARK YOUR CALENDARS–AACR Accelerating Anticancer Agent Development and Validation Workshop

June 18-20, 2008
North Bethesda, MD

This is a postgraduate workshop for clinical and translational investigations focused on strategic planning to develop and validate new anticancer and cancer prevention agents and pathways. This is an intensive and interactive workshop in how to design effective strategies– from clinical trial initiative, to enabling trials, to pivotal efficacy trials– to develop new anticancer and prevention agents, taught by a distinguished faculty from across the academic, industry, consumer, and government (FDA) sectors.

For more information, click here.



PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Prostate Cancer Foundation Young Investigator Awards
Deadline: April 16

DOD BCRP Idea Award
Pre-App/LOI Deadline: April 16

DOD BCRP Impact Award
Pre-App/LOI Deadline: April 16

DOD BCRP Synergistic Idea Award
Pre-App/LOI Deadline: April 16

NIH/Fogarty International Clinical Research Fellowships
Deadline: April 30

William Bingham Foundation
Deadline: April 30

HHMI Early Career Scientist Competition
Mandatory LOI Deadline: April 30

DOD PCRP Idea Development Award
Pre-App/LOI Deadline: May 22

DOD PCRP New Investigator Award
Pre-App/LOI Deadline: May 22

DOD PCRP Prostate Cancer Training Award
Pre-App/LOI Deadline: May 22

DOD PCRP Physician Research Training Award
Pre-App/LOI Deadline: May 22

DOD PCRP Collaborative Undergraduate HBCU Student Summer Training Program Award Award
Pre-App/LOI Deadline: May 22

DOD PCRP Synergistic Idea Development Award
Pre-App/LOI Deadline: May 22

Administrative Supplements for Making Knockout Mice
Deadline: April 1 and June 1

Damon Runyon-Rachleff Innovation Award
Pre-Proposal Deadline: June 2

DOD PRMRP Investigator-Initiated Research Award
Pre-App Deadline: June 4

DOD PRMRP Investigator-Initiated Research Award (Specific appropriation for bone marrow failure disorder research)
Pre-App Deadline: June 4

DOD PRMRP Translational Research Award
Pre-App Deadline: June 4

DOD PRMRP Advanced Technology/Therapeutic Development Award
Pre-App Deadline: June 4

DOD PRMRP Clinical Trial Award
Pre-App Deadline: June 4

DOD PCRP Clinical Consortium Agreement
Pre-App/LOI Deadline: June 11

DOD PCRP Clinical Trial Award
Pre-App/LOI Deadline: June 11

DOD PCRP Health Disparity Research Award
Pre-App/LOI Deadline: June 11

DOD PCRP Health Disparity Training Award
Pre-App/LOI Deadline: June 11

DOD PCRP Laboratory-Clinical Transition Award: Stage 1
Pre-App/LOI Deadline: June 11

DOD OCRP Consortium Development Award
Pre-Application Deadline: June 25

DOD PCRP Laboratory-Clinical Transition Award: Stage 1
LOI Deadline: June 30

DOD PRMRP Investigator-Initiated Research Award
Proposal Deadline: July 2

DOD PRMRP Investigator-Initiated Research Award (Specific appropriation for bone marrow failure disorder research)
Proposal Deadline: July 2

DOD PRMRP Translational Research Award
Proposal Deadline: July 2

DOD PRMRP Advanced Technology/Therapeutic Development Award
Proposal Deadline: July 2

DOD PRMRP Clinical Trial Award
Proposal Deadline: July 2

DOD OCRP Consortium Development Award
Proposal Deadline: July 9

Doris Duke CSDA Bridge Grant
Deadline: September 1


NIH Bulletin – Notices and Funding Opportunities

NIH Announces the Posting of Updated Frequently Asked Questions (FAQs) on Financial Conflict of Interest Requirements for All NIH-Supported Institutions (NOT-OD-08-063)

Revised NIH Parental Leave Policy for the Ruth L. Kirschstein NRSA Awards (NOT-OD-08-064)

Revision of NIH Policy Concerning Concurrent Support from Mentored Career Development (K) Award and a Research Grant (NOT-OD-08-065)

In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01)(PA-08-140)

In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R21) (PA-08-141)

Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01) (PA-08-143)

Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R21)(PA-08-144)

Genetic Screens to Enhance Zebrafish Research (R01) (PAR-08-138)

Enhancing Zebrafish Research with Research Tools and Techniques (R01) (PAR-08-139)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

Janice Green
11100 Euclid Avenue
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
janice.green@uhhospitals.org
 
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