Case Comprehensive Cancer Center Newsletter

October 6, 2008

DIRECTOR'S UPDATE- ACS Institutional Research Grants

The Case Comprehensive Cancer Center is pleased to announce the successful competition of the American Cancer Society Institutional Research Grant (IRG), resulting in four awards to Cancer Center faculty members. Junior faculty with clear independent research were eligible to apply for these awards. After careful scientific review of the 14 applications received, the review committee, chaired by Dr. Ed Stavnezer, identified four awards to be funded. Each funded project demonstrated outstanding potential to evolve into an NCI-funded application within the next 3 years.

The awardees are:

Hui Jin, PhD, Department of Pharmacology
Role of the Adaptor Protein Sh2-B in GH-Induced Growth and Progression of Prostate Cancer

Minh Lam, PhD, Department of Dermatology
Improve Efficacy in Clinical Trial of Primary and Metastatic Skin Cancer by Understanding the Early Events in the Fundamental Mechanism of Action in Pc 4-PDT Induced Cell Death

Brian Ragan, PhD, Department of Family Medicine
Improving Assessment of Cancer Related Risk Factors with Geospatial Technology

Keiko Tamai, PhD, Department of Genetics
Kaiso as a Bimodal Modulator in Wnt/b-catenin Pathway

These investigators will be asked to present their results either at the Cancer Center retreat, or at an upcoming retreat focused on all of the pilot grants awards of the past 2 years.

Congratulations to all.

Please note: The Cancer Center will be issuing another call for IRG projects in March 2009. Be sure to watch the newsletter and our website for the RFA.

Stan Gerson, MD
Director, Case CCC

NCI AWARDS–Avon Foundation; caBIG

The Case Comprehensive Cancer Center has received two awards from the NCI to promote our cancer research efforts:

I. Joe Baar, MD, Associate Professor of Medicine, Ireland Cancer Center and CWRU, and member of the Breast Cancer Clinical Trials Team, received the "Progress for Patients" award for his grant, MUC1 and Poly-ICLC Vaccine for Triple-Negative Breast Cancer. This highly competitive award is part of a program co-sponsored by the NCI along with funds from the Avon Foundation to promote innovative clinical trials research in breast cancer. Funds will be used to initiate the first breast cancer vaccine trial in high risk patients using the MUC1 antigen. Dr. Baar and his colleagues have identified that this antigen is expressed on breast cancer cells and that the MUC1 antigen can invoke an immune response. The trial will assess immunologic response, tolerance and time to recurrence.

II. The Case CCC has been awarded funding to implement tools developed for the biomedical information systems that support cancer research. The Cancer Biomedical Informatics Grid (caBIG) tools support clinical trials, imaging, tissue banking, and integrative cancer research. The award partially supports a staff member to assess and prepare the cancer center to implement appropriate caBIG tools. For more information on this award, please click here.


Please join us in welcoming the following new members of the Case CCC:

Helene Bernstein, MD, PhD
Visiting Associate Professor, Reproductive Biology
Stem Cells and Hematologic Malignancies Program

Mukesh Jain, MD
Professor, Medicine- Cardiology
Developing Program in Cancer-Vascular Biology

Ofer Reizes, PhD
Assistant Professor, Cell Biology
Aging-Cancer Research

FUNDING OPPORTUNITY– Landon Foundation-AACR Innovator Awards

The Landon Foundation and AACR have paired up to offer the following opportunities in cancer research:

Landon Foundation-AACR Innovator Award for Cancer Prevention Research
The Landon Foundation-AACR Innovator Award recognizes outstanding achievement by junior faculty in cancer prevention research in any discipline across the continuum of research. The Award is open to candidates at the level of Assistant Professor at any research institution in the world who completed postdoctoral studies or clinical fellowships on or after July 1, 2006. For details, please click here.

Landon Foundation-AACR Innovator Award for International Collaboration
The Landon Foundation-AACR Innovator Award for International Collaboration provides a two-year, $100,000 institutional grant to support direct research expenses, training and travel relevant to the collaboration. The Award is open to two or more independent researchers working within an established international cancer research collaboration. The co-investigators may be affiliated with any institution involved in cancer research, cancer medicine, or cancer-related biomedical science anywhere in the world; however, the co-investigators may not be affiliated with the same institution nor with institutions within the same country. For details, please click here.

Deadline for both awards is November 20

FUNDING OPPORTUNITY– Prostate Cancer Foundation Creativity Awards

The Prostate Cancer Foundation (PCF) is pleased to announce a funding mechanism for supporting transformational prostate cancer research through development of creative research ideas with high potential and no current funding. We seek applications from individuals proposing high-risk/high-reward concepts that if successful, could provide the basis for dramatically reducing death and suffering from prostate cancer. Creativity awards are intended to bridge the gap between an idea and the results necessary to justify longer term and more significant funding.

High priority for funding will be given to exceptional proposals that bring NEW research methods and techniques in life, physical, or computational sciences to solving the prostate cancer problem that have not previously been directed against prostate cancer. Applicants who have not historically worked in prostate cancer, but are proposing creative hypotheses and research plans for our field, are highly encouraged to apply. Originality and novelty will be rewarded in the peer review process. Potentially high impact basic science programs will be considered with high priority given to exceptional proposals that have the potential to be translated towards clinical investigations or provide "proof of principle".

Deadline: November 21

For details, please click here.

FUNDING OPPORTUNITY– ACS MEN2 Thyroid Cancer Professorship

The American Cancer Society (ACS) is currently accepting applications for the ACS MEN2 Thyroid Cancer Consortium Professorship. The Consortium will be led by a single renowned senior scientist who will be awarded the American Cancer Society MEN2 Thyroid Cancer Professorship and act as leader for the overall program. Appropriate areas of investigation include, but are not limited to: understanding consequences of RET mutations, molecular events underlying the development of MEN2-related tumors, improved animal models of MEN2, new screening and monitoring tools, new imaging approaches, and new pharmacologic and other strategies to blunt the effects of RET mutations.

This award is intended for an outstanding mid-career investigator who has made a seminal contribution and who continues to provide leadership in this general research area. Applications are requested from distinguished investigators in an area that includes multiple endocrine neoplasia type 2 research, including research in the areas of genetics, pathogenesis, diagnosis or treatment of medullary thyroid cancer.

Application Deadline: December 15

For details, please click here.


**All events are open to anyone interested in attending

October 6

Hematology/Oncology Research In Progress Seminar
Sergei Merkulov, PhD
Research Associate, McCrae Lab, Div. of Hem/Onc
Topic: Reengineering Glutathione S-Transferase: Implications for Design of a Protein Drug
12:00 pm WRB 2-136

Pathology Research Seminar Series
Taewhan Kim
Student, Pathology
Topic: Dissertation Defense: The Role of IRAK4 Kinase Activity in TLR-Mediated Signaling Pathway
12:00 pm WRB 1-413

Physiology & Biophysics Seminar
Harihara Baskaran, PhD
Associate Professor, Chemical Engineering
Topic: Engineering Tools to Investigate Cell Migration
4:00 pm SOM E501

Skeletal Research Center Seminar
Luis Solchaga, PhD
Instructor, General Medical Sciences- Oncology
Topic: Spotty Data (The Immunosuppressive Potential of hMSCs)
4:00 pm Millis 123

October 7

Taussig Cancer Center Core Curriculum Series
Matt Kalaycio, MD
Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: Overview of CML
12:00 pm R3-002 Cleveland Clinic

October 8

Grand Rounds
Kevin Bunting, PhD
Associate Professor, Medicine-Hem/Onc
Topic: Novel Approaches for Hematopoietic Stem Cell Transplantation
8:00 am Lerner B-151

CSCRM Seminar
Marc Penn, MD, PhD
Medical Director, Cardiac Intensive Care
Cleveland Clinic
Rahul Aras, PhD
President and CEO, AcelleRX Therapeutics, Inc.
Topic: SDF-1 Gene Therapy: A Biopharmaceutical Approach to Regenerative Medicine
4:30 pm Cleveland Clinic NA5-08

October 9

Taussig Cancer Institute Core Curriculum Series
Brian Bolwell, MD
Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: An Introduction to Bone Marrow Transplantation
12:00 pm R3-002 Cleveland Clinic

Practice-Based Research Network Seminar
Topic: Human Subjects Protection and Data Privacy in PBRN Research
6:00 pm Cuyahoga County Coroner's Office

October 10

Hematology/Oncology Fellows Seminar
Ajita Narayan, MD
Fellow, Div. of Hem/Onc
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Institute Grand Rounds
Ellen Jones, MD, PhD
Associate Professor, Radiation Oncology
Duke University
Topic: Hyperthermia in Oncology: Recent and Ongoing Clinical Trials
8:00 am R3/002-003 Cleveland Clinic

Cell Biology Seminar
Joyce Bischoff, PhD
Associate Professor, Surgery
Children's Hospital of Boston
Topic: Tissue Vascularization Using Blood and Bone Marrow-Derived Progenitor Cells
10:00 am NC1-202

Blood Club
David Danielpour, PhD
Associate Professor, General Medical Sciences- Oncology
Topic: TGF-beta Signaling and Its Deregulation in Prostate Epithelial Cells
12:00 pm BRB 105


For a complete listing of LRI seminars click here.



**For more information on these symposiums, please contact Christine Rhoads.

Family-Centered Care
March 21, 2009
Holiday Inn, Independence
Details to follow

Head and Neck Conference
April 17, 2009
Holiday Inn, Independence
Details to follow

FUNDING OPPORTUNITY– Chemical Biology Consortium

NCI, through its Operations and Technical Support Prime Contractor SAIC-Frederick, Inc., is seeking input and ideas from the scientific community and the biotechnology and pharmaceutical sector about an innovative initiative that will bridge the gap between basic scientific findings and NCI-supported clinical research and in the process establish the NCI as a leader in he area of innovative cancer therapeutics discovery.

The RFI addresses the feasibility of establishing an integrated network of chemical biologists, molecular oncologists, and screening centers from government, industry, and academia with specific drug development skills and expertise to address unmet needs in therapeutic oncology. NCI is calling this network the Chemical Biology Consortium (CBC). The response to this RFI will be used to assess the feasibility of assembling a consortium of experts to participate in the NCI's new Drug Discovery and Development Platform, whose mission is to advance first-in-class, targeted molecular therapeutic agents to the clinic. CBC-related activities will span the entire spectrum from target identification and validation through proof-of-concept (POC) Phase I/II clinical trials. Project Teams will be formed with Project Team Leaders tasked with coordinating the discovery and development of novel cancer therapeutics in an environment that fosters open cooperation and communication.

Deadline: October 27

For more information, please click here.

FUNDING OPPORTUNITY– Susan G. Komen for the Cure Postdoctoral Fellowships

Susan G. Komen for the Cure has extended the Postdoctoral Fellowship pre-application deadline. Postdoctoral Fellowships seek to attract pre-faculty scientists into breast cancer by providing up to $60,000 annually over three years. Fellows develop skills and expertise in one of two research tracks, basic and translational research leading to reductions in breast cancer incidence and/or mortality. Pre-applications are required prior to starting a full application. To view the RFA, please click here.

Pre-application Deadline: October 17
Full Application Deadline: November 20

CALL FOR NOMINATIONS– AACR Future Leaders Symposium

The AACR Associate Member Council seeks institutional nominations of outstanding and innovative young investigators as speakers for the third annual Future Leaders Special Symposium to be held during the AACR 100th Annual Meeting, April 18-22, 2009 in Denver, CO. This is an unprecedented opportunity, during the world's largest meeting for cancer researchers, to showcase how your institution is contributing to the future of cancer research!

Each institution may submit two nominations, but the nominees must represent different areas of cancer research (e.g., laboratory, clinical, or translational research, epidemiology, etc.).

If you would like to nominate someone for this opportunity, please contact Gillian Irwin ( by Wednesday, October 15.

For details, please click here.


World Cancer Research Fund International
Deadline: October 13

Canary Foundation/ACS Postdoctoral Fellowship in the Early Detection of Cancer
Deadline: October 15

NCI Clinical Investigator Development Program
Deadline: October 15

ACS Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Nomination Deadline: October 15

AACR-Rosenthal Family Foundation Award
Nomination Deadline: October 15

AACR GHA Clowes Memorial Award
Nomination Deadline: October 15

AACR/American Cancer Society Award for Research Excellence in Cancer Epidemiology & Prevention
Nomination Deadline: October 15

AACR Award for Outstanding Achievement in Cancer Research
Nomination Deadline: October 15

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Nomination Deadline: October 30

Multidisciplinary Clinical Research Training Program Clinical Research Scholars
Deadline: November 4

Susan G. Komen Promise Grants
Full Application Deadline: December 4

Sallie Rosen Kaplan Fellowship
Deadline: December 15

NCI Short-Term Scientist Exchange Program
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Exploratory Studies in Cancer Detection, Diagnosis, and Prognosis (R21) (PA-08-267)

Non-Competing Grant Awards under the Current Continuing Resolution (NOT-OD-09-002)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Green
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
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