Case Comprehensive Cancer Center Newsletter

October 27, 2008

MARK YOUR CALENDARS- Case CCC Scientific Retreat 2009

The Case CCC Scientific Retreat has been scheduled for July 10-11, 2009 at Sawmill Creek Resort in Huron, Ohio. We hope everyone is able to attend. Details will be released in the coming months.


Congratulations to the following Cancer Center members who were recently awarded pilot project grants from the Case Western University Clinical and Translational Science Collaborative (CTSC):

Henry B. Koon, MD- Identification of Genomic Lesions Promoting Nodal Metastasis in Malignant Melanoma

Mark D. Adams, PhD- Development of a Rapid Molecular Assay to Predict Antibiotic Susceptibility in the Nosocomial Pathogen Acinetobacter Baumannii

James P. Basilion, PhD- Molecular Imaging of Dysplasia in Barrett's Esophagus

Amy Wilson-Delfosse, PhD- Establishment of a CTSC Parkinson's Disease Phenotypic and Genotypic Registry

For more information about the CTSC and these pilot projects, please click here.


Gabrielle Brett received the 2008 J. Nick Baird Outstanding Cancer Professional Award from the Ohio Partners for Cancer Control at its October 17 annual meeting. Ms. Brett is the Northern Ohio Partnership Program Coordinator for the National Cancer Institute's Cancer Information Service (CIS), a position funded by the NCI.

The award honors Ms. Brett for "actively promoting and putting into practice the goals of the Ohio Cancer Plan" and acknowledges her commitment to "making cancer history for all Ohioans." She devotes much of her effort to reducing health disparities by reaching minorities and medically underserved populations with cancer information.

Ms. Brett supports more than 30 Ohio and regional cancer organizations, health professionals, community groups and coalitions in 11 counties. Her home office is at the Ireland Cancer Center of University Hospitals Case Medical Center in Cleveland.

Ireland Cancer Center Director Stanton L. Gerson, MD, nominated Ms. Brett for the award, saying, "Although she is not a cancer center employee, we are well aware of Ms. Brett's regional outreach initiatives to provide NCI information on cancer prevention, treatment and research and network building. We are lucky to have her striving to reduce the cancer burden throughout the state."

Of her work, Ms. Brett says, "Information is key when it comes to improving cancer outcomes or making decisions about risk reduction, as I know all too well. I am thrilled to be in a position where I can share that information with organizations and community members, and I hope that our combined efforts will have a lasting impact."

Ms. Brett and her husband live in Cleveland Heights.

--Written by Pat Faller

MESSAGE FROM NCI- New Clinical Trials Reporting Requirements Take Effect January 2009

The National Cancer Institute (NCI) announces a change in how clinical trials and studies are registered and reported and will launch its Clinical Trials Reporting Program (CTRP) on January 5, 2009. NCI grantees are currently subject to reporting requirements, but starting in 2009, a new set of reporting requirements will apply. Additional registration is not required for trials already reported to CTEP/DCP as NCI will transfer the information.

Starting in January 2009, grantees are to register all new interventional trials and observational studies within 21 days of activation using an online portal or an automated batch upload system. Requested data elements are similar to the ones grantees currently complete for NCI. In addition, grantees will upload supporting documents such as the protocol document, informed consent, IRB approval and a list of participating sites for multi-center studies. Also, over the first six months of 2009, grantees are to register all ongoing interventional trials and observational studies.

For the second half of 2009 and onward, grantees are to electronically submit data from all NCI-funded and sponsored trials and studies that have been registered in the CTRP at intervals specified in the data reporting mechanism. Data will include, but not be limited to, trial and study amendments and select patient demographics.

The CTRP goal is to provide NCI with a more global view of emerging knowledge from cancer trials and to identify important patterns and insights in a timely way in order to assure patient safety and an optimal return on the nation's investment in cancer clinical trials. This goal enhances NCI's commitment to protecting human research participants in NCI-supported trials, safeguarding the integrity of the data resulting from this research, and applying measures that enable effective monitoring of research.

More detailed information about the CTRP requirements will follow through December 2008. For more information about this program please click here.

FUNDING OPPORTUNITY– ASCO Cancer Foundation Translational Research Professorship

The ASCO Cancer Foundation is accepting applications for the Translational Research Professorship. This Professorship provides funds to translational researchers who have made significant contributions to the direction of cancer research. Furthermore, it is expected that these researchers will continue to provide leadership in their research area. In general, applicants must hold the rank of full professor (or equivalent) at an academic medical center.

Letter of Intent Deadline: November 20
External Deadline: January 22, 2009

For details, please click here.

FUNDING OPPORTUNITY– American Cancer Society (ACS) Audrey Meyer Mars International Fellowships in Clinical Oncology

The purpose of the Fellowships is to provide one year of advanced training in clinical oncology at participating cancer centers in the United States to qualified physicians and dentists from other countries, particularly countries where advanced training is not readily available. Applications for training in basic cancer research will not be accepted for the award.

Institutions, not prospective trainees, must submit applications for the American Cancer Society (ACS) Audrey Meyer Mars International Fellowships in Clinical Oncology. If you have someone you would like to nominate for this opportunity, please contact

Internal Deadline: November 14
External Deadline: December 1

For eligibility and other information, please click here.

FUNDING OPPORTUNITY– Charlotte Geyer Foundation

The Charlotte Geyer Foundation provides interim funding up to $100,000 to researchers who have submitted an original R01 or R21 proposal to the National Cancer Institute and have not received a fundable score. Researchers may apply to the Foundation as soon as NCI Summary Statements are received and before the proposal goes to Council.

Deadline: November 15

For details, please click here.


**All events are open to anyone interested in attending

October 27

Case CCC and Neurosciences Faculty Candidate Seminar
Jeongwu Lee, PhD
Staff Scientist, NCI, Neuro-Oncology Branch
Topic: Glioblastoma Initiating/ Stem Cells: The Biology and Therapeutic Implications
11:30 am SOM E501

Hematology/Oncology Research In Progress Seminar
Marvin Nieman, PhD
Instructor, Medicine- Hem/Onc
Topic: Protease Activated Receptor 4 (PAR4) Uses Anionic Residues to Interact with a-thrombin in the Absence and Presence of PAR1
12:00 pm WRB 2-136

Pathology Research Seminar Series
Qingzhong Kong, PhD
Assistant Professor, Pathology
Topic: Transmission of Cervid and Atypical Cattle Prions in Humanized Mouse Models
12:00 pm WRB 1-413

Physiology & Biophysics Seminar
Marco Brotto, PhD
Associate Professor, Nursing and Medicine
University of Missouri at Kansas City
Topic: Novel Insights into Muscle Aging and Sarcopenia: Roles of Calcium and MG29
4:00 pm SOM E501

October 28

Taussig Cancer Institute Core Curriculum Series
Mikkael Sekeres, MD
Assistant Professor, Hematology & Medical Oncology
CWRU/ Cleveland Clinic
Topic: MDS
12:00 pm R3-002 Cleveland Clinic

October 29

Grand Rounds
Gregory Cooper, MD
Professor, Medicine- Gastroenterology
Topic: Colorectal Cancer Screening and Surveillance
8:00 am Lerner B-151

October 30

TREC Seminar cancelled

Taussig Cancer Institute Core Curriculum Series
Lisa Sproat, MD
Taussig Cancer Center
Cleveland Clinic
Topic: Neutropenia
12:00 pm R3-002 Cleveland Clinic

Neurosciences Seminar
James Truman, PhD
Scientist, Janelia Farm
Howard Hughes Medical Institute
Topic: Neuronal Stem Cells: Units of Development and Function of the Drosophila Nervous System
12:10 pm SOM E501

Greenfield Lecture in Pharmacology
Mina Bissell, PhD
Distinguished Scientist, Life Sciences Division
Lawrence Berkeley National Laboratory
Topic: The Architectural Basis of Tissue Specificity: The Relationship Between the Genome and 3D Structure
4:00 pm BRB 105

Practice-Based Research Network Seminar
Topic: Quality Improvement Research
6:00 pm Cuyahoga County Coroner's Office

October 31

Taussig Cancer Institute Grand Rounds cancelled- SWOG

Hematology/Oncology Fellows
Rom Leidner, MD
Fellow, Division of Hem/Onc
Topic: TBA
8:00 am WRN 137

Cancer Center Seminar Series/ Blood Club
Laura Niedernhofer, MD, PhD
Assistant Professor, Microbiology and Molecular Genetics
University of Pittsburgh Cancer Institute
Topic: The Contribution of ERCC1-XPF DNA Repair Nuclease to Cancer and Aging
12:00 pm BRB 105


For a complete listing of LRI seminars click here.



**For more information on these symposiums, please contact Christine Rhoads.

Family-Centered Care
March 21, 2009
Holiday Inn, Independence
Details to follow

Head and Neck Conference
April 17, 2009
Holiday Inn, Independence
Details to follow

Ohio Collaborative Conference on Bioinformatics (OCCBIO)
June 15 - 17, 2009
CWRU campus
For details, click here.

Annual Breast Cancer Update: Highlights of the National Meetings
June 19, 2009
Marriott Cleveland East, Warrensville Heights
Details to follow


Featured Article
Study Suggests New Options for Follicular Lymphoma

Cancer Research Highlights
Gene Signature May Predict Recurrence of Liver Cancer

One in Four Teenage Girls Receives HPV Vaccine

Smoking in Middle Age Decreases Quality of Life in Old Age

More Evidence for Role of ALK in Neuroblastoma

Director's Update
Remembering a Leading Advocate for Cancer Research

FUNDING OPPORTUNTY– Breast Cancer Research Program

The Department of Defense recently released the Program Announcement for the Breast Cancer Research Program (BCRP) FY08 Concept Award and Postdoctoral Award.

Concept Award
The Concept Award supports the exploration of a highly innovative new concept or untested theory that addresses an important problem relevant to breast cancer. The Concept Award is not intended to support a logical progression of an already established research project but, instead, supports high-risk studies that have the potential to reveal entirely new avenues for investigation.

Pre-Application Deadline: November 6
Application Deadline: November 20

For more information, please click here.

Postdoctoral Award
The Postdoctoral Award enables recent medical or other doctoral degree graduates to obtain the necessary experience to pursue an independent career in breast cancer research. Candidates for this award should exhibit a strong desire to pursue a career in breast cancer research.

Under this award mechanism, the postdoctoral trainee is considered the Principal Investigator (PI) and, as such, should write the project narrative with appropriate direction from the mentor. While the PI is not required to have previous experience in breast cancer research, this proposal must focus on breast cancer research. The mentor must possess the appropriate expertise in breast cancer, have current peer reviewed breast cancer funding, and clearly demonstrate a commitment to guiding the PI's research and training.

Postdoctoral Award proposals should either extend the candidate's ongoing research related to breast cancer, or broaden the scope of his or her research to include work that is highly relevant to breast cancer, under the guidance of a designated mentor. Proposals with a multidisciplinary research approach to breast cancer are highly encouraged but not required.

Pre-application submission: November 19
Proposal Deadline: December 3

For more information, please click here.

FUNDING OPPORTUNITY– 2009 Dana Foundation Brain and Immuno-Imaging Grant Program

CWRU has been invited to apply for the 2009 Dana Foundation Brain and Immuno-Imaging Grant Program. This program focuses on improving human brain and brain-immune function in health and disease.

CWRU may submit TWO applications: ONE for Track A, and ONE for Track B:

Track A: Conventional imaging of anatomical or physiological brain functioning; should involve patient-oriented clinical research.
Track B: Cellular and molecular imaging; should have direct clinical relevance; should focus on the biological activities of human brain cells or their interactions with immune cells in health and disease; studies may involve human tissues or animal models.

If you are interested in participating in the CWRU internal competition, please send the following materials electronically to Ann Tillett at

1. CV (standard NIH four-page format),
2. Four-page preliminary proposal (see below), and
3. Letter of support/recommendation from your Chair.

For program details, please click here.

Internal Deadline: October 31

If you have any questions regarding this internal competition and/or the application requirements, please contact Richard Sohn at or 368-1158.


Chemical Biology Consortium
Deadline: October 27

ASCO Young Investigator Award
Deadline: October 30

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Nomination Deadline: October 30

Multidisciplinary Clinical Research Training Program Clinical Research Scholars
Deadline: November 4

Pancreatic Cancer Action Network-AACR Pilot Grants
Deadline: November 10

Pancreatic Cancer Action Network-AACR Career Development Award
Deadline: November 10

Pancreatic Cancer Action Network-AACR Research Fellowship
Deadline: November 10

Landon Foundation-AACR Innovator Award for Cancer Prevention Research
Deadline: November 20

Susan G. Komen for the Cure Postdoctoral Fellowships
Full Application Deadline: November 20

Landon Foundation-AACR Innovator Award for International Collaboration
Deadline November 20

Prostate Cancer Foundation Creativity Awards
Deadline: November 21

International Union Against Cancer (UICC)
Deadline: December 1

AACR-GlaxoSmithKline Outstanding Clinical Scholars
Deadline: December 1

Kimmel Scholar Award
Deadline: December 3

Kimmel Translational Science Award
Deadline: December 3

ASCO Advanced Clinical Research Awards
Letter of Intent Deadline: December 4

Susan G. Komen Promise Grants
Full Application Deadline: December 4

ACS MEN2 Thyroid Cancer Professorship
Deadline: December 15

Sallie Rosen Kaplan Fellowship
Deadline: December 15

ASCO Advanced Clinical Research Awards
Application Deadline: January 8

NCI Short-Term Scientist Exchange Program
Deadline: Open

NIH Bulletin – Notices and Funding Opportunities

Pilot Studies: Oral Complications of Cancer Therapies (R21)

Announcement of Participation of NCI on RFA-NR-09-002, Centers of Excellence in Symptom Management or Centers of Excellence in Health Promotion/Disease Prevention (P30) (NOT-CA-09-002)

Discontinued Availability of Custom Case Sets of Full Tissue Sections from the NCI Cooperative Breast Cancer Tissue Resource (CBCTR) (NOT-CA-09-003)

Tissue Microarrays Available for Investigations of Prognostic Breast Cancer Biomarkers (NOT-CA-09-004)

Cancer Disparities Research Partnership (CDRP) Program: Limited Competition (U54) (RFA-CA-09-502)

Basic and Preclinical Research on Complementary and Alternative Medicine (CAM) (R01) (PA-09-010)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Hassinger
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
If you have trouble viewing this page, click here to view the newsletter online on our website.