Case Comprehensive Cancer Center Newsletter

January 7, 2008


Please join us in welcoming the following new members to the Case CCC:

Ann-Marie Broome, PhD
Assistant Professor, Biomedical Engineering
Developmental Therapeutics Program

Edward Copelan, MD
Staff, Hematologic Oncology & Blood Disorders
Cleveland Clinic
Stem Cells & Hematologic Malignancies Program

Halle Moore, MD
Staff, Solid Tumor Oncology
Cleveland Clinic
Cancer Prevention, Control & Population Research Program

Charles Nock, MD
Assistant Professor, Medicine- Hem/Onc
Developmental Therapeutics Program

Susan Stagno, MD
Associate Professor, Psychiatry
Clinical Program

Yan Xu, PhD
Professor, Chemistry
Developmental Therapeutics Program

REQUEST FOR PROPOSALS – Samuel Waxman Cancer Research Foundation

The Case Comprehensive Cancer Center has been invited to submit one application for an Individual Grant from the Samuel Waxman Cancer Research Foundation's Institute Without Walls 2008 grant cycle.

Eligibility is restricted to established investigators with a tenure track appointment holding. They must have principal investigator status on at least one grant from a major funding source such as NIH, NSF, DOD, ACS.

The goal of the Institute Without Walls program is to leverage existing cancer research expertise into translational and collaborative cancer research. Priority will be given to:
–Proposals addressing promising new areas of study for the applicant, not yet funded by the NIH or other major granting agencies.
–Studies that will directly impact the understanding of the mechanisms of cancer and its treatment.
–Translational studies involving the clinical treatment of individuals with cancer.

Program grants should demonstrate collaboration already in progress with need for further support.

An initial, two-year grant will consist of:
–$100,000 per year of direct cost
–$15,000 indirect cost
–A total of $230,000 over two years

Upon completion of two years, review of progress and approval by the grants review committee, a third year of funding may be considered.

Interested and eligible investigators should submit a one-page proposal (with budget) and a biosketch in NIH four-page format with current research activities to the Cancer Center as a Word document via email to:

Proposal Deadline: Friday, February 1

Senior Leadership will select the proposal to be submitted to the Waxman Foundation. External application deadline is April 1.

For more information, click here.

FUNDING OPPORTUNITY – NIH Shared Instrumentation Grant

The NCRR Shared Instrument Grant (SIG) program is soliciting applications from groups of NIH-supported investigators to purchase or upgrade commercially available instruments that cost at least $100,000. The maximum award is $500,000. Types of instruments supported include confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell sorters, X-ray diffraction systems, and NMR spectrometers among others. This funding opportunity will use the NIH S10 mechanism.

Eligible principal investigators include any technically qualified research scientists. Multiple PDs/PIs are not permitted. To be eligible to apply, three or more NIH funded investigators (Principal Investigators of active P01, R01, U01, R35, R37, DP1 or DP2 research grants) who will be users of the requested instruments must be identified. There is no limit to the number of applications an institution may submit, as long as each application is for different types of equipment.

Applications accepted February 24-March 24.

To view the complete notice click here.

FUNDING OPPORTUNITY – DOD Breast Cancer Research Program

The Department of Defense Breast Cancer Research Program (BCRP) is currently accepting applications for the FY07 BCRP Concept Award.

The BCRP challenges the scientific community to design innovative research that will foster new directions for, address neglected issues in, and bring new investigators to the field of breast cancer research. The BCRP focuses its funding on innovative projects that have the potential to make a significant impact on breast cancer, particularly those involving multidisciplinary and/or multi-institutional collaborations and alliances. The BCRP encourages risk-taking research; however, all projects must demonstrate solid judgment and rationale.

Pre-application Deadline: January 9
Proposal Submission Deadline: January 23

For more information, please click here.

FUNDING OPPORTUNITY – Ohio Cancer Research Associates

Seed money grants are available from Ohio Cancer Research Associates. The independent organization offers $25,000 for two years through its annual competition. The grants awarded by Ohio Cancer Research Associates are made to support research activities broadly related to cancer and leukemia. The organization seeks to fund research that will lead to continued support at the national level.

Ohio Cancer Research Associates grants are design to encourage junior faculty to apply. Full professors are not eligible to apply and applicants must be within six years of their first independent research position.

Ten to twelve grants will be awarded in 2008.

Application Deadline: February 22

For more information, click here, or call (800) 232-6272.

FUNDING OPPORTUNITY – Lance Armstrong Foundation

The Lance Armstrong Foundation has released an RFP for two grants types:

Community Grants: One-, two-, or three-year grants for up to $150,000 each. Applications will be considered in either of two areas of cancer survivorship: 1) evidence-based interventions; and 2) education for healthcare professionals. Access to the online LOI process will be available starting January 28. LOI deadline is March 24.

Research Grants: General research grants are intended to support the early stages of survivorship research projects in order to facilitate subsequent funding from other sources. Offering General Research Grants of up to $75,000 a year for up to three years to support research projects initiated by established investigators, and will award Young Investigator research grants of up to $50,000 a year for up to two years to support career development in the field of cancer survivorship research. Access to the online LOI process will be available starting February 4. LOI deadline is March 14.

For details, please click here.


The Center for Cancer Research (CCR) announces a new training opportunity for physicians interested in dedicating their careers to clinical oncology research.

Potential areas of interest include: medical oncology, pediatric hematology/oncology, radiation oncology, surgical oncology, surgical pathologies or related specialties.

Deadline: January 15

For more information, please click here.


To Dr. Charis Eng, Professor of Genetics at CWRU/ Cleveland Clinic, whose article, Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases, was printed in the December 20, 2007 edition of the New England Journal of Medicine.


**All events are open to anyone interested in attending

January 7

Cancer Genetics/ Biology Journal Club
Xia Liu, PhD
Postdoc, Qu Lab
Div. of Hem/Onc
Topic: An Activating Mutation in SHP-2 Tyrosine Phosphatase Leads to Aberrant Mitosis, Chromosomal Instability, and High Susceptibility to DNA Damage-Induced Carcinogenesis
12:00 pm WRB 2-136

Drug Discovery Basic Science Focus Group Meeting
4:00 pm SOM W416

January 8

Cancer Biology Seminar
Maria F. Czyzyk-Krzeska, MD, PhD
Professor, Molecular Oncogenesis
University of Cincinnati
Topic: Novel Functions of the von Hippel-Lindau Tumor Suppressor in Renal Cancer
11:00 am NC1-202 Cleveland Clinic

January 9

Grand Rounds
Yael Hegerfeldt, MD
Fellow, Medicine- Hem/Onc
Topic: Chronic Eosinophilic Leukemia and Hypereosinophilic Syndrome
8:00 am Lerner B-151

CSCRM Seminar
Stanton Gerson, MD
Director, CSCRM
Director, Case CCC
Professor, Medicine- Hem/Onc
Topic: Highlights of CSCRM in 2007, Plans for 2008, and Poster Presentations
4:30 pm WRB 1413

January 10

Taussig Cancer Center Core Curriculum Series
Kandice Marchant, MD, PhD
Professor, Pathology
CWRU/ Cleveland Clinic
Topic: Coagulation Physiology and Basic Coagulation Tests
12:00 pm Cleveland Clinic R3-002

Prevention and Control Seminar
Elaine Borawski, PhD
Associate Professor, Epidemiology and Biostatistics
Topic: Low SES and Strategies for Smoking Cessation
3:30 pm Wearn 137

TREC Seminar
Susan Redline, MD
Professor, Medicine-Pediatrics
Topic: Association of Metabolic Dysfunction and Hypertension With Poor Sleep in Teens
4:00 pm BRB 732

January 11

Hematology/Oncology Fellows
Greg Chipman, MD
Fellow, Medicine- Hem/Onc
Topic: TBA
8:00 am Wearn 137

Taussig Cancer Center Grand Rounds
Hakan Ilaslan, MD
Staff, Diagnostic Radiology
Cleveland Clinic
Topic: Radiofrequency Ablation
8:00 am R3/002-003 Cleveland Clinic

Cell Biology Seminar
Tamas Horvath, DVM, PhD
Yale University
Topic: The Role of Mitochondrial Uncoupling Proteins in Synaptic Plasticity Neurodegeneration
8:00 am R3/002-003 Cleveland Clinic

Special CSCRM Seminar
Paul Tesar, PhD
CWRU Graduate
Topic: Understanding Pluripotency With Embryonic Stem Cells
10:30 am WRB 2-136

Cancer Center Seminar Series/ Blood Club
Roy Silverstein, MD
Professor, Cell Biology
CWRU/ Cleveland Clinic
Topic: CD36: A Multifunctional Protein Regulator of Angiogenesis, Thrombosis, and Atherosclerosis
12:00 pm BRB 105


For a complete listing of LRI seminars click here.


Cancer Prevention & Control Seminar
January 10
Elaine Borawski, PhD
Associate Professor, Epidemiology & Biostatistics
Topic: Low SES and Strategies for Smoking Cessation
3:30 pm Wearn 137

STATS in Cancer (including interferons) Basic Science Focus Group Mini-Retreat
January 12
9:00 am WRB 3-136

Inflammation, Infection & Cancer Basic Science Focus Group Meeting
January 25
3:00 pm WRB 3-136

Regulation of Cell Death- Apoptosis & Autophagy Basic Science Focus Group Meeting
February 5
3:00 pm WRB 3-136

Prevention and Control Seminar
February 21
Siran Koroukian, PhD
Assistant Professor, Epidemiology & Biostatistics
Topic: Trajectory Care in Elders With Cancer
3:30 pm Wearn 137

Tumor Cell Adhesion, Growth Factor Receptor Signaling, Stromal Interactions, Migration and Metastasis Basic Science Focus Group Mini Retreat
February 26
1:00 pm WRB 2-136


**For more information on these symposiums, please contact Christine Rhoads.

Geriatric Oncology and Primary Care: Promoting Partnerships in Practice and Research
April 3-4
Dively Center
Course Directors: Nathan Berger, MD and Julia Rose, PhD

Update on Cervical Cancer Prevention: New Technology, New Evidence, and New Recommendations
April 18
Ritz Carlton Cleveland
Course Directors: Stephen Waggoner, MD and Kristine Zanotti, MD

Annual Update on Breast Cancer: Highlights of the National Meetings
June 13
Hilton Cleveland East, Beachwood


Join hundreds of Case faculty, staff, and students in presenting your latest research and scholarship at Research ShowCASE, April 16-17.

Limited booth space available for active demonstrations of research. Only one request allowed per person.

Some booth space will be available for exhibits of centers or facilities that provide research support services for the university and/or its affiliates. Case CCC Core Directors are encouraged to present. Space is limited, so please submit your request to present as soon as possible. Deadline to submit is January 31. For more information, click here.

CALL FOR ABSTRACTS – International Society for Stem Cell Research 6th Annual Meeting

June 11-14
Pennsylvania Convention Center
Philadelphia, PA

The ISSCR Annual Meeting provides an opportunity to hear groundbreaking research from all areas of stem cell science. The meeting is an excellent forum for scientists to present and discuss their latest research, with participants from academic, industry and government setting from around the world.

Submission deadline: February 7 (12:00 pm CST)

For details, please click here.


The American Association for Cancer Research (AACR) is now accepting applications for two Fellowships and one Major Research Grant:

AACR Centennial Postdoctoral Research Fellowships in Cancer Research: Will provide $60,000 per year for up to three years to provide salary support and research funding for clinical and postdoctoral fellows in the first, second, or third year of their fellowship status. In addition to financial flexibility these fellowships also provide career flexibility. Fellowship funds may be transferred to move with the grantee if the grantee's fellowship is completed during the grant term - a valuable commodity for a newly-independent investigator.

AACR Centennial Pre-doctoral Research Fellowships in Cancer: Will provide full-time graduate students a rare opportunity to invest in their future cancer research careers. The grant terms are flexible, allowing applicants to tailor their grant funds to fit their individual research funding and salary needs. Grantees may also transfer their funds to a postdoctoral fellowship position, should they advance in their careers during grant term. A grant of $30,000 per year over a maximum period of three years will be awarded for salary support and research funding.

Littlefield-AACR Grants for Metastatic Colon Cancer Research: Support innovative cancer research projects designed to improve the survival and quality of life of patients with metastatic colorectal cancer. Such projects must lead to individualized therapeutic options for treatment or development of promising new cancer therapeutics for metastatic colon cancer which will translate into clinical applications within a one- to two-year period. Due to the intent to support projects on an accelerated track into the clinic, special emphasis will be placed on those where Phase I clinical trials have been successfully conducted. These grants will be provided in an amount between $500,000 - $1,000,000. The AACR will award 2-4 grants in 2008.

Click here for the complete guidelines and instructions or visit proposalCENTRAL to access the online application.

Inquiries may be directed to


Pfizer Scholars Grant in Health Policy
Deadline: January 15

Pfizer Scholars Grants in Public Health
Deadline: January 15

Pfizer Fellowship in Health Disparities
Deadline: January 15

Pfizer Fellowship in Health Literacy/ Clear Health Communication
Deadline: January 15

Canary Foundation/ American Cancer Society
Deadline: January 16

Goldhirsh Foundation Brain Tumor Research Award Program
Deadline: January 16

NIH Director's Pioneer Award Program
Deadline: January 16

Lymphatic Research Foundation
Deadline: January 24

Ohio Department of Development Third Frontier Project
Deadline: January 28

Lasker Foundation, Albert and Mary Medical Research Awards Program
Deadline: February 1

Lasker Foundation Awards, Basic Medical Research, Clinical Medical Research, and Special Achievement in Medical Science
Deadline: February 1

Jane Coffin Childs Memorial Fund for Medical Research
Deadline: February 1

2008 CWRU Presidential Research Initiative (PRI)Grant Program
Deadline: February 4

Ohio Cancer Research Associates
Deadline: February 22

Nancy R. Gelman Foundation
Deadline: February 22

Leukemia and Lymphoma Society Translational Research Program
Deadline: March 1

Lady Tata Memorial Trust International Award for Research in Leukemia
Deadline: March 1

Ladies Auxiliary to the Veterans of Foreign Wars (VFW) of the United States
Deadline: March 8

McDonnell Foundation Research Awards
Deadline: March 12

NIH Shared Instrumentation Grant Program
Deadline: March 24

Cancer Research Institute
Deadline: April 1

NIH Bulletin – Notices and Funding Opportunities

NIH Policy on Late Submission of Grant Applications (NOT-OD-08-027)

Revised PHS 398 (DHHS Public Health Service Grant Application) Now Available (NOT-OD-08-028)

Revised PHS 2271, PHS 3734, and HHS 568 Forms Now Available NOT-OD-08-029)

Revised PHS 2590 (DHHS Public Health Service Noncompeting Continuation Progress Report) Now Available (NOT-OD-08-030)

Appendices to Paper PHS 398 (DHHS Public Health Service Grant Application) to be Submitted on CD (NOT-OD-08-031)

Produced by:
Gillian Irwin
11100 Euclid Avenue, Wearn 152
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax

Janice Green
11100 Euclid Avenue
Cleveland, Ohio 44106-5065
216-844-1862 phone
216-844-7832 fax
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