Cancer Center News

2014 Cancer Center News

Keith McCraeAlvin SchmaierDrs. McCrae and Schmaier Receive ASH Bridge Funding Awards
March 24, 2014
Two Cancer Center members, Drs. Keith McCrae and Alvin Schmaier, are among 15 researchers awarded one-year $100,000 grants from the American Society of Hematology (ASH) that will help sustain their research amidst severe funding reductions for the National Institutes of Health.

Twenty-nine scientists have received Bridge Grants since the program was created in July 2012, including Case CCC member Dr. Yu-Chung Yang, who was part of the first group of recipients. [more]

Anant MadabhushiResearchers Use "Big Data" to Identify Cancers
March 18, 2014
Researchers at CWRU and colleagues used "big data" analytics to predict if a patient is suffering from aggressive triple-negative breast cancer, slower-moving cancers or non-cancerous lesions with 95 percent accuracy.If the tiny patterns they found in magnetic resonance images prove consistent in further studies, the technique may enable doctors to use an MRI scan to diagnose more aggressive cancers earlier and fast track these patients for therapy. Their work is published online in the journal Radiology.

The work comes just two months after senior author Anant Madabhushi, PhD, professor of biomedical engineering at CWRU School of Engineering and director of the Center for Computational Imaging and Personalized Diagnostics, and another group of researchers showed they can detect differences between persistent and treatable forms of head and neck cancers caused by exposure to human papillomavirus, with 87.5 percent accuracy. In that study, digital images were made from slides of patients' tumors. [more]

Neal MeropolDr. Neal Meropol Recognized as ASCO Fellow
March 12, 2014
Neal Meropol, MD, Case CCC Associate Director for Clinical Research, was named as a Fellow of the American Society of Clinical Oncology (ACSO). This distinction recognizes ASCO members for their extraordinary volunteer service, dedication, and commitment to ASCO. The award will be presented at the 2014 ASCO Annual Meeting during the Opening Session on Saturday, May 31. [more]

Nima SharifiDr. Nima Sharifi Recognized With 2014 AACR Outstanding Achievement in Cancer Research Award
March 6, 2014
Nima Sharifi, MD, Kendrick family endowed chair for prostate cancer research, Department of Cancer Biology, Lerner Research Institute at the Cleveland Clinic, will be recognized with the 34th Annual American Association for Cancer Research (AACR) Outstanding Achievement in Cancer Research Award at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.

Since 1979, the AACR Award for Outstanding Achievement in Cancer Research has honored an investigator younger than 40 years of age to recognize his or her meritorious achievements within the field of cancer research.

Sharifi is being recognized for his seminal contributions as a young investigator to the field of prostate cancer biology. He will present his lecture, "Androgen Metabolism Drivers in Prostate Cancer: From Mechanism to Therapy," Monday, April 7, 4:30 p.m. PT, in room 20D in the San Diego Convention Center. [more]

Charis EngDr. Charis Eng Honored With the 17th Annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
March 5, 2014
The American Association for Cancer Research (AACR) will award the 17th annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship to Charis Eng, MD, PhD, at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.

Eng is the Sondra J. and Stephen R. Hardis endowed chair in cancer genomic medicine and founding director of the Genomic Medicine Institute at the Cleveland Clinic's Lerner Research Institute in Cleveland, Ohio. She is being recognized for her unstinting support and active promotion of women working in cancer research, medicine, and genetics. She will present her lecture, "PTEN Hamartoma Tumor Syndrome Previvorship: What now?," Saturday, April 5, 5:15 p.m. PT, in Ballroom 20D in the San Diego Convention Center. [more]

University Hospitals unveils new website, app to help patients find cancer clinical trials
March 4, 2014
A website and mobile-device app designed by University Hospitals Seidman Cancer Center is providing cancer patients with information on clinical trials that they might be able to access as part of their treatment.

The website, at http://clinicaltrials.uhseidman.org, and app – available on the iPhone, iPad and Android devices – have information on more than 150 available cancer clinical trials offered in collaboration with the Case Comprehensive Cancer Center. [more]

Paul TesarDr. Paul Tesar Recognized with Professorship of Innovative Cancer Therapeutics
March 3, 2014
Dr. Paul Tesar was appointed the Dr. Donald and Ruth Weber Goodman Professorship of Innovative Cancer Therapeutics at a ceremony held on Thursday, February 27, 2014.

Originally from Cleveland, Dr. Tesar is a CWRU alumnus, receiving his undergraduate degree in biology under the mentorship of Dr. Stephen Haynesworth. Dr. Tesar's potential was evident early on, attracting the notice of the National Institutes of Health, which bestowed on him a scholarship to complete his PhD at the University of Oxford.

Building on the work of the 2012 Nobel Prize winners in Medicine who discovered how to turn skin cells into stem cells, Dr. Tesar's lab took this landmark discovery even further and discovered how to transform skin cells directly into brain cells, or specifically, oligodendrocytes. [more]

Case Comprehensive Cancer Center Researchers Discover Pathway of Protein that Helps Cancer Cells Survive
February 13, 2014
A team of researchers from Case Western Reserve School of Medicine has discovered how the cancer-related protein Bcl-2 signals cancer cells to live longer. The breakthrough emerged when the scientists discovered that Bcl-2 alters the level of calcium ions in lymphoma and leukemia cells that are resistant to cancer treatments. Published in the journal Proceedings of the National Academy of Sciences (PNAS), the research findings could help lead to the development of drugs that attack Bcl-2 in malignancies and produce better outcomes for cancer treatment.

"One of the deadliest and most remarkable characteristics of cancer cells is that regardless of where they are growing, and no matter what types of treatments are employed, including many different forms of chemotherapy and radiation therapy, the cancer cells have the ability to survive," said Clark W. Distelhorst, MD, Professor, Medicine-Hematology/Oncology, Pharmacology, Case Western Reserve School of Medicine and co-leader of the Basic Sciences Program at the Case Comprehensive Cancer Center. "Since 1993 our team has been conducting research on key mechanisms by which the protein Bcl-2 keeps cancer cells alive." [more]

Study Finds Mammography Beneficial for Younger Women
January 24, 2014
Researchers from University Hospitals Case Medical Center and Case Western Reserve University School of Medicine have published new findings in the February issue of American Journal of Roentgenology that mammography remains beneficial for women in their 40s. According to the study, women between ages 40 and 49 who underwent routine screening mammography were diagnosed at earlier stages with smaller tumors and were less likely to require chemotherapy. [more]

Op-Ed: Reproducibility of Preclinical Academic Studies
January 21, 2014
This op-Ed piece by Dr. Bing-Cheng Wang, co-Leader of the GU Malignancies Program of the Case Comprehensive Cancer Center and Professor of Medicine at CWRU and MetroHealth Medical Center, comments on a global issue in scientific publications- concern over reproducibility in lab findings and the complexity of validation studies. This has implications in how we conduct research.

Recently the biomedical research community was shaken by the widely publicized findings that an alarming proportion of peer-reviewed preclinical studies are not reproducible. The problem surfaced after publication of two commentaries detailing the inability of scientists at pharmaceutical companies to reproduce results from the published literature in 67% to 90% of cases (Nat. Rev. Drug Discov.10, 712, 2011; Nature 483, 531-533, 2012). Many of the studies are in the field of oncology. Surprisingly, the reproducibility of published data did not significantly correlate with journal impact factors, the number of publications on the respective target, or the number of independent groups that authored the publications. [more]

Cleveland Clinic, Case Western Reserve School of Medicine Team Discovers Key Mechanisms to Inhibit Triple Negative Breast Cancers
January 16, 2014
A team of researchers from the Cleveland Clinic and Case Western Reserve School of Medicine have identified critical complex mechanisms involved in the metastasis of deadly "triple negative" breast cancers (TNBC). These tumors are extremely difficult to treat, frequently return after remission, and are the most aggressive form of breast cancer in women. The discovery of this critical interaction of mechanisms could be used to develop new life saving treatments to kill metastatic tumors in TNBC.

"In previous findings published over the past 10 years, our teams have described key mechanisms in these critical proteins,” said Khalid Sossey-Alaoui, PhD, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic. "A key component in the deadly metastatic potential of TNBC tumors is that they spread through tissues outside the breast very quickly. The two proteins that we studied, WAVE3 and TGF-β, when together, promote tumor aggressiveness."

"We found important biological implications," said William Schiemann, PhD, an associate professor, Division of General Medical Sciences-Oncology, Case Western Reserve School of Medicine, and co-leader of the Breast Cancer Program at the Case Comprehensive Cancer Center. "For the first time, we uncovered an interplay between the two proteins that can inhibit or suppress TNBC – a discovery that has the potential to inhibit proliferations of the tumor." [more]

Researchers at Case Comprehensive Cancer Center Discover Ovarian Cancer Biomarker
January 8, 2014
Researchers at Case Western Reserve University have identified a microRNA biomarker that shows promise in predicting treatment response in the most common form of ovarian cancer – a breakthrough that has the potential to improve outcomes for patients with the disease.

A CWRU research team led by Analisa DiFeo, PhD, an assistant professor of General Medical Science-Oncology at the Case Comprehensive Cancer Center, found that the biomarker miR-181a is a molecular driver of epithelial ovarian cancer (EOC). The research team also found that elevated levels of miR-181a in ovarian tumors are associated with chemotherapy resistance and disease progression. [more]

Cleveland Clinic Researchers Create Online Colorectal Cancer Risk Calculator
January 3, 2014
Researchers at Cleveland Clinic have developed a new tool called CRC-PRO that allows physicians to quickly and accurately predict an individual’s risk of colorectal cancer, as published in the current edition of the Journal of the American Board of Family Medicine.

CRC-PRO, or Colorectal Cancer Predicted Risk Online, is designed to help both patients and physicians determine when screening for colorectal cancer is appropriate. Current guidelines recommend patients are screened at the age of 50. However, with this new tool, physicians will be better able to identify who is truly at risk and when screenings for patients are necessary. [more]