Lan Zhou, MD, PhD
Associate Professor, Pathologylan.email@example.com 216.368.1671 (o) 216.368.0494 (f)
The research in my laboratory is devoted to understanding how fucosylation affects Notch-dependent regulation of hematopoietic stem cell proliferation, early myeloid lineage specification and committed neutrophil proliferation and differentiation. Active projects include: 1) characterization of the banormal hematopoietic phenotypes, particularly myeloproliferative phenotypes in mice deficient in selectin ligand activity as a result of lacking alpha (1,3)-fucosyltransferase, in mice deficient in FX protein, an enzyme essential for GDP- fucose synthesis, and in mice deficient in Notch receptor O- fucose. 2) determination of the role of Notch in hematopoietic stem cell proliferation and self-renewal, and myeloid versus lymphoid lineage specification. 3) characterization of Notch in myeloid development and its regulation by O-fucosylation. 4) characterization of bone marrow specific niche for hematopoietic stem cells. 5) studying the role of Notch and its interaction with other signaling pathways in pancreatic cancer initiation and progression. Our clinical related research focuses on the application of using real-time PCR in prenatal RhD genotyping from fetal DNA present in the plasma from D- negative pregnant women, and application of molecular diagnostic assays in infectious diseases and solid tumors and hematologic neoplasms.