Bing-Cheng Wang, PhD
Co-Leader, Molecular Oncology Programbxw14@case.edu 216.778.4256 (o) 216.778.4321 (f)
Research in the Wang laboratory focuses on the roles of Eph receptor tyrosine kinases in invasive growth and distal metastasis of cancer cells. The 14 members of Eph kinases are by far the largest subfamily of receptor tyrosine kinases in a mammalian system. They interact with the membrane-anchored ligands called ephrins and mediate cell-cell contact signaling. Over the past decade, we have made several major contributions in unraveling the intricate interplays between Eph kinases and other cell regulatory pathways in controlling tumor etiology and malignant progression. Most recently, a novel reciprocal regulatory loop between EphA2 and Akt was discovered in glioblastoma and prostate cancer (Figure 1). The discovery revealed an intricate dichotomy of EphA2, which can either promote or suppress tumor progression, depending on the ligand occupancy status of EphA2. This body of work constitutes a significant part of our current understanding of Eph/ephrin system in cancer biology.