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Horst A. von Recum, PhD

Associate Professor, Biomedical Engineering

horst.vonrecum@case.edu 216.368.5513 (o) 216.368.4969 (f)

Member, Cancer Imaging Program 

 

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The research in our laboratory focuses on novel platforms for the delivery of molecules and cells. In the molecular delivery projects we are examining novel affinity-based systems for delivery of therapeutic agents for HIV therapies, wound dressings, ocular disease,  localized chemotherapy and other applications. Affinity-based delivery uses molecular interactions to control the rate of release beyond that capable by other means such as diffusion and degradation.  This allows for control of delivery to better match the physiological need of the drug.

The cellular delivery projects are examining using directed differentiation to produce tissue engineered constructs from stem cell sources. Stem cells show great promise as a therapeutic tool due to their  unlimited replication potential and their plasticity, or capacity to become many different cell types. Better control of differentiation and selection, will allow for rapid expansion of high purity differentiated cells suitable for tissue engineering, toxicology and pharmacology, as well as cellular modeling, without the need for isolating cells from primary sources.