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Gregory P. Tochtrop, PhD

Associate Professor, Chemistry

gpt6@case.edu 216.368.2351 (o) 216.368.3006 (f)

Member, Developmental Therapeutics Program

 

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Research in our lab centers on the chemistry and biology of lipids. Our central interests revolve around the identification of novel small molecules, and careful investigations into the chemistry and physiology of known molecules. From a training point of view, our work spans from pure synthetic organic chemistry to animal biology in disease models, and students in the laboratory have projects involving: target-oriented synthesis, diversity-oriented synthesis, protein biochemistry, metabolomics, and cell signaling. Our laboratory specializes in organic synthesis and protein biochemistry and we have developed strong collaborative relationships with other research groups at CWRU School of Medicine, and the Cleveland Clinic.

We are generally interested in two physiologic processes that are primarily driven by an exquisite network of small molecules:

  • The Linkage Between Oxidative Stress Pathways and Lipid Peroxidation
  • The Role of the Fatty Acid Binding Protein Family in Lipid Signaling