Yong Li, PhD
Professor, Cancer Biologyliy2@ccf.org 216.444.1168 (o) 216.445.6269 (f)
Over the last twenty years, numerous studies have documented the potent pro- and anti-tumorigenic functions of miRNAs and other noncoding RNAs. Yet the vast noncoding landscape of the human genome in cancer remains largely uncharted. My research aims to elucidate the role of noncoding RNAs in gene - environment interaction and to define the precise noncoding molecular events that are responsible for cancer initiation, cancer progression, and cancer susceptibility. I am investigating the role of carcinogenic hydrocarbons and microRNAs in the pathogenesis of multiple myeloma, lymphoma, and other cancers and the molecular mechanisms that mediate carcinogen-induced toxic response.