Cathleen R. Carlin, PhD
Professor, Molecular Biology and Microbiologycxc39@case.edu 216.368.8939 (o) 216.368.3055 (f)
Case Western Reserve University
Member, Molecular Oncology Program
The focus of my research program is to elucidate fundamental cell biological mechanisms underlying intracellular membrane trafficking and how these mechanisms are usurped by human pathogens and disease processes. One of the major efforts in my laboratory has been to gain fundamental new insights into the nature of polarized EGF receptor (EGFR) trafficking pathways that govern epithelial cell functions and how these pathways are co-opted to dismantle epithelial cell architecture during the genesis of epithelial carcinomas. My laboratory has had the leading role in identifying mechanisms for regulation of the basolateral expression of the EGFR in polarized epithelia leading to development of multiple cell lines with defective EGFR sorting to be employed in these studies. More recently, we have applied our knowledge of EGFR biology to unraveling the role of this molecule in tumor progression in triple-negative breast cancer and have now developed methods for translating our results from tissue culture cells to in situ tumor development.