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James M. Anderson, MD, PhD

Professor, Pathology 216.368.0279 (o) 216.368.0494 (f)

Member, Developmental Therapeutics Program


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Our research efforts are centered around the development of a better understanding of blood and tissue/material interactions as they relate to implantable devices and biomaterials. The overall focus of our efforts is on the cellular and humoral responses to implanted materials. Studies currently ongoing include an analysis of the wound healing response to vascular graft materials, in vivo biocompatibility testing with the focus on macrophage and foreign body giant cell adhesion and activation, and a determination of those factors which lead to the biodegradation of biomaterials. In addition, we are investigating human blood/material interactions using an in vitro system and interrelating variations in protein adsorption, cellular components, coagulation parameters, platelet activation and release, and complement activation.