Drew Adams, PhD
Assistant Professor, Genetics and Genome Sciencesdja59@case.edu 216.368.4922 (o)
My work involves pairing expertise in high-throughput screening/assay development and organic synthesis to identify and optimize new starting points for therapeutics. I've previously executed high-throughput screens aimed at inhibiting NSD2/MMSET/WHSC1, a histone methyltransferase implicated in cancer by recurrent genomic alterations, and elevating oxidative stress, a cancer hallmark. I've also elucidated the true cellular target (NAMPT) of an anti-cancer agent previously thought to target GLUT1 and developed a new high-throughput assay to measure radiation response in high throughput that enabled profiling of over 600 cancer cell lines for radiation response. Having joined CWRU in March 2015, my new lab aims to continue working in the area of cancer therapeutics including by initiating collaborations with biological specialists.
Yard BD, Adams DJ, Chie EK, Tamayo P, Battaglia JS, Gopal P, Rogacki K, Pearson BE, Phillips J, Raymond DP, Pennell NA, Almeida F, Cheah JH, Clemons PA, Shamji A, Peacock CD, Schreiber SL, Hammerman PS, Abazeed ME (2016)
A genetic basis for the variation in the vulnerability of cancer to DNA damage.
Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Haber DA, Clish CB, Bittker JA, Palmer M, Wagner BK, Clemons PA, Shamji AF, Schreiber SL (2016)
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Nat Chem Biol;12(2):109-16
Yard, B.; Chie, E. K.; Adams, D. J.; Peacock, C.; Abazeed, M. E. (2015)
Radiotherapy in the era of precision medicine
Seminars in Radiation Oncology;25, 227-236
Adams, D. J.; Ito, D.; Rees, M. G.; Seashore-Ludlow, B.; Puyang, X.; Ramos, A. H.; Cheah, J. H.; Clemons, P. A.; Warmuth, M.; Zhu, P.; Shamji, A. F.; Schreiber, S. L. (2014)
NAMPT is the Cellular Target of STF-31-Like Small Molecule Probes
ACS Chem. Biol.;
Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF, Wong KK, Mesirov JP, Loeffler JS, Schreiber SL, Hammerman PS, Meyerson M (2013)
Integrative radiogenomic profiling of squamous cell lung cancer.
Boskovic ZV, Hussain MM, Adams DJ, Dai M, Schreiber SL (2013)
Synthesis of piperlogs and analysis of their effects on cells.
Adams DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, Schreiber SL (2013)
Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.
ACS Chem Biol;8(5):923-9
Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL (2012)
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.
Proc Natl Acad Sci U S A;109(38):15115-20
Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, Wagner BK, Schreiber SL (2012)
A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.
ACS Chem Biol;7(7):1152-7
Evans, D. A.; Adams, D. J.; Kwan, E. E. (2012)
Progress Toward the Syntheses of (+)-GB 13, (+)-Himgaline, and Himandridine. New Insights Into Imine/Enamine Aldol Cyclizations
J. Am. Chem. Soc.;134, 8162-8170
Evans, D. A.; Adams, D. J. (2007)
Total Synthesis of (+)-Galbulimima Alkaloid 13 and (+)-Himgaline
J. Am. Chem. Soc.;129, 1048-1049
Paley RS, Liu JM, Lichtenstein BR, Knoedler VL, Sanan TT, Adams DJ, Fernández J, Rablen PR (2003)
Simultaneous and stereoselective formation of planar and axial chiralities in enantiopure sulfinyl iron diene complexes.