Mohamed Abazeed, MD, PhD
Assistant Professor, Medicineabazeem@ccf.org 216.445.8416 (o) 216.636.2498 (f)
Cleveland Clinic Lerner College of Medicine
Associate Staff, Radiation Oncology, Cleveland Clinic
Member, GI Cancer Genetics Program
genomics, radiotherapy, personalized
My research focuses on identifying the genomic abnormalities which give rise to therapeutic resistance in cancers and using this information to develop personalized therapeutic strategies in a new strategy of biologically-guided treatment. As a Radiation Oncologist with training in radiation sciences, genomics, and cellular and molecular biology I use my experiences in both patient care and basic science to try to develop a clinically relevant research program to study cancers and to translate laboratory discoveries into potential improvements in clinical care. The goal of my effort, through a highly integrative and collaborative research program, is to nominate therapeutic targets in cancer and to motivate an evolution in the use of therapy from a generic approach to one in which therapies are selected based on the molecular alterations identified in a patient’s tumor, thereby enhancing efficacy and limiting toxicity in the context of a new approach of precision therapy. We have recently developed a large body of data annotating the radiogenomic landscape of cancer and we are focused on studying recently discovered genomic alterations in order to better understand and therapeutically target cancers.