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Mohamed Abazeed, MD, PhD

Mohamed Abazeed, MD, PhD

Assistant Professor, Medicine

abazeem@ccf.org 216.445.8416 (o) 216.636.2498 (f)

Cleveland Clinic Lerner College of Medicine

Associate Staff, Radiation Oncology, Cleveland Clinic

Member, GI Cancer Genetics Program

 

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Keywords

genomics, radiotherapy, personalized

My research focuses on identifying the genomic abnormalities which give rise to therapeutic resistance in cancers and using this information to develop personalized therapeutic strategies in a new strategy of biologically-guided treatment. As a Radiation Oncologist with training in radiation sciences, genomics, and cellular and molecular biology I use my experiences in both patient care and basic science to try to develop a clinically relevant research program to study cancers and to translate laboratory discoveries into potential improvements in clinical care. The goal of my effort, through a highly integrative and collaborative research program, is to nominate therapeutic targets in cancer and to motivate an evolution in the use of therapy from a generic approach to one in which therapies are selected based on the molecular alterations identified in a patient’s tumor, thereby enhancing efficacy and limiting toxicity in the context of a new approach of precision therapy. We have recently developed a large body of data annotating the radiogenomic landscape of cancer and we are focused on studying recently discovered genomic alterations in order to better understand and therapeutically target cancers.