Barnholtz-Sloan, Jill

Danielpour, David

DiFeo, Analisa

Guda, Kishore

Jacobberger, James

Leahy, Patrick

Pink, John

Schiemann, William

Sun, Shuying

Veigl, Martina

Member Directory

SHUYING SUN, PhD Assistant Professor General Medical Sciences (Oncology) Phone: 216.368.4699 Fax: 216.368.4880 email: shuying.sun@case.edu

Research Interests

Deep sequencing data analysis
Microarray data analysis (DNA methylation and gene expression)
Statistical genetics (haplotype inference and haplotype analysis, case control association studies)
Bayesian methods, Markov Chain Monte Carlo algorithms, and linear models

Sequencing Data Interest Group (SDIG)

Recent Publications

Sun S, Greenwood CM, Neal RM. Haplotype inference using a Bayesian Hidden Markov Model. Genet Epidemiol 31:937-948, 2007.

Sun S, Potter D, Yan P, Huang T, and Lin S. A quantile approach to analyzing differential methylation hybridization (DMH) microarrays. Poster proceedings of the 4th International Symposium on Bioinformatics Research and Applications ISBRA. 2008;87-90, 2008.

Clendenning M, Baze ME, Sun S, Walsh K, Liyanarachchi S, Fix D, Schumemann V, Comeras I, Deacon M, Wenstrup RJ, Thibodeau ST, Lynch HT, Hampel H, de la Chapelle A. Origins and prevalence of the American Founder Mutation of MSH2. Cancer Res 68:2145-2153, 2008.

Clendenning M, Senter L, Hampel H, Robinson K L, Sun S, Buchanan D, Walsh MD, Nilbert M, Green JS, Potter J, Lindblom A, de la Chapelle A. A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome. J Med Genet 45:340-345, 2008.

Lin HL, Zuo T, Lin C, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L, Lin S, Yan P, Cheng A, Ostrowski M, Huang TH. Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of cystatin M in epithelial cells. Cancer Res 68:10257-10266, 2008. PMCID: PMC2821873.

Sun S, Yan PS, Huang TH, Lin S. Identifying differentially methylated genes using mixed effect and generalized least square models. BMC Bioinformatics 10:404, 2009. PMCID: PMC2800121.

Greenwood CM, Sun S, Veenstra J, Hamel N, Niell B, Gruber S, Foulkes WD. How old is this mutation? - a study of three Ashkenazi Jewish founder mutations. BMC Genet 11:39, 2010.

Han L, Zheng S, Sun S, Huang T. Zhao Z. Genome-wide DNA methylation profiling in 40 breast cancer cell lines. Advanced Intelligent Computing Theories and Applications. Lecture Notes in Computer Science 2010, 6215:277-284.

Sun S, Chen Z., Yan P, Huang Y. Huang T, Lin S Identifying hypermethylated CpG islands using a quantile regression model. BMC bioinformatics 2011, 12:54.

Sun S, Huang Y., Yan P, Huang T, Lin S. Preprocessing differentially methylation hybridization microarray data. BioData Mining 2011, 4:13. doi:10.1186/1756-0381-4-13

Yu X, Guda K, Willis J, Veigl M, Wang Z, Markowitz S, Adams MD, and Sun S. How well do alignment programs perform on sequencing data with varying qualities and from repetitive regions? BioData Mining; 5:6, 2012

Adams M, Veigl M, Wang Z, Molyneux N, Sun S, Guda K, Yu X, Markowitz S, Willis J. Global Mutational Profiling of Formalin Fixed Human Colon Cancers from a Pathology Archive. Modern Pathology; advance online publication 10 August 2012; doi: 10.1038/modpathol.2012.121.