GENERAL MEDICAL SCIENCES (ONCOLOGY)

JOHN J. PINK, PhD Assistant Professor General Medical Sciences (Oncology) Director of the Translational Research Core Facility Case Comprehensive Cancer Center Phone: 216/368-5420 Fax: 216/368-8919 email: jrp16@case.edu

Research Interests

β-lapachone

Selected Publications

Bey EA, Wuerzberger-Davis SM, Pink JJ, Yang CR, Araki S, Reinicke KE, Bentle MS, Dong Y, Cataldo E, Criswell TL, Wagner MW, Li L, Gao J, Boothman DA. Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses. J Cell Physiol 209:604-610, 2006.

Ai H, Pink JJ, Shuai X, Boothman DA, Gao J. Interactions between self-assembled polyelectrolyte shells and tumor cells. J Biomed Mater Res A 73:303-312, 2005.

Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA. Development of {beta}-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clin Cancer Res 11:3055-3064, 2005.

Nasongkla N, Shuai X, Ai H, Weinberg BD, Pink J, Boothman DA, Gao J. cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem Int Ed Engl 43:6323-6327, 2004.

Tagliarino C, Pink JJ, Reinicke KE, Simmers SM, Wuerzberger-Davis SM, Boothman DA. Calpain activation in beta-lapachone-mediated apoptosis. Cancer Biol Ther 2:141-152, 2003.

Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA. Beta-lapachone-induced apoptosis in human prostate cancer cells: involvement of nqo1/xip3. Exp Cell Res 267:95-106, 2001.