General Medical Sciences (Oncology)

Dr. Guda

KISHORE GUDA, DVM, PhD

Assistant Professor
General Medical Sciences (Oncology)

Phone: 216.368.5665
Fax: 216.368.8928
email: gkishore@yahoo.com


Research Interests

  • Understanding the molecular basis of aberrant glycosylation and its role in colon cancer development
  • Identifying the genetic causes underlying Familial Barrett's esophagus (FBE) and esophageal adenocarcinomas
  • Development of RNA-based (coding/non-coding) biomarkers for assessing cancer risk in Barrett's esophagus

Recent Publications

Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao H, Xu Y, Willis J, Sedwick D, Markowitz S, Ewing R and Wang Z. DNMT1 stability is regulated by proteins coordinating de-ubiquitination and acetylation-driven ubiquitination. Sci Signal. 2010 Nov 2;3(146):ra80, 2010. PMC journal-in process

Tomsic J*, Guda K*, Liyanarachchi S, Hampel H, Natale L, Markowitz SD, Tanner SM, de la Chapelle A. Allele-specific expression of TGFBR1 in colon cancer patients. Carcinogenesis. 2010 Oct;31(10):1800-4. 2010(*equal contribution).PMCID: PMC2950937

Gray-McGuire C*, Guda K*, Adrianto I, Lin CP, Natale L, Potter JD, Newcomb P, Poole EM, Ulrich CM, Lindor N, Goode EL, Fridley BL, Jenkins R, Le Marchand L, Casey G, Haile R, Hopper J, Jenkins M, Young J, Buchanan D, Gallinger S, Adams M, Lewis S, Willis J, Elston R, Markowitz SD, Wiesner GL.Confirmation of Linkage to and Localization of Familial Colon Cancer Risk Haplotype on Chromosome 9q22. Cancer Res 70(13):5409-18, 2010. (*equal contribution).PMCID: PMC2896448

Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei l, Yang Z,Zheng W, Dawson D, Willis J, Markowitz SD, Satake M, and Wang Z. Phospho-paxillin is an oncogenic in vivo target of the tumor suppressor receptor protein tyrosine phosphatase T. ProcNatlAcadSci U S A107(6):2592-2597,2010. PMCID: PMC2823898

Guda K, Moinova H, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lewis S, Willson JKV, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-SloanJ, Velculescu VE, Kinzler KE, Vogelstein B, Willis J, Gerken TA and Markowitz SD.Inactivating germline and somatic mutations in polypeptide N-acetyl galactosaminyl transferase-12 in human colon cancers.ProcNatlAcadSci U S A106:12921-12925,2009.PMCID: PMC2722285

Guda K, NataleL, LutterbaughJ, Wiesner GL, Lewis S, Tanner S, Tomsic J, Valle L, de la chapelle A, ElstonRC, Willis J, and MarkowitzSD. Infrequent Detection of Germline Allele-Specific Expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients.Cancer Res 69(12): 4959-61,2009. PMCID: PMC2739986

Guo C, Sah FJ, Beard L, Willson JKV, Markowitz SD and Guda K. The non-coding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47(11):939-946, 2008.PMCID: PMC2739997