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Primary Faculty

Kishore Guda, DVM, PhD

Kishore Guda, DVM, PhD

Assistant Professor, General Medical Sciences (Oncology) 216.368.5665 (o) 216.368.8928 (f)

Research Interests

  • Understanding the molecular basis of aberrant glycosylation and its role in colon cancer development
  • Identifying the genetic causes underlying Familial Barrett's esophagus (FBE) and esophageal adenocarcinomas
  • Development of RNA-based (coding/non-coding) biomarkers for assessing cancer risk in Barrett's esophagus

Chak A, Chen Y, Vengoechea J, Canto M, Elston R, Falk G, Grady WM, Guda K, Kinnard M, Markowitz SD, Mittal S, Prasad G, Shaheen N, Willis J, and Barnholtz-Sloan J. Variation in Age at Cancer Diagnosis in Familial versus Non-Familial Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):376-83. PMCID: PMC3275661

Leidner RS, Ravi L, Leahy P, Chen Y, Bednarchik B, Streppel M, Canto M, Wang J, Maitra A, Willis J, Markowitz SD, Barnholtz-Sloan J, Adams M, Chak A, and Guda K. The microRNAs, miR-31 and miR-375 as candidate markers in Barrett's esophageal carcinogenesis. Genes Chromosomes Cancer. 2012 May;51(5):473-9. PMCID: PMC3547654

Nickel G, Barnholtz-Sloan J, Gould MP, McMahon S, Cohen A, Adams MD, Guda K, Cohen M,Sloan AE, and LaFramboise T. Characterizing Mutational Heterogeneity in a Glioblastoma Patient with Double Recurrence. PLoS One. 2012;7(4):e35262. PMCID: PMC3335059

Yu X, Guda K, Willis J, Veigl M, Wang Z, Markowitz SD, Adams MD, and Sun S. How do alignment programs perform on sequencing data with varying qualities and from repetitive regions? BioData Min. 2012 Jun 18;5(1):6. PMCID: PMC3414812

Balasubramanian D, Akhtar-Zaidi B, Song L, Beard L, Myeroff L, Guda K, Lutterbaugh J, Willis J, Crawford GE, Markowitz SD, and Scacheri PC. H3K4me3 equally protects from DNA methylation at both CpG-island and non-CpG island start sites in colon cancer. Genome Med. 2012 May 28;4(5):47. PMCID: PMC3506913

Adams MD, Veigl ML, Wang Z, Molyneux N, Sun S, Guda K, Yu X, Markowitz SD, and Willis JW. Global Mutational Profiling of Formalin Fixed Human Colon Cancers from a Pathology Archive. Modern Pathology. 2012 Dec;25(12):1599-608. PMC journal-inporcess

Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao H, Xu Y, Willis J, Sedwick D, Markowitz S, Ewing R and Wang Z. DNMT1 stability is regulated by proteins coordinating de-ubiquitination and acetylation-driven ubiquitination. Sci Signal. 2010 Nov 2;3(146):ra80, 2010. PMC journal-in process

Tomsic J*, Guda K*, Liyanarachchi S, Hampel H, Natale L, Markowitz SD, Tanner SM, de la Chapelle A. Allele-specific expression of TGFBR1 in colon cancer patients. Carcinogenesis. 2010 Oct;31(10):1800-4. 2010(*equal contribution).PMCID: PMC2950937

Gray-McGuire C*, Guda K*, Adrianto I, Lin CP, Natale L, Potter JD, Newcomb P, Poole EM, Ulrich CM, Lindor N, Goode EL, Fridley BL, Jenkins R, Le Marchand L, Casey G, Haile R, Hopper J, Jenkins M, Young J, Buchanan D, Gallinger S, Adams M, Lewis S, Willis J, Elston R, Markowitz SD, Wiesner GL. Confirmation of Linkage to and Localization of Familial Colon Cancer Risk Haplotype on Chromosome 9q22. Cancer Res 70(13):5409-18, 2010. (*equal contribution).PMCID: PMC2896448

Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei l, Yang Z,Zheng W, Dawson D, Willis J, Markowitz SD, Satake M, and Wang Z. Phospho-paxillin is an oncogenic in vivo target of the tumor suppressor receptor protein tyrosine phosphatase T. ProcNatlAcadSci U S A107(6):2592-2597,2010. PMCID: PMC2823898

Guda K, Moinova H, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lewis S, Willson JKV, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Velculescu VE, Kinzler KE, Vogelstein B, Willis J, Gerken TA and Markowitz SD. Inactivating germline and somatic mutations in polypeptide N-acetyl galactosaminyl transferase-12 in human colon cancers.ProcNatlAcadSci U S A106:12921-12925,2009.PMCID: PMC2722285

Guda K, Natale L, Lutterbaugh J, Wiesner GL, Lewis S, Tanner S, Tomsic J, Valle L, de la chapelle A, Elston RC, Willis J, and Markowitz SD. Infrequent Detection of Germline Allele-Specific Expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients. Cancer Res 69(12): 4959-61,2009. PMCID: PMC2739986

Guo C, Sah FJ, Beard L, Willson JKV, Markowitz SD and Guda K. The non-coding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47(11):939-946, 2008.PMCID: PMC2739997

Fink SP and Guda K: Application of next generation sequencing in RNA biomarker discovery in cancer research. Edited by Hani Choudhry and Wei Wu, Wellcome Trust Sanger Institute, UK. Springer Publishing (2013, in press)